Indonesia's biodiversity holds great potential for drug development, including through the use of traditional medicinal plants such as tapak liman (Elephantopus scaber L.), suruhan (Peperomia pellucida L. Kunth), and temu ireng (Curcuma aeruginosa Roxb.). These plants have been used in traditional medicine and are known to contain bioactive compounds with potential anticancer properties. Tapak liman contains compounds capable of inducing apoptosis in cancer cells. Suruhan is known to have cytotoxic and immunomodulatory effects, while temu ireng contains compounds with antioxidant and anticancer activity. This study aims to identify and quantify the bioactive compounds in these three plants using Gas Chromatography-Mass Spectrometry (GC-MS) and to explore their therapeutic potential in cancer treatment. The results of GC-MS analysis successfully identified six main compounds that have potential as anticancer agents, namely Phytol, Caryophyllene, Apiol, Germacrone, Germacrene B, and one additional compound. Temu ireng contains Germacrone, Germacrene B, and Caryophyllene, while suruhan contains Caryophyllene, Apiol, and Phytol. Meanwhile, tapak liman shows the presence of bioactive compounds that support cytotoxic activity. The focus of this study is on the interaction of bioactive compounds with the Bcl-2 protein, which plays a role in inhibiting apoptosis in cancer cells. Additionally, molecular analysis revealed that Germacrone, Germacrene B, Caryophyllene, and Apiol can also bind to the p53 protein, known as a guardian of the genome and a trigger for apoptosis. These findings suggest that the three plants have high potential as natural sources of anticancer agents. Further in vitro and in vivo studies are recommended to test the biological efficacy of these compounds in the context of cancer therapy, thereby bridging traditional knowledge with modern scientific approaches in the development of natural-based medications.

The lack of integration between science and local wisdom in science education remains a challenge in developing students' critical thinking skills and cultural literacy. This study aims to analyze the effect of STEM-based science learning integrated with ethnoscience on critical thinking skills and cultural literacy of elementary school students. This research is a quantitative study with a quasi-experimental method using a nonequivalent control group design. Samples were selected purposively and consisted of experimental and control groups. The instruments used include a critical thinking skills test and a cultural literacy questionnaire. Data analysis was performed using a paired sample t-test. The results showed a significant difference in posttest scores between the experimental and control groups, with a significance value of 0.000 <0.005. The average difference was 19.78 points for critical thinking skills (81.14 - 61.36) and 16.86 points for cultural literacy (82.50 - 65.64). This finding suggests that integrating STEM-based science learning with ethnoscience can significantly enhance students' critical thinking skills and cultural literacy. The novelty of this study lies in the learning approach that combines the STEM framework with local ethnoscience values, providing an innovative alternative for shaping students who think reflectively while developing cultural awareness from an early age.

This study aims to determine the effect of compensation and work discipline on teacher loyalty in the Samarinda City District. The research method used is quantitative, using observational and survey approaches. The sample comprised 93 respondents, consisting of teachers in the Samarinda City District. Data were collected via a questionnaire distributed through Google Forms using a Likert scale. The data were analyzed using SPSS for validity and reliability testing, classical assumption testing, multiple linear regression, t-test, and F-test as model fit tests (Goodness of Fit), as well as the coefficient of determination (Adjusted R²). The results indicate that both compensation and work discipline have a positive effect on teacher loyalty. Improvements in fair compensation provision and consistent enforcement of work discipline can enhance teachers’ loyalty to their employing institution. The model fit test (Goodness of Fit) shows that the regression model used in this study meets the criteria for adequacy and significance, making it suitable for predicting teacher loyalty.

This study aims to determine the accountability and transparency in the management of Direct Cash Assistance (BLT) in Kota Raja Village, Tanjung Jabung Timur Regency. This study was conducted using a qualitative descriptive method. The types of data used are primary data and secondary data. The data collection techniques used were questionnaires and observations. The population in this study was The population in this study were 40 village government officials, namely the Village Head, Village Secretary, Planning Head, Finance Head, RT Head, Hamlet Head and BPD members consisting of the BPD Chair, BPD Deputy Chair, BPD Secretary, Several BLT Recipient Communities in Kotar Raja Village. The data analysis method used in this study is a quantitative descriptive method. The results of this study indicate that the management of Direct Cash Assistance (BLT) in Kotar Raja Village has implemented the principles of Accountability and Transparency.

Literary works are the identity of a nation, including Indonesian literary works. Indonesia, with its diverse culture, has created many literary works that are already global, and are born from regional writers and progressively become widespread in the world of literature. This article examines how the effects of Indonesian government’s literary development influence the quality and quantity of literary works. Through qualitative method, this paper analyzes that the government’s policy plays an important role because it contains plans that are arranged and realized by the experts for the important benefit of society. It may also improve the quality and quantity of literary works from authors’ and publishers’ sides. In conclusion, such policy should be pushed forward to build an awareness of the cultural forms and to preserve Indonesian culture to the international scope.

Kantor Imigrasi Kelas I TPI Jambi adalah lembaga pemerintah yang bertugas melayani masyarakat terkait masalah imigrasi, seperti pengajuan paspor, izin tinggal, dan pengawasan lalu lintas orang antar negara. Saat ini, pencatatan nomor surat keluar masih dicatat secara manual menggunakan buku agenda, yang sering menyebabkan duplikasi nomor surat, kesalahan pencatatan, dan keterlambatan dalam pengambilan data. Untuk mengatasi masalah ini, dirancang sebuah sistem informasi yang bekerja melalui situs web yang mengelola penomoran surat keluar secara otomatis dan terstruktur. Sistem ini menggunakan metode pengembangan prototipe dan alat pemodelan UML (Unified Modeling Language). Hasil dari desain ini adalah sistem informasi yang mampu mengelola penomoran surat keluar secara otomatis, terintegrasi, dan disimpan dalam database yang mudah dan cepat untuk diakses. Fitur utama dari sistem ini mencakup pembuatan format penomoran otomatis sesuai dengan jenis dan klasifikasi surat, penyimpanan arsip digital surat, pencarian data berdasarkan berbagai kriteria, dan manajemen pengguna. Dengan implementasi sistem ini, diharapkan proses administrasi korespondensi di Kantor Imigrasi Kelas I TPI Jambi menjadi lebih cepat, efisien, dan akurat.

Education has a strategic role as a means of character formation, the dissemination of national values, and the strengthening of national integration in a multicultural society. In the context of Indonesia, which is rich in ethnic, cultural, and religious diversity, education functions as a medium for the transformation of Pancasila values and nationalism. This article aims to analyze the role of education in strengthening the dynamics of national integration through the literature review method of various scientific articles in the field of Civic Education (PKn). This research reveals that education and teachers, parents, and the community contribute to internalizing the values of tolerance, diversity, and national awareness. Citizenship, participatory, and inclusive education is the key to the success of dynamic and sustainable national integration. This article also suggests the enforcement of character education and the modification of the curriculum based on Pancasila values to strengthen the unity of the nation.

This study examines the effect of institutional ownership and managerial ownership on the performance of companies in trade, services, and investment listed on the Indonesia Stock Exchange for the period 2021-2023. The analysis technique used is multiple linear regression analysis and the data collection technique used is purposive sampling. In the study, company performance was measured using Return on Assets (ROA). The results of the study indicate that the first and second hypotheses are rejected, namely institutional ownership does not have a significant effect on company performance, while managerial ownership has a significant negative effect on company performance.

This study aims to describe the lingual units used in the utilization activities of Mbah Tonjong River by the people of Kedung Glatik Hamlet, as well as to examine the relationship between language and local culture reflected in the use of these lingual units. The approach used is qualitative with the method of language ethnography, where data is collected through participatory observation, in-depth interviews, and documentation. The analysis was conducted using the Sapir-Whorf ethnolinguistic theory which emphasizes that language shapes people's perspective and socio-cultural reality. The results show that lingual units in activity expressions such as adus kali, jeguran, kungkum, as well as ritual terms such as nazar and munjung not only function as naming activities, but also reflect cultural values, belief systems, and meaning constructions that live in the community. Thus, language in this context becomes an important medium in maintaining cultural identity while representing the community's relationship with their natural and spiritual environment. This research contributes to the development of ethnolinguistic studies and the preservation of local languages and cultures.

The global expansion of ultra-processed meat products (e.g., sausages, nuggets) faces dual challenges: microbiological safety risks from conventional thermal processing and rising consumer demand for clean-label, nutritious options. High-Pressure Processing (HPP) emerges as a promising non-thermal technology to address these concerns by inactivating pathogens while preserving sensory and nutritional quality. However, its industrial adoption is hindered by significant energy efficiency and scalability constraints. This systematic literature review synthesizes recent research to critically analyze these barriers. Methodologically, we conducted a Systematic Literature Review (SLR) using databases such as Scopus, ScienceDirect, Web of Science, and PubMed, focusing on studies related to High-Pressure Processing (HPP) applications in ultra-processed meats. Our analysis reveals that HPP consumes 2.5–3.2 kWh/kg up to 26× more energy than thermal pasteurization primarily due to hydraulic system demands and adiabatic heat dissipation during batch cycling. Scalability limitations stem from batch-based processing (3–7 min/cycle), vessel size constraints (<500 L), and capital costs reaching $2.5 million per unit, resulting in only 18% adoption by large-scale manufacturers. Energy recovery inefficiencies and product matrix variations (e.g., lipid-protective effects in emulsified meats) further exacerbate these challenges. Emerging solutions include semi-continuous systems (35% throughput increase), pulsed HPP protocols (18% energy reduction), and solar-hybrid installations (40% emission cuts), though economic viability remains problematic. We conclude that while HPP offers unparalleled safety and quality benefits, its scalability and energy intensity require coordinated innovations in process engineering, renewable energy integration, and cooperative industry models to achieve sustainable implementation.