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 The Community Service Program (PKM) was implemented with the primary objective of improving the motivation and skills of Global International School high school students in managing independent business units established within the school environment. This activity was designed as a practice-based entrepreneurial development effort, especially for students directly involved in school business activities. The program was implemented through a series of training sessions covering entrepreneurial motivation, digital and conventional marketing strategies, and sales practice simulations. The motivation training aimed to build an independent and resilient mindset in facing business challenges, while the promotional strategy training emphasized the importance of branding, the use of social media, and effective communication with consumers. During the implementation process, students were encouraged to actively participate, be creative, and directly apply the material learned through simulations and group discussions. Evaluation results showed that this activity successfully increased the enthusiasm and confidence of students in running their own businesses. They also began to understand the basic concepts of branding, targeted promotional strategies, and the importance of building relationships with consumers. The enthusiasm of the participants was very high, especially during the promotional and direct sales practice. Overall, this PKM activity had a positive impact on students' mental and technical readiness to face the business world. This program also has the potential to be further developed as the basis for a practice-based entrepreneurship curriculum, as well as a medium for character building, creativity, and student independence at the secondary education level.

Character education plays a crucial role in shaping students who excel not only academically but also possess strong moral and social values. In this regard, the government, through the Ministry of Education and Culture, has launched the Strengthening Character Education (PPK) policy as a strategic step to create a generation of character. This study aims to explore how the PPK policy is implemented in elementary schools and analyze the factors that support and hinder its implementation. The method used in this study is descriptive qualitative, with data collection techniques through observation, in-depth interviews with principals and teachers, and documentation studies. The results show that the PPK policy has been implemented through the integration of character values into the learning process, extracurricular activities, and school culture. Several factors supporting the success of this implementation include the principal's visionary leadership, active teacher involvement, and support from parents and the community. However, several challenges remain, such as a lack of supporting facilities, uneven teacher training, and difficulties in consistently integrating character values across all subjects. Overall, the PPK policy in elementary schools has had a positive impact on student character development, although further strengthening is still needed in terms of training, evaluation, and collaboration between all stakeholders. Supporting factors for successful implementation include the visionary leadership of the principal, active teacher involvement, and support from parents and the community. However, several obstacles remain, such as a lack of supporting facilities, uneven teacher training, and difficulties in integrating character values consistently across all subjects. Overall, the PPK policy in elementary schools has had a positive impact on student character development, although further strengthening is needed in terms of training, evaluation, and synergy between stakeholders.

This study aims to determine the influence of students' learning habits on learning outcomes in Mathematics subjects in grade IV students of SD Negeri 200307 Padang Sidempuan. The background of this research is the importance of the role of structured and consistent learning habits in supporting the achievement of optimal learning outcomes, especially in logical and analytical subjects such as Mathematics. This study uses a quantitative approach with a descriptive survey method to obtain an objective picture of the relationship between variables. The population in this study is all grade IV students, and the sampling technique was carried out by purposive sampling, with a sample of 26 students selected based on certain criteria. Data collection was carried out through an instrument in the form of a Likert scale questionnaire as many as 60 previously validated statements, in order to measure the level of students' learning habits. Meanwhile, student learning outcome data is obtained from their academic scores in Mathematics subjects. Data analysis was carried out using a parametric statistical test in the form of a t-test to test the proposed hypothesis. The test results showed that the tcount value of 1.909 was greater than the ttable of 1.695, which means that there was a significant influence between students' learning habits on Mathematics learning outcomes. Thus, it can be concluded that good study habits make a real contribution to improving student learning outcomes. These findings are an important basis for teachers and schools to continue to encourage and foster positive learning habits among students. The implications of this study also recommend the need to strengthen independent learning strategies and effective study time management as part of the learning program in elementary schools.  

This study aims to determine the effect of the use of Word Search Puzzle media on English vocabulary mastery in grade IV students at MIS Nurul Hidayah Medan for the 2024/2025 academic year. Vocabulary mastery is an important aspect of learning English, as it is the basis for language skills such as reading, writing, speaking, and listening. In an effort to improve students' vocabulary skills, innovative, interesting, and interactive learning media is needed. One of the media used in this study is Word Search Puzzle, which is a game to find words in a letter box that can stimulate students' interest in learning and make it easier for them to recognize and remember new vocabulary. This study uses an experimental method with a One-Group Pretest-Posttest Design. The sample in this study is all fourth grade students of MIS Nurul Hidayah Medan, which totals 19 people. The research instrument was in the form of a multiple-choice test of 20 questions that measured students' English vocabulary mastery before and after treatment. The data was analyzed using the Paired Sample T-Test statistical test with the help of SPSS software. The results of the study showed a significant increase in the average score of students, from 55.26 in the pretest to 82.36 in the posttest. The hypothesis test showed a significance value of 0.000 (sig < 0.05), which means that Ho was rejected and Ha was accepted. Thus, it can be concluded that the use of Word Search Puzzle media has a significant influence on improving the English vocabulary mastery of grade IV students. These findings indicate that game-based learning media can be an effective strategy in English learning at the elementary school level.

This study aims to deeply uncover the learning management tactics implemented by teachers in an effort to improve student learning satisfaction at the elementary school level. Learning satisfaction is an important indicator of the success of the educational process because it is closely related to motivation, active involvement, and student academic outcomes. This study was conducted at SDN 3 Kaliombo, Jepara, using a descriptive qualitative approach. Data collection techniques used included observation of learning activities, interviews with teachers, and documentation in the form of learning notes and class activity plans. The results show that teachers use a variety of innovative and adaptive learning strategies, including a scientific approach, collaborative learning, the use of interactive learning media, and conducive and student-friendly classroom management. The role of teachers is not only as a deliverer of material, but also as a facilitator, motivator, and guide who creates a learning atmosphere that is fun, communicative, and meaningful for students. The tactics used by teachers also consider student characteristics, including their learning styles, levels of understanding, and emotional needs. Active student involvement in the learning process is key to improving their learning satisfaction. This study emphasizes the importance of teachers' role in designing and implementing appropriate learning strategies to support the achievement of educational goals. The implications of these findings suggest that ongoing training for teachers is essential to strengthen their professional capacity in implementing more creative, responsive, and student-oriented learning approaches.

This study aims to evaluate the relationship between affiliate marketing and celebrity endorse on purchasing decisions at TikTok Shop among Generation Z in Boyolali. This research is motivated by the increasing use of TikTok as a popular online shopping medium among Gen Z, as well as the development of digital marketing strategies through affiliates and public figures. The population in this study includes Gen Z in Boyolali who have made purchases at TikTok Shop. A sample of 100 respondents was obtained through the Slovin formula calculation. This study uses a quantitative method, with an online questionnaire distributed through Google Forms. Data analysis was conducted using the SmartPLS 3.0 application to test the relationship between variables. The results of this study indicate a positive and significant relationship between affiliate marketing and celebrity endorse on purchasing decisions. This finding provides a theoretical contribution to strengthening the Theory of Planned Behavior in the context of digital marketing, as well as suggesting strategies for business actors in developing more effective promotions at TikTok Shop.

Background : Self-management of hyperglycemia refers to a series of efforts carried out independently by individuals suffering from diabetes or hyperglycemia to manage and control their health condition. These efforts include regulating diet, physical activity, medication adherence, blood glucose monitoring, and preventive measures to avoid complications. Such complications may include vascular issues like heart disease and stroke, as well as neuropathic problems such as nerve damage. Proper implementation of self-management practices can help stabilize blood glucose levels and significantly improve the overall quality of life for patients. General Objective : This study aims to examine the effect of self-management on the risk of complications in patients with hyperglycemia in the working area of the Kandangan Health Center, Kediri Regency.Research Method : This research utilized a quasi-experimental design with a one-group pretest-posttest approach accompanied by a control group. The sampling technique applied was probability sampling using simple random sampling, involving a total of 45 respondents. The research instruments included the Diabetes Self-Management Questionnaire (DSMQ) and observation sheets to assess the risk of complications. The study population consisted of all hyperglycemic patients residing in Putuk Hamlet, Banaran Village, Kandangan District, Kediri Regency. Data processing was carried out through editing, coding, and tabulation, followed by data analysis using the Wilcoxon statistical test. Results : The Wilcoxon test results showed a significance value of p = 0.000 (p < 0.05), indicating a significant effect of self-management on reducing the risk of complications in hyperglycemic patients. Therefore, the alternative hypothesis (H1) was accepted. Recommendation : The implementation of self-management in hyperglycemic patients is essential to prevent long-term complications. Thus, healthcare professionals, especially nurses, are encouraged to provide continuous education regarding diabetes self-management. This will enable patients to manage their health conditions independently and reduce the risk of further complications.

Improving the quality of children's health is one of the main priorities in achieving the Sustainable Development Goals (SDGs), particularly in addressing stunting prevention in Indonesia. Stunting remains a serious challenge in public health development, especially among young children who suffer from chronic malnutrition. To tackle this issue, effective nutritional education is essential, especially for young mothers who play a central role in caregiving and determining their children's dietary intake. In line with the shift in information consumption patterns from conventional media to digital platforms, social media is becoming increasingly significant as a channel for health communication and education. One emerging phenomenon in this context is the rise of public figures from the medical profession actively sharing health-related content online, commonly referred to as “doctor influencers.” This study aims to analyze the digital communication strategies employed by doctor influencers, using the Instagram account @mizaafrizal, owned by Dr. Miza Afrizal, as a case study, focusing on how he educates young mothers about child nutrition. This research adopts a descriptive qualitative approach, utilizing data collection techniques such as content observation, in-depth interviews, and literature review on digital communication and health promotion. The findings indicate that Dr. Miza employs a persuasive and interactive communication strategy through the use of humanistic language, visually engaging content, and scientifically supported information in each post. He also leverages Instagram features like reels, stories, and the comment section to establish two-way communication with his followers. Dr. Miza’s credibility as a pediatrician enhances the reception of his messages. His approachable, clear, and educational style of delivery successfully captures the attention of young mothers and increases their understanding of the importance of nutrition in early childhood development. These findings highlight the influential role of doctor influencers as change agents in raising public awareness about child nutrition. Moreover, they contribute positively to digital-based health promotion efforts in Indonesia, showing the potential of social media as a powerful platform to support national health initiatives.  

This study aims to analyze the influence of the school environment and family environment on the learning interest of 8th-grade students at SMPN 1 Pangkalanbaru. Learning interest plays a crucial role in shaping students' academic performance and motivation. A conducive environment, both at school and at home, is believed to significantly contribute to the development of students' enthusiasm for learning. This research employed a quantitative method with a descriptive approach and utilized multiple regression analysis techniques to test the hypotheses. Data were collected through structured questionnaires distributed to 149 students from the 8th grade. The findings indicate that both the school and family environments have a positive and significant impact on students' interest in learning. The school environment's influence was confirmed by a simple linear regression coefficient of 0.229, while the family environment showed a stronger effect with a regression coefficient of 0.355. When tested simultaneously, both variables contributed to a combined effect on students' learning interest, with an R² value of 0.263, indicating that 26.3% of the variance in learning interest can be explained by these two factors. The remaining 73.7% is influenced by other variables not examined in this study, such as peer influence, personal motivation, teaching methods, and access to learning resources. These results underscore the importance of providing a supportive and engaging environment at both school and home to enhance students’ academic motivation. It is recommended that schools foster a positive atmosphere through effective teacher-student interactions, while families are encouraged to actively support their children's learning routines and emotional well-being. Further research is needed to explore other contributing factors and to develop holistic strategies that promote learning interest among junior high school students.

The Batanghari River is a vital water source in Jambi Province, used by the community for various purposes, including domestic, agricultural, and fisheries needs. However, with increasing human activities, such as the discharge of household waste, industrial waste, and agricultural waste, the river's water quality is at risk of microbiological contamination that can endanger public health and the environment. This study aims to identify the presence of bacteria in the Batanghari River water, in order to assess the potential for biological contamination that can negatively impact public health and the surrounding ecosystem. The method used in this study included taking water samples from several locations along the river. After sampling, bacterial isolation and identification were carried out using Nutrient Agar (NA) media using the pour method. The results of the isolation process showed the growth of bacterial colonies that varied in shape, size, and color, indicating microbiological contamination, especially by heterotrophic bacteria. These findings indicate that the Batanghari River water contains microorganisms that reflect the potential for microbiological contamination. Therefore, this study emphasizes the importance of regular water quality monitoring and the need for sustainable management measures to maintain the health of the ecosystem and surrounding community. With routine monitoring, it is hoped that potential contamination that could be harmful to health can be detected early. Furthermore, the results of this study are expected to form the basis for better policy-making in water resource management and increase public awareness of the importance of maintaining water quality for sustainable life and environmental health. This study provides a preliminary overview of the microbiological condition of the Batanghari River water and emphasizes the need for greater attention in water resource management to prevent negative impacts on health and the environment.

The Catholic Spiritual Revival (KRK) was a large-scale spiritual event organized by the Catholic Charismatic Renewal Body of the Diocese of Malang, aimed at revitalizing the faith and service spirit among Catholics in the post-COVID-19 period. Held on November 2, 2024, at the New Hongkong Ballroom Araya Malang, the event brought together participants from 18 different prayer communities, with a target audience of 1,200 people. To support the success of this initiative, the Publication Division—comprised of a community service team from the Faculty of Economics and Business at Ma Chung University—was tasked with planning and implementing an effective promotional strategy. The team focused on a cost-efficient and high-impact digital publicity approach, which included creating digital content for social media platforms, hosting webinars, and developing a targeted online promotion campaign. The implementation of this digital strategy proved to be highly successful. Ticket sales surpassed expectations, with over 900 tickets sold two weeks before the event and actual attendance exceeding 1,200 people. These outcomes demonstrated the strong appeal and reach of the event’s publicity efforts. In addition to increasing awareness, the visual and content strategies helped build community engagement and enthusiasm ahead of the event. This report presents a comprehensive review of the planning and execution phases of the publication strategy, highlighting key challenges, creative processes, and collaborative efforts. It also offers practical recommendations for future events of similar scale, especially in leveraging digital media to enhance participation and outreach. The success of KRK 2024 underscores the value of strategic communication and visual branding in religious and community-based events.

The Catholic Spiritual Revival (KRK) was a large-scale spiritual event organized by the Catholic Charismatic Renewal Body of the Diocese of Malang, aimed at revitalizing the faith and service spirit among Catholics in the post-COVID-19 period. Held on November 2, 2024, at the New Hongkong Ballroom Araya Malang, the event brought together participants from 18 different prayer communities, with a target audience of 1,200 people. To support the success of this initiative, the Publication Division—comprised of a community service team from the Faculty of Economics and Business at Ma Chung University—was tasked with planning and implementing an effective promotional strategy. The team focused on a cost-efficient and high-impact digital publicity approach, which included creating digital content for social media platforms, hosting webinars, and developing a targeted online promotion campaign. The implementation of this digital strategy proved to be highly successful. Ticket sales surpassed expectations, with over 900 tickets sold two weeks before the event and actual attendance exceeding 1,200 people. These outcomes demonstrated the strong appeal and reach of the event’s publicity efforts. In addition to increasing awareness, the visual and content strategies helped build community engagement and enthusiasm ahead of the event. This report presents a comprehensive review of the planning and execution phases of the publication strategy, highlighting key challenges, creative processes, and collaborative efforts. It also offers practical recommendations for future events of similar scale, especially in leveraging digital media to enhance participation and outreach. The success of KRK 2024 underscores the value of strategic communication and visual branding in religious and community-based events.

This community service activity aimed to provide guidance and capacity building for micro, small, and medium enterprises (MSMEs), specifically chicken satay vendors operating in the parking area of Taman Anggrek Mall, Jakarta. These culinary MSMEs have strong potential due to their strategic location, which attracts high foot traffic. However, many of these business owners still face challenges in managing and developing their businesses, particularly in terms of managerial skills, financial record-keeping, and marketing strategies. Therefore, this program was designed to enhance their business competitiveness by improving their managerial abilities, introducing simple bookkeeping practices, and promoting the use of digital platforms for marketing. The implementation of the program began with an initial observation to identify the specific needs and challenges faced by the MSME actors. This was followed by interactive training sessions covering topics such as the importance of basic financial management, how to create simple financial reports, and effective yet low-cost digital marketing strategies. In addition to the training, the team also provided intensive one-on-one mentoring to ensure that participants could apply the materials in their daily business operations. The outcomes of the program showed positive developments. The MSME participants began to recognize the importance of keeping financial records as a basis for making business decisions. They were also able to identify internal management issues such as inventory control and business planning. In terms of marketing, most of the vendors have started using digital platforms like WhatsApp Business and Instagram to promote their products, allowing them to reach a wider audience.It is expected that this community engagement initiative will continue and serve as a model for similar training programs targeting culinary MSMEs in other busy urban areas. Such efforts are essential to developing more independent, professional, and competitive MSMEs in the digital era.

Motor development in infants is a crucial process that occurs gradually and follows the principles of age-appropriate development. Each fundamental motor stage—such as tummy time, rolling over, sitting, crawling, standing, and walking—must be passed through sequentially to ensure optimal motor concept development. Skipping or insufficient stimulation of these stages may lead to difficulties in understanding functional body movements. One of the main causes of delayed motor development includes a lack of motor stimulation time, overly restrictive parental supervision, and low levels of motivation and stimulation provided to the child. Tummy time, or placing the baby in a prone position while awake, is a proven effective form of motor stimulation that supports the development of the baby’s neck, back, and arm muscles. This activity also assists infants in reaching subsequent developmental milestones such as rolling over and crawling. This Community Service Program (PkM) was conducted at the Physioroom Clinic and was attended by 15 mothers with infants aged 3 to 6 months. The objective of the program was to enhance mothers’ knowledge regarding the importance of tummy time in supporting infant motor development. The program's implementation included educational sessions, tummy time practice demonstrations, group discussions, and interactive Q&A sessions. To measure the increase in participant knowledge, a pre-test and post-test were administered before and after the activity.The results of this PkM activity showed an increase in the average knowledge score from 6.4 in the pre-test to 8.6 in the post-test. This improvement demonstrates the program’s effectiveness in educating mothers about the benefits of tummy time for infant motor development. It is hoped that the mothers will consistently apply this stimulation at home to optimally support their children's growth and development.

Micro, Small, and Medium Enterprises (UMKM) play a crucial role in driving local economic growth, particularly in the food and beverage sector. However, many UMKM, such as Cipta Rasa Mulya, still face significant challenges in adopting modern marketing approaches to expand their reach and enhance their competitiveness. This community service program focuses on addressing two major issues: the lack of effective digital marketing utilization and the weak brand identity—especially in packaging design—of the dairy products produced by the UMKM. Through a structured and intensive training program, this initiative aims to provide UMKM actors with comprehensive knowledge and practical skills in rebranding and digital marketing. The activities include workshops on digital branding strategies, hands-on mentoring sessions for social media management, product photography, and brand storytelling, as well as ongoing evaluations to monitor progress and implementation. The expected outcomes of this program are multifaceted, including improved brand awareness among consumers, more attractive and informative packaging, increased product variety, and broader market reach through the use of digital platforms such as Instagram, TikTok, and e-commerce channels. By enhancing the UMKM’s ability to present their products professionally and utilize social media for marketing purposes, this program supports the development of more competitive and sustainable business practices. In the long term, it is anticipated that such interventions will not only increase the visibility of Cipta Rasa Mulya’s dairy products but also strengthen their position in both local and national markets. Ultimately, this initiative highlights the importance of combining technological adaptation with creative branding in empowering UMKM and stimulating inclusive economic growth.

SMK Negeri 1 Bawen is located in Bawen District, Semarang Regency, and has six Expertise Programs, namely Agricultural Product Agribusiness, Plant Production Agribusiness, Livestock Production Agribusiness, Agricultural Mechanization, Food, and Tourism. Graduates of SMK Negeri 1 Bawen have spread across various regions of the archipelago and work in various sectors of the business and industrial world. This proves that SMK Negeri 1 Bawen is able to produce graduates with qualified vocational skills. This community service activity aims to provide additional knowledge to the students of SMK Negeri 1 Bawen about the importance of processing banana peels into value-added products, such as banana peel flour and cookies made from banana peels. In addition, this activity also provides information about food safety and the content of bioactive compounds in banana peels, which can be used to support health and innovation of food products. The community service program with the title "Banana Peel Processing for Students of SMK Negeri 1 Bawen Semarang Regency" is designed to increase students' insight and creativity. With this activity, it is hoped that students will not only have technical skills, but also understand aspects of sustainability, product innovation, and the use of food waste based on local wisdom. This knowledge is expected to be a valuable provision for students when entering the world of work and when contributing to the surrounding community. The results of this activity show that SMK Negeri 1 Bawen students already have a good foundation of vocational skills. Nevertheless, they still require strengthening thematic insights, especially in terms of innovative product processing, waste management, and sustainability concepts.

This community service initiative was designed to improve the digital competence of the PKK (Family Welfare Empowerment) group in Simogirang Village, Prambon Sub-district, Sidoarjo Regency, with a focus on utilizing social media and internet-based tools to optimize the branding of local UMKM (Micro, Small, and Medium Enterprises) products. The program adopted an andragogical approach that emphasizes adult learning, integrating methods such as direct instruction, hands-on demonstrations, and guided simulations. Key digital platforms including Instagram, WhatsApp Business, Google Docs, and Google Drive were introduced and practiced during the sessions. A total of 40 participants took part in the training. Evaluation results indicated that 85% of the participants successfully mastered the digital branding techniques, achieving over 85% accuracy in practical exercises. This achievement was evidenced by the creation of functioning business accounts, digital catalogs, and various forms of promotional content tailored to their UMKM products. The implementation of these digital tools led to a noticeable increase in consumer engagement and demand for village products, particularly cassava chips and handmade crafts, signifying a positive impact on local economic activities. To ensure long-term benefits and continuous improvement, a dedicated WhatsApp group was established as a support forum for participants to share experiences, ask questions, and receive guidance post-training. Despite its success, the initiative faced challenges related to unstable internet infrastructure in certain areas of the village, highlighting the need for improved digital access. In conclusion, this initiative not only enhanced the digital literacy of rural women but also contributed to their economic empowerment, aligning with broader efforts to promote smart village development and digital transformation in rural Indonesia.

The transformation of education in the digital era demands inclusive, creative, and relevant learning innovations in line with technological developments. To address these challenges, utilizing digital platforms is a strategic step in driving the digitalization of education. One innovative solution that is becoming widely used is no-code platforms like Thunkable, which enable users, including students, to create applications without having to master complex programming. This article reviews the results of a community service activity conducted at SMA Negeri 2 Sorong City, focusing on improving digital literacy and strengthening 21st-century skills through training in creating educational applications based on Thunkable. This activity utilized experiential learning and project-based learning approaches, implemented through hands-on training, interactive demonstrations, independent practice, and participatory evaluation. This training not only targeted students as the primary participants but also involved teachers as facilitators who accompanied the learning process and encouraged the application of training outcomes in classroom activities. Evaluation results showed a significant increase in student enthusiasm, critical thinking skills, and creativity in designing simple educational applications tailored to learning needs and local contexts. Despite obstacles such as limited digital devices and uneven internet access, this activity still succeeded in creating an innovative and transformative learning space. Furthermore, this training makes a significant contribution to supporting the implementation of the Pancasila Student Profile, particularly in the areas of digital literacy, independence, mutual cooperation, and creativity. It also serves as an effective means to instill the value of digital responsibility and foster a learning culture that is adaptive to technological change. The success of this program demonstrates that a simple yet applicable technology-based approach like Thunkable can be replicated in other schools, particularly in the 3T (disadvantaged, frontier, and outermost) regions, with the support of structured and collaborative training.

Inflammation is the body's natural biological response to tissue injury, infection, or other harmful stimuli. Inflammatory processes play an important role in maintaining the body's homeostasis, but excessive or chronic inflammation can trigger various degenerative diseases, including arthritis, cancer, and cardiovascular disorders. One of the main mediators of inflammation is the enzyme cyclooxygenase-2 (COX-2), which is in charge of converting arachidonic acid into pro-inflammatory prostaglandins. Inhibition of COX-2 activity is an important strategy in controlling inflammation. Selective COX-2 inhibitors (Coxibs) have been developed to reduce the gastrointestinal side effects commonly caused by conventional nonsteroidal anti-inflammatory drugs (OAINS). However, the use of Coxibs still poses a significant cardiovascular risk, so the search for alternatives from natural ingredients continues. Flavonoid compounds, which are abundant in fruits, vegetables, teas, and spices, show great potential as natural COX-2 inhibitors. Flavonoids have a polyphenol structure that allows for strong interactions with COX-2 active sites through hydrogen bonding and hydrophobic forces. This study is a literature review that examines the potential of flavonoids from natural ingredients as COX-2 inhibitors based on an in silico approach. This method was carried out through a literature search on the Google Scholar database using the keywords "Flavonoid", "COX-2", "In Silico", "Molecular Docking", and "Anti-inflammatory". The results of the analysis of ten articles showed that compounds such as myricetin, quercetin, rutin, catechin, and epicatechin-3-O-gallate have a high bonding affinity with COX-2, even exceeding in some cases standard drugs such as diclofenac and dexamethasone. Low bond energy values (ΔG) and optimal amount of hydrogen bonds support this potential. The findings indicate that flavonoids from natural ingredients can be developed into candidates for selective anti-inflammatory drugs COX-2 that are safer and more effective than existing synthetic therapies.

Mindfulness or mindfulness is increasingly promoted in Western countries as a psychological strategy to improve emotional regulation and self-control, including in the context of reducing aggressive behavior, especially when individuals experience a state of exhaustion or ego depletion. However, the effectiveness of this approach in the context of non-Western cultures has not been widely explored. This study aims to replicate the study of Yusainy and Lawrence (2015) in Indonesia to test whether the induction of mindfulness can also moderate aggression after ego depletion in different cultural environments. This experimental research involved 119 Indonesian students as participants. Using a laboratory design, participants were divided into conditions of induction of mindfulness and control, and were asked to complete a reaction time competition task that had been modified to measure aggression (through the intensity of the sound explosions released against a fictitious opponent). In addition, an additional measure of the frequency of delayed maximum burst release was used to evaluate more subtle forms of aggression, particularly in female participants. The results showed that mindfulness significantly moderated the relationship between ego-depletion and aggression conditions, especially in low- to moderate-provoking situations. Mindfulness induction also showed improved self-control performance after participants completed aggression tasks. Another important finding is that the positive effect of mindfulness on aggression reduction is most visible in more subtle indicators of aggression, especially in groups of women who experience ego thinning. In conclusion, the results of this study reinforce the cross-cultural validity of the Western mindfulness approach and emphasize the importance of using more sensitive aggression measures, especially in assessing the effects of psychological interventions on female populations in non-Western cultures such as Indonesia.