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Chronic Kidney Disease (CKD) is a global health problem with a continuously increasing prevalence and mortality rate. Global data indicates that kidney disorders have affected more than 850 million people, with CKD being one of the leading causes of death. North Sulawesi is recorded as one of the provinces with the highest prevalence of CKD. Blood creatinine is used as the primary marker of kidney function, while hypertension is a comorbidity commonly found in CKD patients and can act as both a cause and a consequence of impaired kidney function. Several studies have reported varying results regarding the relationship between creatinine levels and blood pressure. Purpose to analyze the association between serum creatinine levels and blood pressure in chronic kidney disease patients with hypertension at ODSK Hospital, North Sulawesi Province. Methods the research design used an observational analytic cross-sectional design. This study used an observational analytic cross-sectional design. It was a retrospective study utilizing secondary data from medical records for the period of June 2022 to August 2025. Total sampling method was employed with a sample size of 65 patients who met the inclusion criteria. Based on the Spearman correlation test results, the significance values between creatinine and systolic pressure was 0.685, and between creatinine and diastolic pressure was 0.787 (p-value >0.05). There is no significant correlation between serum creatinine levels and blood pressure in chronic kidney disease patients with hypertension at ODSK Hospital, North Sulawesi Province.

Type 2 Diabetes Mellitus (T2DM) is a global health problem with continuously increasing prevalence, covering the majority of diabetes cases worldwide. Persistent hyperglycemia in T2DM progressively damages the kidneys. Early assessment of kidney function, especially through the examination of urea levels and estimated glomerular filtration rate (eGFR) values, is important to predict CKD prognosis and guide therapeutic intervention. To discover the profile of urea levels and eGFR values in Type 2 Diabetes Mellitus patients at ODSK Hospital, North Sulawesi Province. This study is a descriptive quantitative observational study with a cross-sectional design, conducted retrospectively using secondary data from the medical records of Type 2 Diabetes Mellitus patients at ODSK Hospital, North Sulawesi Province during the period February 2024–August 2025 who met the inclusion criteria. From a total sample of 658 Type 2 Diabetes Mellitus patients, the majority of patients had high urea levels (53.3%). Based on sex, the proportion of high urea levels in males (57.2%) was higher compared to females (50.5%). Meanwhile, the distribution of eGFR values showed that the G1 category was the most frequent (23.9%). However, the majority of other patients (75.1%) were already in categories G2 to G5, which indicates a decrease in kidney function. This decrease in kidney function was slightly more detected in male patients (76.1%) compared to female patients (74.4%). Type 2 Diabetes Mellitus patients at ODSK Hospital, North Sulawesi Province, have high urea levels and the majority have decreased eGFR values.

Internet use in Indonesia is highest among adolescents aged 15 to 19 years. Internet use can have a negative impact if users do not use social media appropriately, such as cyberbullying behavior. One of the impacts of cyberbullying is self injury. This study aims to determine the relationship between cyberbullying and self injury in adolescents. Methods: This studyused a descriptive descriptive correlation design with a cross sectional approach. Respondents in the study amounted to 233students of SMAN 9 Pekanbaru with sampling techniques using stratified random sampling. Cyberbullying was measured using The Cyber Victim And Bullying Scale (CVBS) questionnaire, and self injury was measured using the Self Harm Inventory (SHI). Data were analyzed using chi-square. Results: The majority adolescents have experienced cyberbullying actions moderate 153 (65.7%) and majority adolescents have experienced mild self injury 161 respondents (69.1%). Chi square analysis showed a significant relationship between cyberbullying and self injury (p = 0.000). Conclusion: There is a significant relationship between cyberbullying and self injury in adolescents. Increasing positive activities for self-development can reduce the effects of cyberbullying such as self injury.

Introduction: Dengue Hemorrhagic Fever (DHF) is a serious disease transmitted by the aedes aegypti mosquito. Dengue Hemorrhagic Fever (DHF) is an infectious disease transmitted through the bite of the Aedes aegypti mosquito and is still a public health problem. The high incidence of dengue fever is often caused by a lack of knowledge, attitudes, and actions of the community in carrying out appropriate prevention efforts. The goal is to identify the picture of community behavior in dengue prevention, including aspects of knowledge, attitudes, and actions. Method: was a quantitative descriptive with 100 respondents selected by random sampling in East Sidomulyo Village, Marpoyan Damai. Data were collected through questionnaires and analyzed univariately. Results: The variables of community behavior were obtained in the knowledge of most of the people who were low as many as 52 respondents (52%), most of the people's attitudes were obtained negative attitudes as many as 77 respondents (77%), the actions of the community mostly had less actions with the number of 59 respondents (59%), and the behavior of the community was relatively low. Conclusions and Suggestions: This study shows that the majority of the people of East Sidomulyo Village have lacking knowledge, attitudes, and actions in the prevention of dengue. Low preventive behavior is caused by a lack of knowledge and concern. Intensive, community based education is needed to raise awareness and preventive measures in an ongoing manner.

The increasing use of digital devices among adolescents raises concerns regarding eye health, particularly myopia. Non-ergonomic postures, such as using gadgets in a lying position, may increase accommodative stress on the eyes and contribute to visual impairment. To analyze the association between the duration and viewing distance of gadget use in a lying position and the occurrence of myopia among eighth-grade students at SMPN 119 Central Jakarta. An observational analytic study with a cross-sectional design was conducted involving 74 eighth-grade students. Data on gadget use habits, including duration and viewing distance, were collected using a structured questionnaire. Visual acuity was assessed using a Snellen chart. Bivariate analysis was performed using the Chi-square test with a significance level of p < 0.05. Decreased visual acuity was found in 62.2% of respondents. There was no significant association between viewing distance and myopia (p = 0.080). However, a significant association was identified between gadget use duration exceeding two hours per day and the occurrence of myopia (p = 0.002). The duration of gadget use in a lying position was significantly associated with myopia, whereas viewing distance was not. Limiting the duration of gadget use may help prevent visual impairment among adolescents.

Radiographic examination of the wrist plays a crucial role in diagnosing fractures, particularly in traumatic cases, and requires precise projection selection, proper immobilization, and adequate radiation protection to obtain high-quality diagnostic images. In theory, wrist radiography commonly includes anteroposterior (AP) and lateral projections; however, observations at the Radiology Installation of RSU PKU Muhammadiyah Delanggu showed that fracture examinations are generally limited to posteroanterior (PA) and lateral projections. This difference highlights a gap between theoretical recommendations and clinical practice, as several references emphasize the importance of projection variation to enhance diagnostic accuracy. This study aimed to describe the wrist joint radiographic examination procedures for fracture cases at RSU PKU Muhammadiyah Delanggu and to examine the immobilization techniques applied during the procedure. A descriptive qualitative design with a case study approach was used, conducted from May to June 2025. The subjects included three radiographers, while the object of study was wrist radiography in fracture cases. Data were obtained through direct observation, interviews, and documentation, and analyzed descriptively. The findings showed that PA and lateral projections were consistently used, with immobilization achieved using sandbags and foam pads to ensure stability and minimize motion artifacts. Radiation protection was implemented through lead aprons, collimation, and appropriate exposure adjustments. Overall, the procedures followed established radiography guidelines, particularly the Bontrager standard, ensuring both diagnostic quality and patient safety.

Sindrom metabolik merupakan isu kesehatan yang semakin menonjol di Indonesia, dengan prevalensi mencapai 21,66% dan angka lebih tinggi pada populasi urban. Literasi gizi, sebagai kapasitas individu untuk memahami dan menerapkan informasi nutrisi, dipandang berperan penting dalam mengarahkan perilaku makan serta memengaruhi status metabolik. Namun, pada komunitas adat seperti masyarakat Badui, struktur sosial-budaya dan pola hidup tradisional dapat menciptakan dinamika yang berbeda dibandingkan populasi umum. Penelitian ini bertujuan menganalisis hubungan antara tingkat literasi gizi dan parameter kesehatan metabolik pada masyarakat Badui Luar. Studi observasional dengan desain potong lintang ini melibatkan 41 responden dewasa. Literasi gizi diukur menggunakan kuesioner terstandar, sedangkan parameter metabolik meliputi lingkar perut, tekanan darah, kadar glukosa darah puasa, trigliserida, dan HDL yang diperiksa menggunakan metode klinis sederhana. Analisis korelasi Pearson digunakan untuk menilai hubungan antarvariabel. Hasil penelitian menunjukkan bahwa literasi gizi berada pada kategori cukup baik (123,73 ± 7,89), namun tidak berhubungan signifikan dengan seluruh parameter metabolik (r –0,218 hingga 0,241; p>0,05). Pola ini mengindikasikan bahwa faktor budaya, aktivitas fisik agraris, serta pola konsumsi tradisional kemungkinan berperan lebih dominan dalam membentuk profil metabolik masyarakat Badui dibandingkan literasi gizi formal.

This study aims to evaluate the relationship between skinfold calliper measurements and handgrip strength with segmental fat and muscle composition among adults in Kota Bambu, providing evidence for simple and applicable community-based screening tools. A cross-sectional design was applied to 135 participants aged 18–96 years. Skinfold thickness was assessed at four anatomical sites (biceps, triceps, suprailiac, scapular), handgrip strength was measured using a digital dynamometer, and segmental body composition was obtained via bioelectrical impedance analysis. Findings demonstrated a moderate positive correlation between handgrip strength and arm skeletal muscle mass (r = 0.371–0.407; p < 0.01), indicating that handgrip performance reflects segmental muscle contractility and functional reserve. Skinfold measurements showed moderate-to-strong positive correlations with both local and central subcutaneous fat distribution (r = 0.562–0.635; p < 0.01), confirming their sensitivity in estimating segmental adipose accumulation. These results highlight that calliper and handgrip strength can serve as practical, low-cost preliminary screening indicators for mapping muscle and fat distribution in urban communities, although they are not substitutes for comprehensive body composition assessment. Further longitudinal studies integrating advanced physiological and functional parameters are recommended to enhance predictive validity and clinical applicability.

Acute pain is a complex phenomenon frequently experienced by post-surgical patients. If not properly managed, it can hinder the recovery process and increase the risk of chronic complications. This study aims to conduct an in-depth analysis of the concept of acute pain in surgical patients from a nursing perspective to improve the quality of care. The method used was a narrative literature review, analyzing various research articles and clinical protocols related to surgical pain management. The study findings indicate that acute post-surgical pain involves sensory and emotional dimensions influenced by the type of surgical procedure, individual pain threshold, and the effectiveness of pharmacological and non-pharmacological interventions. Furthermore, the role of nurses in conducting accurate pain assessments and patient education is a key factor in successful pain management. The implications of this study emphasize the importance of implementing integrated multimodality pain management protocols and improving nurses' competency in conducting intensive monitoring. Optimizing pain management is expected to accelerate patient mobilization, shorten hospital stays, and increase patient satisfaction with nursing services.

This study aims to develop an educational application based on a Graphical User Interface (GUI) using MATLAB App Designer that functions as an interactive simulation for evaluating blood pressure. The application allows users to input systolic and diastolic blood pressure values along with supporting information such as name and age. The input data are then analyzed and classified into several blood pressure categories according to the standards of the American Heart Association (AHA), including normal, hypotension, stage 1 hypertension, stage 2 hypertension, and hypertensive crisis. The classification results are presented visually through an interactive pie chart with dynamic percentages and legends to enhance user understanding. In addition, all data are automatically stored in a Microsoft Excel file containing a summary of blood pressure categories and session timestamps. The system is designed with a simple interface and intuitive interaction, making it suitable for early health education purposes. Although the application still relies on manual data input, it has the potential to serve as an effective learning tool for increasing public awareness of the importance of regular blood pressure monitoring. 

Stunting remains a major chronic nutritional problem in Indonesia, including Aceh, and has serious impacts on children’s physical growth and cognitive development. Prevention efforts require appropriate, practical, and sustainable nutritional interventions, including the use of local foods such as pumpkin, which is rich in beta-carotene, vitamin A, carbohydrates, and fiber, and can be combined with animal and plant protein sources. This study aimed to evaluate the effectiveness of an instant pumpkin-based porridge in improving the weight and height of children aged 6–24 months who are at risk of stunting in the Gunung Meriah Health Center area. The study used a quasi-experimental design with a nonequivalent control group involving 41 children divided into intervention and control groups. The intervention group received the instant porridge for 21 days. Data analyzed using paired t-tests and independent t-tests showed significant improvements in the intervention group’s weight and height (p<0.05). The pumpkin-based instant porridge proved effective as a local food–based nutritional intervention and has the potential to be integrated into supplementary feeding programs and regional nutrition policies with broader coverage and longer duration..

During gravidity, back pain is a significant issue, especially due to changes in posture along with increasing physical load in the third trimester. Muscle relaxation and stretching exercises for pregnant women can help reduce back pain, one of which is the butterfly exercise. That study aims until determine the impact to the butterfly activity on gravidity in their third trimester at TPMB Amilia Intarti Klampisrejo, Pasuruan Regency. A quantitative method was used with a quasi-experimental approach employing a one-group pre-test also post-test design. The study involved 32 third-trimester gravidity as respondents. Data were collected using purposive sampling, before-and-after measurements, and assessed with the Numeric Rating Scale (NRS). The intervention be carried out over a period of four weeks. The findings show that the butterfly pregnancy exercise effectively reduces back pain in third-trimester gravid. Therefore, the butterfly exercise can serve as an alternative method to help alleviate back pain and enhance comfort during pregnancy.  

Research on the relationship between physical activity and morbidity levels of inmates, particularly in women's prisons, is still very limited. This study aims to provide empirical data that can be used as a basis for developing better physical training programs in women's prisons, while also supporting improvements in the quality of life of inmates and their readiness to return to society. This study used a quantitative design with a cross-sectional study approach. Activities carried out included data collection and measurement of the independent and dependent variables. This study analyzed variables related to the relationship between physical activity and morbidity levels among inmates at the Class II Pondok Bambu Women's Prison, East Jakarta. The results of the study showed (1) variations in the distribution of physical activity levels were relatively balanced between the low (34.6%), medium (33.3%), and high (32.1%) categories. (2) Morbidity rates in the sample indicated a significant burden of disease, the proportion of prisoners with low levels of morbidity was 39.7%, medium 24.4%, and high 35.9%. (3) Statistical analysis showed a significant relationship between physical activity levels and levels of morbidity in prisoners, the bivariate test (Chi-Square) produced p < 0.001, so the hypothesis that there is a relationship between physical activity and morbidity is accepted. (4) In an Islamic perspective, physical activity is believed to strengthen the body, prevent disease, and maintain physical and spiritual balance.

Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation, inflammation, and neoangiogenesis, largely driven by dominant T helper 1 (Th1) and T helper 17 (Th17) immune responses. Psoriasis is associated with metabolic, psychological, cardiovascular, and arthritic comorbidities. Vitamin D plays an important role in the management of psoriasis. Calcitriol (1,25(OH)₂D₃), regulates keratinocyte proliferation, differentiation, and apoptosis. Vitamin D supports the formation of the cornified envelope as well as epidermal lipid and ceramide production, also acts synergistically with the epidermal calcium gradient to maintain barrier function. In addition to its epidermal effects, vitamin D exerts immunomodulatory actions by enhancing regulatory T cells and anti-inflammatory cytokines (interleukin (IL)-10, IL-4, transforming growth factor-beta (TGF-β)), while suppressing Th1/Th17 activity and production of pro-inflammatory cytokines (IL-2, IL-17, tumor necrosis factor-alpha (TNF-α)). These mechanisms highlight its potential role in psoriasis therapy. Topical vitamin D₃ analogues are effective for mild to moderate disease due to the high expression of vitamin D receptors in psoriatic keratinocytes. Oral supplementation has also been explored for its systemic immunomodulatory effects, although findings remain inconsistent.  

Background: Sexually Transmitted Infections (STIs) represent a global public health challenge. The increasing number of Sexually Transmitted Infection (STI) cases is a serious concern worldwide. A lack of education or minimal knowledge, along with risky behavior, contributes significantly to the high STI rates, particularly among the young age group. Purposes: The objective of this study is to conduct a comprehensive analysis of the major types of Sexually Transmitted Infections (STIs)—namely Gonorrhea, Hepatitis B, HIV/AIDS, Syphilis, and HPV—by identifying their risk factors and determining the most effective prevention strategies. Method:The researchers employed a literature review method. The data search process was conducted systematically on Google Scholar, limiting sources only to articles available in full text and having open access. Results: The literature review concludes that the factors of knowledge, attitude, behavior, and age significantly influence an individual's risk of contracting Sexually Transmitted Infections (STIs). Therefore, prevention efforts must be carried out comprehensively, encompassing promotive (awareness enhancement), preventive (prevention), curative (treatment), and rehabilitative (recovery) activities. Practically, this prevention must include sexual health education, adoption of safe sexual behavior, implementation of routine health checks (screening), and vaccination (specifically for Hepatitis B and HPV). Conclusion: Overall, controlling the spread of STIs requires active and collaborative roles from all parties—including the government, health workers, and the community. The main key to suppressing the spread and burden of STI diseases in the community is through improving appropriate sexual health education, improving access to health services, and periodic health screening.  

Myopia is a multifactorial disease, affected by various hereditary and environmental conditions. This literature review aims to evaluate the association between risk factors in incidence of myopia in children aged 6 to 12 years old. A cross-sectional study of elementary students in MI Patihan Kidul, Ponorogo, East Java was performed. Eligible samples were 6 to 12 years old students. Examination was performed on September 7th 2023. The students underwent short history taking, body mass index (BMI), and visual acuity examination. Age, sex, BMI, family history of myopia, sleeping time, screen time, and duration of outdoor activity were examined as risk factors. A total of 336 children met the inclusion criteria, of which 48 (14.2%) of them had myopia. Family history of myopia was proven to increase the risk for myopia on their children (p value 0.012, OR 0.436).  Heredity is a well-established risk factor for myopia. This literature review provides evidence on the positive correlation between family history and the occurrence of myopia in children. 

The body may experience insulin resistance or an insufficient production of the hormone, blood sugar levels rise continuously, leading to a chronic metabolic condition called Type 2 Diabetes Mellitus. Among non-pharmacological approaches proven effective in managing hyperglycemia, physical exercise particularly the Prolanis workout program has shown notable benefits. This study assesses how joining the Prolanis Exercise Program influences blood glucose reduction in Type 2 Diabetes patients at Kuta Baro Health Center, Aceh Besar. This research utilized a quasi-experimental method applying a one-group pretest–posttest framework. Participants, numbering 25 individuals, were selected through an accidental sampling process.. Throughout a four-week implementation of the Prolanis Exercise Program, measurements of blood glucose levels were taken both prior to and subsequent to the program. The findings revealed a notable decline in mean blood sugar levels, decreasing from 158.84 mg/dL before the intervention to 121.92 mg/dL afterward. Based on the Paired Samples t-Test (p < 0.05), the Prolanis Exercise intervention was found to have a significant effect in lowering blood glucose levels. This finding demonstrates that regular participation in Prolanis Exercise serves as an effective non-pharmacological approach for controlling Type 2 Diabetes Mellitus. Community Health Centers are advised to consistently continue developing and facilitating routine Prolanis Exercise activities, in addition to providing ongoing education on healthy lifestyles to patients. Patients are expected to actively engage in this program as part of their diabetes self-management.

Long-term treatment adherence is critical for schizophrenia patients, yet non-adherence remains a significant global challenge, contributing to relapse, re-hospitalization, and increased healthcare costs. Understanding the underlying multidimensional factors is crucial for developing effective interventions. This systematic literature review aims to identify and categorize the dominant factors contributing to medication non-adherence among schizophrenia patients, based on current quantitative evidence (2019-2024). A systematic search of Google Scholar and PubMed targeted quantitative cross-sectional studies using the PICOST framework. Article selection followed PRISMA guidelines, and quality was assessed using the JBI Critical Appraisal Checklist. Seven articles were included in the final narrative synthesis. The synthesis confirms that non-adherence is multifactorial. Identified factors were categorized into three groups: (1) Patient-related factors (e.g., poor illness insight, feeling cured, treatment fatigue); (2) Treatment-related factors (e.g., medication side effects, therapy duration); and (3) System and social factors (e.g., low family support, stigma, poor therapeutic alliance). Non-adherence is a complex issue arising from the interplay of patient, treatment, and social factors. Low family support and poor patient knowledge consistently emerge as key determinants. Interventions require a holistic approach extending beyond pharmacotherapy, focusing on comprehensive psychosocial education for patients and families, active side-effect management, and strengthening the family's role in care.

The prevalence of correct handwashing behavior with soap in Aceh Province is 36%. School-age children are the time to instill PHBS values ​​and have the potential to be agents of change to promote PHBS both in the school environment, family, and society. The impact of lazy handwashing with soap can cause various diseases such as diarrhea, flu, hepatitis A, and impetigo (a contagious infection that usually occurs in children who rarely wash their hands, this disease is characterized by red skin which then develops into small blisters). The purpose of this study is to determine the effectiveness of mini posters as a health promotion media on handwashing behavior with soap in elementary school students. The research method is one group pretest posttest design. The sampling technique is total sampling, while the number of samples in this study was 80 students from grades 5 and 6 of elementary school. The results of the study obtained before the intervention of mini posters washing hands with soap behavior of elementary school students 77.5% of students did not wash their hands with soap after urinating and defecating. After the intervention of mini posters washing hands with soap behavior of elementary school students 87.5% did wash their hands with soap. There is an effect of mini poster intervention on increasing handwashing behavior in elementary school students with a p value of 0.000 < 0.05. The results show that mini posters are a reference for the effectiveness of health promotion in preventing infectious diseases in elementary school children by implementing a handwashing program with soap in the school environment

Food safety is a crucial aspect of public health, particularly for elementary school children who frequently consume street food or snacks sold within school environments. Food handlers play a key role in determining the level of hygiene and sanitation of the food served. This study aims to analyze the factors associated with food handlers’ hygiene behavior in elementary school canteens in Telanaipura District, Jambi City. This research employed a quantitative method with a cross-sectional approach involving 41 food handlers as respondents. Data were collected through structured interviews using questionnaires and direct observations based on hygiene and food sanitation standards in accordance with the Regulation of the Minister of Health No. 1096/Menkes/PER/VI/2011. Data were analyzed using univariate and bivariate methods with the Chi-Square test at a significance level of p < 0.05. The results showed that most food handlers exhibited poor hygiene behavior (61.0%). There were significant relationships between knowledge (p = 0.048), attitude (p = 0.000), and availability of facilities and infrastructure (p = 0.000) with hygiene behavior, while education level showed no significant association (p = 0.187). It can be concluded that improving hygiene behavior requires continuous training, supervision, and provision of adequate sanitation facilities to support food safety in school environments.