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Muhammad Zainul Haq; Siti Komariyah; Lilis Yuliati

International Journal of Economics, Commerce, and Management 2025 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

In the last ten years, Indonesia has been carrying out massive infrastructure development. The goal is to facilitate community mobility which has an impact on economic growth. Infrastructure development also aims to increase the Human Development Index even though it does not directly affect it. One of the provinces that contributed to infrastructure development was East Java, with the Human Development Index during the 2018-2022 period increasing and tending to stagnate. For this reason, the purpose of this study is to identify the influence of infrastructure development on the Human Development Index, including identifying the influence of poverty on the Human Development Index. The research methodology used is quantitative with  a Geographically Weighted Panel Regression (GWPR) approach that allows to comprehensively identify the Regional Development Index in East Java. The results obtained were that the variables of Infrastructure Development with the dimensions of Road Length (6,172) and Number of Schools (2,686) had an impact on the Human Development Index in East Java. Meanwhile, the poverty variable (-6,139) has no effect on the Human Development Index (HDI). However, simultaneously the variables of Infrastructure Development and Poverty affect the National Development Index (HDI) with a calculation of 64.42 > 2.4202.

A.Fadli Mappisabbi; Steviani Batti; Nurasia Natsir

International Journal of Economics, Management and Accounting 2025 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

Fraud poses a significant threat to organizational integrity and public trust, especially within governmental institutions. This study explores the critical role of forensic accountants in uncovering fraud within the Audit Board of the Republic of Indonesia. Using a case study approach, the research examines the application of advanced forensic data analytics by forensic accountants. It highlights the essential skills and characteristics that make forensic accountants effective, as well as their contributions to enhancing internal controls and governance mechanisms. The study demonstrates the impact of forensic accounting on fraud detection, prevention, and deterrence. The findings emphasize the importance of integrating forensic accounting expertise within the Audit Board's operational framework to strengthen its capacity to combat financial fraud. It also identifies challenges faced by forensic accountants, such as technological limitations and cultural resistance, and suggests strategies to overcome these barriers. By shedding light on the role of forensic accountants in safeguarding public sector integrity, this research contributes to the growing knowledge on forensic accounting practices in Indonesia. The insights can inform policies and capacity-building initiatives aimed at improving the Audit Board’s fraud detection capabilities, ultimately fostering greater public trust and accountability.

Ovie Yanti

Kajian Administrasi Publik dan ilmu Komunikasi 2025 Asosiasi Peneliti Dan Pengajar Ilmu Sosial Indonesia

This research describes the Implementation of Population Administration Policies on Administrative Vulnerable Populations (Study on Suku Anak Dalam in Bungo Regency, Jambi Province). Based on the results of the research, it can be concluded that the implementation of population administration in administratively vulnerable populations such as Suku Anak Dalam (SAD) has been implemented by the Bungo District Government through the Bungo District Population and Civil Registration Office, but only a small proportion of SAD residents are recorded and obtain population documents. This is due to the absence of specific regulations governing the data collection and recording of administratively vulnerable populations such as SAD. In addition, the causes of the lack of optimal administration of administratively vulnerable populations such as SAD in Bungo Regency, Jambi Province are limited resources and funds, as well as natural factors due to the distance from the city, a nomadic and closed lifestyle, plus language problems that are difficult to understand. Therefore, in order to achieve Orderly Population Administration specifically for vulnerable populations such as SAD, there needs to be a policy that applies specifically to SAD residents in addition to policies that apply generally in population administration data collection. In addition, the relevant agencies can carry out cross-sectoral cooperation and need to make special plans regarding the financing of data collection and form a Special Officer Unit to carry out data collection of administratively vulnerable populations such as SAD in the Bungo Regency area.

Arif Mahulana Sidik; Fauzi Syarief

Jurnal Penelitian Komunikasi dan Sosialisasi 2025 Asosiasi Peneliti dan Pengajar Ilmu Sosial Indonesia

The advancement of information and communication technology has driven the utilization of social media as a strategic communication tool in various sectors, including national defense. The Ministry of Defense of the Republic of Indonesia (Kemhan RI), through the Defense Information Bureau, leverages social media platforms to educate the public on defense issues via the Podcast Pertahanan Negara (PODCAST) program. This study aims to analyze the communication approach employed by the Defense Information Bureau in PODCAST and its effectiveness in enhancing public defense literacy. This research adopts a qualitative method with a case study approach. Data collection techniques include in-depth interviews with relevant stakeholders, content observation of PODCAST episodes, and document analysis. The findings indicate that the Defense Information Bureau implements a digital communication strategy based on engagement, interactivity, and education through discussions with expert speakers and the delivery of information in an engaging manner. The program has proven effective in increasing public understanding of defense issues, yet it still faces challenges in reaching a broader audience and encouraging active public participation. The study underscores the importance of optimizing digital communication strategies in national defense education. Recommendations include enhancing two-way audience interaction, diversifying content formats, and collaborating with various stakeholders to expand the reach of defense education through social media.

Muhammad Hatta; Fittri Royani; Agus Maulizar; Herman Saputra; Darmansyah Darmansyah +2 more

International Journal of Law, Crime and Justice 2025 Asosiasi Penelitian dan Pengajar Ilmu Hukum Indonesia

Cybercrime has become a serious threat to the stability of the world economy along with the increasing dependence on digital systems. The study analyzes the negative impact of cybercrime on the global economy, focusing on direct and indirect financial losses, disruptions to productivity and supply chains, and the implications of policies and mitigation efforts. The results of the study show that cybercrimes, such as ransomware, data theft, and phishing, cause significant financial losses to individuals, companies, and governments, and have an impact on consumer and investor confidence. In addition, cyberattacks on financial and industrial infrastructure disrupt business operations and exacerbate global economic inequality. Effective mitigation efforts involve strengthening cybersecurity regulations, investing in data protection technology, and increasing public awareness of the threat of cybercrime. With a deeper understanding of the economic impact of cybercrime, it is hoped that a more comprehensive strategy can be implemented to increase the resilience of the global economy against digital threats

Irgi Biantara; Bambang Budi Raharjo

Journal of Health Sciences, Public Health and Pharmacy 2025 International Forum of Researchers and Lecturers

Health is a basic human need, so it requires high awareness so that people maintain their health. One way to protect yourself and your family from the financial risks arising from health care costs is by having health insurance. The impact of this insurance provides protection against possible future losses and invests part of the funds collected from policyholders. Health insurance is important not only for reducing the financial burden of health services but also for ensuring that individuals have access to timely and quality medical care. The purpose of this theoretical study is to determine the impact of health insurance on the utilization of health services from a public health perspective. The method used is a theoretical study, which analyzes existing theories and previous research to understand the effects of health insurance. This approach is intended to draw conclusions regarding how insurance affects public health and health service usage. The results of this theoretical study indicate that, from a public health perspective, health insurance has a positive impact in various ways. It helps reduce the risk of disease, minimizes the economic burden when individuals fall ill, reduces financial risks, provides peace of mind, and facilitates access to quality medical services. Furthermore, insurance contributes to preventive care and early treatment. Accessibility to health services is identified as a crucial factor in enhancing the positive impact of insurance on the welfare and health of the community in Indonesia.

Antoni Tri Mahendra; Didik Budiyanto; Sri Oetami Madyowati

Mikroba : Jurnal Ilmu Tanaman, Sains Dan Teknologi Pertanian 2025 Asosiasi Riset Ilmu Tanaman Dan Hewani Indonesia

The use of probiotics is very important in cultivation activities. Probiotics are live microorganisms that have a beneficial effect on the host by balancing the microflora in their intestines. In increasing the nutritional content of artificial feed (pellets), the bacteria in probiotics have a mechanism for forming several enzymes for digesting feed. This study aims to determine the effect of giving delacto probiotics at different doses in artificial feed on the absolute weight growth of tilapia (Oreochromis niloticus). Probiotics are mixed with feed using a biofloc cultivation system. The method used in this research was an experimental method with a Completely Randomized Design (CRD) with 4 treatments and 6 replications, namely by adding different doses to the treatments. Treatments A (8ml/kg), B (16 ml/kg), C (24 ml/kg) and D (32 ml/kg). The parameter observed was absolute weight growth. Water quality supporting parameters include temperature, pH and DO. Data were analyzed using the ANOVA test. Based on the research results, it shows that giving different doses of delacto probiotics has a significant effect on the absolute weight growth of tilapia (Oreochromis niloticus). Treatment A (8 ml/kg) gave the lowest absolute weight growth of 32.83 grams and treatment D (32 ml/kg) gave the highest absolute weight growth of 40.57 grams. Water quality parameters include water temperature ranging from 25.3 – 26.1֯C, acidity ranging from 7.5 – 8.0. And dissolved oxygen ranges from 4.7 – 5.3 ppm. The results of analysis of variance (ANOVA) for the three water quality parameters showed no differences between treatments (Oreochromis niloticus) fry.

Prima Farhan Septian; Didik Budiyanto; Sumaryam Sumaryam

Mikroba : Jurnal Ilmu Tanaman, Sains Dan Teknologi Pertanian 2025 Asosiasi Riset Ilmu Tanaman Dan Hewani Indonesia

Vannamei shrimp is one of the shrimp species with economic value and is one of the national leading commodities. On the other hand, one of the problems in vannamei shrimp cultivation is its slow growth, slow growth is caused by the less optimal absorption of nutrients in the feed. In dealing with these problems, one of the things that is done is the administration of probiotics. The addition of probiotics such as Biolacto containing Lactobacillus sp bacteria to the feed can increase the appetite of shrimp. This study aims to determine the effect of biolacto probiotics on feed on the growth of the absolute weight of vannamei shrimp. This study used a Complete Random Design (RAL) with four treatments: A (feed without a mixture of probiotics), B (probiotics 2 gr/100 gr feed), C (probiotics 4 gr/100 gr feed), and D (probiotics 6 gr/100 gr feed). Treatment B with a concentration of probiotics 2gr/100g feed gave the highest absolute weight growth of 9.2 gr. Water quality data during the study were obtained with water temperature ranging from 28.5 – 29.2°Celsius, salinity ranging from 36 – 37 ppt, pH ranging from 7.5 – 8.0, and dissolved oxygen ranging from 4.0 to 4.63 mg/l. The results of the ANOVA analysis of the four water quality parameters showed no difference between treatments and were in the optimal range of life of vannamei shrimp (Litopenaeus vannamei).

Made Saha Apta Raditya; Didik Budiyanto; Sumaryam Sumaryam

Mikroba : Jurnal Ilmu Tanaman, Sains Dan Teknologi Pertanian 2025 Asosiasi Riset Ilmu Tanaman Dan Hewani Indonesia

Giving probiotics such as probiotic boster on feed greatly helps the growth of absolute weight in Catfish seeds because the good bacteria contained in these probiotics help facilitate catfish seeds in digesting the feed so as to increase the efficiency of the feed. This study aims to see how effective the probiotic administration is. The study was conducted in Kramas District, Gianyar regency, Bali Province for 30 days using experimental methods, using a complete randomized design with a total of 4 treatments and 6 repetitions. Treatment A is by giving 3 ml of probiotic boster every 1 kg of feed. Treatment B by giving 5 ml probiotic boster every 1 kg of feed. Treatment C by giving 7 ml probiotic boster every 1 kg of feed. Treatment D by giving 9 ml probiotic boster every 1 kg of feed. In this study showed significantly different results on the addition of probiotic boster with different doses on the growth of absolute weight of catfish fry aged 1 month-2 months. Treatment D gave the highest result with an absolute weight gain of 55.33 grams, and treatment a showed the lowest result with an absolute weight gain of 25.17 grams. Water quality Data during the study obtained water temperature ranges from 27-29 oC, acidity ranges from 7-8, and dissolved oxygen ranges from 3.34 to 4.26 ppm. The results of the analysis of variance (ANOVA) of the three parameters of water quality there is no difference between the treatment and the life range of catfish fry (Clarias sp.)

Bintang Adriani Hutasoit; Suyit Ratno; Lyra Kartika; Alya Zulfa Ramadhani; Driana Stefani Tambunan +2 more

Jurnal Pendidikan Kimia, Fisika dan Biologi 2025 Asosiasi Riset Ilmu Pendidikan Indonesia

This study aims to determine the increase in students' knowledge through learning based on analytical and innovative models in understanding light material. The method used in this study is the analytical research method. This study is a classroom action research conducted on fifth grade elementary school students. The research sample consisted of 13 students. Data collection was carried out through written test techniques given to students before and after the application of the learning model. The data obtained were analyzed using techniques to see the analysis of the increase in students' understanding of light material. The results of the data analysis showed that there were still many students who did not understand the concept of light well, especially in terms of the properties of light and its application in everyday life. Therefore, it is necessary to apply more interactive and innovative learning methods so that students can more easily understand the material. This study recommends the use of more varied learning strategies to optimally improve student understanding.

Susanti Marito Barus; Komang Dharmawan; Luh Putu Ida Harini

International Journal of Applied Mathematics and Computing 2025 Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Determining the price of option contracts is a crucial aspect of financial markets, particularly for investors aiming to manage risk and make informed investment decisions. In this study, the price of an Asian call option is calculated using the Monte Carlo Stratified Sampling method based on the stock price data of Tesla, Inc. (TSLA) from January 2021 to December 2023. This method has been proven to reduce variance compared to the Standard Monte Carlo simulation, leading to faster price convergence and more efficient results. The parameters used in the simulation include the initial stock price  (S_0), number of simulations (N), maturity time  (T)dividend = 0, risk-free rate (r), strike price ( K), and volatility

Satriya, Rafdi Ma’ruf; Kartikawati, Marina; Kalmah, Kalmah; Hidayati, Ratna

Ocean Engineering : Jurnal Ilmu Teknik dan Teknologi Maritim 2025 Fakultas Teknik Universitas Maritim AMNI Semarang

PT Pelindo Multi Terminal is a company engaged in loading and unloading services for liquid bulk, dry bulk and containers. Hazard Identification, Risk Assessment and Risk Control (HIRARC) is a method for identifying potential hazards that exist in each type of work. The aim of this research is to determine hazard identification, risk assessment and risk control using the Hazard Identification, Risk Assessment and Risk Control (HIRARC) method at PT Pelindo Multi Terminal. Research was carried out on all aspects of each liquid bulk to dry bulk operation which have the potential to cause accidents and occupational health. Data collection techniques are field observation, interviews and documentation. Descriptive data analysis using the HIRARC model with comparison of the effectiveness of IBPR. The results of the research show that IPBR risk control in the low risk category shows an increase in the presentation of signs of success in risk control, in this case there is an increase in the low risk category by 55%, while HIRARC risk control in the low risk category shows an increase in the presentation of signs of success in risk control. , in this case there is an increase in the low risk category by 90%, in this case it can be seen that HIRARC is more effective in controlling work risks. PPE equipment is adjusted to the type of work being carried out because there are still inconsistencies in wearing PPE. Keywords: Hazard Identification, Risk Assessment, Risk Control, HIRARC.

Kodrat Eko Putro Setiawan; Indra Puji Astuti; Erny Untari; Doni Susanto; Luthfi Ustadziyatul Ummah

Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia 2025 Fakultas Teknik Universitas Maritim AMNI Semarang

This training on creative writing and writing scientific journal articles aims to improve literacy at the Integrated Islamic Junior High School Bakti Ibu Madiun, especially improving writing skills. The participants of this activity amounted to 20 people. The methods in this training activity are lectures and questions and answers, practice and mentoring. The lecture and question-and-answer method was used to deliver materials related to creative writing and scientific journal articles. The creative writing materials presented included: hierarchy of writing, including ideas consisting of imaginary and factual. Scientific journal article writing materials presented include: the definition of scientific articles, scientific articles for journals, and journal article outlines. The practice and mentoring method was used to follow up on the material that had been delivered in the previous method. This training activity provides benefits, among others: teachers get assistance in creative writing, namely writing interesting experiences when teaching or other activities related to activities at school and writing scientific journal articles, namely writing research related to the learning process at school. The teachers were also given examples and several ways to find references for writing materials used through searches on Google Scholar, mass media or journals in universities.

Dilma Rochmi Ashina Sarma; Agnes Istiharjanti; Mudy Oktiningrum

Jurnal Rumpun Ilmu Kesehatan 2025 Pusat Riset dan Inovasi Nasional

Non-pharmacological therapies for managing dysmenorrhea include yoga exercises and clary sage aromatherapy. This pre-experimental research determined the effect of yoga exercises and clary sage aromatherapy to relieve dysmenorrhea pain scale among 11th and 12th-graders at Advanced High School Nurul Islami Semarang with a one-group pretest-posttest design. The population in this study consists of students from the XI and XII grades of Advanced High School Nurul Islami Semarang, 70 students, with a research sample of 42 respondents. The data collection technique for this research was purposive sampling. The numeric rating scale serves as the measuring tool. The statistical test conducted before and after yoga exercises and clary sage aromatherapy in this study is the Wilcoxon test, obtaining a p-value of 0.000 < 0.05. The result accepts the alternative hypothesis (Ha). This indicates that yoga exercises and clary sage aromatherapy relieve dysmenorrhea pain in 11th and 12th graders at Advanced High School Nurul Islami Semarang. The conclusion is that yoga exercises and clary sage aromatherapy have an impact on reducing dysmenorrhea.  

Deasi N. Paji; Masrida Sinaga; Galuh Wiedani K.D. Larasati

Jurnal Rumpun Ilmu Kesehatan 2025 Pusat Riset dan Inovasi Nasional

According to the anthropometric standards for evaluating children's nutritional status, stunting is a growth failure condition based on the weight-for-age (W/A) or height-for-age (H/A) index, where the measurement results fall within the threshold (Z-Score) of -2 SD to -3 SD (short/stunted) and -3 SD (very short/severely stunted). In 2023, 27.3% of the toddlers in Penfui Timur Village were still stunted. The purpose of this study is to ascertain how stunting reduction policies are being implemented in Penfui Timur Village, Kupang Regency. This research used a qualitative descriptive method with data collection techniques of in-depth interviews, observation and documentation. The informants in this study is 8 informants, consisting of 2 main informants and 6 supporting informants. The main informants are the head of the Penfui Timur village and the nutrition staff of the Tarus Health Center. The supporting informants are 2 posyandu cadres, mothers of stunted toddlers, pregnant women, village residents, and teenage girls.The data analysis process in this research begins by collecting data from interviews and then reducing the resulting data. After that, the data is presented and concluded. The study's result showed that although the policy has been applied effectively, it still falls short of the implementation theory's requirements. The implementers' low educational and human resource levels, the ignorance of expectant mothers and parents of children with stunted growth, and the lack of facilities and infrastructure are the contributing reasons. Although the village government's communication component with other implementing parties has been functioning smoothly, communication with the leaders of the target community has not been at its best. The policy implementers are already familiar with the methods and duties associated with their respective areas of responsibility. The bureaucratic structure's policy implementers are already familiar with the technical facets of reducing stunting. Based on the results of the study, it is recommended to increasing the knowledge involved in  implementation policy for stunting reduction

Sania Putri; Endah Yuni Puspitasari; Endang Asliana

Jurnal Ekonomi, Bisnis dan Manajemen (EBISMEN) 2025 FEB Universitas Maritim Semarang

The existence of micro, small and medium enterprises, especially in Bandar Lampung City, is not free from obstacles, one of which is related to bookkeeping or financial reporting. Mobile accounting-based applications are present as one of the technologies that are expected to overcome the problems faced by micro, small and medium enterprises. This study was conducted to determine the factors that influence the interest in implementing mobile-based accounting in micro, small and medium enterprises in Bandar Lampung City. The theory used in this study is UTAUT which consists of performance expectations, social influences and facilitating conditions. From the results of the study, it was obtained that performance expectations influenced the interest in implementing mobile accounting. Social influences did not affect the interest in implementing mobile accounting. Conditions that helped influence the interest in implementing mobile accounting.

Retno Rahayu Ningsih; Rizki Yeni Wulandari; Yunina Elasari

Jurnal Ventilator: Jurnal riset ilmu kesehatan dan Keperawatan 2025 Stikes Kesdam IV/Diponegoro Semarang, Indonesia

The sub-optimal execution of discharge planning often leads to an increase in readmission rates, ultimately resulting in patients bearing the costs of extended hospital stays. Data regarding the implementation of discharge planning in Indonesia reveals that 61% of nurses in Yogyakarta and 54% of nurses in Bandung do not conduct discharge planning Observational data indicated that nurses were not implementing discharge planning in accordance with the established Standard Operating Procedures (SOP) in the ward. The objective of this study is to evaluate the level of optimization in discharge planning practices at General Hospital of Pringsewu. Data collection methods conducted on November 9th 2024, involved interviews, questionnaires, and observations. The findings highlighted a nursing management issue that the sub-optimal implementation of discharge planning in the Surgical Ward at The General Hospital of Pringsewu. The planned intervention is to provide education on the importance of optimal discharge planning. The intervention was carried out on December 20th 2024, through educational sessions that emphasized the significance of discharge planning. Following the educational activity, there was a measurable improvement in the nurses' knowledge regarding discharge planning. Pre-test results ranged from 50% to 70%, while post-test results ranged from 80% to 95%. It is anticipated that the enhancement of nurses' knowledge will lead to the optimization of discharge planning practices in the surgical ward, thereby improving the overall quality of patient care provided by nurses.

Fitri Dwi Jayanti; Utami Puji Lestari

International Journal of Management Research and Economics 2025 Institut Teknologi dan Bisnis (ITB) Semarang

Social performance audit and Corporate Social Responsibility (CSR) are important factors in ensuring corporate sustainability, especially for companies listed on the Indonesia Stock Exchange (IDX). Social performance audit functions as an evaluation tool for the social and environmental impacts generated by the company, while CSR plays a role in building positive relationships with stakeholders and improving the company's reputation. This study aims to analyze the effect of social performance audit and CSR on corporate sustainability in order to provide insight for management in strategic decision making. This study uses a quantitative method with a multiple linear regression approach to test the relationship between social performance audit, CSR, and corporate sustainability. Data were obtained from annual reports and sustainability reports of companies listed on the IDX for the past five years. The research sample was selected using a purposive sampling method with certain criteria to ensure the relevance of the data collected. The results of the study indicate that social performance audit and CSR have a positive and significant effect on corporate sustainability. Companies that implement social audits transparently and run effective CSR programs tend to be more sustainable financially, socially, and environmentally. These findings indicate that integrating sustainability strategies into business models can increase competitiveness and investor confidence. This research provides implications for corporate management, investors, and regulators to strengthen social audit and CSR practices to create a more responsible and sustainable business environment

Isti Dikari; Agustinus R. J. Sengkey; Djony. A. Sunkudon

Jurnal Praba : Jurnal Rumpun Kesehatan Umum 2025 STIKES Columbia Asia Medan

This study aims to examine the differences in 50-meter running speed between 9-year-old students, specifically between boys and girls at Madrasah Ibtidiayah An Nur Tondano. The research employs an ex post facto design with a sample of 30 students selected through simple random sampling, comprising 15 boys and 15 girls. Data were collected through a 50-meter sprint test, with time measured using a stopwatch accurate to one-tenth of a second. The research hypothesis posits that there is a significant difference in running speed between the two groups, with the expectation that boys will demonstrate superior performance compared to girls. Data analysis was conducted using an independent-samples t-test at a significance level of α = 0.05. The results revealed that the average running time for boys was lower than that for girls, indicating that boys have significantly higher running speeds. These findings provide important insights into the differences in motor abilities between boys and girls at this age and can serve as a basis for developing more adaptive physical education strategies and differentiated training programs tailored to the characteristics of each group.

Defi Eka Kartika; Sofia Harni; Rosa Desri Meliyanti TB

VitaMedica : Jurnal Rumpun Kesehatan Umum 2025 STIKES Columbia Asia Medan

Pursed lips breathing is a method that can be used to breathe effectively and get the amount oxygen needed. The benefits of pursed lips breathing or pursed lips breathing are reducing hyperinflation in the lungs by increasing intra-airway pressure to prevent lung collapse and can also increase the speed of respiratory air flow, and optimize the process. The effect of applying pursed lips breathing on reducing shortness of breath. Application Method: This type of application is a quasi-experiment with a pre test-post test design with a control group. The population in this study was patients with chronic obstructive pulmonary disease who experienced shortness of breath when hospitalized. The sample consisted of one person in the intervention group. The instruments used were questionnaires and flip sheet media. Data was collected using a questionnaire and analyzed using descriptive methods. Patients with chronic obstructive pulmonary disease who experienced shortness of breath after being given the intervention experienced a significant reduction in shortness of breath. Pursed lips breathing is a breathing exercise that can be done independently and has an effective effect on reducing shortness of breath in COPD patients.