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Bioinformatics is an interdisciplinary field that combines biology, computer science and statistics to analyze biological data and translate it into effective therapies. With technological advances, such as next-generation genetic sequencing, bioinformatics enables the development of personalized therapies based on an individual's genetic profile. This approach provides more effective treatment and reduces the risk of side effects. In addition, the integration of artificial intelligence (AI) accelerates big data analysis, predicts therapy response and identifies disease biomarkers. Despite challenges such as the need for big data infrastructure and ethical privacy issues, the outlook for bioinformatics is bright. Through global collaboration and a multi-omics approach, bioinformatics is expected to become a key foundation in future medical therapy innovation.

This study aims to find out about . What is the mechanism for drafting regulations on changes to the Regional Revenue and Expenditure Budget (APBD). What are the implications and legal impacts on regulatory mechanisms for amending the Regional Revenue and Expenditure Budget (APBD) which are not in accordance with statutory provisions. The method of data collection in this study was carried out by normative empirical, namely research that uses and processes primary data and side by side with secondary, empirical normative research is focused on the implementation of statutory (normative) legal provisions in action in every particular legal event that occurs in a society (empirical) related to the mechanism of Changes to the Regional Revenue and Expenditure Budget. The results of the study show that the Regional Revenue and Expenditure Budget, hereinafter abbreviated as APBD, is the regional government's annual financial plan that is discussed and agreed upon jointly by the local government and the Regional People's Representative Council (DPRD), and stipulated by regional regulations/Perda. The APBD budget year covers a period of one year, starting from January 1 to December 31. The Regional Revenue and Expenditure Budget consists of the Revenue Budget originating from Regional Original Revenue (PAD), which includes regional taxes, regional levies, regional wealth management results and the share of balancing funds, which includes Profit Sharing Funds, General Allocation Funds (DAU) and Funds Special Allocation. Also known as legitimate income such as grants or emergency funds. While the expenditure budget is the budget used for various purposes of carrying out government tasks in the region. The Regional Government submits a draft Regional Regulation concerning changes to the Regional Revenue and Expenditure Budget (APBD) for the current fiscal year to obtain approval from the Regional People's Representative Council (DPRD) before the end of the fiscal year. After obtaining approval from the Regional People's Legislative Council (DPRD) regarding the draft regional regulation regarding the Revised Regional Revenue and Expenditure Budget (APBD-P), then the process of evaluating and establishing the draft Regional Regulation concerning the Revised Regional Revenue and Expenditure Budget (APBD-P) and the draft Regional Head Regulations regarding the translation of the Amended Regional Revenue and Expenditure Budget (APBD-P) into Regional Regulations and Regional Head Regulations. There are two legal implications of the mechanism of the Amended Regional Revenue and Expenditure Budget (APBD-P) regulations which are not in accordance with statutory provisions. First, all processes of a series of changes that do not meet the normative requirements cannot be followed up directly. Second, administratively, all types of regional government work programs originate from the remaining budget from the previous year. (APBD-P) as the legal basis

This research aims to identify and synthesize previous research related to optimizing Problem-Based Learning (PBL) in improving students' critical thinking skills in mathematics learning through a systematic literature review. Data was collected from relevant scientific articles published in the last 10 years using certain keywords through databases such as Google Scholar, Scopus, and Web of Science. The results of the literature review show that the application of PBL consistently plays a role in improving students' critical thinking abilities, especially when supported by strategies such as the use of relevant contextual problems, structured feedback, and directed teacher guidance. These findings confirm the constructivist theory which states that meaningful learning occurs when students are actively involved in authentic problem solving. However, there are variations in results across educational levels and countries, indicating the importance of contextual adaptation in the implementation of PBL. In addition, the lack of comprehensive practical guidance and long-term evaluation instruments is a major obstacle. The conclusions of this research emphasize the need to develop clearer PBL implementation guidelines and more accurate evaluation instruments to measure its impact on students' critical thinking abilities, as well as the potential of PBL in improving the quality of mathematics learning that encourages critical thinking skills as an important competency in 21st century education.

This study examines the implementation of the Project-Based Learning (PjBL) model through a miniature ecosystem project to enhance the creativity of fifth-grade students at SD Negeri Winajaya III. The research employed a quasi-experimental design with a pre-test and post-test group. The results revealed a significant improvement in students' creativity after implementing the PjBL model. Students demonstrated increased abilities in designing, developing, and evaluating projects. Additionally, PjBL facilitated collaborative and independent learning. These findings highlight the relevance of PjBL to the Merdeka Curriculum, which emphasizes project-based learning to foster 21st-century skills.

The level of knowledge of the patient's family in the Stroke Unit at RSUD dr. Soediran Mangun Soemarso regarding "Prevention of Decubitus in Bedrest Patients in the Stroke Unit of Dr. Soediran Mangun Sumarso Wonogiri Hospital" is still quite low. Therefore, the group carried out PKM health education regarding the prevention of decubitus ulcers in bedrest patients in order to increase the knowledge of the patient's family in the Stroke Unit of RSUD dr. Soediran Mangun Soemarso Wonogiri. The activity target to be achieved from this activity is 100% of patient families in the Stroke Unit of RSUD dr. Soediran Mangun Soemarso Wonogiri who attended the event knew and understood how to prevent decubitus ulcers in bed rest patients.

Madrasah Tsanawiyah Azzidin Medan is a junior high school in Medan Denai District that promotes not only through manual media, but also through social media. However, during the period of 2023, the number of students who want to attend Madrasah Tsanawiyah Azzidin has decreased from 85 students in 2022 to 73 students in 2023. This is because there are still many teachers, education staff and school marketing staff who are unable to convey good and positive communication to prospective consumers through e-wom facilities, so they are less able to give a positive impression when conducting promotions. As a result, promotions with e-wom have not been utilized optimally, which makes parents of students as consumers unable to communicate carefully every message and positive impression through the school, because they still prioritize manual promotions, so that many of these prospective consumers have not been moved, so they decide not to attend Madrasah Tsanawiyah Aidin Medan Denai so that training and teaching are needed regarding the implementation of e-WOM. The method of implementing this training is done by conducting lecture methods, as well as through real presentations and simulations in implementing e-WOM applications on social media to carry out promotional activities in order to increase the number of students attending Madrasah Tsanawiyah Azzidin Medan. From the results of community service in the form of training on implementing e-WOM marketing applications, it can be seen that 37 education personnel, teachers and marketing personnel at Madrasah Tsanawiyah Azzidin Medan can improve their ability to implement the use of e-WOM applications when conducting promotions to increase the number of students who will attend Madrasah Tsanawiyah Azzidin Medan.

This study aims to examine the relationship between mental health, non-physical work environment, and the performance of generation Z employees in Bekasi City. Generation Z, who were born between 1995 and 2010 or are currently in the age range of 13-28, are known for their characteristics that include high proficiency in using technology, high levels of involvement in social media. However, Generation Z employees have negative characteristics, namely being easily anxious and stressed when things don't go as they wish. Generation Z feels stress at work caused by their perception of a very competitive work environment, long working hours, and tight deadlines in completing their tasks. This study uses a qualitative method through the distribution of questionnaires. The population in this study were 50 generation Z employees in Bekasi City. This study tested the hypothesis and analyzed the data using SmartPLS (Partial Least Square) Computer Software version 3.0. The results of the analysis show that the influence of mental health has a significant influence on employee performance, while the influence of the non-physical work environment has a significant influence on employee performance.

Reminiscence therapy is a psychological treatment specifically designed for the elderly to improve mental health status by recalling and accessing memories that still exist. In addition to helping strengthen memories, reminiscence therapy also provides emotional benefits, such as increasing self-confidence, creating feelings of being valued, and building social bonds with fellow residents of the orphanage. The purpose of the intervention is to maintain memory function in the elderly of Al-Hikmah Orphanage Foundation using Reminiscence therapy. The method used is a combination of empowerment and capacity building to empower the elderly to recognize the potential and value of their life experiences. Based on the results of research conducted using pre-test and post-test, it can show that these elderly people still have clear memories of the past.

This paper examines the evolution of international law from its early foundations to its contemporary form. Starting with the basic legal principles, it highlights significant milestones, such as the Peace of Westphalia in 1648, which established the concept of state sovereignty. The study also explores the contributions of Hugo Grotius, who is often regarded as the "Father of International Law," whose work significantly shaped the modern legal framework that governs relations between states. In addition, he analyzed the development of global institutions such as the United Nations, which emerged after World War II and played a crucial role in encouraging international cooperation and advancing international law in the 20th century. Particular attention is paid to treaty law, emphasizing how treaties between countries are important for maintaining global order. Using a qualitative research approach, this study provides a comprehensive understanding of historical and contemporary shifts in international law. It discusses how countries have balanced their sovereignty by pursuing global cooperation and broader peace. These findings underscore important moments in the evolution of international law, offering insights into the ongoing challenges and opportunities for global governance in the modern era.

In the effort to explore the true dimensions of life, humans should not focus solely on the empirical and a priori levels. To achieve a deeper understanding, one must free oneself from all forms of attachment to things that are empirical and a priori. Deep reflection is necessary so that the fundamental principles can be discovered, leading to a more essential understanding of reality. This paper aims to analyze the metaphysical dimension contained within the dolop ritual. The findings of this study show that metaphysical reflection can overcome the limited view of reality that is apparent on the surface, which often feels "real" but is actually deceptive. Unknowingly, such views fall into the ideological realm that restricts and binds, causing humans to become trapped in the sacralization of space, time, and place that color the Kasada ritual ceremony. Based on these findings, the study of the metaphysical dimension continues by delving deeper into the existence and meaning of the symbols present. This exploration ultimately concludes that the metaphysical dimension in the dolop ritual of the Dayak Agabag community is, in fact, a representation or miniature of life itself. This ritual is not merely a ceremony, but a broader representation of life that must be understood in a deeper context.

The maritime conflict between Indonesia and China in the South China Sea arises from overlapping claims, particularly concerning Indonesia’s Exclusive Economic Zone (EEZ) near the Natuna Islands. China’s assertion of sovereignty through its Nine-Dash Line, which Indonesia does not recognize under the 1982 United Nations Convention on the Law of the Sea (UNCLOS), has fueled tensions. These have been exacerbated by aggressive actions, including Chinese vessels' incursions and illegal fishing within Indonesia’s EEZ. Despite these conflicts, both nations emphasize maritime cooperation to enhance bilateral ties.This study examines the dynamics of Indonesia-China maritime cooperation and conflicts in the South China Sea and their implications for regional stability. Employing a literature-based methodology, it investigates challenges and potential resolutions, including diplomacy and third-party mediation through bodies like the International Court of Justice. The findings highlight that resolving disputes effectively requires a legal framework and multilateral collaboration through ASEAN. The study concludes with recommendations for bolstering diplomatic engagement and sustainably managing maritime resources to ensure stability across the Indo-Pacific region.

Indonesia is a country known for its richness in natural, diverse and beautiful marine resources. Coral Reefs are one of the ecosystems that must be protected and preserved as best as possible, so that they can become a place to live for marine animals such as fish and others. Australia's also a country known for its diverse and beautiful marine ecosystem. However, both countries are experiencing problems, namely that coral reefs are not maintained, so Humans overexploit coral reefs and cause fatal damage to coral reefs and other marine animals. ICRI, as one of the organizations that can maintain and preserve the sustainability of coral reefs, can be a bright spot for both of the countries to work together to maintain and protect marine ecosystems very well.

This study aims to understand the social constructs that affect the use of makeup in Open University students. The factors discussed include the influence of social media, social factors, culture, and their impact on confidence in meeting existing beauty standards. Using a qualitative descriptive approach, this study explores social norms that contribute to the perception of beauty and the practice of using makeup. The results of the study are expected to provide a deeper understanding of the perception of beauty among female students.

Social media has emerged as a transformative platform for youth skill development, particularly in diplomatic literacy. This qualitative study investigates how university students leverage social media to enhance their soft skills, focusing on communication, critical thinking, and cultural sensitivity. Through interviews and focus group discussions with 30 university students, the research explores the mechanisms by which digital platforms facilitate skill development. Findings reveal that social media provides unique opportunities for global interaction, information evaluation, and cross-cultural understanding. Students reported significant improvements in communication skills, critical thinking abilities, and cultural awareness through engaged social media use.

Reza Indragiri Amriel's book "Ajari Ayah, Ya Nak!" was published in 2014 and offers a fresh perspective on the crucial role of parents, particularly fathers, in educating and guiding their children. The author invites readers to consider how father-child interactions can become a process of mutual learning, with a focus on the father's role as an educator and how children learn from their own experiences. The aim of this abstract is to examine the messages and values contained in the book, as well as its connection to the progress of family education in Indonesia. The book emphasizes the importance of fathers being actively involved in their children's education and how this can influence their character in the future. This article seeks to understand how Reza Indragiri Amriel portrays the role of fathers in family education and how this influences the personal development of children. We do so by employing a qualitative approach. The findings are expected to provide readers with an understanding of the importance of parental collaboration in educating their children.

This research discusses the position of a siri wife as an heir based on a will from the perspective of Islamic inheritance law. According to the context of Islamic law, the position of an unregistered wife is often a problem, especially in relation to the inheritance rights that she should receive. This research aims to examine how wills can affect the inheritance rights of siri wives. The method used is literature study with analysis using data collection techniques through literature study or document study, which is the most appropriate method for normative legal research. The research results show that even though the siri wife is not recognized as a legal wife in the context of positive law, the will made by the husband can give the siri wife inheritance rights. However, this recognition depends on the intention and clarity in the preparation of the will. It is hoped that this research can provide a better understanding of the rights of unregistered wives in the Islamic inheritance system and encourage the need for reform in inheritance law regulations in Indonesia to create justice for all parties.

This article examines Joshua's Integrity in Joshua 5:13-15 with a historical-critical approach to identify the values ​​of leadership with integrity based on Joshua's experience meeting the Commander of the Lord's Host. The research method in the form of a literature study is used to explore the meaning of the Bible text and its relevance to modern leadership challenges. The results of the study show that Joshua's leadership is characterized by full obedience, humility, and respect for divine authority. These values ​​are the foundation for today's leaders in overcoming the temptations of egoism and worldly strategies. The implementation of these values ​​includes recognizing the presence of God, making decisions based on moral principles, and developing humility to create dignified, effective, and common-good-oriented leadership.    

This research investigates the connection between faith and knowledge as outlined in Surah Al-Mujadalah, particularly focusing on the two key conditions for attaining higher ranks in the sight of Allah SWT: tafassuh fil majlis (creating space in gatherings) and bersegera dalam melakukan kebaikan (rushing to do good deeds). These principles emphasize that faith and knowledge should not be mere theoretical concepts but must be reflected in practical actions that benefit society and align with Islamic values. The analysis uses a tafsir approach and social context to elucidate how these conditions serve as indicators of true faith and knowledge. By examining relevant scholarly opinions and historical contexts, this paper explains the significance of these conditions in fostering social harmony and personal development, ultimately leading to spiritual elevation. The application of these principles in daily life results in a positive societal impact and the elevation of one's status in the eyes of Allah SWT. Thus, the study reinforces that faith and knowledge, when paired with humble  

Dhikr is the practice of remembering Allah by mentioning His name, either verbally or in the heart, as well as through physical actions or deeds with the aim of drawing closer to Him. This study uses a qualitative approach with a library research method. The data sources for this research are books, journals, and research reports related to dhikr and its benefits, both from an Islamic perspective and from a psychological standpoint. The objective of this research is to describe the role of dhikr as a medium for Islamic spiritual counseling to bring peace of mind through the integration of Islamic values from a psychological perspective. The findings of this study indicate that dhikr brings many benefits, including gaining forgiveness from Allah, calming the heart and soul, avoiding heedlessness, and receiving abundant rewards from Allah. In terms of psychology, dhikr can promote relaxation, enhance mental focus, help overcome life challenges, boost motivation, influence physical health, support harmonious social relationships, and improve the effectiveness of healing for patients undergoing therapy or treatment.

The concepts of justice and peace in Islam are fundamental elements that underlie the social, political and moral structure in Islamic society. Justice (al-'Adl) in Islam includes not only legal or distributive justice, but also social and spiritual justice which demands a balance between individual rights and collective interests. This research aims to provide a deeper understanding of the importance of these two concepts in creating a harmonious and civilized society, as well as how Muslims can contribute to creating a better world. This research is descriptive-analytic in nature, namely describing and analyzing in depth how Islam views justice and peace based on available sources. Following are the research steps: Determine the main research theme (justice and peace), collect data sources, read and analyze relevant texts, identify Islamic principles related to justice and peace. These principles of justice are strengthened by the teachings of the Koran and Sunnah which emphasize the importance of equal treatment, eliminating injustice and fulfilling human rights. Peace (as-Salam) in Islam is not only interpreted as the absence of conflict, but as a state of harmony rooted in justice and a sense of social responsibility. This research can provide deeper insight into the concept of justice in Islam. Islam teaches that justice is not only applied in the context of human relationships with God, but also in relationships between humans. This research can examine how these principles of justice can be applied in various contexts of daily life, including government, economics and social relations.