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A chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance or impaired insulin secretion is classified as type 2 diabetes mellitus. The prevalence of diabetes continues to rise each year and has become one of the major challenges in global health due to its potential to cause serious complications, such as cardiovascular disease, kidney failure, neuropathy, and vision impairment. In addition to pharmacological therapy, the use of herbal plants is increasingly being developed as a complementary therapy because they are considered safer, more readily available, and contain bioactive compounds with potential antidiabetic properties. This review article aims to assess the effectiveness of several herbal plants namely cinnamon (Cinnamomum cassia), fenugreek (Trigonella foenum-graecum), bitter melon (Momordica charantia), and moringa (Moringa oleifera) in aiding the management of type 2 diabetes mellitus based on various research findings. This study employs a literature review method by collecting and analyzing various national and international scientific publications related to the antidiabetic activity of these four plants. The review results indicate that all plants have potential as adjunct therapies for diabetes because they contain active compounds such as flavonoids, polyphenols, cinnamaldehyde, charantin, quercetin, trigonelline, and saponins, which can help reduce blood glucose levels, optimize cellular response to insulin, increase GLUT4 activity, and help minimize oxidative damage. Based on the study results, moringa and cinnamon plants demonstrated the most consistent effectiveness in contributing to blood sugar control in individuals with type 2 diabetes mellitus. Thus, these herbal plants have the potential to be used as complementary therapies in the management of type 2 diabetes mellitus; however, their use must still adhere to proper dosing and should not replace primary medical therapy.

A chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance or impaired insulin secretion is classified as type 2 diabetes mellitus. The prevalence of diabetes continues to rise each year and has become one of the major challenges in global health due to its potential to cause serious complications, such as cardiovascular disease, kidney failure, neuropathy, and vision impairment. In addition to pharmacological therapy, the use of herbal plants is increasingly being developed as a complementary therapy because they are considered safer, more readily available, and contain bioactive compounds with potential antidiabetic properties. This review article aims to assess the effectiveness of several herbal plants namely cinnamon (Cinnamomum cassia), fenugreek (Trigonella foenum-graecum), bitter melon (Momordica charantia), and moringa (Moringa oleifera) in aiding the management of type 2 diabetes mellitus based on various research findings. This study employs a literature review method by collecting and analyzing various national and international scientific publications related to the antidiabetic activity of these four plants. The review results indicate that all plants have potential as adjunct therapies for diabetes because they contain active compounds such as flavonoids, polyphenols, cinnamaldehyde, charantin, quercetin, trigonelline, and saponins, which can help reduce blood glucose levels, optimize cellular response to insulin, increase GLUT4 activity, and help minimize oxidative damage. Based on the study results, moringa and cinnamon plants demonstrated the most consistent effectiveness in contributing to blood sugar control in individuals with type 2 diabetes mellitus. Thus, these herbal plants have the potential to be used as complementary therapies in the management of type 2 diabetes mellitus; however, their use must still adhere to proper dosing and should not replace primary medical therapy.

Drug-Related Problems (DRPs) are common in patients with type 2 Diabetes Mellitus (T2DM) who receive combination therapy involving oral antidiabetic agents and insulin. This literature review aims to identify the main types of DRPs and the factors contributing to their occurrence based on recent studies from PubMed, ScienceDirect, ResearchGate, and Google Scholar. The most frequently reported DRP is drug interaction, followed by underdosing, overdosing, therapy without indication, untreated indications, adverse drug reactions, and patient-related problems such as non-adherence. Several factors contribute to the occurrence of DRPs, including polypharmacy, inappropriate dosing, the presence of comorbidities, limited patient knowledge regarding therapy, and inadequate clinical monitoring. These conditions may increase the risk of poor glycemic control and treatment failure. Therefore, effective management of DRPs is essential to improve therapeutic outcomes. The findings of this review emphasize the important role of pharmacists in conducting medication reviews, identifying DRPs early, and implementing appropriate interventions to enhance patient safety and optimize treatment in T2DM patients.

Drug-Related Problems (DRPs) are common in patients with type 2 Diabetes Mellitus (T2DM) who receive combination therapy involving oral antidiabetic agents and insulin. This literature review aims to identify the main types of DRPs and the factors contributing to their occurrence based on recent studies from PubMed, ScienceDirect, ResearchGate, and Google Scholar. The most frequently reported DRP is drug interaction, followed by underdosing, overdosing, therapy without indication, untreated indications, adverse drug reactions, and patient-related problems such as non-adherence. Several factors contribute to the occurrence of DRPs, including polypharmacy, inappropriate dosing, the presence of comorbidities, limited patient knowledge regarding therapy, and inadequate clinical monitoring. These conditions may increase the risk of poor glycemic control and treatment failure. Therefore, effective management of DRPs is essential to improve therapeutic outcomes. The findings of this review emphasize the important role of pharmacists in conducting medication reviews, identifying DRPs early, and implementing appropriate interventions to enhance patient safety and optimize treatment in T2DM patients.

Background: Diabetes Mellitus (DM) is a disease that cannot be completely cured or cannot even be completely cured. The vile shard plant is empirically used by the community to treat diabetes (DM). This study aims to conduct phytochemical screening and test the activity of 96% ethanol extract of kejibeling leaves (Strobilanthes crispus (L.) Bl.) as a herbal antidiabetic in male white mice (Mus musculus) with alloxan induction. Method: This research is an experimental laboratory research with a true experimental posttest control design using a completely randomized design (CRD) with 5 treatments and 5 replications. Treatment P1 (without treatment) as normal control (N), P2 as positive control (+), P3 as negative control (-), P4 kejibeling leaf extract 250 mg/kg BW, P5 kejibeling leaf extract 500 mg/kg BW. Result:The results of phytochemical screening showed the presence of alkaloids, flavonoids, tannins, saponins, terpenoids and steroids. SPSS results show that the data is normally distributed (p>0.05) and homogeneous (p>0.05). The results of the ANOVA on the treatment of giving keji beling leaf extract 250 mg/Kg BW showed a sig. 0.393 (p>0.05) and treatment of 500 mg/Kg BW obtained a sig value. 0.517 (p>0.05). Conclusion:The conclusion from the research results shows that administering doses of 250 mg/kg BW and 500 mg/kg BW of keji beling leaf extract can reduce blood sugar levels in mice. It is hoped that the results of this research will be useful for the community as an antidiabetic therapy using kejibeling leaves (Strobilanthes crispus (L.) Bl.).

Type 2 Diabetes Mellitus is a chronic disease with an increasing prevalence and requires long-term therapy, resulting in a significant economic burden on healthcare systems. This study aimed to analyze the cost-effectiveness of antidiabetic drug use among Type 2 Diabetes Mellitus patients in the inpatient unit of Dr. R. Hardjanto Hospital, Balikpapan. This research employed an observational analytic design with a cross-sectional approach and retrospective data collection from medical records and administrative data for the period January–December 2023. A total of 54 patients who met the inclusion criteria were included as study samples. Therapeutic effectiveness was assessed based on the achievement of random blood glucose levels ≤200 mg/dL, while the analysis focused on direct medical costs. Cost-effectiveness was evaluated using the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The results showed that Metformin–Apidra therapy achieved higher clinical effectiveness (92%) with an average cost of IDR 3,636,721 and an ACER value of IDR 39,529. Meanwhile, Glimepiride–Sansulin therapy demonstrated 81% effectiveness with a lower average cost of IDR 2,519,259 and an ACER value of IDR 31,101. The ICER value of IDR 10,158 indicates the additional cost required to achieve a 1% increase in effectiveness. In conclusion, Metformin–Apidra therapy is more clinically effective, whereas Glimepiride–Sansulin therapy is more cost-effective economically.

Brotowali stem (Tinospora crispa L.) is a plant that grows abundantly in Central Kalimantan and has been empirically used for generations as an antidiabetic remedy by the Dayak Ngaju community. Brotowali stem contains secondary metabolite compounds, including alkaloids, which possess various pharmacological activities, one of which is antidiabetic activity. This study aimed to determine the alkaloid content of Tinospora crispa stem extract in aquadest, ethyl acetate, and n-hexane fractions. The research employed an observational descriptive method by analyzing qualitative data through color reaction tests and quantitative data using UV-Vis spectrophotometry to determine alkaloid levels. The qualitative analysis results showed positive color reactions indicating the presence of alkaloid compounds. Quantitative analysis using UV-Vis spectrophotometry revealed that the total alkaloid content in the aquadest fraction was 20.19 mg or 20.19%, in the n-hexane fraction was 20.54 mg or 20.54%, and in the ethyl acetate fraction was 31.07 mg or 31.07%. The highest total alkaloid content was found in the ethyl acetate fraction. In conclusion, the extract of Tinospora crispa stem positively contains alkaloids, with the highest alkaloid content obtained in the ethyl acetate fraction at 31.07%.

Papaya fruit (Carica papaya L.) is a tropical plant widely consumed as food and known to contain various bioactive metabolites with potential health benefits. The increasing interest in natural products as functional resources highlights the importance of reviewing the chemical characterization and health applications of papaya bioactive compounds. This article aims to systematically review the types of bioactive metabolites found in papaya fruit, the chemical characterization methods applied, and their potential applications in the health sector. This review was conducted through a literature study of relevant scientific articles, focusing on metabolite identification and biological activity evaluation. The results indicate that papaya fruit contains diverse bioactive metabolites, including flavonoids, phenolic compounds, alkaloids, saponins, terpenoids, and proteolytic enzymes. These compounds are commonly characterized using chromatographic and spectroscopic techniques. Several studies have reported that papaya bioactive metabolites exhibit biological activities such as antioxidant, antimicrobial, anti-inflammatory, and antidiabetic effects. This review suggests that papaya fruit has promising potential as a functional natural resource for health and pharmaceutical applications.

This paper presents a narrative review focusing on the significance of in silico methodologies in identifying and evaluating natural bioactive compounds as promising antidiabetic agents. By examining scientific publications from 2020 to 2025, the review highlights substantial evidence that various plant-derived metabolites such as flavonoids, phenolic acids, terpenoids, and glycosides from Orthosiphon stamineus, Moringa oleifera, Syzygium polyanthum, Tinospora crispa, and Albizia saman demonstrate notable affinity toward several crucial enzymes implicated in type 2 diabetes, including DPP-4, SGLT-2, α-glucosidase, and PTP1B. Findings from molecular docking analyses and ADMET simulations indicate that many of these compounds exhibit favorable pharmacokinetic behavior, strong receptor interactions, and minimal toxicity, suggesting their potential as multitarget natural therapeutics with synergistic modes of action. Utilizing in silico screening as an initial step effectively predicts biological activity and pharmacological profiles prior to experimental validation through in vitro and in vivo testing, thus reducing both time and research expenditure. The synergy between computational modeling, medicinal chemistry, and phytochemical exploration establishes a scientific framework that supports the advancement of rational, safe, and sustainable herbal-based antidiabetic drug development derived from Indonesia’s vast biodiversity and encourages self-reliance within the national pharmaceutical sector.

Diabetes Mellitus is a metabolic disorder caused by the pancreas failing to produce insulin hormone adequately. Based on the cause, diabetes mellitus is classified into three types, including type 1 DM, type 2 Diabetes Mellitus, and gestational diabetes mellitus. Hyperglycemia can also occur due to food consumed that is not balanced with physical activity carried out so that fat accumulates in the body and causes blood to be unable to enter the body's cells, ultimately increasing blood sugar levels. Signs and symptoms that often appear in Diabetes Mellitus patients are polydipsia (excessive thirst), polyuria (frequent urination due to excessive urine production), polyphagia (quickly feeling hungry even though you eat a lot and want to eat continuously) and weight loss without a clear cause. Symptoms of diabetes mellitus can be controlled by increasing physical activity, following a healthy diet, and getting enough rest. Several studies have proven that bay leaves have the potential as an antidiabetic. This study aims to determine the content of secondary metabolic compounds and the antidiabetic activity of bay leaf extract using α-amylase enzyme inhibition in vitro. This research method uses laboratory experiments. This study uses α-amylase enzyme inhibition to determine the antidiabetic activity contained in bay leaf extract. The method used is DNSA. The results of this study obtained a yield of bay leaf extract of 30%, water content of simplicia of 6.24%, drying loss of simplicia of 5.3%, ash content test of 5.6%, water content test of extract of 6.34%, drying loss test of extract of 7.03%. Bay leaf extract positively contains secondary metabolite compounds, namely saponins, tannins, flavonoids, and alkaloids. The results of IC50 in bay leaf extract of 66.705 ppm are classified as strong antidiabetic. The results of acarbose of 56.818 ppm are classified as strong antidiabetic.

Eleutherine bulbosa (Mill.) and Allium cepa L. (including garlic and onion peel) are medicinal plants that have long been traditionally used to treat cancer, diabetes, hypertension, infectious diseases, and inflammation. Recent scientific studies emphasize the importance of extract standardization to ensure consistent quality, safety, and efficacy. Standardization includes specific parameters—such as organoleptic identification, water- and ethanol-soluble extract values, phytochemical profiles, and determination of marker compounds—and nonspecific parameters such as moisture content, loss on drying, total ash, and acid-insoluble ash. Ethanol extract of E. bulbosa showed moisture and drying loss values below 10%, total flavonoid content of around 1.2%, and positive phytochemical tests for alkaloids, flavonoids, saponins, and quinones. Onion peel extract contains a high flavonoid content (7.84 mg QE/g) with moderate antioxidant capacity (DPPH IC₅₀ 152.65 µg/mL), while fermented garlic (black garlic) contains more than 12% polyphenols and more than 2% flavonoids, as well as a high level of S-allyl-L-cysteine (SAC) as a stable bioactive compound. The pharmacological activities of these standardized extracts include strong antioxidant effects, α-glucosidase inhibition for antidiabetic activity, induction of apoptosis and anti-angiogenesis as anticancer potential, membrane disruption and enzyme inhibition for antimicrobial activity, as well as COX/LOX modulation for anti-inflammatory effects. These activities are directly correlated with the secondary metabolite composition of each material. With their phytochemical richness and diverse biological activities, E. bulbosa and A. cepa have great potential as raw materials for standardized herbal products. Further in vivo studies and clinical trials are needed to validate their therapeutic efficacy and to support the development of evidence-based phytopharmaceuticals.

A 55-year-old female patient came to F Hospital complaining of blurred vision in her left eye for 3 years and a gradual decrease in vision. The vision in her left eye had been increasingly blurry and disrupting activities for 4 months before coming to the hospital. The patient reported discomfort and blurriness when looking at a distance, but there was no disturbance in close-up vision. The patient also reported foggy vision and glare, especially during the day. The patient did not complain of dizziness, nausea, or vomiting. When looking at objects, there was no change in size, and she had never seen floating objects. The patient had undergone cataract surgery on her right eye 2 months ago. She had a history of type 2 diabetes mellitus since 2017 and was regularly taking antidiabetic medication. The patient reported wearing glasses for 3 years. The general status was normal, while the left local status showed 2/60 vision, arcus senilis (+), cloudy lens, and shadow test (-). Fasting blood sugar examination showed hyperglycemia, and tonometry showed increased intraocular pressure. Based on this, the patient was diagnosed with a mature senile cataract of the left eye. The patient underwent surgery on the left eye using phacoemulsification and has a good prognosis. Appropriate cataract management can significantly improve the patient's quality of life.

A 64-year-old male patient presented to the emergency department (ED) of RS Cut Meutia with complaints of left-sided chest pain radiating to both arms, which had been occurring for two days prior to his hospital admission. The chest pain was described as sharp, sudden, and progressively worsening, and it persisted without relief from positional changes. The pain intensity was rated as 9/10 and was accompanied by cold sweats and nausea. The patient had a history of type 2 diabetes mellitus for 15 years and had been on antidiabetic medications, although he could not recall the names of the medications. The patient was a smoker but had quit smoking upon being diagnosed with diabetes. Vital signs and general status were within normal limits upon examination. Local examination of the heart revealed a murmur on auscultation. Laboratory results showed anemia, leukocytosis, hyperglycemia, and hypercholesterolemia. Electrocardiography (EKG) indicated signs of inferior STEMI (ST-Elevation Myocardial Infarction). The patient was treated with furosemide 1 amp/12 hours, atorvastatin 1x20 mg, arixtra 1x0.25 mg, aspilet 1x8 mg, clopidogrel 1x75 mg, nitrokaf retard 2x2.5 mg, and bisoprolol 1x2 mg, along with non-pharmacological management, including three-way catheter insertion and oxygen therapy at 2-4 liters per minute. Acute Coronary Syndrome (ACS) carries a poor prognosis if not managed promptly and correctly. Understanding the appropriate management of ACS is crucial in preventing further myocardial occlusion and improving patient outcomes. Therefore, rapid and accurate intervention is vital in improving the prognosis for patients with ACS.

Type 2 Diabetes Mellitus (DM) is a disease caused by impaired insulin function, impaired insulin secretion, or both, resulting in a hyperglycemic condition. Patients with type 2 DM generally exhibit characteristics such as a Random Blood Glucose level exceeding 200 mg/dL and an HbA1c  level exceeding 6.5%. The accuracy of medication administration to patients must also consider the rationality of antidiabetic therapy in order to influence the success rate of optimal therapy. This study aims to evaluate the rationality of patient appropriateness and indication appropriateness in outpatients with type 2 DM at Tabanan Regional Public Hospital (RSUD Tabanan). This study employed a semi-quantitative observational research design with a retrospective approach by reviewing patient medical records from the initiation of therapy. Sampling was conducted using purposive sampling, whereby samples had to meet predetermined inclusion criteria. The results indicated that the age group with the highest prevalence of DM patients at RSUD Tabanan was over 56 years old (74%), with a predominance of females (63%). The most common comorbidity among DM patients was hypertension alone (24.5%). Based on the findings, the percentage of patient appropriateness rationality among DM outpatients at RSUD Tabanan was 97.5%, while the percentage of indication appropriateness rationality in type 2 DM outpatients at RSUD Tabanan was 98.5%.

Justicia gendarussa Burm. f., commonly known as gandarusa, is a medicinal shrub widely distributed in South and Southeast Asia. Traditionally, it has been used for treating rheumatism, headache, asthma, bronchitis, skin infections, and as a male contraceptive. Phytochemical analyses revealed the presence of alkaloids (gendarusin A, gendarusin B), flavonoids (quercetin, kaempferol, apigenin), saponins, tannins, phenolics, terpenoids, and Patentiflorin A, a compound with promising anti-HIV activity. Pharmacological investigations demonstrated its anti-inflammatory, analgesic, antimicrobial, antioxidant, antidiabetic, hepatoprotective, immunomodulatory, anticancer, and contraceptive potentials. This review highlights the phytochemical profile, pharmacological properties, and future prospects of J. gendarussa, emphasizing its potential as a phytopharmaceutical candidate. Further studies are required to standardize extracts, confirm clinical efficacy, and ensure long-term safety.

Background: Chinese betel (Peperomia pellucida L.) is an herbal plant rich in bioactive compounds such as flavonoids, alkaloids, and tannins that have the potential to be antioxidants, antimicrobials, and antidiabetics. However, the stability and absorption of its active compounds in the body is still a challenge. Microencapsulation technology and  a floating drug delivery sistem (FDDS) can improve the effectiveness and stability of herbal preparations. Objective: This study aims to formulate and evaluate floating microencapsulation preparations containing Chinese betel herb ethanol extract using modern drug delivery technology. Methods: Ethanol extracts were obtained by maceration method and formulated by ionic gelation technique using a combination of sodium alginate and chitosan at three concentration variations (0.25%, 0.5%, and 0.75%). The evaluation included morphological analysis with SEM, ex vivo buoyancy test on the stomach of Wistar rats, determination of moisture content, and physical stability test using the cycling test method. Results: Microencapsulation with a concentration of 0.75% showed the most compact and delicate morphology, the lowest moisture content (0.64%), and the best physical stability. All formulations are capable of floating, with the longest buoyancy time at a concentration of 0.25% for 8 hours. There were no significant physical changes after six cycles of extreme temperatures. Conclusion: Microencapsulation preparations of Chinese betel ethanol extract in a natural polymer-based floating system show good stability and potential as an innovative herbal formulation to extend retention time in the stomach.    

Diabetes mellitus is a metabolic disorder characterized by high blood sugar levels continuously. Insulin resistance is the main cause of type 2 diabetes mellitus, so it is very important to control it to maintain blood sugar levels. Traditional ingredients have long been used to treat diabetes. One of the traditional ingredients used is cinnamon which has been proven to have a potential effect on the management of type 2 diabetes mellitus. The content of cinnamon that has an antidiabetic effect is cinnamaldehyde which provides a distinctive taste and aroma. The method used is by analyzing journals that meet the inclusion and exclusion criteria. Articles were searched for in the search media PubMed, Science Direct, and Google Scholar. The results of analyzing the articles found were a decrease in blood glucose levels, HbA1c, HOMA-IR, and an increase in insulin levels between the blood glucose of the control group of experimental animals and the blood glucose of the group that received cinnamaldehyde intervention. The conclusion of this study is that cinnamaldehyde intervention can reduce blood glucose levels, HbA1C, HOMA-IR and increase insulin levels in the blood.

This study focuses on the production of herbal tea made from avocado leaves (Persea americana Mill.) and explores its potential as a health-promoting beverage. Avocado leaves are known to contain various bioactive compounds, including flavonoids, tannins, and saponins, which have antioxidant, antidiabetic, and antihypertensive properties. The production process involves selecting healthy leaves, washing, drying using a low-temperature oven (50–60°C), and grinding the dried leaves into powder. The final tea product was tested organoleptically to assess its taste, aroma, and color, and phytochemically to confirm the presence of bioactive compounds. The organoleptic test results showed that the tea has an acceptable flavor and aroma, while phytochemical tests confirmed the presence of beneficial compounds. Consumption of avocado leaf tea demonstrates potential as a functional beverage that may contribute to lowering blood pressure and blood sugar levels, as well as providing a calming effect. The findings of this study are expected to serve as a reference for the development of value-added herbal products derived from local raw materials. Such products could support efforts to improve public health and encourage the diversification of functional beverages within the community, providing both health and economic benefits for local populations.

Lombok Island is home to a rich culinary heritage, with traditional dishes deeply rooted in Sasak culture and potential functional food value. This literature review investigates five iconic Lombok dishes—Ayam Taliwang, Plecing Kangkung, Sate Bulayak, Ares, and Beberuk Terong—focusing on their nutritional profiles, bioactive compounds, and health-related properties. Adopting the PRISMA-ScR approach, this study synthesizes 30 scientific articles published between 2014–2024 and compares findings with the Indonesian Food Composition Table (TKPI). Results reveal the presence of bioactive compounds such as capsaicin, curcumin, allicin, flavonoids, and nasunin, with antioxidant, antidiabetic, immunomodulatory, and cardioprotective effects. The review highlights challenges in food safety (e.g., acrylamide, aflatoxin risks), along with the need for standardized recipes and modern packaging strategies. The paper recommends further scientific validation and sustainable innovation to transform Lombok's traditional cuisine into evidence-based functional food products that strengthen local identity, promote public health, and boost Indonesia’s healthy food industry.

This study aimed to identify the secondary metabolite compounds present in the ethanol extract of Plukenetia volubilis L. (sacha inchi) shells through phytochemical screening and LC-MS analysis. The extraction was performed using the maceration method with 95% ethanol as solvent, resulting in a yield of 47.33%. Qualitative phytochemical tests revealed the presence of alkaloids, flavonoids, tannins, terpenoids, saponins, and glycosides in the extract. Further LC-MS analysis tentatively identified several phenolic and flavonoid compounds with known biological activities, including sinapinic acid, 1-o-sinapoylglucose, and azelaic acid from the dicarboxylic acid group. The presence of these compounds highlights the potential of sacha inchi shell extract as a natural antioxidant and antidiabetic agent. These findings support the valorization of sacha inchi agricultural waste as a promising raw material for pharmaceutical and nutraceutical applications.