Metabolic syndrome (MetS) is influenced by parental traits and diet. Drosophila melanogaster is a potential disease model organism, sharing physiology and genetic similarities with humans. Previous research had focused on Drosophila melanogaster as a model organism for obesity and diabetes, but not for MetS. This research aimed to determine the effect of both parental diet and high sugar fat (HSF) intake on glucose, cholesterol, and triglyceride hemolymph levels of Drosophila melanogaster. Wild flies were purified in either control (standard) or MetS media (extra 3% sucrose and palm oil). Seventy-five pairs were divided into 5 groups, according to parental origin and feeding media, and maintained in five generations (F1-F5). Glucose, triglyceride, and cholesterol levels were measured using a colorimetric assay in three replications of each generation per group. Glucose, triglyceride, and cholesterol levels were significantly different in all treatment groups, the control groups, and between generations in each group (p<0.05). Higher glucose and triglyceride levels appeared in the youngest generation (F5) of all groups, and in the flies reared on HSF diets. Maternal HSF-exposed groups demonstrated a more pronounced impact of parental metabolic state on the glucose and triglyceride levels of the earlier generation. These findings highlight that parental exposure to HSF and prolonged HSF intake independently and synergistically lead to persistent and amplified metabolic dysregulation across generations. Drosophila melanogaster, modeled in this study, represents a novel experimental organism that is suitable for studying the epigenetic inheritance of MetS, gaining more consideration for the metabolic health consequences of long-term dietary habits and parental metabolic state.

The presence of natural antioxidants in medicinal plants plays a crucial role in inhibiting the detrimental effects of oxidative stress. The aim of this research is to explore more deeply all parts of A. esculenta L from flowers, fruits, seeds, leaves, and stems for the levels of compounds and antioxidant and enzyme inhibitor activities. The flowers demonstrated the highest TPC with 173.15942 ± 6.5083 mg GAE/g. The stems exhibited the lowest TPC value at 69.1967 ± 2.8408 mg GAE/g. The flowers also showed TFC value of 83.157 ± 2.021 mg QE/g while the stems displayed the lowest with 36.7240 ± 1.337 mg QE/g. IC50 value that the flowers possessed the highest antioxidant activity with 22.6539 ± 1.6452 mg/mL, whereas the stems displayed a slightly lower. In terms of the inhibitor of a-amylase activity, the flowers had an IC50 value of 102.4885 ± 11.4370 mg/mL whereas the stems had a lower. The highest IC50 value of the a-glucosidase inhibitor was 76.95 ± 12.0888 mg/mL in the flowers, and the lowest was in the stems. The highest IC50 of pancreatic lipase inhibitor was 109.5943 ± 9.7391 mg/mL in the flowers, and the lowest was in the stems. This study show that there is a relationship between the high content of total phenolic and total flavonoids on antioxidants, antidiabetic and antilipase activities.

The Cargo oil pump is one of the auxiliary units on board a ship, used to transfer cargo from one location to another during loading and unloading operations. On the MT?Pangrango vessel, an issue occurred with the cargo oil pump: its performance declined, resulting in slow suction during the unloading process. This problem hindered efficient cargo operations, as the pump was not functioning properly.This study aims to identify the contributing factors, impacts, and countermeasures for the decreased performance of the cargo oil pump. The research methodology applied in this thesis involved a descriptive approach combined with Miles and Huberman’s analytical method, with data validity tested via triangulation. Data collection techniques used to identify the problem included observation, interviews, documentation, and literature review.The results revealed that the pump’s shaft was worn due to excessive friction, and the ball bearing s exhibited wear and disintegration caused by lack of lubrication (grease). The recommended corrective actions were to add material to the shaft , perform realignment to correct any shaft misalignment, and implement routine maintenance—specifically, monthly grease lubrication. These measures, when properly applied, can significantly reduce the risk of Cargo oil pump damage.

The phenomenon of online gambling has become a serious problem in various regions, including West Aceh Regency. data on cases handled by the West Aceh District Syar'iyah Court in the period 2021 to 2024 shows a significant increase in cases. Online gambling as part of jarimah maisir has different characteristics from conventional forms of gambling, namely digital, hidden, cross-regional, and difficult to detect by the naked eye by law enforcement officials and the general public. The problems in this study are How is the application of qanun jinayat law against online gambling offenders in the jurisdiction of the West Aceh District Syar'iyah Court, What are the obstacles faced in applying the law to online gambling offenders based on qanun jinayat law, and What are the efforts to prevent online gambling violations in the West Aceh area. This research uses empirical legal methods with a field research approach and case studies. The results showed that the application of Aceh Qanun Number 6 of 2014 concerning Jinayat Law against online gambling offenders was in accordance with the procedures of jinayat law, but its implementation was still not optimal. The Syar'iyah Court has handled a number of cases, but the number is not proportional to the potential violations. The main obstacles include limited regional authority in blocking sites, lack of digital forensic experts, absence of district-level cyber units, and weak coordination between agencies. Prevention is carried out through digital education by DISKOMINSA, thematic dakwah by the Islamic Sharia Office, as well as the Gampong Tolak Judi Online programme involving the community and the formation of the Gampong Pageu Task Force.

Abstract. Brake pads are a crucial component of brake parts, especially for motor vehicles. Regulations restricting the use of asbestos have prompted researchers to seek alternatives. In this study, brake pads will be made using biomass waste from sawdust obtained from the activities of furniture MSMEs in the Bangkinang area, Kampar, Riau. The utilization of this biomass waste is intended to minimize waste volume and provide an alternative raw material and production process for brake pads that are low-cost and abundantly available. In this study, brake pads are made with a mixture of sawdust filler matrix and epoxy resin reinforcement matrix. Next, the brake pad samples will be tested for physical characteristics in the form of density and water absorption. Mechanical strength is tested through a bending test using the Universal testing test. Brake pad performance will be tested through wear test values. The results of the test on physical and mechanical properties obtained a density of 0.73 g/cm3, a maximum bending load of 452.67 N, a flexural strength of 187.97 MPa, and an elastic modulus of 184.69 MPa. The physical characteristics of this composite show that sawdust can be an alternative raw material for brake pads that is cheap and abundantly available, thus supporting environmental sustainability.

An experiment was conducted to study the effect of adding different levels of urea fertilizer (ppmUrea-N0,75,150,225,300) on the effectiveness of bio-nitrification in the studied soil. The study treatments forthis experiment were (4 soils of different textures and locations × 5 urea levels × 3 replicates) in an experimentin which a completely randomized design (CRD) was used. It was incubated at laboratory temperature (25°C)for 40 days, during which the amount of formed nitrates and remaining ammonium was measured every tendays, noting the replacement of lost water every two days.The highest percentage of formed nitrates (39.8%) was recorded from the ammonium added to Basrah soilafter ten days of incubation, followed by Kut soil, which recorded 29.8%, and less than that in Shatra soils(24.2%) and Fajr soils (23.7%). After that, the efficiency of nitrification decreased in the subsequent incubationperiods up to 40 days of incubation.The percentage of ammonium remaining from urea added to the soil was recorded after the four incubationperiods at 20.0 ppm (when adding 225 ppm urea to the Qurna soil), which differed significantly from the rest ofthe studied soils.

Several of the best-selling small-molecule medications and natural alkaloids contain piperidine, a crucial saturated heterocyclic scaffold with a wide variety of biological functions. The hydrazide-hydrazone moiety's exceptional use in the pharmacological and biological domains made it particularly appealing. Objective: Designing and synthesizing a novel set of 4-Piperidin-1-yl-benzoic acid substituted hydrazides, Ac1-c3 and Bc1-c5, as potentially antimicrobial agents and characterizing them using IR, 1H-NMR, and mass spectroscopy. Methods: By esterifying 4- Piperidin-1-yl-benzoic acid Ac1 and then treating with hydrazine hydrate it to produce Ac3 in a good yield. The hydrazide Ac3 was condensed with the proper aldehydes or ketone to synthesis the hydrazones Bc1–c5. The in vitro bacterial activity was evaluated anti two Gram-negative bacteria, Pseudomonas aeruginosa, and Candida albicans, as well as two Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis. Results: The majority of tested compounds demonstrated significant efficacy anti Pseudomonas aeruginosa, Candida albicans. Notably, compound Bc3 emerged as the most effective derivative within the series. Conclusions: The Compounds (Bc1–c4) that were synthesized demonstrated moderate to good antimicrobial activity against a number of bacterias species and Candida albicans.

Kondisi degradasi lingkungan dan ketimpangan pembangunan pada akhirnya melahirkan konsep Blue Economy yang mana salah satu sektornya adalah wisata bahari yang berkontribusi besar dalam meningkatkan pendapatan masyarakat dan negara. Akan tetapi, pembangunan pariwisata yang ada di berbagai daerah belum tentu menjamin kesejahteraan masyarakat lokal destinasi wisata, termasuk di Karimunjawa. Maka dari itu, upaya pembangunan pariwisata di Karimunjawa perlu direformulasi sesuai dengan prinsip-prinsip dan konsep Blue Economy. Penelitian ini bertujuan untuk menganalisis pembangunan pariwisata berkelanjutan di Karimunjawa dengan pendekatan Blue Economy. Penelitian ini menggunakan pendekatan kualitatif-kuantitatif (mix method). Sumber data penelitian terdiri atas sumber data primer dan sekunder yang diperoleh dengan metode observasi partisipatif, wawancara, dan dokumentasi. Adapun analisis data dilakukan dengan metode analisis SWOT dan teknik analisis interaktif. Hasil penelitian menunjukkan bahwa pembangunan pariwisata di Karimunjawa harus diarahkan pada strategi Grow and Build dan atau stretegi Expansion. Pembangunan ini dapat mengkolaborasikan lima actor utama yaitu pemerintah, bisnis, masyarakat, akademisi, dan Lembaga swadaya masyarakat (LSM) dalam konsep pentahelix.

This study aims to analyze the role of daily journal writing habits in improving the self-confidence of fifth-grade elementary school students in expressing their opinions through a philosophical education approach that includes ontological, epistemological, and axiological perspectives, as well as physiological, sociological, and anthropological principles. The research method used is qualitative descriptive based on literature review. The object of research is the concept of daily journal writing in the context of elementary education, while the subjects are fifth-grade elementary students in general. Data were collected through document studies of articles and books, and analyzed using content analysis with source triangulation for data validity. The results show that daily journals help increase students’ self-confidence by facilitating self-reflection, supporting knowledge construction, and instilling values of honesty and courage. These findings support the implementation of daily journals as a reflective learning strategy grounded in the philosophy of basic education.
Penelitian ini bertujuan untuk menganalisis peran kebiasaan jurnal harian dalam meningkatkan kepercayaan diri siswa kelas V sekolah dasar untuk mengemukakan pendapat dengan pendekatan filsafat pendidikan yang meliputi tinjauan ontologis, epistemologis, aksiologis, serta prinsip fisiologis, sosiologis, dan antropologis. Metode penelitian yang digunakan adalah kualitatif deskriptif berbasis studi pustaka. Obyek penelitian adalah konsep kebiasaan jurnal harian dalam konteks pendidikan dasar, sedangkan subyek penelitian adalah siswa kelas V sekolah dasar secara umum. Teknik pengumpulan data dilakukan melalui studi dokumentasi artikel dan observasi literatur ilmiah terkait. Teknik analisis data menggunakan analisis konten dengan triangulasi sumber untuk validitas data. Hasil penelitian menunjukkan bahwa jurnal harian mampu meningkatkan kepercayaan diri siswa dengan memfasilitasi refleksi diri, membangun konstruksi pengetahuan, serta menanamkan nilai kejujuran dan keberanian. Temuan ini mendukung penerapan jurnal harian sebagai strategi pembelajaran reflektif yang berlandaskan filsafat pendidikan dasar.

Student motivation is an important factor that influences student engagement and academic achievement. Although many studies have examined learning motivation in classroom settings with non-interactive presentation media, limited research has explored how gamification affects motivation and learning outcomes in economics education. This study investigates the impact of using Blooket—a game-based learning platform—on students’ motivation and academic performance in economics classes during the 2024/2025 academic year. The study aims to: (i) evaluate the impact of Blooket on students’ learning motivation, (ii) assess the impact of Blooket on students’ learning outcomes. Data were collected through questionnaires and tests involving 40 high school students divided into experimental and control groups. The findings revealed that students taught using Blooket demonstrated significantly higher motivation and better learning outcomes compared to those taught using traditional methods. This study highlights the impact of the gamification medium 'Blooket' in fostering a more engaging and motivating learning environment, offering practical insights for educators seeking to enhance student participation and performance through digital tools.