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Cardiovascular disease includes several heart and cardiovascular problems. One in three deaths in the world is caused by heart disease. Handling and preventing deaths from cardiovascular disease needs to be improved. Flavonoids are phytochemicals commonly found in plants. Quercetin is one of the most common flavonoids. Quercetin is also known to have potential as an alternative intervention for people with heart disease. Therefore, the positive impact of quercetin on cardiovascular disease needs to be reviewed. This article uses a literature review method by reviewing articles from the last ten years (2014–2024) through trusted websites. The results of the study show a link between quercetin, cardiovascular disease, and the dose administered. It can be concluded that quercetin has a strong antioxidant effect, which can overall overcome and prevent cardiovascular disease.    

Purple yam is one of the tubers that serves as a source of antioxidants but has not been optimally utilized. Therefore, it needs to be diversified by processing it into snack bars. This study aims to develop snack bars made from purple yam flour, sorghum flour, and mung bean flour, which have the potential to serve as antioxidant sources and are preferred by panelists. In this study, snack bars were prepared using composite flour (sorghum:mung bean) and purple yam flour in varying ratios: 95:5, 90:10, 85:15 for the composite flour and 20%, 30%, and 40% for the purple yam flour. The snack bars were evaluated for color, texture, moisture content, antioxidant activity, and preference level. Selected samples were further analyzed for ash content, protein content, fat content, anthocyanin content, and crude fiber content. The experimental design used was a Completely Randomized Design (CRD) with two factors. The snack bars with a composite flour ratio (sorghum:mung bean) of 85:15 and 30% purple yam flour were identified as the best treatment, preferred by panelists and exhibite high antioxidant activity. These snack bars had a moisture content of 13.40%, ash content of 8.83% (db), protein content of 19.75% (db), fat content of 8.80% (db), crude fiber content of 9.54% (db), antioxidant activity of 68.02% (RSA), and anthocyanin content of 37.40 mg/100g

Sunlight is the main source of energy for life, but ultraviolet radiation can have negative impacts on the skin, such as sunburn, pigmentation, wrinkles, premature aging, and the risk of skin damage due to excessive exposure. One way to protect the skin from these effects is to use sunscreen. Carrots contain antioxidant compounds that can bind free radicals and prevent cell damage due to oxidation, so they have the potential to be used as a natural ingredient in making sunscreen. This research aims to formulate and test the physical properties of carrot extract lotion as a sunscreen and determine the extract concentration that has the optimal Sun Protection Factor (SPF) value. The method used is experimental by making lotion formulations, testing their physical properties, and measuring the SPF value of each formulation. The research results showed that the KN, F1, F2, and F3 lotion formulations had a semi-solid form which met the formulation requirements. However, KN's SPF value is only 1.23 which does not meet sunscreen standards. Meanwhile, F1 has SPF 8.3 (extra effect category), F2 with SPF 15.06 and F3 with SPF 24.1 (ultra category). F3 shows the best results because with SPF 24.1, this formulation is close to SPF 25 which can protect the skin for up to 4 hours with twice daily use. The higher the concentration of carrot extract, the better its effectiveness in lotion formulation as a sunscreen.

Technicians in radiology departments are continuously exposed to ionizing radiation, which can affect biological systems. This study aimed to investigate the effects of low-level ionizing radiation (IR) on antioxidant enzymes and blood components in radiology personnel. The study involved forty participants aged 30 to 45 years, divided into three groups: G1 as the control group (n=10), G2 consisting of 15 radiologists, and G3 comprising 15 radiology technology workers. Participants in G2 and G3 had work experience ranging from 5 to 15 years and were employed in X-ray and CT scan departments at General K1 Hospital, Kirkuk. The measured parameters included white blood cells (WBCs), platelets, and lymphocytes, as well as malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and albumin as indicators of redox status. The results showed a significant increase in MDA levels among radiology workers compared to the control group, while SOD, TAC, and albumin levels decreased (P<0.05). Additionally, radiation-exposed workers had a higher mean count of WBCs and lymphocytes than the control group (P<0.05), whereas platelet levels were significantly lower (P<0.05). This study indicates that occupational radiation exposure can cause short-term changes in blood cells and increase the circulating redox state in healthcare workers operating in CT and IR environments compared to those not exposed to radiation. These findings highlight the importance of regular health monitoring for radiology personnel to mitigate potential long-term effects of radiation exposure.

Aloe vera gel contains antioxidative phenolic compounds. Fresh aloe vera gel is less accepted by the community due to its bitter taste from its latex. An acceptable alternative to aloe vera products is an aloe vera gel beverage because people of all ages currently favor light drinks. This study aims to produce aloe vera gel beverages with high antioxidant content by varying the gel size and boiling duration for easy consumption and preference by panelists. This research employed a completely randomized design (CRD) with two treatment factors, namely variations in gel size (0.5x1 cm, 1x2 cm, 2x3 cm) and boiling duration (10 minutes, 15 minutes, 20 minutes). The obtained data were subsequently analyzed Analysis of Variance (ANOVA). If differences were found, Duncan's Multiple Range Test (DMRT) was conducted at a significance level of 5%. The research results indicate that variations in gel size and boiling duration affect antioxidant activity, moisture content, total sugar content, gel texture, and preference level. The acceptable aloe vera gel beverage, preferred by the panelists which made with a gel size of 0.5x1 cm and a boiling duration of 10 minutes, with exhibited the highest antioxidant activity 6.72% RSA, moisture content 94.15%, total sugar content 13.35%, hardness (6.25 g/cm2, and deformation 2.81 mm.

Dioscorea pentaphylla L. tubers, locally known as tomboreso tubers by Indonesian people, grow wild in forests in various parts of Indonesia but are not well-underutilized. This article aims to comprehensively review the phytochemistry, nutritional, anti-nutritional, and bioactivity of tomboreso tubers. The method used is a literature study with a database of online articles downloaded from Google Scholar related to the topic discussed. Various earlier studies reported that tomboreso tubers are rich in phytochemical compounds, such as alkaloids, flavonoids, polyphenols, terpenoids, tannins, glycosides, and saponins. Tomboreso tubers are also rich in complete nutritional content, such as protein content (1.69-9.20%), fat (0.14-6.24%), fiber (1.28-7.24%), starch (3.71-61.26%), minerals, amino acids, and fatty acids. Furthermore, tomboreso tubers also contain anti-nutritional compounds that are less beneficial to health, such as tannins, oxalates, hydrogen cyanide, phenols, flavonoids, phytates, a-amylase inhibitors, and trypsin inhibitors. Tomboreso tubers have been shown to have various biological activities, such as anti-bacterial, anti-mutagenic, and antioxidant, from various earlier studies. To make tomboreso tubers safe to eat and an alternative food source with low anti-nutritional content, further research must be done on their exploration, utilization, and further processing to reduce anti-nutritional compounds.

Essential oils of Marjoram (Marjorana hortensis) has been evaluated for possible antioxidant activity. Essential oils were hydrodistilled and the chemical composition of volatile fraction was determined by GC. γ-Terpinene, sabinene, β-phellandrene, terpinen-4-ol and di (2-ethylhexyl) phthalate were the major constituents of Marjoram.  The reducing power of essential oils of Marjoram was measured by the ferricyanide method. Different concentrations of Marjoram oil (MO) 25, 50, 75, 100 and 200 ppm were investigated. Higher absorbance at 700 nm of the reaction mixture indicated greater reducing power. The reducing power of an antioxidant is an important parameter reflecting one aspect of its antioxidant properties. The obtained results revealed that increasing the antioxidant capacity is MO in all tested concentrations.   The antioxidant capacity of fat-soluble antioxidant was expressed as equivalents of α-tocopherol (nmol/g oil) using a molar absorption coefficient of α-tocopherol (є= 4.0 × 103 M-1 Cm-1. The percent of H2O2 scavenging activity of the tested EOs increased in the MO at all tested concentrations. There was a significant difference among all EOs samples in the percent of H2O2 scavenging activity. a positive correlation has been observed between concentrations and antioxidant activity for 3 days' test period. There were significant differences among the tested EOs in their antioxidant activities. For 3 days, the antioxidant activity of the tested EOs decreased statistically in MO. BHT on the peroxide value of sunflower oil as mmol eq O2/kgoil in the seventh day

Kersen and carrots are local fruits and vegetables that often found in Indonesia. Kersen contain antioxidant activity, and carrots contain vitamin A, that beneficial for body. The purpose of this study to determine effect of kersen puree substitution and addition of carrots on the acceptability of jelly candy. This study used a pure experimental method with a 3x2 factorial design, namely 3 levels of kersen puree (40%, 50%, and 60%) and 2 levels of carrots (25% and 50%). The panelists is school-age children at MI Tarbiyatush Shibyan, totaling 45 students. The hedonic test data were analyzed using two-way anova with Duncan's further test to determine the real difference. Interaction of kersen puree substitution and carrot addition affected the color, but not affect the aroma, taste, and elasticity of jelly candy. Jelly candy with F3G2 formula with 60% kersen puree substitution and 50% carrot addition was most preferred. In 100 grams of F3G2 formula, jelly candy contains 318 kcal energy, 62.10% glucose, 3.05% fiber, 88.60 mg beta-carotene, and 78.60% antioxidant activity. Based on these results, jelly candy with kersen puree substitution and carrot addition is beneficial for school-age children because contains high antioxidants and vitamin A.

Phytochemistry is a method used to determine the compounds found in plant essence. Phytochemical identification is carried out using chemical substances used in a reaction to determine the collection of secondary metabolite compounds. Indonesia is a country that has various types of medicinal plants, one of which is the leaves of Katang-katang (Ipomoea pes-caprae). Katang-katang is a tropical vine that is easy to find and belongs to the Convolvulaceae family. The utilization of this medicinal plant is one of the alternatives in an effort to treat a disease.  Along the road in the sandy beach area, many of these plants are found growing creeping on the edge of the shoreline, this plant has a trumpet-like flower and is known as Katang-katang (Ipomoea pes-caprae). (Ipomoea pescaprae L.). Empirically, people often use katang-katang plants to treat infections in wounds, relieve pain, and as antioxidants. The active compounds of katang-katang as antibacterial are terpenoids, steroids, saponins, tannins and flavonoids. The active compound that plays the most role is thought to be the flavonoid compound content.

Counseling and training on making moringa leaf pudding in Bintana Village aims to increase public awareness of the nutritional benefits of moringa leaves and provide skills in processing them into innovative food products. Moringa leaves are known to be rich in nutrients and antioxidants that are beneficial for health. This activity involves education on the nutritional content of moringa leaves, demonstrations of making pudding, and hands-on practice sessions by participants. The results of the activity showed that the community has a high interest in adopting the innovation of utilizing moringa leaves as an alternative to healthy food. In addition, taste evaluations showed that moringa leaf pudding was well received. It is hoped that this innovation can increase consumption of healthy food and encourage the use of local plants in food diversification.

Chamomile flowers (Matricaria chamomilla) are known to have anti-inflammatory, antioxidant, and antipruritic properties that may be beneficial in the treatment of dermatitis, especially in children. Atopic and contact dermatitis are common skin conditions that often cause itching, inflammation, and discomfort. This study aims to evaluate the effectiveness of chamomile flowers in reducing dermatitis symptoms in children through a systematic literature review and meta-analysis. A literature search was conducted in the PubMed, Scopus, and Cochrane Library databases using relevant keywords. The analysis results indicate that topical application of chamomile extract significantly reduces inflammation and itching compared to a placebo and is nearly comparable to mild corticosteroids. However, further studies with larger sample sizes are needed to confirm its effectiveness and safety.

Background: Diabetes mellitus type 2  is a chronic metabolic disorder characterized by persistent hyperglycemia and endocrine dysfunction, including disturbances in luteinizing hormone, testosterone, and insulin levels. Moringa pterygosperma, known for its antidiabetic, antioxidant, and anti-inflammatory properties, has been explored for its therapeutic potential in mitigating diabetes-induced complications.Objective: The present study aimed to estimate the effects of Moringa pterygosperma extraction on endocrine and metabolic parameters against the diabetic rats induced by alloxan, by the mensurate the on LH, testosterone, glucose, and insulin levels.Methods: Forty adult male albino Wistar rats were used in the present study which was divided into four equal groups: Control, Negative Control, Treatment one which used 100 mg/kg extract, and Treatment two which used 200 mg/kg extract). Diabetes was induced with alloxan monohydrate (100 mg/kg). After 41 days, serum samples were analyzed for testosterone, LH, glucose, and insulin concentrations. Results: The NC group showed significant reductions in testosterone (0.0926 ± 0.0081 ng/mL) and insulin (0.560 ± 0.09274 µIU/mL) levels, with increased luteinizing hormone (0.592 ± 0.03 ng/mL) and glucose (464.6 ± 18.71 mg/dL) concentrations, indicating severe endocrine and metabolic disruptions. Treatment with Moringa pterygosperma extract significantly improved these parameters in a dose-dependent manner. The T2 group exhibited near-normal levels of testosterone (0.1769 ± 0.01 ng/mL), insulin (2.140 ± 0.1435 µIU/mL), LH (0.3163 ± 0.063 ng/mL), and glucose (105.8 ± 9.34 mg/dL).

Empowering the community using one of the cooking spices to become something which has high selling power because of its effectiveness will increase people's enthusiasm for using it. Tamarind fruit has bioactive compounds which often used as natural antioxidants and will be made into phytosome system gel preparations which can improve better penetration of drugs into the skin. The aim of this service was that the community is expected to provide education about tamarind fruit in Klambir V Village, Medan, Indonesia. This community service method was carried out using leaflets, modules, power points and presentations to the community. The result of this service was an increase in public knowledge of tamarind fruit as an antioxidant by 87%.

Liver damage induced by hepatotoxic compounds such as N-acetyl-p-aminophenol (N-APAP) remains a significant global health concern. Hepatotoxicity caused by N-APAP, particularly in cases of overdose or prolonged use, can lead to a reduction in glutathione levels in the liver, resulting in oxidative stress and cellular damage. This condition contributes to an increased incidence of liver diseases, including toxic hepatitis and acute liver failure, which can lead to serious complications and even death. Although various pharmacological therapies, such as N-acetylcysteine (NAC), are available to address N-APAP-induced liver damage, limitations such as side effects, high costs, and variable efficacy have driven the search for safer and more affordable therapeutic alternatives. Therefore, research on natural hepatoprotective agents, such as extracts from the rhizomes of fingerroot (Boesenbergia rotunda), has become increasingly relevant in addressing this issue. The aim of this study was to evaluate the hepatoprotective potential of ethanol extract from fingerroot rhizomes (Boesenbergia rotunda) in protecting the liver from N-acetyl-p-aminophenol (N-APAP)-induced damage. Specifically, this research focuses on measuring glutathione levels as a key indicator of the liver's protective mechanism against oxidative stress. In this study, 30 male White rats were randomly divided into six groups, each consisting of five rats. All rats were orally administered the extract at predetermined doses for 10 consecutive days, except for the negative and positive control groups. On the 10th day, all groups (except group 1) were treated with paracetamol (800 mg/kg body weight) to induce liver damage. Twenty-four hours after induction, the rats were sacrificed and liver samples were collected. Glutathione levels were measured using the ELISA immunosorbent assay. Statistical analysis showed that administering the ethanol extract of Fingerroot rhizomes (EERTK) for 10 days prior to N-APAP induction significantly increased the average antioxidant enzyme GSH-Px levels in the liver homogenate of rats in the EERTK 250 mg/kg BW (43.36 ± 1.34 U/mg protein), EERTK 500 mg/kg BW (55.70 ± 2.15 U/mg protein), and 750 mg/kg BW (53.14 ± 2.57 U/mg protein) group compared to the negative control group (N-APAP 800 mg/kg BW), which had the lowest average antioxidant enzyme GSH-Px level (33.86 ± 3.52 U/mg protein).

This search intended to speculate the role of lavender ethanolic extract by reducing the toxicity of manganese in male rats. 32 white male Norwegian rats were divided into 4 equal groups. Group 1: as a control group left without treatments (only 1 ml of distilled water/ animal/ day). Group 2: were dosed manganese chloride at a concentration of 100 mg/ kg b.w. / day. Animals in Group 3 and Group 4 were dosed Manganese chloride at a concentration of 100 mg/kg b.w. then lavender ethanolic extract at a concentration of 200 and 400 mg/kg respectively, all by oral gavages and treated daily for six weeks. Then the next criteria were investigated: Neurotransmitters (dopamine and Ach (acetylcholine) in the mid brain) serotonin in serum. Oxidation indicators (glutathione and malondialdehyde in the brain and superoxide dismutase and catalase in serum). The results exhibited in both groups 3 and 4 there were a significant decrease in the concentrations of Ach accompanied by a significant increase in levels of dopamine and serotonin, also return levels of MDA (Malondialdehyde) to normal, as well as a significant increase in GSH (Glutathione) concentrations in rats mid brain. Moreover, the significant rising of SOD (Superoxide dismutase) and CAT (Catalase) levels in serum of rats in these groups indicated a noticeable improvement was achieved by lavender ethanolic extraction as compared to group 2. Conclusion, the antioxidant and antitoxic activity of lavender ethanolic extract promises in grate achievement in various health fields, including medicine, food industries and cosmetics.

This research aims to formulate and examine the physicochemical characteristics and antioxidant activity of sacha inchi (Plukenetia volubilis L.) as a plant-based milk. Moreover, this research also aims to conduct organoleptic tests on the products. The sacha inchi milk is formulated with five ratios: SI1 (sacha inchi 1:10 parts water), SI2 (sacha inchi 2:10 parts water), SI3 (sacha inchi 3:10 parts water), SI4 (sacha inchi 4:10 parts water), and SI5 (sacha inchi 5:10 parts water). Organoleptic tests are carried out by assessing the aspects of taste, color and aroma of the product with a score range of 1 (least preferred) - 5 (most preferred). The results of the organoleptic test showed that the most preferred sacha inchi peanut milk formulation was SI5 with a preference level reaching a score of 4.48. The SI5 formulation is more dominantly preferred because it is richer in taste, color and aroma. Then continued with physicochemical testing which includes water content, ash content, fat content, protein content, carbohydrate content, calcium content, pH, and viscosity and IC50 antioxidant activity test using UV-Vis Spectrophotometer instrument. The results of physicochemical tests and IC50 antioxidant activity conducted in this study were respectively: water content (74.10%), ash content (0.65%), fat content (19.15%), protein content (4.29%), carbohydrate content (1.82%), calcium content (0.043%), pH (6.01), viscosity (209 mPa∙S), and IC50 antioxidant activity (429.10 ppm).  

Green tea is widely known as a beverage rich in antioxidants with numerous health benefits. However, excessive consumption may have negative effects, particularly on gut health. This article discusses the impact of excessive green tea consumption on stomach irritation, mineral absorption disruption, gut microbiota imbalance, and caffeine-related side effects. It concludes that moderate consumption of green tea (2-3 cups per day) is safe and beneficial. Proper consumption management can maximize green tea benefits without adverse effects on gut health.

Decoction water betel leaf is a traditional Balinese medicine containing the active compound hydroxychavikol, has antioxidant and antidyslipemic activity. From the results of the study it was reported that decoction water of betel leaf contains the active compound hydroxycavicol (HC). The active compound hiroksikavikol has activity as an antioxidant and antidyslipidemia. As an anti-oxidant, it can scavenge ROS and inhibit the activity of free radicals. As an antidyslipidemia, it can normalize lipid metabolism by lowering total cholesterol, triglyceride, LDL and VLDL levels and increasing blood serum HDL levels. Oxidative stress and dyslipidemia are major risk factors for heart disease caused by atherosclerosis. Atherosclerosis is the occurrence of plaque formation in the lumen of blood vessels triggered by oxidative stress through endothelial cell dysfunction, inflammation and lipid peroxidation. Oxidative stress causes endothelial cell dysfunction, increased contractility, VSMC growth, monocyte invasion and lipid peroxidation, inflammation and increased deposition of extracellular protein matrix. Based on these things, it was concluded that HC loloh boiled water of betel leaf has antioxidant and antidyslipidemic activity to prevent heart disease.

Perineal wounds are tears that occur during childbirth, either spontaneously or through assisted delivery. If not properly treated, they can lead to infections. The healing time varies depending on hygiene and the mother's health condition. Perineal wound healing can be facilitated through non-pharmacological treatments, including binahong leaves. The binahong plant has antibacterial, antioxidant, and anti-inflammatory properties, making it potentially effective in accelerating perineal wound healing. This study aims to determine the effect of boiled binahong leaf water on perineal wound healing in postpartum mothers at Susiani, Amd. Keb Independent Midwife Practice Banyuwangi in 2024. The research was conducted at TPMB Susiani, Amd. Keb Banyuwangi, Gang Lombok Perum Villa Asri I Block A-6 Sukowidi, Klatak Village, Kalipuro District, Banyuwangi Regency, from May to June 2024. This study evaluated the effect of boiled binahong leaf water on perineal wound healing using a quasi-experimental design with a posttest-only control group. Of 40 postpartum mothers, 20 received binahong leaf treatment, while 20 did not. The sampling technique used was consecutive sampling. The boiled binahong leaf water was administered for five days, twice daily in the morning and evening. Data analysis was performed using the Wilcoxon test with SPSS. Ethical approval number: 179/01/KEPK-STIKESBWI/V/2024. The results showed that after the intervention, nearly all respondents experienced a reduced wound severity by day 5, with perineal wounds showing signs of healing. The Wilcoxon test yielded an Asymp. Sig. (2-tailed) value of 0.000, indicating a significant effect of this therapy, with 60% of mothers in the intervention group experiencing good wound healing. The data indicate an impact on perineal wound healing in postpartum mothers at Susiani, Amd. Keb Independent Midwife Practice Banyuwangi in 2024. Binahong leaves can serve as a complementary alternative for postpartum mothers with perineal tears.

Cassia alata L or generally knowles as Chinese leaves contain phytochemical compounds, one of which is flavonoids which have the potential as antioxidants, antioxidants can be used to prevent diseases with oxidative stress. The purpose of this study was to determine the content of phytochemical screening and qualitative testing of antioxidant activity ethanol ekstract of Chinese leaves (Cassia alata L) using the DPPH method. This study is a qualitative study with an extraction process using the maceration method with 96% ethanol solvent. Phytochemical screening and antioxidant activity testing were carried out by adding specific reagents. The results of phytochemical screening and antioxidant activity testing of Chinese leaves (cassia alata L) ekstract contain bioactive compounds such as flavonoids, saponins, tannins and antioxidant activity testing with DPPH reagents showed that Chinese leaves (cassia alata L) extract has antioxidant activity which is indicated by a change of the color from purple to yellow. From the results obtained, it can be concluded that the flavonoid compound content in Chinese leaves (cassia alata L) extract can potentially act as an antioxidant.