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Ferritin is considered a protein that contains iron and includes two types of subunits: ferritin light chain (FTL) and ferritin heavy chain (FTH), which increases when inflammation increases, especially in the heart and kidneys, and helps in converting ferrous iron into iron. The light subunit is present in the liver and spleen and has a role in storing iron (1). Coronavirus (COVID-19) caused by the new coronavirus SARS-CoV-2 is a disease It is new to humanity, as it is accompanied by symptoms during the disease, including blood abnormalities, with activation of the immune system and phagocytic monocytes, and damage to the lungs. In our study, we showed that ferritin is an indicator of the severity of the disease and mortality (2). Acute respiratory syndrome (Coronavirus), which causes pneumonia and damages the heart, liver, and kidneys, is caused by the appearance of acute inflammatory cytokines that lead to death (3). A cytokine is a small protein that transmits messages to help stimulate the body’s immune response, and its rise causes increased inflammation, and these Cytokines secreted by macrophages (TNF-α, IL-10, IL-6) where there is high inflammation in the plasma. An indicator of the progress and severity of the disease (3).

This study examines the synthesis and characterization of new compounds produced from chalcone, confirming their favorable yield and excellent purity utilizing Using FT-IR and 1H and 13C NMR spectroscopy. The compounds showed efficacy comparable to that of conventional antibiotics, demonstrating substantial bactericidal activity against Staphylococcus aureus and Escherichia coli. Interestingly, molecule S10 had stronger antibacterial activity, possibly as a result of its efficient electronic pairings. Furthermore, the compounds demonstrated resilience for up to 45 seconds when tested for stability under helium-neon laser irradiation. Longer exposure (60 seconds), however, caused discernible color and melting point alterations, suggesting thermal or photochemical deterioration. These results point to the possibility of additional pharmacological uses for molecules produced from chalcone.

This study aims to analyze the science literacy skills of students in primary schools in Medan City. The method used was a quantitative approach with a descriptive design. Data were collected through a science literacy test given to 31 students from 3 primary schools. The results showed that students' science literacy skills were still at a low level, with only 28% of students achieving an adequate level of literacy. The findings indicate the need for improvement in science teaching in primary schools to improve students' science literacy skills. This research is expected to provide insights for educators and policy makers in formulating more effective strategies to improve science literacy among primary school students.

This study aims to analyze the science literacy skills of students in primary schools in Medan City. The method used was a quantitative approach with a descriptive design. Data were collected through a science literacy test given to 31 students from 3 primary schools. The results showed that students' science literacy skills were still at a low level, with only 28% of students achieving an adequate level of literacy. The findings indicate the need for improvement in science teaching in primary schools to improve students' science literacy skills. This research is expected to provide insights for educators and policy makers in formulating more effective strategies to improve science literacy among primary school students.

This paper aims to examine how the values of local customs and culture of South Tapanuli can be integrated in the character-building program of students in Madrasah. In the context of education, character is one of the important aspects that must be considered to form a generation that has good morality and a sense of love for the country. Along with the times, the process of preserving local culture is also increasingly threatened, so the integration of local culture in character education becomes very relevant. This paper uses a qualitative research method with a systematic literature review approach to identify cultural values that exist in South Tapanuli society, such as the concept of gotong royong, respect for parents, and the principles of simplicity and togetherness. These values are believed to be a strong foundation in the character-building process in Madrasahs, as well as instilling pride in the local culture itself. The results of this study indicate that the application of South Tapanuli customary and cultural values in character building in Madrasahs not only enriches the curriculum, but also strengthens social relations between students and between students and the surrounding environment.

This study examines the education of Ahlus Sunnah Wal Jamaah theology, focusing on its concept, classification, and implementation in Muslim life. Using a literature review method, this research explores primary Islamic sources, such as classical theological books, along with modern academic references that explain the 20 Attributes (Sifat 20) in Ahlus Sunnah Wal Jamaah doctrine. The analysis is conducted descriptively and critically to understand how this theology is taught and applied in various aspects of life. The findings reveal that theological education plays a crucial role in shaping Muslim beliefs and character while maintaining relevance in the Islamic education system. This study also recommends more effective teaching strategies for comprehending and internalizing Ahlus Sunnah Wal Jamaah theology.

The Maharah qiroah learning strategy at Pondok Pesantren Rofiu Darojah plays a crucial role in enhancing students' Arabic reading skills. This study aims to analyze the applied strategies and the challenges faced in improving students' reading competence. A qualitative research method with a descriptive approach was used, involving interviews with the parents’ caregivers, teachers, and students. The findings indicate that the qiroah mufasshiroh, talaqqi, and drill methods are effective in improving students' comprehension and reading fluency. However, challenges remain, such as difficulties in understanding complex sentence structures and a lack of independent reading practice. Therefore, further efforts are needed, including strengthening nahwu and shorof learning, increasing reading practice intensity, and utilizing educational technology. With the implementation of more innovative strategies and full support from educators, students’ reading abilities are expected to improve significantly.

This article discusses the evaluation of the effectiveness of Aqidah Akhlak learning through a literature review that focuses on lecture and discussion methods. In learning Aqidah Akhlak, choosing the right method is the key to success in delivering material and shaping students' character. The lecture method is effective in conveying basic information in a systematic manner, while the discussion method emphasizes more on the active involvement of students and the development of critical thinking skills. This article examines various scientific literature to analyze the advantages, disadvantages, and relevance of these two methods in the learning of Aqidah Akhlak. The results of the study show that the use of both methods in an integrated manner can provide more optimal results, with lectures as an introduction and discussions as a deepening of the material. These findings provide a theoretical perspective for educators in designing effective learning strategies.

This paper discusses the procedures for MT ship permit transfer documents. Southen Koala from Special Pier PT. Sari Dumai Oleo towards PT Special Pier. Sari Dumai Sejati at the Class I Dumai Harbormaster and Port Authority Office by PT. Bahari Eka Nusantara Dumai Branch. The methods used in this research are the field method (field research) and the library method (library research). Based on the research results above, it can be concluded that the MT ship Shifting Permit Document Procedure. South Koala from PT special pier. Sari Dumai Oleo towards PT special pier. Sari Dumai Sejati at the Class I Dumai Harbormaster and Port Authority Office by PT. Bahari Eka Nusantara Dumai Branch, is a complex process and involves various parties. This process starts from submitting documents, verification, to implementation permits in the field. The ship movement permit process must comply with the regulations and procedures of PT. Bahari Eka Nusantara ensures the Dumai Branch for safety and smooth operations.    

This study examines the relationship between interest rates, inflation, and investment, as well as their impact on economic growth. High interest rates tend to hinder investment by increasing capital costs, while uncontrolled inflation can create economic uncertainty that negatively affects investment decisions. Based on the Fisher Effect concept, the nominal interest rate is the sum of the real interest rate and the expected inflation rate, indicating that changes in inflation directly influence central bank interest rate policies. An analysis of various journals reveals that interest rates have a negative relationship with investment, while inflation can have both positive and negative effects depending on its level. If inflation remains stable, investment tends to increase; however, if inflation is too high, purchasing power declines, and investors seek safer assets. On a macroeconomic scale, healthy investment is a key factor in driving economic growth, as it contributes to job creation and increased production. Therefore, a balanced monetary policy is essential to maintaining inflation stability, interest rates, and investment growth to ensure sustainable economic development.

The rapid advancement of digital technology has transformed marketing strategies in various industries, including insurance. Digital marketing plays a crucial role in increasing brand awareness, attracting potential customers, and influencing purchasing decisions. This study aims to explore the role of digital marketing as a promotional tool in enhancing the purchase of insurance products at PT. Asuransi Allianz Life Indonesia using a qualitative approach.This research adopts a qualitative methodology with a case study approach. Data collection was conducted through in-depth interviews with key informants (Chief Account Officer Allianz) and insurance agents at Allianz Life Indonesia. Additionally, document analysis and observations of the company’s digital marketing strategies were used to gain comprehensive insights. The collected data were analyzed using thematic analysis to identify patterns and key themes related to the effectiveness of digital marketing in influencing customer decisions.The findings reveal that digital marketing plays a significant role in shaping customer perceptions and purchasing decisions. Social media engagement, personalized content, and interactive customer communication are key factors in building trust and increasing customer interest in insurance products. Moreover, challenges such as digital competition, data privacy concerns, and customer skepticism towards online promotions were identified as barriers that need to be addressed to enhance digital marketing effectiveness.The study implies that insurance companies should continuously adapt their digital marketing strategies by leveraging data analytics, improving customer interaction, and providing transparent and informative content. By strengthening these aspects, digital marketing can serve as a powerful tool to enhance competitiveness and sustain growth in the insurance industry within the digital era.

In the last ten years, Indonesia has been carrying out massive infrastructure development. The goal is to facilitate community mobility which has an impact on economic growth. Infrastructure development also aims to increase the Human Development Index even though it does not directly affect it. One of the provinces that contributed to infrastructure development was East Java, with the Human Development Index during the 2018-2022 period increasing and tending to stagnate. For this reason, the purpose of this study is to identify the influence of infrastructure development on the Human Development Index, including identifying the influence of poverty on the Human Development Index. The research methodology used is quantitative with  a Geographically Weighted Panel Regression (GWPR) approach that allows to comprehensively identify the Regional Development Index in East Java. The results obtained were that the variables of Infrastructure Development with the dimensions of Road Length (6,172) and Number of Schools (2,686) had an impact on the Human Development Index in East Java. Meanwhile, the poverty variable (-6,139) has no effect on the Human Development Index (HDI). However, simultaneously the variables of Infrastructure Development and Poverty affect the National Development Index (HDI) with a calculation of 64.42 > 2.4202.

Fraud poses a significant threat to organizational integrity and public trust, especially within governmental institutions. This study explores the critical role of forensic accountants in uncovering fraud within the Audit Board of the Republic of Indonesia. Using a case study approach, the research examines the application of advanced forensic data analytics by forensic accountants. It highlights the essential skills and characteristics that make forensic accountants effective, as well as their contributions to enhancing internal controls and governance mechanisms. The study demonstrates the impact of forensic accounting on fraud detection, prevention, and deterrence. The findings emphasize the importance of integrating forensic accounting expertise within the Audit Board's operational framework to strengthen its capacity to combat financial fraud. It also identifies challenges faced by forensic accountants, such as technological limitations and cultural resistance, and suggests strategies to overcome these barriers. By shedding light on the role of forensic accountants in safeguarding public sector integrity, this research contributes to the growing knowledge on forensic accounting practices in Indonesia. The insights can inform policies and capacity-building initiatives aimed at improving the Audit Board’s fraud detection capabilities, ultimately fostering greater public trust and accountability.

This research describes the Implementation of Population Administration Policies on Administrative Vulnerable Populations (Study on Suku Anak Dalam in Bungo Regency, Jambi Province). Based on the results of the research, it can be concluded that the implementation of population administration in administratively vulnerable populations such as Suku Anak Dalam (SAD) has been implemented by the Bungo District Government through the Bungo District Population and Civil Registration Office, but only a small proportion of SAD residents are recorded and obtain population documents. This is due to the absence of specific regulations governing the data collection and recording of administratively vulnerable populations such as SAD. In addition, the causes of the lack of optimal administration of administratively vulnerable populations such as SAD in Bungo Regency, Jambi Province are limited resources and funds, as well as natural factors due to the distance from the city, a nomadic and closed lifestyle, plus language problems that are difficult to understand. Therefore, in order to achieve Orderly Population Administration specifically for vulnerable populations such as SAD, there needs to be a policy that applies specifically to SAD residents in addition to policies that apply generally in population administration data collection. In addition, the relevant agencies can carry out cross-sectoral cooperation and need to make special plans regarding the financing of data collection and form a Special Officer Unit to carry out data collection of administratively vulnerable populations such as SAD in the Bungo Regency area.

The advancement of information and communication technology has driven the utilization of social media as a strategic communication tool in various sectors, including national defense. The Ministry of Defense of the Republic of Indonesia (Kemhan RI), through the Defense Information Bureau, leverages social media platforms to educate the public on defense issues via the Podcast Pertahanan Negara (PODCAST) program. This study aims to analyze the communication approach employed by the Defense Information Bureau in PODCAST and its effectiveness in enhancing public defense literacy. This research adopts a qualitative method with a case study approach. Data collection techniques include in-depth interviews with relevant stakeholders, content observation of PODCAST episodes, and document analysis. The findings indicate that the Defense Information Bureau implements a digital communication strategy based on engagement, interactivity, and education through discussions with expert speakers and the delivery of information in an engaging manner. The program has proven effective in increasing public understanding of defense issues, yet it still faces challenges in reaching a broader audience and encouraging active public participation. The study underscores the importance of optimizing digital communication strategies in national defense education. Recommendations include enhancing two-way audience interaction, diversifying content formats, and collaborating with various stakeholders to expand the reach of defense education through social media.

Cybercrime has become a serious threat to the stability of the world economy along with the increasing dependence on digital systems. The study analyzes the negative impact of cybercrime on the global economy, focusing on direct and indirect financial losses, disruptions to productivity and supply chains, and the implications of policies and mitigation efforts. The results of the study show that cybercrimes, such as ransomware, data theft, and phishing, cause significant financial losses to individuals, companies, and governments, and have an impact on consumer and investor confidence. In addition, cyberattacks on financial and industrial infrastructure disrupt business operations and exacerbate global economic inequality. Effective mitigation efforts involve strengthening cybersecurity regulations, investing in data protection technology, and increasing public awareness of the threat of cybercrime. With a deeper understanding of the economic impact of cybercrime, it is hoped that a more comprehensive strategy can be implemented to increase the resilience of the global economy against digital threats

Health is a basic human need, so it requires high awareness so that people maintain their health. One way to protect yourself and your family from the financial risks arising from health care costs is by having health insurance. The impact of this insurance provides protection against possible future losses and invests part of the funds collected from policyholders. Health insurance is important not only for reducing the financial burden of health services but also for ensuring that individuals have access to timely and quality medical care. The purpose of this theoretical study is to determine the impact of health insurance on the utilization of health services from a public health perspective. The method used is a theoretical study, which analyzes existing theories and previous research to understand the effects of health insurance. This approach is intended to draw conclusions regarding how insurance affects public health and health service usage. The results of this theoretical study indicate that, from a public health perspective, health insurance has a positive impact in various ways. It helps reduce the risk of disease, minimizes the economic burden when individuals fall ill, reduces financial risks, provides peace of mind, and facilitates access to quality medical services. Furthermore, insurance contributes to preventive care and early treatment. Accessibility to health services is identified as a crucial factor in enhancing the positive impact of insurance on the welfare and health of the community in Indonesia.

The use of probiotics is very important in cultivation activities. Probiotics are live microorganisms that have a beneficial effect on the host by balancing the microflora in their intestines. In increasing the nutritional content of artificial feed (pellets), the bacteria in probiotics have a mechanism for forming several enzymes for digesting feed. This study aims to determine the effect of giving delacto probiotics at different doses in artificial feed on the absolute weight growth of tilapia (Oreochromis niloticus). Probiotics are mixed with feed using a biofloc cultivation system. The method used in this research was an experimental method with a Completely Randomized Design (CRD) with 4 treatments and 6 replications, namely by adding different doses to the treatments. Treatments A (8ml/kg), B (16 ml/kg), C (24 ml/kg) and D (32 ml/kg). The parameter observed was absolute weight growth. Water quality supporting parameters include temperature, pH and DO. Data were analyzed using the ANOVA test. Based on the research results, it shows that giving different doses of delacto probiotics has a significant effect on the absolute weight growth of tilapia (Oreochromis niloticus). Treatment A (8 ml/kg) gave the lowest absolute weight growth of 32.83 grams and treatment D (32 ml/kg) gave the highest absolute weight growth of 40.57 grams. Water quality parameters include water temperature ranging from 25.3 – 26.1֯C, acidity ranging from 7.5 – 8.0. And dissolved oxygen ranges from 4.7 – 5.3 ppm. The results of analysis of variance (ANOVA) for the three water quality parameters showed no differences between treatments (Oreochromis niloticus) fry.

Vannamei shrimp is one of the shrimp species with economic value and is one of the national leading commodities. On the other hand, one of the problems in vannamei shrimp cultivation is its slow growth, slow growth is caused by the less optimal absorption of nutrients in the feed. In dealing with these problems, one of the things that is done is the administration of probiotics. The addition of probiotics such as Biolacto containing Lactobacillus sp bacteria to the feed can increase the appetite of shrimp. This study aims to determine the effect of biolacto probiotics on feed on the growth of the absolute weight of vannamei shrimp. This study used a Complete Random Design (RAL) with four treatments: A (feed without a mixture of probiotics), B (probiotics 2 gr/100 gr feed), C (probiotics 4 gr/100 gr feed), and D (probiotics 6 gr/100 gr feed). Treatment B with a concentration of probiotics 2gr/100g feed gave the highest absolute weight growth of 9.2 gr. Water quality data during the study were obtained with water temperature ranging from 28.5 – 29.2°Celsius, salinity ranging from 36 – 37 ppt, pH ranging from 7.5 – 8.0, and dissolved oxygen ranging from 4.0 to 4.63 mg/l. The results of the ANOVA analysis of the four water quality parameters showed no difference between treatments and were in the optimal range of life of vannamei shrimp (Litopenaeus vannamei).

Giving probiotics such as probiotic boster on feed greatly helps the growth of absolute weight in Catfish seeds because the good bacteria contained in these probiotics help facilitate catfish seeds in digesting the feed so as to increase the efficiency of the feed. This study aims to see how effective the probiotic administration is. The study was conducted in Kramas District, Gianyar regency, Bali Province for 30 days using experimental methods, using a complete randomized design with a total of 4 treatments and 6 repetitions. Treatment A is by giving 3 ml of probiotic boster every 1 kg of feed. Treatment B by giving 5 ml probiotic boster every 1 kg of feed. Treatment C by giving 7 ml probiotic boster every 1 kg of feed. Treatment D by giving 9 ml probiotic boster every 1 kg of feed. In this study showed significantly different results on the addition of probiotic boster with different doses on the growth of absolute weight of catfish fry aged 1 month-2 months. Treatment D gave the highest result with an absolute weight gain of 55.33 grams, and treatment a showed the lowest result with an absolute weight gain of 25.17 grams. Water quality Data during the study obtained water temperature ranges from 27-29 oC, acidity ranges from 7-8, and dissolved oxygen ranges from 3.34 to 4.26 ppm. The results of the analysis of variance (ANOVA) of the three parameters of water quality there is no difference between the treatment and the life range of catfish fry (Clarias sp.)