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Dysregulation of the immune system is associated with many medical conditions, including: Cardiovascular disease, diabetes, cancer. Most popular model today. In biomedical research, rodents, despite the many advantages they offer, there are also many drawbacks to its use. Recently, another in vivo model, the chicken Embryos and their chorioallantoic membranes are resurfaced for a variety of uses. This model includes cost-effectiveness, time-efficiency, Easier to use. This review describes how to use chicken embryos. As a model for immune-based research because it gradually develops the embryonic immune system, Systems functionally similar to humans. This study examined mainly intended to describbe the immune system of birds, highlighting the differences and similarities with the human immune system A system containing a repertoire of lymphoid tissue, immune cells, and other important functions. A literature search was carried out systematically through the PubMed, NCBI, Google Scholar databases using keywords, namely, “Chicken embryo model, Perspective, Novel and relevant models Immunity, based research”. Based on these keywords, 21350 articles were obtained and 50 articles that meet the inclusion and exclusion criteria were selected. Those helped to describe general in-ovo immune ontogeny. Future studies are suggested to better tailor the use of chicken embryo models for testing carrying out specific experimental hypotheses or preclinical studies.

Environmental stress can affect the development of the embryo, including causing the death of the embryo. Environmental factors that can cause stress include salinity and zinc sulfate, zinc sulphate is a trace element and can affect embryonic development. The purpose of this study was to analyze the environment in Chicken embryonic development. A literature search was carried out systematically through the PubMed, NCBI, Google Scholar databases using keywords, namely, “heat, stress, embryo, chicken”. Based on these keywords, the articles obtained were first selected by setting several inclusion criteria. Articles that do not meet the inclusion criteria are eliminated, and articles that meet the criteria will be analysed to obtain data. Based on the search results 21326 articles were obtained, and 21 articles that meet the inclusion criteria were selected. The result above also showed that heat stress give impact to development of embryo. From the results of the research conducted, it can be concluded that the environment has an impact on the development of the embryo. Further studies are needed, especially those related to other types of stress that can affect embryonic development in various types of animals.

Free-range chicken eggs are a source of high-value animal protein but are susceptible to quality deterioration during storage. This study aimed to evaluate the effect of Averrhoa bilimbi L. leaf extract concentration and storage duration on the internal quality (Egg White Index, Egg Yolk Index, Haugh Unit, yolk color) and pH of free-range chicken eggs. An experimental method was employed using a Completely Randomized Design (CRD) with a 4 x 4 factorial pattern. The first factor was leaf extract concentration (0%, 5%, 10%, 15%), and the second factor was storage duration (7, 14, 21, and 28 days). The results showed that immersion in 5% Averrhoa bilimbi L. leaf extract significantly maintained internal egg quality compared to the control up to 14 days of storage. This treatment produced optimal values for the Egg White Index, Egg Yolk Index, Haugh Unit, and yolk color score, while also inhibiting the pH increase indicative of egg spoilage. However, an excessively high concentration (15%) resulted in physical quality degradation. It is concluded that Averrhoa bilimbi L. leaf extract has potential as an effective natural preservative for maintaining the freshness of free-range chicken eggs, with the best concentration at 5% for short- to medium-term storage.

Canine dwarfism is a growth disorder resulting from physiological dysfunction within the endocrine system, primarily due to growth hormone (GH) deficiency commonly caused by abnormal pituitary development. GH and Insulin-like Growth Factor 1 (IGF-1) play essential roles in regulating the growth of bones, muscles, skin, and internal organs through the hypothalamic–pituitary–liver axis. Under normal conditions, the hypothalamus controls GH secretion, which subsequently stimulates the liver to produce IGF-1 as the main mediator of growth. Genetic abnormalities such as LHX3 mutations can impair somatotroph cell differentiation and reduce GH production, ultimately leading to decreased IGF-1 levels. The deficiency of these hormones disrupts chondrocyte proliferation in the epiphyseal plates, decreases muscle protein synthesis, and negatively affects the development of tissues such as skin, hair, and reproductive organs. This study was conducted using a literature review method by searching scientific databases and selecting relevant publications addressing the physiological, clinical, and pathophysiological aspects of canine dwarfism. Literature analysis indicates that GH deficiency leads to clinical manifestations such as stunted body size, thin and easily shedding hair, dry and infection-prone skin, reduced muscle mass, metabolic disturbances, and delayed reproductive maturation. Diagnosis is established through clinical evaluation, IGF-1 measurement as an indicator of GH activity, and radiographic assessment of epiphyseal plate development. Overall, a comprehensive understanding of the relationship between physiological abnormalities and clinical signs is crucial for early detection and appropriate management of dwarfism, providing a strong scientific foundation for understanding the hormonal mechanisms disrupted in this condition.

This study aims to analyze the interfaith solidarity of UINSU Law students after natural disasters in North Sumatra and Aceh and to identify the forms of social activities and humanitarian values developed through these humanitarian actions. The research method used is a qualitative method with a field research approach through observation, interviews, and documentation. The research data sources were obtained from students, social volunteers, and disaster-affected communities involved in humanitarian activities. The results of the study indicate that UINSU Law students have an important role in helping communities through fundraising activities, humanitarian volunteers, psychosocial assistance, and interfaith cooperation. The interfaith solidarity carried out by the students was able to strengthen social relationships, increase tolerance, and create social harmony in post-disaster communities. In addition, the values of religious moderation, social concern, and unity became the main foundations of the students’ humanitarian activities. The presence of students among disaster victims gave a positive impact on the social recovery process and strengthened the sense of brotherhood and humanity within Indonesia’s multicultural society.

This research aims to reinterpret the vision of the Protestant Batak Christian Huria (HKBP) "to be a blessing to the world" from the perspective of diakonia. This research uses a literature method with a qualitative approach through the study of theological literature, history, and church documents. The results of the study show that diakonia is the main entrance to the gospel message in the Land of Batak that brings social, educational, and health transformation to the community. However, in its development, HKBP's diakonic practice tends to be centered on church institutions and has not fully involved the active participation of congregation members. In addition, there is a tendency for service that is charitable without sustainable empowerment. Therefore, it is necessary to reinterpret the vision of HKBP by emphasizing the formation of a diaconal congregation, where all members of the congregation should be equipped and encouraged to be involved in the service of love in the community. Thus, diakonia is not only a program of the church, but a real and transformative practice of living of faith, so that the church truly becomes a blessing to the world. Furthermore, strengthening congregational capacity through contextual theological education and the development of local needs-based ministries is an important strategy in realizing a responsive and inclusive church. This approach is expected to be able to encourage the sustainability of diakonia services which not only has a short-term impact, but also builds independence and community welfare holistically.

Library material processing is an essential activity in library management to support collection organization and facilitate users’ access to information. The Library of the Museum of the History of the Qur’an of North Sumatra possesses a diverse collection of materials, including Islamic books and general books; therefore, a well-planned and systematic collection processing system is required. This internship activity aims to describe the process of processing Islamic and general library materials through cataloging and book labeling activities at the Library of the Museum of the History of the Qur’an of North Sumatra. The method used in this internship was a descriptive qualitative approach, with data collection techniques including observation, documentation, and direct practice in the processing of library materials. The results of the internship indicate that cataloging and book labeling play a significant role in creating organized collections, facilitating information retrieval, and supporting the effectiveness of library services. Thus, processing library materials through cataloging and labeling constitutes a strategic effort to enhance the quality of collection management at the Library of the Museum of the History of the Qur’an of North Sumatra.

This study aims to improve the interpersonal intelligence of children aged 5–6 years through the implementation of the edutainment method at TKIT Darul Qur’an Madani, Parepare. The research employed Classroom Action Research (CAR) with Kurt Lewin’s model, conducted in two cycles, each consisting of planning, implementation, observation, and reflection stages. The subjects were 14 children from group B who initially showed low social interaction, cooperation, and empathy with peers. Data were collected through observation, interviews, documentation, and anecdotal notes, then analyzed descriptively using qualitative and quantitative approaches. The findings revealed a significant improvement in children’s interpersonal intelligence. In the first cycle, most children were categorized as Beginning to Develop and Developing as Expected. However, in the second cycle, through edutainment activities based on role playing with professional themes, 85% of the children achieved the Very Well Developed category. These results indicate that the edutainment method is effective in creating enjoyable, interactive, and meaningful learning experiences, which encourage children to communicate, collaborate, understand emotions, and develop empathy.

This study aims to analyze the acoustic characteristics of coconut-fiber-based Cement-Bonded Particleboard (CBPB) through measurements of the Sound Absorption Coefficient (SAC, α) and Transmission Loss (TL). CBPB samples were fabricated with thickness variations of 12, 16, and 20 mm and tested using an impedance tube in accordance with ISO 10534-2:1998 for SAC and ASTM E90-09 (2016) for TL measurements. The study examined the effect of panel thickness on sound absorption and transmission loss across a frequency range of 125–4000 Hz. The results showed that the α value increased with both frequency and panel thickness, reaching a maximum of 0.78 at frequencies of 2500–3150 Hz for the 20 mm panel. The TL measurements indicated that the highest transmission loss reached 42 dB at a frequency of 4000 Hz. These findings suggest that thicker CBPB panels provide better acoustic performance, both in absorbing sound and reducing transmission. Overall, coconut-fiber-based CBPB demonstrates strong potential as an eco-friendly structural acoustic material suitable for applications in sustainable building design, interior partitions, and noise control solutions.

Umbilical cord care is an important part of newborn care because the umbilical cord that has not fallen off has the potential to become an entry point for germs if not cared for hygienically. In the community, traditional umbilical cord care practices are still widely practiced and often do not comply with medical standards. This study aims to determine the effect of umbilical cord care education on cleanliness and duration of umbilical cord detachment in newborns in the Bongo 2 Community Health Center, Boalemo Regency. This study used a pre-experimental design with a one-group pretest-posttest approach. The study sample consisted of 24 newborns selected using a total sampling technique. The intervention in the form of umbilical cord care education was given to the parents of the babies, then measurements were taken of umbilical cord cleanliness and duration of umbilical cord detachment before and after education. Data analysis was performed using a paired t-test or Wilcoxon signed-rank test with a significance level of p < 0.05. The results showed an increase in umbilical cord cleanliness after education, with a p value = 0.001. In addition, the average duration of umbilical cord detachment decreased significantly after education, with a p value = 0.000. This study concludes that umbilical cord care education has a significant effect on improving hygiene and optimizing the duration of umbilical cord removal in newborns.

In order to guarantee the best possible maternal health and fetal growth throughout pregnancy, complementary services for expectant mothers are required. These services include nutrition, mental health, and supplementary medical treatment. According to data, 70% of pregnant women have low back discomfort. According to a different poll, eight out of ten third-trimester pregnant women report having back pain. Doing Childpose (Balasana) exercises is one more way to lessen this problem. This study sought to ascertain if Childpose (Balasana) exercises were beneficial in lowering low back pain complaints among pregnant women in their third trimester at the South Bolango City Health Center. This study employed a quasi-experimental pretest-posttest approach with a sample of 34 pregnant women in the third trimester. There were twenty participants in the study's sample. Childpose or balasana exercises are beneficial in relieving back discomfort in third trimester pregnant women at the South Bolango Health Center, according to the data, which indicated a P-value of 0.000 <0.05.

Emesis gravidarum is a common condition experienced by pregnant women during the first trimester and can negatively affect maternal comfort, nutritional intake, and overall pregnancy well-being. Various biological and psychosocial factors are believed to influence its occurrence, including pregnancy interval and the level of family support. This study aimed to analyze the relationship between pregnancy interval and family support with the incidence emesis gravidarum among first-trimester pregnant women. A quantitative analytic study with cross-sectional design was conducted involving 30 pregnant women in their first trimester. Data were collected using structured questionnaires to assess pregnancy interval, family support (emotional, informational, instrumental, and appraisal support), and the incidence of emesis gravidarum. Statistical analysis was performed using SPSS, including univariate analysis to describe respondent characteristics and bivariate analysis using the Chi-square test to determine the relationships between variables, with a significance level set at p < 0.05. The results showed that short pregnancy intervals were significantly associated with a higher incidence of emesis gravidarum. In addition, pregnant women who reported low levels of family support were more likely experience moderate severe emesis gravidarum compared to those receiving adequate support. Statistical testing confirmed that both pregnancy interval and family support had significant relationship with the occurrence of emesis gravidarum. In conclusion, pregnancy interval and family support are important factors influencing the incidence of emesis gravidarum in the first trimester. Strengthening family involvement and promoting optimal pregnancy spacing are recommended as part of comprehensive antenatal care to reduce pregnancy discomforts and improve maternal health outcomes.

Despite global efforts, maternal mortality remains a critical public health challenge. A major contributing factor is the delay in recognizing and responding to obstetric emergencies. A pregnant woman's awareness of potential danger signs and her subsequent proactive attitude toward early detection are considered pivotal in facilitating timely and life-saving healthcare access. This study was undertaken to investigate the direct correlation between the level of knowledge pregnant women possess regarding pregnancy danger signs and their attitude toward the early identification of maternal emergencies.This research utilized an analytic survey design, a cross-sectional approach. The study sample was drawn using accidental sampling, comprising 110 pregnant women. Data were collected via structured questionnaires and analyzed statistically using the Spearman Rank correlation test. The descriptive analysis revealed a positive outcome regarding knowledge: the majority of participants (70) demonstrated a sufficient level of knowledge about pregnancy danger signs. However, this did not translate into a desired behavioral disposition, as a majority of participants (40) simultaneously displayed a poor attitude toward the early detection of maternal emergencies. The inferential statistical analysis confirmed this disconnect: the Spearman Rank test yielded a calculated ρ-value (pcount) of 0.068, which was less significant than the critical ρ-table value (ptable) of 0.364. Crucially, the significance level(p=0.72) exceeded the predetermined alpha (α=0.05).The study concludes that there is no significant relationship between a pregnant woman's knowledge of obstetric danger signs and her attitude toward seeking the early detection of maternal emergencies.

Family planning represents a community-based effort to promote awareness and participation through delaying the age of marriage, regulating births, strengthening family resilience, and improving family welfare to achieve small, joyful, and prosperous families (Suriana et al., 2021). The government targets Couples of Reproductive Age (CRA) to reduce population growth in Indonesia, as CRA consists of legally married couples who actively engage in sexual relations that may result in pregnancy. In addition to CRA, postpartum mothers also serve as a key target group in family planning programs. The “Four Too” components contribute to high-risk pregnancies that may lead to complications during pregnancy, childbirth, and the postpartum period, and maternal and infant mortality. These include being too young (under 20 years), too old (over 35 years), too many children (more than four), and too close birth spacing (less than two years) (Oktarina, 2022). This study employed a quantitative research design, specifically an analytical quantitative approach with a correlational design using the cross-sectional method. The sample consisted of 40 participants. The results show that 45% of respondents had a satisfactory level of knowledge about IUD contraception, 32.5% had a moderate level, and 22.5% had a low level of knowledge. In nursing practice, increasing knowledge about contraception—particularly IUD family planning—can enhance interest in its use. Moreover, the study recommends that husbands provide support for mothers in using IUD contraception.

Femoral fractures resulting from road traffic accidents (RTAs) are a major cause of morbidity in developing countries, particularly among economically active young adults. Despite the increasing rate of RTAs in Nigeria, there is a lack of localized data concerning the radiographic distribution and epidemiological characteristics of femoral fractures. This study provides region-specific baseline data for clinical decision-making and public health interventions. A retrospective descriptive study was conducted using patient case notes and radiographic records of 141 individuals with femoral fractures resulting from RTAs, presented at Erichris Diagnostic Centre, Benin City, between January 2019 and December 2022. Radiographs were evaluated to determine fracture location (proximal, middle, or distal third). Data were analyzed using SPSS version 20, and results were presented using descriptive and inferential statistics. Associations between fracture type, age, and gender were examined using Chi-square tests with significance set at p < 0.05. The majority of patients were males (87.2%) and within the 16–30-year age group (72.3%), with a mean age of 31.6 years. The right femur was affected in 55.3% of cases. Middle third femoral shaft fractures were the most prevalent (63.8%), followed by proximal (26.3%) and distal fractures (9.9%). There was no statistically significant association between gender and fracture type (p > 0.05) or between age group and fracture type (p > 0.05). This study demonstrates a high incidence of middle shaft femoral fractures among young adult males due to RTAs in Benin City. These findings highlight the urgent need for targeted road safety policies, improved trauma care infrastructure, and preventive strategies directed at high-risk groups. The data provided serve as a critical reference for orthopedic management and public health planning.

This study aims to examine the role of life cycle and bio-accounting in achieving sustainable broiler chicken production and to analyze whether environmental intelligence moderates these relationships. The life cycle approach is viewed as a comprehensive method for assessing resource efficiency, waste management, and environmental impacts throughout each stage of broiler production. Bio-accounting serves as a tool to measure and record biological aspects affecting livestock performance, feed consumption, emissions, and production efficiency. A quantitative method was employed through surveys distributed to small- and medium-scale broiler farmers. The results indicate that both life cycle and bio-accounting have a positive and significant effect on sustainable broiler production. Moreover, smart environmental strengthens these effects, as farmers with higher levels of environmental intelligence are better able to utilize bio-accounting information and life cycle assessments to manage resources efficiently and reduce environmental impacts. These findings highlight the importance of integrating life cycle analysis, bio-accounting practices, and environmental intelligence to enhance the sustainability of broiler production.

This study aims to analyse the design and optimization of digital marketing to increase the brand awareness of the IdRink MSME through the integration of a website and Instagram. The research employed a Research and Development (R&D) method using the Four-D model (Define, Design, Develop, Disseminate), combined with prototyping techniques and evaluation through blackbox testing. Data were collected through interviews, literature review, observation, Google Analytics, Instagram Insight, and A/B testing questionnaires administered to 100 respondents. The results show that the development of a WordPress-based website and a structured Instagram content plan significantly improved IdRink’s digital performance. Within one month, the audience growth rate increased by 256%, average post reach reached 216%, and website traffic recorded 298 users. Brand awareness measurement indicated brand recognition of 74% and brand recall of 79%, higher than the comparison brand in the local beverage category. These findings indicate that integrating a website and Instagram as a digital marketing strategy is effective in moving IdRink from the unaware-of-brand stage to recognition and recall, expanding market reach, strengthening customer engagement, and building a more professional brand image among young urban consumers. The study recommends maintaining content consistency and utilising digital analytics to support future marketing decision-making.

This study investigates the role of fintech and digital finance as intermediary variables in the influence of sharia financial literacy on increasing sharia financial inclusion in Aceh Province. This study examined 308 respondents spread across various regions of Aceh Province and analyzed using SEM AMOS and a purposive sampling technique. After conducting various tests, this study demonstrated that sharia financial literacy, fintech, digital finance, and sharia financial inclusion have been well-functioning. Sharia financial literacy has been proven to enhance fintech, digital finance, and sharia financial inclusion in Aceh. Correspondingly, fintech and digital finance also have a positive and significant impact on sharia financial inclusion. Furthermore, fintech and digital finance have also been shown to partially mediate the relationship between sharia financial literacy and sharia financial inclusion

This study aims to analyze the implementation of internal control in the receivables audit process and evaluate its effectiveness in minimizing the risk of bad debts in a health center environment. Receivables, especially those originating from health services to JKN participants and general patients, can cause problematic receivables if not managed effectively. This study uses a descriptive qualitative approach with data collection through observation, interviews and documentation review during the audit by a public accounting firm. The results of the study indicate that there are still weaknesses in the internal control structure such as suboptimal separation of duties, an unintegrated receivables information system and a weak bad debt reserve policy. In addition, late payments by third parties and poor patient administration knowledge are also external factors that influence the high risk of bad debts. Therefore, improving the internal control system, implementing information technology and strengthening coordination with the guarantor are very important to reduce the risk of bad debts and increase accountability for financial management in the health center environment.

Auditor switching is very important for companies because it maintains the independence of auditors and has objectivity in assessing the fairness of the company's financial statements and maintaining public trust.  This study aims to determine the role of company growth in moderating the relationship between audit report lag and public ownership to auditor switching. This research was conducted using quantitative methods and the data source used, namely secondary data taken from the Indonesia Stock Exchange in the form of annual financial statements. The population in this study is 70 companies in the infrastructure sector in 2019 – 2023. The sampling technique used is purposive sampling. The sample in this study is 21 companies with a total of 105 sample data. The data analysis technique used in this study is logistics regression using the Eviews version 12 application. The results of this study show that simultaneously Audit Report Lag and Public Ownership have an effect on Auditor Switching. While partially Audit Report Lag has no effect on Auditor Switching, Public Ownership has no influence on Auditor Switching. The role of Company Growth is able to moderate the relationship between Audit Report Lag and Auditor Switching. The role of Company Growth is not able to moderate the relationship between Public Ownership and Auditor Switching.