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The optimal therapeutic impact of local vaginal drug delivery systems is strongly influenced by the physical characteristics balance of Solid Vaginal Suppositories. A comprehensive review regarding the comparison of mechanical profiles, specifically melting time and crushing strength parameters, from various base classifications constitutes the primary objective of this literature research. The implementation of a Literature Review study design was executed through the extraction of empirical data from twelve experimental journals published within the last ten years. Excessively rapid phase transformation characteristics at physiological basal temperatures and low compression resistance were consistently demonstrated by lipophilic bases such as Oleum Cacao. The risk of structural deformation during the distribution process is highly susceptible to unmodified lipid preparations. High surface elasticity accompanied by a delay in molecular hydration duration reaching 120 minutes was recorded in the utilization of Glycerinated Gelatin Base. Structural rigidity exceeding 4 kgF and disintegration time efficiency under 60 minutes were optimally demonstrated by Polyethylene Glycol (PEG) Base. An enhancement in mechanical resistance against external shocks during the storage period is offered by the thorough modification of the synthetic polymer ratios. Therefore, the determination of the PEG base as the most optimal material is recommended to maintain the quality stability of pharmaceutical products. Compendial regulation standards regarding the physical strength testing of pharmaceutical preparations must be obeyed by every institution to ensure long-term treatment effectiveness. Thus, the alignment between active substance release duration and physical preparation endurance can be realized for absolute patient comfort.

This review article evaluates the physical characteristics and stability of Oil in Water (O/W) and Water in Oil (W/O) creams through a comparative literature study published between 2021 and 2026. The evaluation focuses on important parameters, including viscosity, spreadability, adhesion, pH, and accelerated stability testing. The findings reveal that O/W creams generally have lower viscosity and greater spreadability, making them more suitable for daily cosmetic and therapeutic applications due to their lighter texture and better aesthetic acceptance. In contrast, W/O creams demonstrate higher physical stability, stronger adhesion, and superior occlusive properties, which are beneficial for protecting sensitive active ingredients and maintaining skin hydration over longer periods. The differences in performance are strongly influenced by the optimization of emulsifier Hydrophilic-Lipophilic Balance (HLB) values and the ratio between oil and water phases. Both cream types show good biocompatibility with skin pH ranging from 4.5 to 6.5, indicating their safety and effectiveness for topical pharmaceutical and cosmetic formulations.

Chronic kidney disease (CKD) is a growing global health concern that frequently remains undiagnosed until advanced stages. Early detection through simple laboratory screening is essential to prevent disease progression and associated cardiometabolic complications. This community service program aimed to assess kidney function using serum creatinine and estimated glomerular filtration rate (eGFR), while increasing public awareness regarding CKD prevention. A total of 59 participants were included, with a mean age of 39.15 ± 15.39 years (range 16–75 years), predominantly female (74.58%). The mean serum creatinine level was 1.0 ± 0.19 mg/dL, and the mean eGFR was 91.08 ± 20.53 mL/min/1.73 m². Most participants demonstrated normal kidney function (28.8%) or mild decline (21.6%). A progressive reduction in eGFR with increasing age was observed, reflecting the physiological decline in nephron mass and renal perfusion. The program also provided education on kidney-protective practices, including optimal blood pressure control, diabetes management, adequate hydration, and avoidance of nephrotoxic agents. This intervention improved participants’ understanding of CKD risk factors and the importance of regular screening. In conclusion, serum creatinine and eGFR evaluation offer simple, accurate, and practical tools for early CKD detection, supporting promotive–preventive strategies to slow disease progression and enhance quality of life in at-risk populations.

Water is an essential component in the body that plays a role in various physiological functions, including concentration and learning performance in adolescents. However, teenagers' awareness to consume enough water is still low. This service activity aims to increase the knowledge and awareness of SMP Negeri 1 Kolaka students about the importance of drinking water through health education. The activity method was carried out by interactive counseling using PowerPoint media displayed through an LCD projector and conducted in the school hall on 19 November 2024, attended by 70 students from classes VII to IX. The material was delivered in an engaging manner and was complemented by discussion sessions. The results of the activity showed an increase in student enthusiasm and participation, as well as an awareness to start bringing drinking water to school and reduce the consumption of sugary drinks. This activity proved effective in fostering students' understanding of the importance of adequate hydration for health. The students expressed a greater willingness to incorporate healthier habits, particularly bringing water to school and making informed choices about hydration. Moreover, they became more aware of the negative impacts of sugary drinks. The activity's success highlights the importance of continued support from schools to create a healthy learning environment and to encourage healthy behaviors that can positively impact students' overall health and academic performance.

Fever in children, if not properly managed, can lead to several negative effects such as excessive fluid loss through evaporation, dehydration, seizures, decreased consciousness, and even death if left untreated. Non-pharmacological interventions to reduce fever include water tepid sponge therapy and cool patch therapy. This study used a quasi-experimental design with a pretest and posttest three-group approach. Respondents were divided into three groups: water tepid sponge, cool patch, and control. Data were analyzed using the Wilcoxon test and the Mann-Whitney test. The Wilcoxon test showed a significance value of 0.000 in the Water Tepid Sponge group, 0.000 in the Cool Patch group, and 0.002 in the control group. The Mann-Whitney test showed no significant difference between the pre-test body temperature of the Water Tepid Sponge group and the control group (p = 0.063 > 0.05), while a significant difference was found in the post-test (p = 0.000 < 0.05). For the Cool Patch group, there was no significant difference in the pre-test compared to the control (p = 0.672), but a significant difference was found in the post-test (p = 0.001). The Mann-Whitney test comparing the pre-test and post-test temperature differences between the Water Tepid Sponge and Cool Patch groups showed a significance value of 0.000. The mean rank for temperature reduction in the Water Tepid Sponge group was 35,27, while in the Cool Patch group it was 17,73. Both Water Tepid Sponge and Cool Patch therapies have an effect on reducing fever in pediatric patients in the Parkit Ward of QIM Hospital Batang. Water Tepid Sponge therapy is more effective than Cool Patch therapy in reducing fever.

Diarrhea remains the leading cause of morbidity and mortality among infants in Indonesia, especially in areas with limited access to clean water and sanitation. This community service activity aims to improve mothers' understanding of the signs and symptoms of diarrhea in children, raise mothers' awareness of maintaining their children's hygiene and health to prevent diarrhea, and provide practical training on the initial treatment of diarrhea. The methods used include interactive lectures, group discussions, demonstrations on making oral rehydration solution (ORS), handwashing practice, and distribution of leaflets. The participants consisted of 30 mothers of young children in Bangun Rejo Village, Tanjung Morawa Subdistrict. Evaluation was conducted using pre-test and post-test knowledge assessments. The results of the activity showed a significant increase in mothers' knowledge regarding the prevention and management of diarrhea. Participants were able to identify diarrhea symptoms, practice making ORS, and were more prepared to take their children to healthcare facilities if dehydration signs were present. This activity demonstrated that community-based health education is effective in enhancing mothers' knowledge and preparedness in preventing diarrhea.

Infused water is a functional beverage made by soaking slices of fruits, vegetables, and herbs in mineral water to produce a natural flavor and enhance nutritional content. In recent years, infused water has become part of a healthy lifestyle trend due to its claimed benefits, including detoxification, improved hydration, and immune system enhancement. This article aims to review the latest scientific literature on the potential benefits of infused water on immune function, particularly in the context of regular consumption of natural ingredients such as lemon, ginger, strawberries, and herbs that are rich in vitamin C, antioxidants, and flavonoids. The review was conducted by searching scientific databases such as PubMed, Google Scholar, and ScienceDirect, using inclusion criteria that covered publications from 2020 to 2024. The findings indicate that infused water containing vitamin C, gingerol, and polyphenolic compounds can help improve immune function by reducing oxidative stress, suppressing inflammatory responses, and stimulating immune cell activity such as lymphocytes and macrophages. Furthermore, optimal hydration from infused water supports various physiological processes of the immune system. In conclusion, infused water holds potential as a simple, natural, and cost-effective strategy to support immune health. However, further research is needed to evaluate its efficacy, optimal formulations, and dosage for maximum benefit.

Uric acid is the final product of purine metabolism, which can increase due to high purine intake or impaired renal excretion. Accumulation of uric acid in the body is at risk of causing joint inflammation and other metabolic disorders. Early detection and dietary education are strategic steps to prevent complications of hyperuricemia. This activity uses the Plan-Do-Check-Act (PDCA) approach by examining uric acid levels using POCT and education on managing purine consumption. The examination was carried out on 62 adult participants. Educational leaflets were delivered directly and individually to each participant. All participants had uric acid levels in the normal range (median 4.2 mg/dL), with the lowest value of 3.5 mg/dL and the highest 6.5 mg/dL. Most participants were women and were in the middle to elderly age group. Although no cases of hyperuricemia were identified, preventive education remains essential to maintain uric acid levels within optimal ranges and reduce future metabolic risks. Lifestyle interventions focusing on diet and hydration are critical for sustainable uric acid control and long-term health outcomes.   Keywords: Uric Acid, Purine, Hyperuricemia, Diet, Nutrition Education

Hyperemesis gravidarum is excessive nausea and vomiting in pregnant women which interferes with daily activities because it is usually made worse by dehydration. The cause of hyperemesis gravidarum is not known for certain, but it is likely caused by an increase in the serum hormones estrogen and HCG (chorionic gonadotropin hormone). The aim of this research is to analyze the relationship between nutritional status and hyperemesis gravidarum in pregnant women at Tanah Jambo Aye Community Health Center, North Aceh. This study used a case control design. Pain Case Study This research was conducted to determine whether parity, nutritional status and stress are related to hyperemesis gravidarum in pregnant women. There is a relationship between nutritional status and the incidence of hyperemesis gravidarum in pregnant women at the Tanah Jambo Aye Community Health Center, North Aceh. Pregnant women with poor nutritional status will experience hyperemesis gravidarum 7.5 times compared to pregnant women with good nutritional status. Pregnant women are expected to always seek information about hyperemesis gravidarum and risk factors for hyperemesis gravidarum.

Nausea and vomiting are symptoms that a reasonable and often happen in the first trimester of pregnancy. It usually occurs in the morning, but can occurs at any time including at night. This condition can cause dehydration or lack of fluid and electrolyte inbalance, hence the condition of pregnant mother's get worse. Lemon aromatherapy is one of alternative method to decrease nausea and vomiting in the first trimester of pregnancy. It provides relaxation and sedative by stimulating the limbic system. This study was conducted to find the effect of lemon aromatherapy to decrease nausea and vomiting in the first trimester of pregnancy. Design used in this study was pre-experiment (one-group pretest-posttest designed). The population were all pregnant women that have nausea and vomiting in the first trimester of pregnancy. The samples were 12 respondent taken by purposive sampling according to the inclusion criteria. The independent variable was lemon aromatherapy. While the dependent variables were nausea and vomiting in the first trimester of pregnancy. Data were collected using structured questionnaire and observation. Data were then analyzed using statistic test (wilcoxon signed rank test) with level of significance α≤0.05.

Dehydration occurs when the body loses too much water and essential fluids in the body. Diarrhea is the main cause of dehydration in toddlers. Toddlers often get diarrhea because their immune system is still vulnerable. If the problem of dehydration is not addressed immediately, it can lead to other health problems such as shock risk. This study aims to determine the effect of video education and demonstration on the ability of first aid dehydration due to diarrhea in mothers with children 0-5 years in Siding Tuban Village. The research design used was Pre Experimental with a one group pretest-postest approach, a sample of 16 respondents taken from 66 populations through Purposive Sampling. Research instrument Ability was measured by observation sheet and analyzed using Wilcoxon Signed Rank test (α=0.05). Before the intervention, 93.8% of respondents had poor skills and after the intervention, 100% of respondents had good skills, which showed an increase in the value of dehydration first aid skills. The results of the analysis obtained p-value=0.000 (<α), meaning that there is an effect of education on the ability of first aid for dehydration due to diarrhea in children. The combination of video and demonstration methods improves the mother's ability to dehydrate children due to diarrhea through visualization and hands-on practice, facilitating understanding and effective application. It is expected that mothers can carry out first aid for dehydration due to diarrhea in children without guidance, reducing the risk of child mortality.

Nausea and vomiting are common conditions experienced during pregnancy, especially in the first trimester, and are considered a normal physiological response that occurs in around 50%-80% of pregnant women. However, if this condition worsens and persists, it can develop into hyperemesis gravidarum, a pregnancy disorder that occurs in around 1 in 1000 pregnant women. This condition is at risk of causing dehydration and electrolyte imbalance and acidoketosis. This study aims to analyze the factors that influence the incidence of hyperemesis gravidarum in BPM Muliyanti, Luengsa Village, Madat District, East Aceh Regency in 2023. The type of research is Descriptive Correlation research with a cross-sectional design. The research sample consisted of 36 respondents, who were selected using a sampling technique with Purposive Sampling. Based on the results of the bivariate analysis using the Pearson Chisquare test, it is known that the p-value is 0.028, so it can be concluded that there is a statistically significant relationship between Maternal Parity and the Incidence of Hyperemesis Gravidarum in Pregnant Women in BPM Muliyanti, Luengsa Village, Madat District. East Aceh Regency Drugs in 2023. 

Postoperative nausea and vomiting is one of the side effects that often occurs in spinal anesthesia. Nausea and vomiting affect patient morbidity such as stress, discomfort, dehydration, prolonging treatment time and increasing treatment costs. This study aims to determine the effect of acupressure therapy on the incidence of nausea and vomiting after spinal anesthesia in the recovery room at the Imelda Workers Indonesia General Hospital, Medan. This type of research is quantitative research with quasi-experimental research methods. Data reports in the province of North Sumatra showed that there were 25,602 patients who underwent surgery. Meanwhile, at the Indonesian Umim Workers Hospital in Medan, data on surgical patients for January-March 2024 totaled 666 patients, and 250 patients had spinal anesthesia. This research was carried out in February - June 2024 at the Imelda Indonesian Workers General Hospital, Medan. The research sample was taken as many as 20 respondents. incidence of nausea and vomiting after spinal anesthesia at the Imelda Workers Indonesia General Hospital, Medan. Based on the characteristics of respondents based on age, they were in the age range of 36-40 years, namely 55%, based on gender, the majority of respondents were women, namely 60%, respondents based on smoking history were the majority 65%, the distribution of respondents with a history of nausea and vomiting was the majority 55% and the majority of respondents with nausea and vomiting were 60%. The recommendation for this research is that acupressure therapy can be applied in nursing practice so that patients are able to perform it independently. For the Imelda Workers Indonesia General Hospital, Medan, it is necessary to score the risk of nausea and vomiting in patients before surgery to minimize the incidence of post-operative nausea and vomiting.

Postoperative nausea and vomiting is one of the common side effects of spinal anesthesia. Nausea and vomiting affect patient morbidity such as stress, discomfort, dehydration, prolonging treatment time and increasing treatment costs. This study aims to determine the effect of acupressure therapy on the incidence of nausea and vomiting after spinal anesthesia in the recovery room of the Imelda Labor Indonesia General Hospital, Medan. This type of research is a quantitative study with a quasi-experimental research method. Data reports in the province of North Sumatra, there are 25,602 patients undergoing surgery. While at the Umim Labor Indonesia Hospital, Medan, the data on surgical patients as of January-March 2024 amounted to 666 patients, 250 patients were found to have spinal anesthesia. This study was conducted in February - June 2024 at the Imelda Labor Indonesia General Hospital, Medan. A sample of 20 respondents was taken.: The results of the statistical test obtained an α value of 0.000 (α <0.05), thus it was concluded that there was an effect of acupressure therapy on the incidence of nausea and vomiting after spinal anesthesia at the Imelda Labor Indonesia General Hospital, Medan. Based on the characteristics of respondents based on age, they were in the age range of 36-40 years, which was 55%, based on gender, the majority of respondents were women, which was 60%, respondents based on a history of smoking were 65%, the distribution of respondents with a history of nausea and vomiting was 55% and the majority of respondents with an incidence of nausea and vomiting was 60%. The recommendation for this study is that acupressure therapy can be applied in nursing practice so that patients are able to do it independently. For the Imelda Labor Indonesia General Hospital, Medan, it is necessary to carry out a risk scoring of nausea and vomiting in patients before surgery to minimize the incidence of nausea and vomiting after surgery.

Hyperthermia is a condition characterized by symptoms such as dehydration, muscle spasms, dizziness, weakness, nausea, vomiting, and fatigue, which can harm the patient's condition. The causes of hyperthermia can vary, ranging from lack of fluids to excessive physical activity. RSU Putri Bidadari has doctors who are experts in treating various diseases, including hyperthermia. However, several obstacles often occur in the direct consultation process, such as long queues, long distances, limited time, and costs. Therefore, a technology-based system is needed that is able to manage hyperthermia symptom data and help diagnose the disease early, so that patients can get information and early treatment quickly. This method is used to manage the symptoms selected by the patient to determine the possibility of the disease with a high level of confidence. Based on the analysis of the selected symptoms, this system is able to produce the most accurate diagnosis with the case of hyperthermia type Heat exhaustion, with a confidence level of 50.26%.

Concrete typically consists of coarse aggregate, fine aggregate, cement, and water. However, cement production generates significant carbon dioxide emissions nearly equivalent to the tons of cement produced. One alternative to conventional concrete, which replaces cement as a binder, is geopolymer concrete. Geopolymer concrete utilizes fly ash or other materials containing silica and alumina as the binder. Unlike cement, which forms a binder through hydration, geopolymer concrete uses a chemical reaction with alkali activators such as Na2SiO3 (sodium silicate) and NaOH (sodium hydroxide). This study investigates the toughness of geopolymer concrete using cylindrical specimens measuring 15 cm x 30 cm with varying Na2SiO3 to NaOH ratios of 1:0.5, 1:1, and 1:1.5, cured at room temperature for 28 days. The study results show that the highest toughness was achieved with a sodium silicate to sodium hydroxide ratio of 1.5, yielding 2.7394 x 105 J/m3. Meanwhile, the toughness values for sodium silicate to sodium hydroxide ratios of 0.5 and 1.0 were 2.3748 x 105 J/m3 and 2.5821 x 105 J/m3, respectively. Thus, increasing the sodium silicate to sodium hydroxide ratio from 0.5 to 1.5 at an activator content of 0.43 affects the toughness of geopolymer concrete.

This research explores the significance of field trocars in land reclamation within Karbala Governorate's Karta-10 area, caused by waterlogging and salinity. Implementing a detailed reclamation strategy, the study underscores the necessity of a 2 to 2.5 meters burial depth for trocars to prevent water and salt-related issues, aligning with industry standards. The investigation discourages reducing trocar depth to cut costs, as it can result in capillary action and salt build-up or require deeper drainage to manage seepage. Findings indicate that shallow trocars reduce water storage capacity, impacting irrigation and crop hydration, whereas deeper trocars offer better management of drainage flow and spacing efficiency. The study indorses a universal trocar depth of 2 to 2.5 meters, accommodating various crops, thus guiding optimal trocar design and placement for effective land reclamation.

Chronic kidney failure is a serious health problem that not only attacks adults, but can also develop since childhood. One of the main risk factors is unhealthy living habits, including lack of personal hygiene, consumption of unhealthy food, and minimal physical activity. In order to increase awareness regarding the importance of a clean and healthy lifestyle among children, health education efforts are needed from an early age, especially in schools as an environment where children spend a lot of time. Many children do not understand the relationship between personal hygiene, diet and kidney health. Based on the results of interviews with teachers and school health staff, there are several unhealthy behaviors among students, such as rarely washing their hands, excessive consumption of sweet drinks, and low daily physical activity. In addition, only a few students understand the importance of maintaining hydration and adequate water intake for kidney health. This outreach activity will be carried out in several stages, including counseling about the importance of a clean and healthy lifestyle, demonstrations teaching correct hand washing and distribution of leaflets about information on a clean and healthy lifestyle.

The largest organ in the human body, the epidermis, serves as the primary barrier against environmental factors that may arise from the outside. Xerosis cutis is a skin condition that causes dry skin. It's caused by a number of things, including the activity of sebaceous and sweat glands decreasing with age, which lowers the amount of water in the stratum corneum and causes moisture loss. This can lead to disturbances in daily activities and a decline in sleep quality. In France, mild to moderate-severe dry skin is prevalent at a rate of 55.65%, while its prevalence is 9%. At Hana Nursing Home, sixty people attended the geriatric population screening activity, with a mean age of 78 years. During this activity, the left hand demonstrated an average water and oil content of 36.6% and 16.4%, respectively. In contrast, the right hand displayed an average water and oil content of 33.7% and 15.1%, respectively. The aim of this activity is to enhance participants' understanding of the significance of maintaining an optimal level of hydration in their epidermis.

Background: Glass Reinforced Concrete (GRC) is an innovative construction material that combines glass fiber with concrete, providing high strength and durability. However, the influence of GRC mixture composition on flexural strength values has not been studied in depth. Therefore, this study aims to analyze the effect of GRC mixture composition variables, such as the ratio between glass fiber and concrete binder, on flexural strength. It is hoped that the results of this research can provide deeper insight into the use of GRC in construction and help develop more efficient and durable construction materials. Results: From the results of the discussion regarding the effect of differences in fiberglass composition on flexural strength, it was found that the addition of 2% fiber resulted in an average flexural strength of 23.01 kgf/cm2, with an increase of up to 49.77 kgf/cm2 at 1% fiberglass. However, with a fiber composition of 0.8%, the highest flexural strength was obtained at 56.84 kgf/cm2. The addition of fibers that exceed the maximum limit can reduce the density of GRC concrete so that its ability to distribute bending strength forces is reduced. Meanwhile, the effect of fly ash substitution on flexural strength shows that replacing some of the cement with fly ash by 20% can increase the flexural strength value of GRC, because the silica and alumina compounds in fly ash can speed up the hydration process. However, of the five specimens tested, none met the SNI 8299:2017 standard which requires a minimum average flexural strength of 100 kgf/cm2