Literature Review: Analisis Komparatif Karakteristik Fisik Berupa Melting Time dan Crushing Strength pada Solid Vaginal Suppositories dengan Berbagai Variasi Basis

Renata Amalia Azizah ; Callista Luna Sadi Qova Gunawan ; Shelfia Putri Chantika ; Axelando Carlos Febiyano ; Margaret Rianti Martalina
Journal of Educational Innovation and Public Healt... 📅 2026 Vol 4, No 2 🔗 DOI: 10.55606/innovation.v4i2.9151
Abstract
The optimal therapeutic impact of local vaginal drug delivery systems is strongly influenced by the physical characteristics balance of Solid Vaginal Suppositories. A comprehensive review regarding the comparison of mechanical profiles, specifically melting time and crushing strength parameters, from various base classifications constitutes the primary objective of this literature research. The implementation of a Literature Review study design was executed through the extraction of empirical data from twelve experimental journals published within the last ten years. Excessively rapid phase transformation characteristics at physiological basal temperatures and low compression resistance were consistently demonstrated by lipophilic bases such as Oleum Cacao. The risk of structural deformation during the distribution process is highly susceptible to unmodified lipid preparations. High surface elasticity accompanied by a delay in molecular hydration duration reaching 120 minutes was recorded in the utilization of Glycerinated Gelatin Base. Structural rigidity exceeding 4 kgF and disintegration time efficiency under 60 minutes were optimally demonstrated by Polyethylene Glycol (PEG) Base. An enhancement in mechanical resistance against external shocks during the storage period is offered by the thorough modification of the synthetic polymer ratios. Therefore, the determination of the PEG base as the most optimal material is recommended to maintain the quality stability of pharmaceutical products. Compendial regulation standards regarding the physical strength testing of pharmaceutical preparations must be obeyed by every institution to ensure long-term treatment effectiveness. Thus, the alignment between active substance release duration and physical preparation endurance can be realized for absolute patient comfort.
Keywords
Crushing Strength; Melting Time; Polyethylene Glycol; Solid Vaginal Suppositories; Suppository Base Variations
How to Cite

Renata Amalia Azizah, et al. (2026). Literature Review: Analisis Komparatif Karakteristik Fisik Berupa Melting Time dan Crushing Strength pada Solid Vaginal Suppositories dengan Berbagai Variasi Basis. Journal of Educational Innovation and Public Health, 4(2). https://doi.org/10.55606/innovation.v4i2.9151

Renata Amalia Azizah; Callista Luna Sadi Qova Gunawan; Shelfia Putri Chantika; Axelando Carlos Febiyano; Margaret Rianti Martalina, "Literature Review: Analisis Komparatif Karakteristik Fisik Berupa Melting Time dan Crushing Strength pada Solid Vaginal Suppositories dengan Berbagai Variasi Basis," Journal of Educational Innovation and Public Health, vol. 4, no. 2, 2026.

Renata Amalia Azizah; Callista Luna Sadi Qova Gunawan; Shelfia Putri Chantika; Axelando Carlos Febiyano; Margaret Rianti Martalina. "Literature Review: Analisis Komparatif Karakteristik Fisik Berupa Melting Time dan Crushing Strength pada Solid Vaginal Suppositories dengan Berbagai Variasi Basis." Journal of Educational Innovation and Public Health, vol. 4, no. 2, 2026.

Renata Amalia Azizah; Callista Luna Sadi Qova Gunawan; Shelfia Putri Chantika; Axelando Carlos Febiyano; Margaret Rianti Martalina. "Literature Review: Analisis Komparatif Karakteristik Fisik Berupa Melting Time dan Crushing Strength pada Solid Vaginal Suppositories dengan Berbagai Variasi Basis." Journal of Educational Innovation and Public Health 4, no. 2 (2026).

Renata Amalia Azizah, et al. (2026) 'Literature Review: Analisis Komparatif Karakteristik Fisik Berupa Melting Time dan Crushing Strength pada Solid Vaginal Suppositories dengan Berbagai Variasi Basis', Journal of Educational Innovation and Public Health, 4(2). doi: 10.55606/innovation.v4i2.9151.

Renata Amalia Azizah; Callista Luna Sadi Qova Gunawan; Shelfia Putri Chantika; Axelando Carlos Febiyano; Margaret Rianti Martalina. Literature Review: Analisis Komparatif Karakteristik Fisik Berupa Melting Time dan Crushing Strength pada Solid Vaginal Suppositories dengan Berbagai Variasi Basis. Journal of Educational Innovation and Public Health. 2026;4(2).

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