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Fungal infections, such as those caused by Curvularia, can interfere with the vegetative growth and reduce the quality of oil palm seedlings, particularly in the main nursery phase. One solution to improve resistance to pathogens and support vegetative growth is by applying the right foliar fertilizer. This study aimed to determine the effect of Kenfolan foliar fertilizer application on vegetative growth and the level of Curvularia infection in oil palm seedlings during the main nursery phase. The study used a Completely Randomized Design (CRD) with five treatments of Kenfolan fertilizer concentrations: 0 ml/L (P1), 1 ml/L (P2), 2 ml/L (P3), 3 ml/L (P4), and 4 ml/L (P5), each repeated three times. The parameters measured included seedling height, stem diameter, number of fronds, and the percentage of Curvularia infection. Data analysis was performed using ANOVA followed by Duncan’s Multiple Range Test (DMRT) at a 5% significance level. The results showed that treatment P4 (3 ml/L) provided the best vegetative growth, with seedling height reaching 40.07 cm, stem diameter of 1.58 cm, and an average of 4.25 fronds. Additionally, treatments P3 (2 ml/L) and P4 (3 ml/L) successfully suppressed Curvularia infection, with no infection found in these treatments. In contrast, treatment P1 (control) showed the highest infection level of 33%, while P5 (4 ml/L) increased the infection compared to P3 and P4. Based on the results, the application of Kenfolan foliar fertilizer at a dose of 3 ml/L (P4) was the most effective in improving vegetative growth and suppressing Curvularia infection in oil palm seedlings in the main nursery phase.

Hypercholesterolemia is a significant global health problem, with a high prevalence in Indonesia. Although conventional therapies such as statins have been the mainstay of treatment, limited efficacy and side effects necessitate the development of new, more effective and selective drugs. This article explores the role of medicinal chemistry in the discovery and development of cholesterol-lowering drugs, focusing on structure-activity analysis (SAR) and molecular targets. Through structure-based approaches, compounds such as statins and PCSK9 inhibitors have been optimized to increase affinity for biological targets. In addition, exploration of new targets and formulation innovations have shown great potential in improving therapeutic efficacy. Thus, medicinal chemistry contributes significantly to providing safer and more effective therapeutic solutions for the management of hypercholesterolemia.  

One of the problems of catfish cultivation (Clarias gariepinus) that can hinder this cultivation business is the slow growth of fish weight. The purpose of this study is to determine the effect of different administration of Mina Pro probiotics on the absolute weight growth of pearl catfish seeds measuring 5-7 cm in the maintenance tub. The method used in this study is an experimental method. The design used in this study was a Complete Randomized Design (RAL) with four treatments and six replicates. The treatment given is: addition of probiotics mina pro at a dose of 2 ml/kg of feed, 4 ml/kg of feed, 6 ml/kg of feed and without the addition of probiotics to feed. Other parameters that were also studied included water quality including temperature, pH and DO.

Diabetes Mellitus is a disease characterized by hyperglycemia and metabolic disorders in the body which are associated with a lack of insulin secretion. Generally, DM therapy can be carried out using pharmacology and non-pharmacology. Non-pharmacological therapy that can be carried out is AAROM therapy and a low carbohydrate diet. The aim of this study was to determine the effect of AAROM therapy and a low carbohydrate diet on reducing blood glucose levels in elderly people suffering from type 2 DM in Ngepoh Village. This type of research isPre-experimentalby designTwo groups pre-post test. The total population was 90 respondents and the sample size was 33 elderly respondents suffering from type 2 DM in Ngepoh Village which were taken by purposive sampling. Data collection in this research used questionnaires and observation sheets. Analyzed with SPSS 20 using testsMan Whitney. The results of this study showed that the average blood glucose value in the control group was 282 mg/dl pre glucose and 177 mg/dl post glucose. Meanwhile, the mean blood glucose value in the treatment group with pre glucose was 295 mg/dl and post glucose was 144 mg/dl and there was an effect of AAROM therapy and a low carbohydrate diet on reducing blood glucose levels in elderly people suffering from type 2 DM in Ngepoh Village (ρ = 0.000 < α= 0.005) So type 2 DM sufferers are expected to be able to control blood glucose, one of them is by doing AAROM Therapy and a low carbohydrate diet. AAROM therapy can reduce insulin resistance, making it easier for glucose to enter cells, preventing obesity, and improving venous blood flow.

Traditional games play an important role in the motor development of elementary school children. However, cultural changes and increasing use of technology have caused these games to be played less and less. This study aims to analyze the effect of traditional games on the motor development of elementary school children. Using a quasi-experimental method with a pretest-posttest control group design, this study involved 20 4th grade elementary school students who were divided into experimental and control groups. The experimental group was given treatment in the form of traditional games such as hopscotch, gobak sodor, and jump rope for 4 weeks. The results showed a significant increase in the gross motor development of children who participated in traditional games compared to the control group. In addition to motor benefits, traditional games also contribute to children's social, cognitive, and character development. Therefore, the integration of traditional games into the physical education curriculum in elementary schools is highly recommended to support children's holistic development.

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to insulin resistance or impaired insulin secretion. Optimal dietary management plays a crucial role in maintaining blood glucose stability. This study analyzes an optimal control model of dietary patterns in the treatment of T2DM using the Runge-Kutta 4th Order (RK4) method. Simulation results show that optimal regulation of calorie intake and glycemic index significantly helps maintain blood glucose levels within the normal range. This study is expected to serve as a reference for medical professionals and nutritionists in designing diet strategies based on mathematical models to enhance the effectiveness of T2DM treatment.

Hypertension is a condition marked by elevated blood pressure, increasing risks of morbidity and mortality. Non-pharmacological treatments such as Tera exercise and acupressure therapy at the Taichong point offer alternative interventions. Tera exercise combines breathing techniques and body movements to reduce anxiety and promote vasodilation, thereby lowering blood pressure. Acupressure at the Taichong point facilitates energy flow, also contributing to blood pressure reduction. This study aims to compare the effectiveness of Tera exercise and Taichong point acupressure in lowering blood pressure among hypertensive patients. A two-group pre-post design was employed with a sample of 44 respondents selected through purposive sampling. Blood pressure data were collected using observation sheets. In the Tera exercise group (n=22), the average systolic pressure decreased from 148.77 mmHg to 143.77 mmHg, and diastolic pressure from 88.00 mmHg to 83.00 mmHg. In the acupressure group (n=22), systolic pressure reduced from 153.36 mmHg to 147.50 mmHg, and diastolic from 92.86 mmHg to 84.00 mmHg. Paired t-test analysis showed a significant difference (p-value = 0.000 < α = 0.05), indicating that acupressure therapy at the Taichong point is more effective in reducing blood pressure. This study concludes that while both therapies are effective, acupressure yields greater reductions and is recommended as a non-pharmacological treatment for hypertension in Trading Village, Tiris District, Probolinggo Regency.

This study aims to determine the effect of the Discovery Learning model assisted by E-LKPD on students' physics learning outcomes. The research was conducted at SMA Negeri 1 Percut Sei Tuan. This type of research is a quasi-experimental design with a pretest-posttest control group design. The sampling technique used in this study was cluster random sampling, consisting of an experimental class and a control class, each with 36 students. The solution to address the research problem was to apply the Discovery Learning model assisted by E-LKPD in the experimental class and conventional learning in the control class. The subjects of this study were students in classes X-3 and X-4. The instrument used was a learning test in the form of 15 multiple-choice questions. Before the different treatments were applied, a pretest was conducted, resulting in an average pretest score of 48.1 for the experimental class and 45.6 for the control class. Normality and homogeneity tests on the pretest data indicated that both classes' data were normally distributed and homogeneous. The two-tailed t-test resulted in a value of tcount < ttabel = = 0.97 < 1.994, which means H0 was accepted, indicating that the initial critical thinking ability of the experimental and control classes was the same. After the different treatments, a posttest was conducted for both classes, which resulted in an average posttest score of 76.5 for the experimental class and 63.5 for the control class. Normality and homogeneity tests on the posttest data showed that both classes' data were normally distributed and homogeneous. The one-tailed t-test resulted in tcount < ttabel = = 4.860 > 1.666, so the alternative hypothesis (Ha) was accepted. It can be concluded that the use of Discovery Learning assisted by E-LKPD has a significant effect on students' learning outcomes on the topic of work and energy in class X at SMA Negeri 1 Percut Sei Tuan.

The use of criminal law in crime prevention efforts tends to only function as a treatment step for symptoms that appear, not as a tool that is able to eliminate the root causes of crime itself. Criminal law focuses on imposing sanctions on perpetrators as a form of retribution and special prevention, but often does not touch on the underlying factors that drive a person to commit a crime, such as economic conditions, social environment, and education. One of the most frequent forms of crime in society is theft, which reflects the existence of structural problems that have not been fully resolved This research uses a descriptive method of analysis. Where the analysis is carried out in accordance with the provisions of the rule of law with a conceptual approach, which refers to the provisions of the law and other legal disciplines. The type of approach in this research is carried out through normative juridical means. By doing legal interpretation associated with legislation, it also examines and tests secondary data, namely primary legal material in the form of the Criminal Code Article 362 concerning Theft, secondary legal material in the form of doctrine or expert opinion, and tertiary legal material in the form of papers, articles and others, The conclusion of this research is that theft is a criminal offense in the Criminal Code which is classified based on the method, place and conditions of its implementation. Article 362 of the Criminal Code defines theft as the act of taking property belonging to another person unlawfully for possession. In addition, there are other types of theft, such as theft with aggravation (Article 363), theft with violence (Article 365), petty theft (Article 364), and theft in the family (Article 367), each with different sanctions. Keywords : Responsibility, theft, Criminal Code.

Adolescence is a crucial developmental phase often marked by a lack of responsibility, which can lead to negative behaviors such as juvenile delinquency and promiscuity. Therefore, developing a responsible character in adolescents is essential to guide them toward positive behavior. One effective approach is through life skills education implemented in the local village (gampong) environment. This community service initiative aims to instill a sense of responsibility in adolescents by involving them in the planting and maintenance of family medicinal plants (TOGA). Through this activity, adolescents are expected to develop care, discipline, and responsibility, which are reflected in their commitment to nurturing the plants. The activity was implemented in Gampong Cot Alue, Ingin Jaya District, Aceh Besar, and carried out over two days, from February 14 to 15, 2025. The method used in the planning and execution of the TOGA planting involved five stages: (1) creating an activity plan, (2) preparing tools and materials, (3) preparing the planting area, (4) plant nurseries, and (5) creating plant identification markers. These stages were designed to introduce a structured approach to life skills and community engagement.The outcomes of the program demonstrated an increase in adolescents' awareness and understanding of the importance of TOGA. Additionally, there was a noticeable improvement in their sense of responsibility and participation in daily activities beyond school. The broader community, particularly the youth, gained valuable knowledge about the benefits of TOGA for disease prevention, treatment, and health maintenance, contributing to a healthier and more proactive lifestyle within the village environment.

Cancer is a chronic disease that poses a major challenge to global health, with increasing mortality rates. Although conventional chemotherapy has been the mainstay of treatment, this approach has limitations, including non-selectivity leading to severe side effects. Therefore, the development of longer-term cancer therapies, such as targeted therapy and immunotherapy, is of great importance. Medicinal chemistry plays a role in the discovery of bioactive compounds, including xanthones from Garcinia mangostana, which exhibit anticancer activity. This article reviews the contribution of medicinal chemistry to cancer therapy through the analysis of molecular signaling pathways and ligand-target interactions, as well as the use of computational techniques in drug design. With this approach, it is expected to improve the effectiveness of therapy and the quality of life of cancer patients.

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. Currently available pharmacological treatments often cause unwanted side effects, so alternative therapies that are safer and more effective are needed. This study aims to analyze the effectiveness of telang flower extract in reducing blood glucose levels and preventing complications. The potential of Clitoria ternatea as an antidiabetic agent was explored through a systematic literature review, using scientific databases such as Google Scholar, ScienceDirect, and Mendeley with the keywords “Clitoria ternatea AND diabetes AND blood glucose.” Inclusion criteria applied included experimental studies conducted on diabetes-induced mice samples, interventions with telang flower extract administration, and publications within the last 5 years (2021-2025). From a total of 1,858 articles identified, by applying the PRISMA-ScR method, 8 articles were obtained that met the inclusion criteria. The analysis showed that telang flower extract was effective in reducing blood glucose levels. This antidiabetic effect is thought to be due to the presence of flavonoids and other bioactive compounds in telang flowers that act as α-amylase enzyme inhibitors, antioxidants, and anti-inflammatories. These findings indicate the potential of Clitoria ternatea as a promising therapeutic alternative in the management of diabetes mellitus.

Based on the results of initial observations that have been carried out at SDN Pesanggrahan 01 Jakarta on August 29, 2023, it is stated that the reading ability of grade 1 students is still low, this is evidenced by the reading test conducted by the class 1A teacher at that time, namely there were 9 out of 23 students and class 1B there were 13 out of 23 students having difficulty in reading. Students find it difficult to understand the concept of letters and words, students also find it difficult to pronounce words and understand the content of reading. In its implementation, this study uses a type of experimental quantitative research through the provision of a special treatment / treatment in the experimental class. The type of True Experiment research was carried out with a Posttest only Group Design design. The sample in this study was taken using Probability sampling technique The results of the Normality Test using Kolmogorof-Smirnov showed that both data were normal. The results of the homogeneity test with a significance level of 0.05 or 5% after processing the data are significant. 0.471 <0.05 then the data is homogeneous. The results of the t-test in this study show that using an independent sample test with in the table it is known that the tcount value is 4.508, seen ttabel in the attached distribution is known ttabel = t0.5/2 (23+23-2) = t0.025 (44) = 1.1. then it is stated that tcount 4.508 > ttable 1.1 with a significance value of. 0.00 > 0.05. then ho is rejected ha is accepted so it can be concluded that there is an effect of picture word card media

Low back pain is still a trigger for health problems that interfere with activities. If not treated properly, it can reduce lumbar mobility so that there is limited movement. There are several treatment strategies for low back pain, namely pharmacology and non-pharmacology. Non-pharmacology therapy that can be done is cupping therapy. The cupping therapy that is carried out is Al Warik point cupping therapy. This study aims to determine the effect of Al Warik point cupping on reducing the pain scale in low back pain sufferers at the Probolinggo holistic nursing therapy clinic. The type of research used a pre-experiment with a one group pre-post test design. The population was 38 low back pain sufferers at the Probolinggo holistic nursing therapy clinic, the sample determination used the accidental sampling technique that met the criteria of 34 respondents. The instrument used the cupping therapy module, data management with the editing, coding, scoring, and tabulating processes. Furthermore, it was analyzed using the Wilcoxon test. The results of this study indicated that the average pain scale value that occurred before cupping therapy at the Al Warik point was 7.00, standard deviation 1.073, and the average pain scale value after cupping therapy at the Al Warik point was 4.74, standard deviation 1.024, the analysis test using the Wilcoxon test showed a decrease in the Low Back Pain Pain Scale at the Holistic Nursing Therapy Clinic in Probolinggo (ρ = 0.000 <α = 0.005). Cupping therapy can be a traditional alternative treatment that can be done routinely for the healing process of low back pain by performing cupping therapy at the Al Warik point.

Diabetes Mellitus (DM) is a chronic disease that requires long-term adherence to treatment. One of the main challenges in managing type 2 DM is the low level of patient adherence to medication. This literature review aims to analyze the effect of health education on improving patients’ knowledge and medication adherence. The review is based on selected scientific articles that discuss the relationship between education, knowledge, and adherence in patients with DM. Findings indicate that health education-delivered through counseling, printed media, self-instructional modules, or home visits—generally improves patients’ understanding of the disease and the importance of regular treatment. This increase in knowledge contributes to better health behavior, particularly in terms of medication compliance. Interactive educational methods that involve healthcare providers and patient families are more effective than one-way communication approaches. Structured and continuous education tailored to patient characteristics has the potential to significantly enhance disease management. Therefore, health education should be prioritized as a key strategy to improve treatment adherence and prevent long-term complications in patients with diabetes mellitus.

Cancer is a disease that results from changes in cell function and structure, which leads to abnormal and uncontrolled cell division. These changes can affect gene expression, leading to uncontrolled cell proliferation, invasion, and metastasis to other tissues and organs. An alternative to cancer treatment can be done by administering phytochemical compounds, one of which is naringenin. This study aims to determine the effect of naringenin on the growth of cancer cells. The method used in this study is a literature review of in vitro experimental articles published in the last ten years and obtained the results of 7 articles. The study results showed that naringenin can inhibit the proliferation, migration, and invasion of cancer cells through several mechanisms. In addition, naringenin has been shown to induce apoptosis and alter the morphology of cancer cells. It can be concluded that naringenin has great potential as an alternative therapy for cancer.

Chitosan is a natural polysaccharide derived from chitin, commonly found in the shells of crustacean animals. The production of chitosan involves several stages: deproteinization, demineralization, and deacetylation, which require the use of acidic and alkaline solutions. This study aimed to evaluate the effectiveness of various types of organic acids and a natural acid source, Averrhoa bilimbi (bilimbi fruit) extract, in the chitosan extraction process from Vannamei shrimp shells. The study employed a completely randomized design with a single factor consisting of four acid treatments: acetic acid (AA), citric acid (CA), lactic acid (LA), and bilimbi fruit extract (BE), each replicated three times. The chitosan obtained from each treatment was analyzed for its chemical characteristics and mineral content, and the results were further analyzed using Principal Component Analysis (PCA). The best results were obtained from the citric acid treatment, which produced chitosan with a moisture content of 6.59%, a degree of deacetylation of 91.72%, ash content of 2.68%, and magnesium and calcium contents of 2.56 mg/100g and 0.15 mg/100g (dry basis), respectively. In contrast, the bilimbi extract treatment resulted in an ash content of 41.64%, with magnesium and calcium contents of 1456.52 mg/100g and 4.17 mg/100g (dry basis), indicating that the bilimbi fruit extract still has low demineralization effectiveness.

Purple yam is one of the tubers that serves as a source of antioxidants but has not been optimally utilized. Therefore, it needs to be diversified by processing it into snack bars. This study aims to develop snack bars made from purple yam flour, sorghum flour, and mung bean flour, which have the potential to serve as antioxidant sources and are preferred by panelists. In this study, snack bars were prepared using composite flour (sorghum:mung bean) and purple yam flour in varying ratios: 95:5, 90:10, 85:15 for the composite flour and 20%, 30%, and 40% for the purple yam flour. The snack bars were evaluated for color, texture, moisture content, antioxidant activity, and preference level. Selected samples were further analyzed for ash content, protein content, fat content, anthocyanin content, and crude fiber content. The experimental design used was a Completely Randomized Design (CRD) with two factors. The snack bars with a composite flour ratio (sorghum:mung bean) of 85:15 and 30% purple yam flour were identified as the best treatment, preferred by panelists and exhibite high antioxidant activity. These snack bars had a moisture content of 13.40%, ash content of 8.83% (db), protein content of 19.75% (db), fat content of 8.80% (db), crude fiber content of 9.54% (db), antioxidant activity of 68.02% (RSA), and anthocyanin content of 37.40 mg/100g

Bullying is one of the problems that often arise in the school environment and is a serious problem in education. In this case, the role of schools as educational institutions in preventing this problem is needed. Teachers as the main actors of the educational process are highly responsible for creating a safe and comfortable learning environment for all students. This study aims to determine the duties of teachers and provide strategic recommendations to improve the effectiveness of dealing with bullying in schools. This study also contributes to the development of more effective educational policies in the prevention and treatment of bullying cases at the secondary school level. The research method in this study used a qualitative approach with a case study design. Data recording techniques were conducted by in-depth observation and document analysis in relation to school guidelines related to bullying. Teachers have a huge influence in preventing bullying with important outcomes such as the creation of a respectful and safe school culture, increased student understanding of the dangers of bullying, positive changes in student behavior, increased courage to report bullying cases, and improved quality of life for students. Thus, providing support to teachers in bullying prevention efforts is fundamental to building a positive learning environment and effectively addressing bullying issues in schools..

One of the infectious diseases that is a problem in the world is Pulmonary TB with the main symptoms of shortness of breath, chest pain when coughing and breathing due to airway obstruction. If not treated, it can cause death, so it needs treatment, one of which is with effective coughing exercises. The activity begins with measuring the respiratory rate, then effective coughing exercise therapy. Education is carried out to relieve the respiratory tract by expelling sputum for Pulmonary TB sufferers and in collaboration with local village officials. The method used in this activity is counseling on effective coughing exercises from a team of nursing lecturers and nursing students during Field Learning Practices of 32 respondents. The results obtained from respondents before being given education were 32 people with a high respiratory rate> 25x / minute and after education there was a change in the normal range of 23-25x / minute as many as 26 people and 6 others with a high respiratory rate> 25x / minute. The output of the PkM that has been implemented is expected to increase the respiratory rate after effective coughing exercises are applied in the community.