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Priyo Wibowo; Sunarmi Sunarmi

Integrated System and Management Technology 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

This study examines the impact of IT-driven innovation management on IT service effectiveness and competitive value creation within smart organizations. As digital transformation accelerates across industries, organizations are increasingly leveraging advanced IT solutions to enhance service delivery, responsiveness, and customer satisfaction. While traditional IT service management (ITSM) models focus on efficiency and structured processes, the integration of innovation management introduces new opportunities to improve service quality and operational agility. Through a quantitative research design, this study employs regression modeling to assess the relationship between IT-driven innovation management and two key outcomes: IT service effectiveness and competitive value creation. Data were collected from 100 technology-intensive organizations that actively integrate innovation into their IT service management processes. The results demonstrate that IT-driven innovation significantly enhances service quality, customer satisfaction, and organizational competitiveness. Furthermore, a curvilinear relationship was identified, indicating that while moderate innovation leads to improved outcomes, excessive innovation may have diminishing returns. These findings highlight the importance of balancing innovation efforts with business goals to achieve optimal performance. The study also compares innovation-driven IT service management with traditional models, illustrating how innovation fosters agility, responsiveness, and long-term value creation. The implications for smart organizations are clear: integrating innovation into IT service management is essential for maintaining a competitive edge in the rapidly evolving digital landscape. Future research should explore the long-term impact of innovation management on organizational sustainability and growth, considering external factors such as market volatility and technological disruptions.

Mutiara Muliani; Dena Salsabila; Yolanda Jn

Jurnal Manajemen Bisnis Digital Terkini 2026 Asosiasi Riset Ilmu Manajemen Kewirausahaan dan Bisnis Indonesia

Pricing is a critical factor determining the success of small and medium-sized enterprises (SMEs) in the market. This study investigates the pricing strategy implemented by Kebab Ajo Lubeg, a culinary SME located near Universitas Putra Indonesia YPTK Padang. The research aims to analyze how pricing methods are applied, the factors considered in price determination, and their influence on consumer purchasing decisions and business strategy. A qualitative descriptive approach was employed, with data collected through semi-structured interviews with the owner and employees, direct observation, and documentation of product offerings and pricing. Findings indicate that Kebab Ajo applies a combination of cost-based pricing, competition-based pricing, and product-based price variation to balance production costs, consumer purchasing power, and market competition. The pricing strategy significantly affects consumer satisfaction, repeat purchases, perceived value, brand image, and business competitiveness. This study provides practical insights for other SMEs in setting appropriate prices while maintaining customer loyalty and profitability, and it contributes to the academic discourse on marketing management and pricing strategies in the culinary sector.

Sri Puspita Sari; Mukrodi Mukrodi

Jurnal Pemimpin Bisnis Inovatif 2026 Asosiasi Riset Ilmu Manajemen dan Bisnis Indonesia

The rapid development of globalization and the acceleration of digital transformation have encouraged organizations to adopt more adaptive and collaborative work practices. In this context, collaborative culture has become a strategic element that plays a crucial role in enhancing organizational effectiveness and competitiveness. This study aims to comprehensively examine the concept, characteristics, forming factors, and theoretical foundations of collaborative culture in modern organizations. The research employs a qualitative approach through a literature review, analyzing reputable national and international journal articles, textbooks, and relevant institutional reports. Data analysis is conducted using a descriptive-analytical technique by synthesizing findings from previous studies. The results indicate that collaborative culture significantly contributes to improved communication quality, work coordination, adaptability, and both individual and organizational performance. Collaborative culture is shaped through the integration of shared vision, open communication, trust, willingness to share resources, collaborative leadership, flexible organizational structures, and the support of collaborative technologies. This study also highlights that the success of digital transformation largely depends on the strength of an effectively internalized collaborative culture. The findings are expected to provide a theoretical reference for organizations and researchers in developing sustainable collaborative culture strategies.

Chadija Chadija; Kasim, Amrah; Achruh, Andi; Syamsuddin Syamsuddin

International Journal of Educational Evaluation and Policy Analysis 2026 Asosiasi Riset Ilmu Pendidikan Indonesia

This study investigates how character education is embedded into the school culture of an Indonesian Islamic junior high school (madrasah), focusing on four core values: religiosity, honesty, tolerance, and discipline. Using a qualitative naturalistic approach, the research was conducted at MTsN 3 Halmahera Utara through in-depth interviews, participant observation, and document analysis involving school leaders, teachers, and students. The findings reveal that character education at the madrasah is not a standalone program but is institutionalized through consistent routines, religious practices, and role modeling. Religiosity is fostered through structured worship, integration of Islamic values into lessons, and spiritual habits. Honesty is promoted via trust-based learning environments, teacher exemplarity, and reinforcement of moral norms. Tolerance is cultivated through inclusive social interactions and respect for religious and cultural differences, while discipline is internalized through habitual rule-following, punctuality, and self-regulation. These findings align with existing theories and regional character education frameworks, confirming that character is best formed through embedded cultural processes and consistent adult exemplarity. The study contributes to the understanding of how Islamic schools can function as moral communities and highlights the importance of alignment between school culture, family support, and wider social contexts in achieving sustainable moral development.

Gunawan Prayitno; Ronaldo Aprili

Integrated System and Management Technology 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

This study investigates the role of Information Technology (IT) governance in enhancing risk management performance and ensuring regulatory compliance within multinational digital enterprises. As digital transformation continues to reshape the global business landscape, organizations face increasing challenges in managing technological risks and complying with complex regulatory requirements across various jurisdictions. The study adopts a quantitative approach, using a survey methodology to collect data from senior IT and compliance managers in multinational digital enterprises. The survey focuses on how IT governance frameworks, such as COBIT 2019 and ISO 27000, are utilized to align IT strategies with business objectives, mitigate risks, and maintain regulatory compliance. The findings indicate that organizations with well-established IT governance structures are better positioned to proactively identify and mitigate risks, ensuring greater consistency in meeting regulatory requirements. These organizations demonstrate improved risk management effectiveness, especially concerning cybersecurity, data privacy, and compliance with global regulations like GDPR. In contrast, organizations with ad hoc or decentralized governance structures struggle with fragmented risk management and compliance efforts. The study further highlights the importance of integrating IT governance frameworks with internal audit functions, specifically the Chief Audit Executive (CAE), to enhance cybersecurity resilience and ensure compliance with global standards. This research contributes to the literature by providing empirical evidence on the integration of IT governance, risk management, and regulatory compliance in multinational enterprises. It also highlights the need for a structured and systematic approach to IT governance to improve organizational performance in managing risks and ensuring consistent regulatory adherence. The study offers practical insights for organizations looking to optimize their IT governance structures in the face of rapid digital transformation.

Rio Herdy Saputra; Dinda Anisa Septiani Putri; Riska Ayu Sekarsari; Adrian Yan Permana; Masitha Tismananda Kumala

Presidensial : Jurnal Hukum, Administrasi Negara, dan Kebijakan Publik 2026 Asosiasi Peneliti dan Pengajar Ilmu Hukum Indonesia

In Indonesia, maritime safety remains a problem. Ship captains and ship owners often disregard maritime safety standards, particularly for fishing vessels. Provisions for criminal liability for domestic fishing vessels that fail to meet maritime safety standards are an important legal instrument for regulating and enforcing maritime safety regulations in the fisheries sector. Failure of vessels to comply with safety requirements, such as the completeness of safety equipment, engine condition, and vessel structure, can potentially lead to accidents that endanger the lives of crew members and negatively impact the marine environment. This study uses a normative research method with a legislative approach. This article focuses on examining aspects of criminal liability, including the subjects, objects, and legal sanctions imposed for violations of maritime safety standards. The results indicate that perpetrators of violations can be subject to criminal sanctions in the form of fines, detention, and even revocation of vessel operating permits, taking into account human rights and environmental protection. Effective and synergistic law enforcement between relevant authorities is essential to provide a deterrent effect, encourage compliance with safety standards, and improve the system for the sustainability of marine resources.

Saad Salem Jassim

Inovasi Kesehatan Global 2026 Lembaga Pengembangan Kinerja Dosen

Derivatives of substituted oxazol-5-one (1–3) and substituted oxazolo-isoxazole (4–6) were successfully synthesized through a multi-step reaction process. Initially, glycine was reacted with acetic anhydride to produce acetyl glycine as a key intermediate. This intermediate subsequently underwent a condensation reaction with various substituted benzaldehydes, leading to the formation of oxazol-5-one derivatives (1–3). In the final synthetic step, these oxazol-5-one derivatives were reacted with hydroxylamine hydrochloride to yield the corresponding oxazolo-isoxazole compounds (4–6). The chemical structures of all synthesized compounds were characterized and confirmed using Fourier Transform Infrared (FT-IR) spectroscopy and proton nuclear magnetic resonance (¹H NMR) spectroscopy. Furthermore, molecular docking studies were carried out to evaluate the potential biological interactions of the prepared compounds. Docking simulations were performed using PyRx software, while visualization and interaction analysis were conducted employing PyMOL and Discovery Studio. The combined experimental and computational approaches provide valuable insights into the structural properties and potential biological relevance of the synthesized compounds.

Zulfikar Zulfikar; Febri Adi Prasetya; Marsiska Ariesta Putri

Programming and Algorithm Fundamentals 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

In high-performance computing (HPC) environments, the need to balance memory efficiency and query performance is crucial for ensuring optimal system performance. Traditional data structures, such as B-trees and hash tables, often prioritize either memory usage or query speed, leading to suboptimal performance in memory-constrained systems. This paper proposes a hybrid data structure that combines the strengths of multiple traditional data structures to optimize both memory usage and query processing speed. The proposed hybrid structure integrates cache-conscious algorithms, dynamic memory allocation, and compression techniques for intermediate query results. The approach is evaluated through extensive benchmarking tests comparing it to standard data structures like B-trees and hash tables under various workloads. Results show that the hybrid data structure reduces memory overhead by up to 30% while maintaining query processing speeds up to 1.5 times faster than conventional methods. Furthermore, the hybrid structure demonstrates robust performance across different types of queries, including both point and range queries, ensuring versatility and efficiency. The findings indicate that this hybrid approach provides a promising solution for HPC systems, where both memory efficiency and query speed are essential. Future research can explore extending the hybrid structure to distributed systems and emerging technologies, further improving its scalability and adaptability to new computational paradigms.

Martha Amanda Sari; Aini Fitri Rohmatul Ilmi; Wawan Hermawan

Jurnal Rumpun Ilmu Bahasa dan Pendidikan 2026 Asosiasi Periset Bahasa Sastra Indonesia

Oral literature is a form of storytelling from one individual to another in a concise manner as a representation of a society's culture. One type that is interesting to study in this field is legends. This study examines the Keong Mas legend using Burhan Nurgiyantoro's structuralism approach theory, which focuses on analyzing the relationship between intrinsic and extrinsic elements in literary works. This study uses a qualitative descriptive method that aims to reveal the narrative structure and social and cultural meanings contained in the legend as a reflection of the moral values and local wisdom of the people of East Java. The information collection method used observation and note-taking. The results of the analysis show that the Keong Mas legend has a cohesive story structure, including theme, characters, plot, setting, and point of view, which simultaneously reflect the values of loyalty, justice, and family conflict in a socio-cultural context. These findings confirm the relevance of oral literature as a medium for the inheritance of living and evolving cultural values, and contribute to the understanding of cultural identity and literary aesthetics in Indonesia, especially in the East Java region.

Miranti Miranti; Sry Rosita; Hendriyaldi Hendriyaldi

Jurnal Manajemen Bisnis Digital Terkini 2026 Asosiasi Riset Ilmu Manajemen Kewirausahaan dan Bisnis Indonesia

This study aims to analyze the effect of workload on employee loyalty at the Class I TPI Immigration Office in Jambi, with performance allowance policies acting as a mediating variable. The research employed a quantitative approach involving 88 respondents selected from the total employee population. Data were collected through structured questionnaires and analyzed using statistical methods to examine both direct and indirect relationships among variables. The results indicate that employees generally perceive their workload as being at a moderate level; however, workload has a significant negative effect on employee loyalty. In contrast, performance allowance policies demonstrate a significant positive influence on loyalty. Furthermore, the findings reveal that performance allowance policies partially mediate the relationship between workload and employee loyalty, indicating their role in mitigating the negative impact of workload. These results suggest that effective performance allowance policies can enhance employee loyalty despite increasing workload demands. Therefore, organizations should balance workload management with fair and performance-based compensation policies to maintain employee loyalty.

Dini Ayu Amalia; Shabrina Arriby Leone; Jauza Alya Yurindhiya; Romadi Romadi; Dimas Anggoro

SOSIAL: Jurnal Ilmiah Pendidikan IPS 2026 Asosiasi Peneliti Dan Pengajar Ilmu Sosial Indonesia

This study examines the impact of Dutch Military Aggression I (1947) and Dutch Military Aggression II (1948–1949) on the political development of Indonesia during the early years of independence. Employing the historical method (heuristics, source criticism, interpretation, and historiography) and a qualitative diachronic-synchronic approach, the research analyses primary and secondary sources concerning internal political dynamics and the Republic of Indonesia’s international relations in the period 1947–1949. The findings reveal that both Dutch military aggressions paradoxically served as crucial catalysts for the acceleration of national political consolidation and maturation in Indonesia. The First Aggression triggered international condemnation, transformed the Republic’s status from “rebels” to a sovereign state defending its independence, strengthened national solidarity, and gave birth to the integration of armed struggle and diplomacy—the precursor to the Total People’s Defense doctrine. Meanwhile, the Second Aggression, marked by the occupation of Yogyakarta and the arrest of republican leaders, led to the establishment of the Emergency Government of the Republic of Indonesia (PDRI), closer civil-military coordination, unification of political parties and societal organizations, and heightened global pressure that ultimately resulted in the recognition of sovereignty in 1949. Overall, Dutch military pressure expedited the transformation of political structures, bolstered the legitimacy of the Republican government, and secured both de facto and de jure recognition of Indonesian independence.

Febrianti Shakira; Hastiani Nasution; Ahmad Wahyudi Zein

Jurnal Inovasi Ekonomi Syariah dan Akuntansi 2026 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

This study aims to analyze the implementation of Good Corporate Governance (GCG) principles at PT Bank Mandiri (Persero) Tbk as one of the state-owned banks that plays a strategic role in the Indonesian banking system. The implementation of GCG is crucial in maintaining public trust, improving performance, and ensuring business sustainability in the banking sector. This research employs a qualitative method with a descriptive approach, focusing on secondary data analysis obtained from annual reports, corporate governance reports, sustainability reports, and official information published on the website of PT Bank Mandiri (Persero) Tbk. The results indicate that Bank Mandiri has consistently implemented the principles of transparency, accountability, responsibility, independency, and fairness in its corporate governance system. These principles are reflected in information disclosure practices, clear organizational structures, regulatory compliance, independent decision-making processes, and fair treatment of all stakeholders. Overall, the implementation of GCG at PT Bank Mandiri (Persero) Tbk contributes positively to strengthening internal control systems, enhancing public trust, and supporting the stability and sustainability of banking operations.

Fahrudin Fahrudin; Agus Hariadi; Suprapti Suprapti; Putri Iriani Anjakusuma

Jurnal Pengabdian dan Pembangunan Lokal 2026 Lembaga Pengembangan Kinerja Dosen

The Community Service Program (PkM) focused on mentoring storytelling competitions was implemented as an effort to improve students' competence in the art of storytelling, while also supporting their preparation for the FLS3N event. The activity was designed through a series of training sessions that included understanding the concept of storytelling, examples of storytelling practices, hands-on practice, and periodic evaluations. During the mentoring process, students showed progress in terms of story mastery, intonation, expression, and confidence. The approach used encouraged active participation so that participants were able to improve their storytelling techniques based on the feedback provided. The results of this activity show that structured and continuous training can improve students' readiness to present stories in a more communicative and interesting manner in upcoming competitions.

Nuris Dwi Setiawan; Hendri Rasminto; Muhamad Sidik

Information System Analysis, Design and Development 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

Digital transformation (DT) has become a critical component for organizations aiming to enhance their operational efficiency, innovation, and competitiveness. However, many organizations struggle to achieve successful digital transformation due to the misalignment between their Enterprise Information Systems (EIS) and organizational strategic goals. This research seeks to design and validate a model for aligning EIS with digital transformation strategies to improve organizational effectiveness. By adopting the Design Science Research (DSR) approach, this study develops a practical model that integrates strategic planning, process management methodologies, and emerging technologies to facilitate alignment between IT and business strategies. The research includes key steps such as requirement analysis, artifact design, expert validation, and case study evaluation to ensure the model's robustness and applicability across different organizational contexts. Findings indicate that the proposed model significantly improves strategic-system alignment, enhances decision-making consistency, and facilitates better integration between business and IT units. The model also addresses common challenges such as resistance to change, skill gaps, and misalignment, fostering a supportive culture for digital transformation. In comparison to existing descriptive frameworks, the proposed model is more structured, adaptable, and actionable, providing organizations with a clear framework to guide their digital transformation efforts. This research contributes to the growing body of knowledge on EIS alignment and offers practical insights for organizations seeking to achieve successful digital transformation. Future research could explore the model's application in various organizational settings and examine its impact on long-term organizational growth and innovation.

Amelia Fitri Indarti; Hanifa Putri Wardhani; Jovanka Jovanka; Siska Amalia; Erik Saut Hatoguan Hutahaean

Jurnal Pengabdian dan Keberlanjutan Masyarakat 2026 Lembaga Pengembangan Kinerja Dosen

Individuals with mental disabilities commonly experience difficulties in self-awareness and emotion regulation, which negatively affect social functioning and psychosocial well-being. These conditions were also observed among beneficiaries in the assisted community, who demonstrated limitations in recognizing emotions, expressing feelings, and engaging in social interactions. This community service program aimed to strengthen self-awareness and emotional regulation skills among individuals with mental disabilities through a psychosocial approach. The program employed activity-based psychoeducation using participatory and supportive methods, including emotional recognition training, self-reflection, positive emotional stimulation, and structured group support. The results indicated improvements in beneficiaries’ ability to identify and express basic emotions, increased self-confidence, enhanced emotional stability, and more active social participation. Qualitative observations revealed behavioral changes from passive tendencies to more responsive and cooperative involvement in group activities. These findings suggest that activity-based psychosocial interventions are effective in improving psychosocial well-being among individuals with mental disabilities.

Christine Diah Wahyuningsih; Desy Ambarwati

Public Service And Governance Journal 2026 Universitas 17 Agustus 1945 Semarang

This study aims to analyze the implementation of gender-based public policy through the Child-Friendly School Program at SDN 01 Bendosari, Plantungan District, Kendal Regency. This research employed a descriptive qualitative approach using in-depth interviews, observation, and documentation as data collection techniques. Data analysis was conducted using the public policy implementation model proposed by George C. Edwards III, which emphasizes four key variables: communication, resources, implementers’ disposition, and bureaucratic structure. The findings reveal that the implementation of the Child-Friendly School policy at SDN 01 Bendosari has been carried out through an integrative approach by incorporating child-friendly principles into existing school programs and culture. Effective policy communication and positive implementers’ disposition, particularly among teachers and the school principal, have supported the implementation process. However, limited financial resources remain a major obstacle to fully optimizing the policy implementation. This study concludes that successful public policy implementation depends not only on regulatory frameworks but also on resource availability, implementers’ commitment, and institutional capacity to adapt policies to local conditions.

Siti Nuraida; Hamdiah Hamdiah; Erwan Setyanor

Jurnal Ekonomi Keuangan Syariah dan Akuntansi Pajak 2026 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

Global social inequality remains one of the fundamental challenges in the contemporary world economic system. The dominance of capitalist economic structures, which emphasize growth and capital accumulation, has proven effective in stimulating economic progress; however, it has simultaneously widened the gap between wealthy and disadvantaged groups at both national and global levels. Meanwhile, socialist economic systems that prioritize income equalization continue to face limitations related to efficiency and innovation. This article aims to examine the role of Islamic economics as an alternative economic framework capable of addressing the challenge of global social inequality. The study employs a qualitative descriptive approach through a literature review of classical and contemporary sources related to global economic systems. The findings indicate that Islamic economics offers a more balanced paradigm by integrating principles of distributive justice, ethical values, and social responsibility within economic activities. Instruments such as zakat, infaq, sadaqah, waqf, along with the prohibition of riba and other exploitative economic practices, serve as essential mechanisms for reducing social inequality. Therefore, Islamic economics holds significant potential as both a normative and practical solution for promoting sustainable global economic justice.

Helen Griselda; Aldi Aditiya Hermawan; Imam Hidayat; Maria Goreti Mona Lako; Nisfu Ramadhan Ayatullah Habibi +2 more

Jurnal Manajemen Kreatif dan Inovasi 2026 International Forum of Researchers and Lecturers

The high unemployment rate in Indonesia highlights the importance of enhancing work readiness among young people from an early educational stage. Work readiness is influenced by several factors, including learning motivation, communication skills, and parental support. This study aims to examine the relationship between learning motivation, communication skills, and parental support with work readiness among twelfth-grade students at SMAK Kasih Anugrah. This research employed a quantitative approach with a cross-sectional design. The population consisted of all 30 twelfth-grade students, and a saturated sampling technique was applied. Data were collected using structured questionnaires and analyzed through univariate and bivariate analysis using the Chi-Square test. The results indicate a significant relationship between learning motivation and work readiness (p-value = 0.021), communication skills and work readiness (p-value = 0.014), and parental support and work readiness (p-value = 0.005). These findings suggest that learning motivation, communication skills, and parental support play a crucial role in improving students’ readiness to enter the workforce. The results of this study are expected to provide practical implications for schools and parents in strengthening students’ preparation for the world of work

Irlon Irlon; Teguh Muryanto; Agnes Novita Ida Safitri

Information System Analysis, Design and Development 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

Digital transformation initiatives have become essential for organizations seeking to remain competitive in today’s rapidly evolving technological landscape. However, many organizations face challenges due to ineffective Information Systems (IS) governance, which hampers strategic decision-making and the successful execution of these initiatives. This study aims to develop an IS governance framework that enhances decision-making quality by aligning IT decisions with organizational goals during digital transformation efforts. The proposed framework addresses existing gaps in current IS governance models, offering a solution to common challenges such as inadequate governance structures, resource constraints, and misalignment between IT and business strategies. The framework was developed through a mixed-method approach, including conceptual framework development, expert consensus via the Delphi method, and organizational validation studies. Key findings reveal that the framework improves transparency in decision-making, enhances accountability for IT decisions, and ensures better alignment between IT strategies and organizational objectives. By embedding agile leadership and data-driven decision-making principles, the framework enables organizations to respond effectively to the fast-changing dynamics of digital transformation. This study also compares the proposed framework to existing models such as COBIT and ITIL, highlighting its unique features, including its adaptability to the fluid nature of digital transformation. The framework's strengths include its comprehensiveness and flexibility, though its application may face challenges in organizations with limited digital maturity or rigid governance structures. Future research directions include exploring the integration of emerging technologies into the framework and its applicability across different organizational contexts.

Intan Wuri Handayani; Lusiana Lusiana; Hadi Firmansyah

Jurnal Riset Rumpun Ilmu Kedokteran 2026 Pusat riset dan Inovasi Nasional

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening mucocutaneous reactions characterized by extensive epidermal necrolysis and mucosal involvement. The entities represent a clinical continuum distinguished by the extent of epidermal detachment (SJS <10% body surface area [BSA], SJS/TEN overlap 10–30%, TEN >30%). Most cases are drug-induced, making early culprit-drug withdrawal and structured supportive care the cornerstones of management. Immunopathogenesis is primarily mediated by drug-specific cytotoxic T cells and NK cells through granulysin, Fas–Fas ligand, and perforin/granzyme pathways, with emerging roles of necroptosis and candidate biomarkers such as RIP3 and galectin-7. Diagnosis relies on timely recognition of the characteristic painful erythematous/targetoid lesions, Nikolsky/Asboe–Hansen signs, multi-site mucositis, accurate BSA assessment, and early severity scoring (e.g., SCORTEN) to guide referral and monitoring. Systemic immunomodulators (corticosteroids, cyclosporine, IVIg, anti-TNF agents) have variable evidence; thus, individualized selection and early multidisciplinary care particularly ophthalmologic involvement are essential to reduce acute mortality and long-term sequelae.