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Probiotics from West Sumatra curd have the potential to improve the production performance of local West Sumatra ducks, where Probiotics are live bacteria given as food sulpementation. Giving probiotics can have a beneficial effect on health where probiotics produce inhibitor compounds so that they can maximize the absorption of food in the intestines of livestock. The purpose of this study was to observe the production performance of ducks given probiotics. The design used was a randomized complete factorial method. The first factor (A) Dosage of probiotics (LAB) is with treatment A1: 1 ml (12.7 x 108 CFU/g); A2: 2 ml (25.4 x 108 CFU/g); A3: 3 ml (38.1 x 108 CFU/g). The second factor (B) is the frequency of probiotic administration, namely B1: 0 times; B2: 1 time; B3: 2 times; B4: 3 times; B5: 4 times; B6: 5 times; B7: 6 times, consisting of 4 replicates with a total of 346 ducks. The observed variables were food consumption, body weight gain, ration conversion, carcass percentage. The results of this study were the average food consumption at a dose of 3 ml with 5 times administration (995.79g). The highest average body weight gain (369.74 grams) dose of 1 ml and 5 times administration. The highest carcass percentage with a dose of 3 ml and a frequency of 5 times (72.63%).

The objective of this study was to analyze the additional effect of eco-enzymes mixed in drinking water on the haught unit value, egg yolk index, and hatch weight of IPB-D1 chickens. A total of 96 chickens were used, comprising 72 females and 24 males. This study used a completely randomized design (CRD) with 4 treatments and 6 replicates. The treatments administered were: P1 = drinking water without eco-enzymes (control), P2 = 1 cc eco-enzymes/L drinking water/3 days, P3 = 2 cc eco-enzymes/L drinking water/3 days, P4 = 3 cc eco-enzymes/L drinking water/3 days. A total of 72 eggs were used to observe egg interior quality, with 3 eggs used per treatment per replicate. A total of 216 eggs were used for hatch weight (9 eggs per treatment and per replicate). The variables measured were egg yolk index, HU value, and hatch weight. Statistical analysis results demonstrated that there were significant differences (P<0.05) in hatched weight, HU value, and egg yolk index. Conclusion: Adding eco-enzymes to drinking water at a dose level of 2 mL/L of drinking water every 3 days can increase the egg yolk index, HU value, and hatch weight of IPB-D1 chickens. Further research is needed on eco-enzymes in chickens and different levels of eco-enzyme dosage.

Coffee production generates large amounts of solid waste, particularly coffee pulp, which can lead to environmental pollution if not properly managed. This study investigates the utilization of coffee pulp waste as a liquid organic fertilizer (LOF) and its effect on the growth of Arabica coffee seedlings (Coffea arabica L.). The experiment was conducted using a randomized complete block design (RCBD) with five treatments (0, 10, 20, 30, and 40 ml/L of LOF) and five replications. Observations were made on seedling height, stem diameter, and number of leaves over a four-month period. The results showed that the application of LOF had a significant effect on plant height and number of leaves. The highest increase in height and leaf count was observed in the 30 ml/L treatment, while the 40 ml/L treatment showed a slight decline, possibly due to nutrient oversaturation. However, stem diameter did not show a statistically significant difference among treatments. Correlation analysis indicated a strong positive relationship between plant height and leaf number (r = 0.800), suggesting synchronized vegetative growth. These findings demonstrate the potential of coffee pulp LOF as an eco-friendly alternative to chemical fertilizers in coffee seedling nurseries. Further research is recommended to evaluate long-term effects and optimal dosages for different growth stages.

The selection of appropriate solvents in sterile injection formulations plays a pivotal role in determining the stability, efficacy, and safety of pharmaceutical products. Among the commonly utilized solvents, Dimethyl Sulfoxide (DMSO), Polyethylene Glycol (PEG), and pyrogen-free water exhibit distinct physicochemical properties and functional roles. This study aims to analyze the characteristics, functions, and implications of these three solvents within the context of sterile injectable preparations. The research methodology involves a comprehensive review of six peer-reviewed scientific articles published within the last five years, focusing on solvent performance, compatibility, and safety profiles. Findings reveal that DMSO is highly effective in dissolving lipophilic compounds due to its strong solvating capacity. However, its use at elevated concentrations may lead to irritation and cytotoxicity, necessitating careful dosage regulation. PEG, particularly in its flexible molecular weight variants, serves as a co-solvent and viscosity modifier, enhancing solubility and stability of active pharmaceutical ingredients. Pyrogen-free water, characterized by its inertness and biocompatibility, remains the gold standard for injection solvents, offering minimal risk and broad applicability across drug classes. The study underscores the importance of aligning solvent selection with the physicochemical nature of the drug, intended route of administration, and patient safety considerations. Furthermore, the potential for combining solvents to achieve optimized formulations is highlighted as a promising avenue for future pharmaceutical development. Such combinations may offer enhanced solubility, reduced toxicity, and improved delivery mechanisms, particularly for complex or poorly soluble compounds. In conclusion, understanding the nuanced roles of DMSO, PEG, and pyrogen-free water is essential for formulating safe and effective sterile injections. This research contributes to the growing body of knowledge supporting rational solvent selection and encourages further exploration into innovative solvent systems for advanced drug delivery.

Penelitian ini bertujuan untuk membandingkan stabilitas paracetamol dalam berbagai bentuk sediaan farmasi: tablet, sirup, dan suppositoria. Stabilitas merupakan parameter penting yang memengaruhi keamanan, efektivitas, dan masa simpan suatu produk obat. Desain penelitian yang digunakan adalah eksperimental deskriptif dengan uji stabilitas dipercepat pada sampel yang disimpan dalam suhu dan kelembapan terkendali selama 3 bulan. Parameter stabilitas fisik dan kimia, seperti karakteristik organoleptik, pH, disolusi, dan kadar zat aktif, dievaluasi secara berkala. Hasil menunjukkan bahwa sediaan tablet mempertahankan stabilitas yang lebih baik dibandingkan dengan sirup dan suppositoria, dengan perubahan minimal pada tampilan fisik dan kadar zat aktif. Sediaan sirup cenderung mengalami degradasi pH dan risiko kontaminasi mikroba, sementara suppositoria menunjukkan deformasi ringan dan migrasi zat aktif. Temuan ini menunjukkan bahwa pemilihan bentuk sediaan berperan penting dalam menjamin stabilitas jangka panjang sediaan paracetamol. Penelitian ini memberikan referensi penting bagi perumusan dan penyimpanan sediaan farmasi.

This article provides a comprehensive review of drug stability testing, specifically focusing on tablet dosage forms. It elucidates the fundamental principles, the critical role of ICH Q1 guidelines, and essential parameters evaluated during stability studies, including physical, chemical, and microbiological aspects. The discussion covers various types of stability studies, standardized storage conditions, and the interpretation of results for determining shelf life and ensuring product quality. Relevant case studies on tablet stability are also integrated to illustrate practical applications. This review aims to provide a structured overview of stability testing methodologies and their significance in pharmaceutical development and quality assurance.

Paracetamol is a widely used analgesic and antipyretic drug in tablet dosage form. Ensuring the stability of paracetamol tablets is essential to maintain drug efficacy, safety, and quality during their shelf life. This study aims to evaluate the physical and chemical stability of paracetamol tablets stored under different temperature and humidity conditions. The review method used in this article involves analyzing published data from several sources, focusing on changes in physical appearance (color, shape, and odor) and chemical parameters such as active pharmaceutical ingredient content over time. The findings indicate that higher temperatures and humidity accelerate degradation and affect the drug's quality, particularly through discoloration and reduction in active content. Packaging also plays a crucial role in maintaining stability, especially in tropical climates. The results highlight the importance of stability testing in pharmaceutical quality assurance and support the application of Good Manufacturing Practices (GMP) and appropriate storage guidelines. This paper contributes to the understanding of stability profiles of commonly used drugs and provides a reference for the formulation and packaging development of heat-sensitive medications.

Limited land in the urban area of Jayapura Regency is a major challenge in the provision of Green Open Space (RTH), even though the existence of RTH is very important to maintain ecological balance and the quality of the community's living environment. In this context, the Dosay Public Cemetery (TPU) has great potential to be optimized as an alternative green space that is multifunctional-ecological, social, and aesthetic. This study aims to assess community perceptions of the utilization of TPU Dosay as a green space, as well as to formulate a strategy for its sustainable development. The approach used was mixed methods, with data collection through a survey using a Likert scale to 35 respondents, open interviews with 9 key informants, as well as SWOT and AHP analysis. The results showed that most people support the development of TPU Dosay as a reflective green space that is comfortable and ecologically valuable. From the results of AHP analysis, policy and regulation aspects are the top priorities in the development strategy, followed by vegetation and accessibility aspects. Strategic recommendations include the preparation of adaptive vegetation zoning, strengthening the local policy framework, active involvement of indigenous communities, and cross-sector collaboration between local governments, academics and the private sector. With the right strategy, the development of TPU Dosay is expected to be an innovative solution in overcoming the shortage of green spaces in Jayapura Regency.

This study aimed to evaluate the effect of compost fertilizer and potassium chloride (KCl) fertilizer, as well as their interaction, on the growth and yield of sweet corn (Zea mays saccharata Sturt). The experiment was conducted from May to August 2022 in Kuning Village, Bambel District, Southeast Aceh, using a factorial randomized block design with two factors: compost dosage (480 g/plot, 960 g/plot, 1,440 g/plot) and KCl dosage (20 g/plot, 40 g/plot, 60 g/plot), each replicated three times for a total of 27 plots. Observed parameters included plant height, stem diameter, leaf area, days to flowering, ear length, and ear weight per plot. Results indicated that compost and KCl fertilizers significantly affected plant height, leaf area, days to flowering, and ear length, but had no significant effect on stem diameter or ear weight per plot. The interaction between compost and KCl produced the highest plant height (165.89 cm) and ear length (21.69 cm) in treatment K3C1. The findings suggest that optimal fertilization using compost and KCl can enhance sweet corn productivity by improving vegetative growth and reproductive development. Nevertheless, the absence of significant effects on stem diameter and ear weight per plot indicates that nutrient balance, especially nitrogen (N) and phosphorus (P), remains crucial for maximizing yields. Therefore, integrating compost and KCl with complementary sources of macronutrients could promote more consistent outcomes. This research also highlights the role of organic matter in enriching soil fertility, maintaining soil structure, and supporting sustainable agriculture. The combination of organic and inorganic fertilizers demonstrates the potential for eco-friendly crop management practices that balance productivity with environmental responsibility. These results provide valuable insights for farmers, agronomists, and policymakers in developing efficient fertilization strategies for sweet corn cultivation within local conditions.

This research was conducted on Jalan Tampok, Tanjung Selamat Village, Sunggal District, Deli Serdang Regency, North Sumatra. A non-factorial Randomized Block Design  was used, consisting of only one factor, with five treatments and four replications: 0, 1, 2, 3, and 4 liters of coconut water fertilizer. The results showed that the use of coconut water fertilizer had no significant effect on plant height 1, 2, and 3 weeks after planting, and fruit weight per plot. However, it had a highly significant effect on plant height 4 and 5 weeks after planting, stem diameter, number of leaves, and root length.   In general, increasing the dosage of coconut water POC tends to result in a better growth response during the vegetative phase of the plant. This suggests that the natural hormones in coconut water can support plant cell division and elongation. However, plant response to treatment is still influenced by environmental factors and dosage, so not all parameters show a significant effect. Further research is needed to determine the optimal dosage that is more effective on production yields.

Propagation of rose plants through stem cuttings is a widely used method; however, its success is often influenced by the availability of adequate plant growth regulators and nutrients. The use of natural materials such as shallot extract as a source of plant growth regulators and cow manure as an organic fertilizer is expected to enhance the growth of cuttings in an environmentally friendly manner. This study aimed to determine the effect of soaking duration in shallot extract, the application of cow manure, and the interaction between both treatments on the growth of rose (Rosa hybrida L.) cuttings. The research was conducted in November 2025 in Sampe Cita Glugur Rimbun Village, Kutalimbaru District, Deli Serdang Regency, North Sumatra, at an altitude of approximately 500 meters above sea level. The study employed a factorial Randomized Block Design with two treatment factors and three replications, resulting in 48 experimental units. The first factor was the soaking duration in shallot extract (0, 4, 8, and 12 hours), while the second factor was the dosage of cow manure (0, 50, 100, and 150 g per polybag). Observed parameters included survival percentage, time of shoot emergence, number of shoots, shoot length, number of leaves, and leaf length. The results showed that all treatments, both individually and in interaction, had no significant effect on all growth parameters. Nevertheless, plant growth increased with plant age, with a relatively high and uniform survival rate of approximately ±90%. These findings indicate that, at the treatment levels applied, shallot extract and cow manure were not effective in significantly improving the growth of rose cuttings, suggesting that further research with different concentrations or treatment combinations is needed.

Background: In Indonesia, coughs and colds increase from 10% to 35.5%. Due to this situation, many mothers are still not fully aware of the proper handling of coughs and colds, which is further exacerbated by the issue of syrup medications containing ethylene glycol that exceed the safe dosage limits, potentially leading to kidney failure in infants. There are two types of cold treatments: pharmacological with oral medications such as powders and syrups, and non-pharmacological with common cold massage. Research objective: This quantitative research determined the effect of educational videos on common cold massage for infants on mothers' cognition and motivation in performing self-massage at the Mranggen I Public Health Care with a pre-experimental method and a one-group pre-test-post-test design. The population in this study consisted of mothers with children aged 4–12 months at the Mranggen I Public Health Care taken with a simple random sampling technique, resulting in 54 mothers. The applied instruments in this research were the Common Cold Cognition questionnaire and maternal motivation. The researchers analyzed the data using univariate and bivariate analysis, employing the Wilcoxon test to identify the non-normally distributed effect of video education on knowledge, and the paired t-test to evaluate its normal distribution effect on motivation. Research Results: Video education has an influence on mothers' cognition and motivation to perform self-massage at Mranggen I Public Health Center, with a p-value of 0.000 < 0.05. Conclusions and suggestions: Respondents, mothers with children aged 4–12 months at the Mranggen I public health care, had excellent knowledge (46.3%) and strong motivation (46.3%). The researcher expects that mothers in the Mranggen I public health care area will seek more information about common cold massages.

The study aims to determine the interaction and effect of drip irrigation on increasing the growth of pak choi plants in dry land. This study used a completely randomized design with a 3x3 pattern, so that there were 9 treatment combinations repeated 4 times so that there were 36 experimental units. The factors are the first factor, the provision of AMF consisting of three levels, namely M0: without AMF, M1: 10 grams of AMF inoculant per polybag, and M2: 30 grams of AMF inoculant per polybag. The second factor, watering arrangements consisting of three levels, namely P0: watering every morning and evening, P1: watering once every 2 days in the morning and evening, and P2: watering once every 4 days in the morning and evening. So that there are combinations of treatments are M0P0, M0P1, M0P2, M1P0, M1P1, M1P2, M2P0, M2P1 and M2P2. . The results of the study showed that the correct dosage of AMF was 30 grams per polybag in each treatment, while the routine watering time in the morning and evening was the best watering arrangement in increasing the growth and yield of pak choi plants. The combination of 30 grams of AMF with routine watering arrangements in the morning and evening with drip irrigation gave the best results for the parameters of plant height, number of leaves, and fresh weight of plants.

Kava (Piper Methysticum) is a plant traditionally used in the South Pacific for its sedative and anxiolytic effects. Its active compounds, kavalactones, are known to have potential as natural anesthetics, with a mechanism of action similar to benzodiazepines and general anesthetics. This study aims to evaluate the effectiveness of Kava as an anesthetic through a systematic literature review and meta-analysis. Literature searches were conducted in PubMed, Scopus, and Cochrane Library using relevant keywords. Meta-analysis results indicate that Kava significantly enhances anesthetic effects compared to placebo, primarily through modulation of GABA-A receptors. However, further research is needed to determine the optimal dosage and long-term safety.

X-ray radiation has been widely used in the medical field for both diagnosis and cancer therapy. However, its biological impact on healthy and cancerous tissues remains a major concern in clinical practice. This study aims to evaluate the biological effects of X-ray exposure, including DNA damage mechanisms, cellular responses, and long-term effects on healthy tissues, as well as its effectiveness in killing cancer cells. A meta-analysis was conducted on studies investigating the effects of X-ray radiation on various tissue types. The findings indicate that while X-rays are effective in destroying cancer cells, uncontrolled exposure can lead to genetic mutations and carcinogenesis in healthy tissues. Therefore, the use of X-rays in cancer therapy must consider optimal dosage to maximize therapeutic effects while minimizing risks to healthy tissues.

Beyond Use Date or BUD is the time limit for a non-sterile or sterile mixed preparation not to be stored and used, calculated from the date or time of compounding. BUD indicates the time limit for the preparation to be in a stable state so it is very necessary to determine the BUD time. This article aims to review BUD information on 20 types of injection preparations in one of the Bandung City Hospitals conducted in 2024 using information collection methods from various sources such as related drug brochures, LexiDrug, and Drug Information Handbook. The results of the study of 13 therapeutic classes with 20 types of injection preparations show that each sterile preparation has different characteristics (active substance, solvent, dosage form and its components, duration of therapy, and storage), thus affecting the stability after reconstitution of each preparation, both those determined by each pharmaceutical industry and information obtained from LexiDrug and Drug Information Handbook. The results of this study can be used as a reference in making more applicable guidelines in determining the BUD of injection preparations in one of the Bandung City Hospitals.

Tomato (lycopersicum esculentum Mill) are a source of vitamins and minerals and have health benefits such as maintaining heart health. The denabd for tomatoes in indonesia continues to increase so it is necessary to take action to increase production by utilizing Fungi Mycorrhizal Arbuscular and manure. FMA is a fungus associated with plants where FMA binds nutrients in the soil. The aim of this research was to determine the effect of gungus mycorrhizal arbuscular and manure. This research was carried out in july – september 2023 in Siderejo village, Langsa Lama District, Langsa City. The research used a 2 factorial Randomized Block Design (RAK) with 3 replications. The first factor is the FMA dose, namely: F0 : 0 gr/plot, F1 : 20 gr/plot, F2 : 40 gr/plot, F3 : 60 gr/plot. The second factor is the dose of fertilizer P1 : 2,08 kg/plot, P2 : 5,6 kg/plot, P3 : 8,4 kg/plot. Date were analyzed using variance (F test) at the 5% and 1% levels. If the treatment has a real effect, continue with the BNJ test at the 5% level.

This article discusses Jesus Christ's sacrifice on the cross as evidence of human atonement and its relevance to believers today. From the perspective of Christian faith, this event is considered a central point in the history of salvation, demonstrating divine grace and justice. Through a search of the meaning of Christ's sacrifice, this article provides a broad understanding of the meaning of Christ's suffering for man's atonement and explains how Christ's sacrifice is concrete evidence of unconditional love and the divine will to blot out human sin. Through the analysis of the meaning of redemption worked out by Jesus Christ, which will expand the theoretical basis of the purpose of Jesus' sacrifice on the cross. This article also provides a theory of the importance of understanding Christ's sacrifice on the cross, thus becoming a reference for believers in terms of faith and belief that through Christ's sacrifice brings redemption to believers. Meanwhile, the relevance of Christ's sacrifice on the cross will also affect several aspects of the believer's life, namely in terms of faith, confession, and holy living. In writing this article, a qualitative approach method is used with a literature study method. The search for the meaning of Christ's sacrifice can be studied from several perspectives, namely the theological perspective, the moral perspective and the psychologist's perspective. From a theological perspective, Christ's sacrifice is a form of God's love for man, so He sent His Son, Jesus Christ, as a sacrifice to redeem believers. So that the work of salvation done by Jesus Christ leads to a victory for believers because they have been redeemed and freed from the power of death, and also becomes a means of improving the relationship between man and God. From a moral perspective, it can be understood that Christ's sacrifice on the cross is an example of sacrifice and an example of love for believers. Thus, this article contributes to the understanding of Christ's sacrifice on the cross as a form of human atonement, and enriches the spiritual life of believers and strengthens faith, motivates spiritual life, and clarifies the moral principles underlying the Christian life.

The Docrtrine of Man and principles discusses the definition of man in the context of the Bible, explaining that man was created by God as a special creature with a body, soul and spirit. There are three views regarding human nature, trichotomy, dichotomy, monochotomy.Sin is defined as a violation of God’s commands, which results in separation. Humans from God and the ongoing negative impacts. Sin has various types and impacts, ranging from God’s judgment to spiritual separation from him.  

Concern for the environment is the responsibility of all parties, both the community, government and related parties. Greening activities are activities to maintain a good environment and provide a good impression of health, beauty and prosperity. Greening activities are carried out using participatory methods involving students and the school. The results of this activity illustrate that this program is not only successful in utilizing abandoned land or making the environment more beautiful, but also successfully increasing the ties of friendship between students and all important elements in the school. The design of the program activities and efforts that have been made by students are expected to provide maximum benefits to the community in the school environment.