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Non-Communicable Diseases (NCDs) such as Diabetes Mellitus and Gout pose a serious threat to the health of the elderly due to their often asymptomatic nature. Cost barriers hinder the elderly community from accessing laboratory services. This community service activity aims to improve health standards and early detection of NCDs through monitoring blood glucose and uric acid levels in the Generasi Kaleb community of the JKI Injil Kerajaan Church, Semarang. The Participatory Health Screening and Education method used includes health education, screening using the Point of Care Testing (POCT) tool, and personal consultation on the results. The service subjects were 50 elderly respondents. The examination results showed a prevalence of abnormal random blood glucose (GDS) of 8%, 32%, had high uric acid levels with a maximum value of 10.3 mg/dL. This activity successfully transformed the elderly's awareness from subjective perception to awareness based on objective data, and encouraged community independence in managing a healthy lifestyle to prevent further NCD complications. .

Artikel pengabdian ini menyajikan program partisipatif yang mengintegrasikan pengelolaan sampah rumah tangga dan kebun hidroponik untuk meningkatkan kesadaran lingkungan di Desa Betro. Program dirancang berdasarkan kondisi awal berupa kebiasaan membuang sampah campur, belum optimalnya pemanfaatan sampah organik, serta masih terbatasnya pemanfaatan pekarangan rumah. Kegiatan dilaksanakan melalui analisis situasi, sosialisasi 3R, pelatihan pemilahan sampah dan pengomposan sederhana, pembuatan demplot hidroponik, serta pendampingan kader. Pendekatan yang digunakan ialah participatory action dan edukasi berbasis komunitas dengan melibatkan unsur PKK, karang taruna, dan perangkat desa. Hasil program menunjukkan peningkatan pemahaman warga tentang pengelolaan sampah, munculnya kebiasaan memilah sampah dari rumah, terbentuknya titik kumpul sampah anorganik yang bernilai jual, serta pemanfaatan kebun hidroponik sebagai media belajar lingkungan dan sumber sayur rumah tangga. Integrasi kedua program mendorong perubahan perilaku yang lebih nyata, terukur, dan berkelanjutan.

This study aims to analyze the relationship between the intensity of glossolalia practice and cognitive functioning among theological college students through a qualitative-exploratory approach. Glossolalia, commonly practiced within charismatic Christian traditions, has generally been examined from theological and phenomenological perspectives, whereas its relationship with cognitive aspects remains relatively underexplored. This study employed in-depth interviews and participant observation involving theological college students who actively engage in glossolalia as part of their regular spiritual practice. The findings indicate that a higher intensity of glossolalia practice is associated with increased self-awareness, improved emotional regulation, and heightened internal focus. These experiences indirectly contribute to several cognitive functions, particularly attention, reflective awareness, and metacognitive reflection. The study also shows that students perceive glossolalia not only as a spiritual expression but also as a practice that supports inner concentration and personal reflection. These findings contribute to interdisciplinary discourse between practical theology and cognitive science by offering insights into how spiritual practices may relate to cognitive processes. Furthermore, this study provides a conceptual foundation for further empirical research using broader samples and measurable cognitive indicators in future investigations.  

Fractures are one of the most common musculoskeletal disorders caused by trauma, repetitive stress, or pathological factors. Supracondylar femur fracture is a type of femur fracture occurring at the distal 12 cm of the femur, and Open Reduction and Internal Fixation (ORIF) is the primary surgical intervention. Post-operative ORIF patients commonly experience impaired physical mobility and impaired skin integrity. This study aimed to provide comprehensive nursing care to a patient post-ORIF for right supracondylar femur fracture in the Mawar 2 Ward of RSUD dr. Soeselo, Tegal Regency. A descriptive method with a nursing process approach was used, employing interview, observation, documentation study, and literature study. Nursing assessments conducted on February 8, 2026 revealed that the patient (Ny. S, female, 68 years) experienced pain at the surgical site with a scale of 7, inability to move both lower extremities (muscle strength score 2), and a post-operative wound approximately 10 cm in length with redness and edema. Two nursing diagnoses were established: impaired physical mobility related to neuromuscular disorders and impaired structural bone integrity, and impaired skin/tissue integrity related to invasive procedure effects. Nursing interventions included mobilization support, pain management, wound care, and collaborative administration of medical therapy. After two days of nursing implementation, both diagnoses were partially resolved. Discharge planning focused on gradual mobilization, independent wound care, and high-protein and high-calorie diet to accelerate recovery.

Background: Hepatocellular Carcinoma (HCC) is an abnormal cell growth in the liver characterized by increased number of dividing liver cells accompanied by malignant transformation. A common paraneoplastic phenomenon in HCC patients is hypoglycemia, which arises due to hepatic dysfunction impairing gluconeogenesis and glycogenolysis, as well as tumor-mediated IGF-II production. This condition causes hypoglycemia as a primary nursing problem requiring comprehensive nursing care. Objective: To describe the nursing care process for a patient with HCC focusing on blood glucose instability management and knowledge deficit intervention. Methods: This study used a descriptive qualitative method through a case study approach. Data were collected through interview, observation, documentation study, and literature review. Results: Two nursing diagnoses were identified: blood glucose instability related to hepatic dysfunction and knowledge deficit related to lack of information exposure. Nursing interventions performed included hypoglycemia management and disease process education. After 2x24 hours of nursing implementation, both diagnoses were partially resolved, as GDS values remained fluctuating and behavioral change had not been fully achieved. Conclusion: Comprehensive nursing management through routine blood glucose monitoring, dextrose administration, nutritional modification, and health education can improve blood glucose stability and patient knowledge in HCC patients.

The development of an economic activity in a city is often one of the influences on changes in the use of residential space in the surrounding area. One of the phenomena that we can see in big cities in Indonesia is the use of residences as rental housing such as boarding houses and rents aimed especially at workers in foreign areas. This study aims to analyze the use of residential space by the community as temporary residence for employees of Mie Gacoan restaurant in Serang City, Banten, and see how it affects the spatial dynamics of the residential area. This study uses a primary and secondary data-based case study method with a qualitative descriptive approach. The results of the study show that the existence of economic activities around residential areas can encourage an increase in the need for temporary housing for workers in rural areas. This phenomenon makes some people take advantage of their residences by making them rental residences such as boarding houses and rented ones. This can affect the spatial structure of the residential area, such as increasing population density, increasing activities in the residential environment, and the presence of small economic activities by the community. Therefore, this phenomenon states that the development of economic activity in an urban area can trigger changes in the use of space in the surrounding residential area.

The digitalization of tax administration has become one of the Indonesian government's strategic initiatives to improve efficiency, transparency, and taxpayer compliance. However, the implementation of digital tax systems among Micro, Small, and Medium Enterprises (MSMEs), particularly distributor-sector MSMEs in Batam City, still faces various administrative and technical challenges. This study aims to examine the experiences, risk perceptions, and adaptation strategies of distributor MSME actors in responding to the digitalization of tax administration following the implementation of the Harmonization of Tax Regulations Law (UU HPP). The research employed a qualitative approach using a phenomenological method. Data were collected through in-depth interviews with seven distributor MSME owners in Batam City who had utilized digital tax systems such as e-Filing and Coretax. The findings indicate that most business actors still experience limitations in technical understanding, concerns regarding reporting errors, and difficulties adapting to changes in digital tax systems and regulations. To address these challenges, MSME actors developed several adaptation strategies, including the use of tax consultants, hybrid manual-digital bookkeeping systems, and informal assistance through the internet and business networks. This study highlights that the success of tax digitalization requires a more adaptive approach, stable systems, and policies that are aligned with the characteristics of local MSMEs.

Background: Menstruation is a natural physiological process that indicates the functional maturity of the female reproductive system. Menstrual cycle disorders can be influenced by several factors, including stress and obesity. Stress may cause hormonal changes through the hypothalamic-pituitary axis, leading to decreased luteinizing hormone (LH) levels and menstrual irregularities. Obesity can also affect ovarian function and disrupt the menstrual cycle. Objective: To determine the relationship between stress and obesity with menstrual cycle disorders among female adolescents at SMAN 1 Majene in 2026. Methods: This study used an analytical observational design with a cross-sectional approach. Data on stress levels, obesity status, and menstrual cycle disorders were collected simultaneously from 84 female respondents. The chi-square test was used to analyze the relationships among variables. Results: The analysis showed a significant relationship between stress and menstrual cycle disorders (p = .006; α < .05). A significant relationship was also found between obesity and menstrual cycle disorders (p = .002; α < .05). Many obese respondents experienced irregular menstrual cycles. Conclusion: There is a significant relationship between stress and obesity with menstrual cycle disorders among female adolescents at SMAN 1 Majene.

Human Papillomavirus (HPV) infection is typically the cause of cervical cancer, one of the cancers with a high death rate among women. Despite their widespread use, conventional therapeutic approaches still have drawbacks, such as the emergence of cancer cell resistance and severe side effects. Natural compounds are now used as safer alternative treatments as a result. Soursop leaves (Annona muricata L.) are one plant that has been shown to have anticancer potential. Through phytochemical screening, compound identification using GC-MS, cell viability testing using the MTT Assay, and BCL2 gene expression analysis using qPCR, this study attempts to examine the potential of soursop leaf extract as an anticancer agent against cervical cancer cells (HeLa cells). The results of the phytochemical examination showed that steroids, phenolics, and alkaloids were present. Ostole, bisacumol, and ricinoleic acid were found to be the predominant components when the active chemicals were identified by GC-MS. With an IC²₀ value of 5.01 μg/mL, the MTT experiment demonstrated that soursop leaf extract could decrease cell viability as the concentration rose. Furthermore, BCL2 gene expression was significantly reduced, especially in treatments with doses of 500 and 1000 μg/mL, according to the results of qPCR gene expression analysis. The overall findings suggest that soursop leaf extract may be used as a natural anticancer treatment against HeLa cells by lowering the expression of the BCL2 gene.

Circulating tumor DNA (ctDNA) has emerged as a promising liquid biopsy biomarker for real-time monitoring of tumor dynamics. In urothelial carcinoma (UC), effective monitoring of treatment response remains a clinical challenge due to the limitations of conventional imaging and invasive procedures. This systematic review aims to synthesize the existing evidence on the association between ctDNA dynamics and treatment response monitoring across various stages and therapeutic settings. A comprehensive systematic review was conducted. We included cohort studies, randomized controlled trials, and meta-analyses that evaluated ctDNA in UC patients undergoing treatment. Data were extracted on patient population, methodology, treatment, sampling strategy, clinical outcomes, and statistical associations. The review encompassed 80 studies. Baseline ctDNA positivity was strongly prognostic, associated with a 4- to 6-fold increased risk of recurrence or death (HR 4.23-6.56). Dynamic ctDNA clearances or significants reduction during treatment, were strongly associated with improved outcomes. Showing hazard ratios for adverse events as low as 0.10-0.31. ctDNA demonstrated time advantages of 53-90 days over radiographic detection. ctDNA is a potent tool for monitoring treatment response in urothelial carcinoma. It provides superior prognostic and offers a significant lead time for detecting treatment failure. Future research must focus on standardizing methodologies and validating ctDNA-guided therapeutic.

This community service study investigates a marketing training program implemented by theology students of STT Kadesi Bogor at the GPIA Sidoasri congregation in Sumbermanjing Wetan District, Malang Regency, East Java. The program targeted eighteen women members of the congregation to improve their economic capacity through the marketing of low-cost everyday clothing via three channels: door-to-door sales, a small storefront at the church, and online commerce through TikTok. The study applied a pre- test/post-test design evaluated using the Normalized Gain (N-Gain) method to measure changes in knowledge and skill across five indicators: marketing knowledge, selling skills, online media usage, basic financial recording, and entrepreneurial motivation. Results indicated a moderate-to-high N-Gain across all measured indicators, with an average N-Gain score of 0.656 (moderate category), and the highest individual gain in entrepreneurial motivation (0.76, high category). Sales data over the three-month period (January–March 2025) recorded a total profit of Rp1,967,500 across 345 garments sold, representing an income supplement of approximately 27–35% relative to participants' baseline household income for the most active participants. A marked sales decline in February and March was attributed to seasonal demand shifts ahead of Eid al-Fitr, as consumers redirected purchases toward formal Muslim attire. The program demonstrated that congregation-based economic empowerment rooted in a biblical theology of work, stewardship, and the dignity of labor can yield measurable and holistic socioeconomic outcomes for Christian women in rural communities.

This study aims to identify and evaluate the cultural tourism potential of Kalurahan Grogol in Gunungkidul Regency to inform the development of a community-based cultural tourism village. The research employed a qualitative descriptive approach supported by quantitative scoring techniques using a 1–5 Likert scale across four assessment dimensions: cultural value, physical value, tourism value, and experiential value. The analysis applied Du Cros and McKercher’s Market Appeal–Robusticity Matrix to map the market attractiveness and cultural robustness of each cultural asset. Data were collected through semi-structured interviews, observations, and documentation studies of 46 tangible and intangible cultural assets in Kalurahan Grogol. The findings reveal that most cultural assets exhibit moderate to high cultural robustness, indicating that local cultural practices remain active and socially sustained within the community. Prominent cultural assets such as Rasulan, Karawitan Lestari Budoyo, Reog Sedyo Laras, Gejlok Lesung, Sega Berkat, and Tempe Godhong are positioned in Quadrant A1, characterized by high market appeal and high robustness, making them highly potential as leading cultural tourism attractions. Meanwhile, assets in Quadrants B and C present opportunities to develop creative, educational, spiritual, and wellness-based experiential tourism products. The study also finds that several sacred traditions categorized in Quadrant D are more appropriately preserved through non-commercial approaches. The absence of cultural assets in the D3 category indicates that the cultural system of Kalurahan Grogol remains adaptive and regenerative amid modernization. This research contributes theoretically by extending the application of the Market Appeal–Robusticity Matrix into the context of community-based cultural tourism villages. It provides strategic recommendations for sustainable cultural tourism development that remain sensitive to local cultural authenticity.

Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

Muscle-invasive bladder cancer (MIBC) is an aggressive malignancy associated with high morbidity, reduced survival, and impaired quality of life. Radiotherapy (RT) has been widely used as a bladder-preserving strategy, particularly for patients unsuitable for surgery or systemic chemotherapy. RT may also enhance tumor immunogenicity through programmed death-ligand 1 (PD-L1) upregulation, providing a rationale for combination therapy with immunotherapy. This study aimed to evaluate the effectiveness of combining immunotherapy and radiotherapy in MIBC treatment. A systematic review was conducted following PRISMA 2020 guidelines using the PICO framework. Literature searches were performed in PubMed, Embase, Cochrane, ClinicalTrials.gov, Web of Science, and Scopus databases for studies published between 2016 and 2025. Risk of bias was assessed using the Cochrane Risk of Bias Tool and ROBINS-I. Of 105 identified studies, five met the inclusion criteria and were included in the final analysis. Only one Phase II randomized controlled trial demonstrated low risk of bias in randomization and allocation concealment. ROBINS-I assessment indicated moderate to serious risk in confounding and participant selection domains. Clinical findings showed promising outcomes, with complete response rates ranging from 35%–50% and partial response rates from 25%–40%. Median overall survival ranged from 24–30 months, with favorable disease-free and progression-free survival outcomes. Combined immunotherapy and radiotherapy demonstrate potential to improve survival and disease control in MIBC; however, further rigorous clinical studies are needed to optimize patient-centered treatment strategies.  

The wave of digitalization triggers a severe morality crisis among the younger generation through constant exposure to negative content, cyberbullying, and global communication ethics degradation. This descriptive qualitative study aims to analyze the specific internalization of Christian values at GPIB Harapan Kasih Congregation Bekasi to shield youth morality amidst ongoing technological disruption. Employing intensive in-depth interviews and participatory observations, data were analyzed interactively through systemic reduction, structured display, and final verification. The results indicate that the digital morality crisis explicitly manifests as pornography normalization, virtual toxicity, and the severe erosion of academic honesty. In response, pastoral strategies utilizing highly contextualized digital ethics sermons and youth cell groups prove thoroughly effective. The deep internalization of self-control and integrity successfully stimulates a holistic self-censorship mechanism across the youth's cognitive, affective, and behavioral domains. This study concludes that consistent accountability-based mentorship effectively transforms Christian youth from passive digital victims into active agents of change within global cyberspace.

This study examines the application of the professional code of ethics for Christian Religious Education (CRE) teachers in building student integrity in secondary schools during the digital era. The primary issues discussed include the extent to which the code of ethics is implemented, its impact on students’ moral-spiritual standards, and the challenges of aligning professional ethics with a ministry calling. Using a library research approach, this study analyzes biblical texts, ethics textbooks, and scientific journals published within the last ten years. The findings indicate that the professionalism of CRE teachers must be grounded in Kingdom of God values by integrating pedagogical competence with theological calling through In-Persona Christi theory and the concept of vocatio. Authentic teacher exemplarity is identified as the most effective instrument for adolescent character formation amid the post-truth era, where digital information often blurs moral judgment. This study recommends a kenosis pedagogy approach, requiring educators to be authentically present, humble, and free from intellectual arrogance in order to achieve meaningful transformation of student character, integrity, and moral-spiritual maturity within contemporary Christian educational practice and school life contexts.

This article explores the integration of epigenetics and Christian restoration theology as a new framework for understanding trauma and human restoration holistically. Epigenetics demonstrates that life experiences, particularly trauma, can influence gene expression without altering DNA structure and may even be transmitted across generations. Meanwhile, Christian restoration theology emphasizes the grace of God as a power that restores humanity completely in spiritual, psychological, relational, and embodied dimensions. This study employs a qualitative library research approach by examining recent scientific and theological literature relevant to trauma, epigenetic change, restoration, and Christian understandings of grace. The findings reveal that trauma leaves measurable biological imprints within the body, yet epigenetic changes remain reversible through healthy relationships, therapeutic interventions, and spiritual practices. These results indicate that human restoration should not be viewed only as an inward spiritual experience, but also as a holistic process involving psychological healing and biological renewal. Therefore, grace can be understood as a transformative power that works comprehensively within the spiritual, psychological, and biological dimensions of human existence, opening possibilities for intergenerational healing and renewed life for contemporary theological reflection.

The development of information technology and the use of social media have increased the potential for defamation against various institutions, including educational institutions. The reputation of schools or educational institutions is an important social asset because it is directly related to public trust, institutional credibility, and the continuity of the educational process. However, the Indonesian legal system still places greater emphasis on protecting individual reputation than institutional reputation, creating a need to reexamine the legal position of educational institutions in responding to attacks on their good name. This study aims to analyze legal protection for the reputation of educational institutions within the Indonesian legal system and to formulate a more comprehensive reconstruction of legal protection that is relevant to the development of digital spaces. This research uses a normative legal method with statutory and conceptual approaches. Data sources consist of primary legal materials, including Law Number 1 of 2023 concerning the Criminal Code and the Electronic Information and Transactions Law, as well as secondary legal materials in the form of legal literature and educational theory. The results show that defamation provisions in the Criminal Code and the ITE Law have not explicitly provided adequate protection for the reputation of educational institutions. Therefore, legal protection reconstruction is needed through affirming educational institutions as legal subjects whose reputation deserves protection, strengthening reputation recovery mechanisms, and integrating educational ethics perspectives into legal regulation.

This study aims to reconstruct a Greek Exegesis learning model based on formative hermeneutics by integrating syntactic analysis with the spiritual transformation of theology students. Traditional Greek instruction often emphasizes technical grammar and textual translation, thereby creating a gap between academic rigor, interpretive sensitivity, and spiritual formation. To address this issue, the present research develops and evaluates an instructional model that positions grammatical inquiry not merely as a linguistic exercise, but as a formative process for understanding Scripture responsibly. This research employs a quantitative descriptive-correlational design involving 30 theology students as participants. Data were collected through syntactic analysis tests and Likert-scale instruments measuring hermeneutical awareness and spiritual disposition. The results show that the implementation of the formative hermeneutical model achieved a high effectiveness level of 81.7%. Students’ syntactic competence reached 78%, which falls into the good category, while spiritual transformation attained 84.8%, categorized as very good. These findings indicate that the model significantly improves both analytical competence and spiritual development. This study proposes an integrative pedagogical framework in which syntactic analysis functions as a formative hermeneutical practice that shapes theological virtues, interpretive responsibility, faith maturity, and holistic ministerial readiness among theology students within diverse contemporary theological education contexts and ministries.

Indonesia merupakan produsen padi terbesar di kawasan ASEAN dengan produksi mencapai 60,3 juta ton pada tahun 2025. Meskipun demikian, tingginya produksi tersebut belum mampu meningkatkan ekspor beras secara signifikan dan Indonesia masih menghadapi tantangan dalam memenuhi kebutuhan pangan secara berkelanjutan. Kondisi ini menunjukkan bahwa peningkatan output pertanian belum tentu mencerminkan efektivitas penggunaan faktor-faktor produksi yang mendukungnya. Penelitian ini bertujuan untuk menganalisis pengaruh luas lahan sawah, jumlah petani, dan penyaluran pupuk bersubsidi terhadap produksi padi di Indonesia menggunakan pendekatan fungsi produksi Cobb-Douglas. Penelitian ini menggunakan metode kuantitatif dengan data cross section pada 10 provinsi penghasil padi terbesar di Indonesia tahun 2025. Analisis dilakukan menggunakan regresi linier berganda setelah model memenuhi pengujian asumsi klasik. Hasil penelitian menunjukkan bahwa luas lahan sawah berpengaruh positif dan signifikan terhadap produksi padi dengan elastisitas sebesar 1,038743. Sebaliknya, jumlah petani berpengaruh negatif dan tidak signifikan, sedangkan penyaluran pupuk bersubsidi berpengaruh positif namun tidak signifikan. Temuan ini mengindikasikan bahwa peningkatan produksi padi lebih dipengaruhi oleh ketersediaan dan pemanfaatan lahan yang produktif dibandingkan penambahan tenaga kerja maupun subsidi input pertanian. Penelitian ini menyimpulkan bahwa peningkatan produksi padi memerlukan kebijakan yang berfokus pada efisiensi penggunaan sumber daya, perlindungan lahan pertanian produktif, serta penerapan teknologi pertanian yang mampu meningkatkan produktivitas secara berkelanjutan.