Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review

Muhammad Rizki Fadil ; Fabian Gamal Sutrisno ; Siti Fira Rahmawaty ; Archie Fontana Iskandar
Jurnal Sains dan Kesehatan (JUSIKA) 📅 2026 Vol 10, No 1 🔗 DOI: 10.57214/jusika.v10i1.1141
Abstract
Circulating tumor DNA (ctDNA) has emerged as a promising liquid biopsy biomarker for real-time monitoring of tumor dynamics. In urothelial carcinoma (UC), effective monitoring of treatment response remains a clinical challenge due to the limitations of conventional imaging and invasive procedures. This systematic review aims to synthesize the existing evidence on the association between ctDNA dynamics and treatment response monitoring across various stages and therapeutic settings. A comprehensive systematic review was conducted. We included cohort studies, randomized controlled trials, and meta-analyses that evaluated ctDNA in UC patients undergoing treatment. Data were extracted on patient population, methodology, treatment, sampling strategy, clinical outcomes, and statistical associations. The review encompassed 80 studies. Baseline ctDNA positivity was strongly prognostic, associated with a 4- to 6-fold increased risk of recurrence or death (HR 4.23-6.56). Dynamic ctDNA clearances or significants reduction during treatment, were strongly associated with improved outcomes. Showing hazard ratios for adverse events as low as 0.10-0.31. ctDNA demonstrated time advantages of 53-90 days over radiographic detection. ctDNA is a potent tool for monitoring treatment response in urothelial carcinoma. It provides superior prognostic and offers a significant lead time for detecting treatment failure. Future research must focus on standardizing methodologies and validating ctDNA-guided therapeutic.
Keywords
Bladder Cancer; Liquid Biopsy; Minimal Residual Disease; Treatment Monitoring; Urothelial Carcinoma
How to Cite

Muhammad Rizki Fadil, et al. (2026). Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review . Jurnal Sains dan Kesehatan (JUSIKA), 10(1). https://doi.org/10.57214/jusika.v10i1.1141

Muhammad Rizki Fadil; Fabian Gamal Sutrisno; Siti Fira Rahmawaty; Archie Fontana Iskandar, "Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review ," Jurnal Sains dan Kesehatan (JUSIKA), vol. 10, no. 1, 2026.

Muhammad Rizki Fadil; Fabian Gamal Sutrisno; Siti Fira Rahmawaty; Archie Fontana Iskandar. "Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review ." Jurnal Sains dan Kesehatan (JUSIKA), vol. 10, no. 1, 2026.

Muhammad Rizki Fadil; Fabian Gamal Sutrisno; Siti Fira Rahmawaty; Archie Fontana Iskandar. "Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review ." Jurnal Sains dan Kesehatan (JUSIKA) 10, no. 1 (2026).

Muhammad Rizki Fadil, et al. (2026) 'Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review ', Jurnal Sains dan Kesehatan (JUSIKA), 10(1). doi: 10.57214/jusika.v10i1.1141.

Muhammad Rizki Fadil; Fabian Gamal Sutrisno; Siti Fira Rahmawaty; Archie Fontana Iskandar. Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review . Jurnal Sains dan Kesehatan (JUSIKA). 2026;10(1).

Artikel Terkait

Analisis Faktor yang Berhubungan dengan Kinerja Perawat di Instalasi Rawat Inap Rsud Ratu Zalecha Martapura

Aqiella Farida Salsabila; Rosihan Adhani; Iwan Aflanie; Syamsul Arifin; Nia Kania

Hubungan Pengetahuan, Persepsi, Sikap, dan Sarana-Prasarana dengan Perilaku Personal Hygiene Saat Menstruasi pada Santriwati di Pondok Pesantren Tahfidzil Qur'an Daarussa'adah Pesawaran Tahun 2026

Anggie Pebriani; Dhiny Easter Yanti; Christin Angelina Febriani

Gambaran Hasil CT Scan pada Pasien Diabetes Melitus dengan Stroke di RSKD Dadi Makassar Tahun 2024–2025

Muhammad Arif Taufik; Prema Hapsari Hidayati; Dian Fahmi Utami; Mochammad Erwin Rachman; Muh. Jabal Nur

Dampak Stigma terhadap Kesejahteraan Psikologis Keluarga yang Merawat Orang dengan Gangguan Jiwa di Kabupaten Pamekasan

Willi Holis; Ida Wahyuni; Ahmad Zaini Arif

Membran Berbasis Β-Trikalsium Fosfat Sebagai Membran Barier Pada Guided Bone Regeneration: Tinjauan Naratif

Maria Rini Wulan Dhari; Eddy Eddy; Rosalina Tjandrawinata; Tansza Permata Setiana Putri

Hubungan Pengetahuan Ibu terhadap Kejadian Karies pada Anak PAUD Qalby Play School Kab. Bogor

Faradillah Usman; Fidzah Nur Fajrina Murad; Wirda Aulia; Nurul Fatimah
Tren Sitasi Jurnal