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Haryanto Haryanto; Sahrul Gunawan; Atiqah Ainunnisa' Andy Putri; Andi Eka Purwanti; Salsabila Ramadhani +5 more

Jurnal Ventilator: Jurnal riset ilmu kesehatan dan Keperawatan 2025 Stikes Kesdam IV/Diponegoro Semarang, Indonesia

This study aims to investigate the effects of tamarind leaf extract (Tamarindus indica L.) on neuropharmacological activity in mice using calculated percentages of responses based on the parameters PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA. This research was conducted as a laboratory experiment using a completely randomized design (CRD) with three treatment concentrations: 1%, 2%, and 4%. Observations were performed to assess the percentage of activity produced by each sample concentration, followed by descriptive–quantitative analysis to determine the dose–response pattern. The results showed that tamarind leaf extract produced varying responses across concentrations. The SSSP, ANA, and RO effects demonstrated increased activity at the 2% concentration, whereas other parameters (PSM, PSL, SM, SL, and DSSP) showed decreased activity. Interestingly, the SSSP parameter exhibited a positive dose–response pattern with the highest activity of 55.84% at 2%. Overall, the effectiveness of tamarind leaf extract depends on the concentration level. The 2% concentration appears to be the optimal dose for several neuropharmacological effects, while the 4% concentration was most effective only for SSSP. These findings highlight the importance of multi-concentration testing to determine effective dosing of natural products for biological applications and the need for further investigation.

Elva M. Sumirat; Nur Cynthia Roman; Aida Insani Azzahra; Sri Lestari Zainudin; Marsha S. Daud +2 more

Inovasi Pendidikan dan Anak Usia Dini 2025 Asosiasi Riset Ilmu Pendidikan Indonesia

This study aims to understand and explain in depth the role of teachers in the care of children aged 3–5 years at the Siti Hajar Kindergarten and its influence on child development. This study used a qualitative approach with the aim of obtaining a comprehensive picture of the interactions between teachers and children in daily care activities. Data were obtained through observation, interviews, and documentation that describe care practices in the TPA environment. The results show that teachers have a very important role, including as guides in learning activities, mediators in children's social and emotional development, motivators to foster interest in learning, role models of positive behavior, and communication bridges between children and parents. These roles contribute significantly to character formation, social skills development, increased learning motivation, and children's emotional well-being. Despite facing various obstacles, such as limited facilities and challenges in maintaining children's concentration, teachers continue to strive to provide optimal care through enjoyable learning strategies and active communication with parents. This study recommends increasing teacher capacity and strengthening collaboration between educational institutions and families to support the sustainable growth and development of early childhood.  

Ridho Rizky Amanda

Venus: Jurnal Publikasi Rumpun Ilmu Teknik 2025 Asosiasi Riset Ilmu Teknik Indonesia

The stability of slopes in open-pit coal mining in Indonesia is significantly influenced by geological faults, which are a major factor causing slope failures. This study aims to examine the impact of faults on slope stability by conducting a systematic literature review of 25 scientific publications from 2018 to 2025. The results indicate that faults and fault zones consistently reduce rock mass integrity through several mechanisms, including stress concentration in weak zones, the formation of preferential sliding surfaces, amplification of hydro-mechanical effects from groundwater and rainfall, and the reduction of rock strength parameters. Case studies in Kalimantan and Sumatra confirm these mechanisms with slope failures aligning with fault orientations. Kinematic and numerical analyses using the Limit Equilibrium Method (LEM), Finite Element Method (FEM), and Distinct Element Method (DEM) show a reduction in the safety factor (SF) by up to 36% on slopes affected by faults. Practical recommendations include continuous monitoring using Slope Stability Radar (SSR), optimization of slope geometry with angles < 18° in fault zones, groundwater control, reinforcement with anchors and bolting, and UAV-based discontinuity mapping for hazard zoning. This study concludes that managing slopes in fault zones requires an integrated approach combining detailed geological investigation, multi-method numerical analysis, real-time monitoring, and specific mitigation design.

Anggraini, Nanda; Nuraini, Vivi; Karyantina, Merkuria

Agrobioteknologi 2025 Fakultas Teknologi dan Industri Pangan Unisri Surakarta

Mochi is a cake made from glutinous rice flour with other ingredients and then steamed. White sweet potato flour is used as a substitute because it contains high levels of fiber, with the addition of elephant ginger extract, which is expected to be able to neutralize the unpleasant taste and scent of white sweet potato flour. The aim of this study was to determine the right formulation in order to obtain white sweet potato flour substitution mochi and a high concentration of elephant ginger extract. This study used a completely randomized design (CRD), which consisted of two factors, namely the concentration of glutinous rice flour and white sweet potato flour (90:10, 80:20, and 70:30) and the percentage of elephant ginger extract (to 100 ml of water) (1.5%, 3%, and 4.5%). The best results of the chemical analysis were white sweet potato flour 30 g and ginger extract 4.5%, with a moisture content of 23.66%, an ash content of 0.25%, a total sugar content of 7.64%, and fiber of 2.60%. Based on the results of the physical analysis, the colour L*47.62 (bright brown), a* -4.68 (slightly green), b* 12.20 (yellowish) and a hardness value of 8.90 N, gumminess of 6.27 N, chewiness of 1.73 N, cohesiveness of 0.71 N, and adhesiveness of 1.17 N. Mochi with white sweet potato flour substitution and concentration of elephant ginger extract can be a nutritions food and a source of fiber.

Aldo Geo Frengky Saragih; Anggun Maharani; Elit Manaman Gulo; Hotma Br Butar Butar; Mutia Patmasari Batubara +2 more

Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam 2025 Pusat riset dan Inovasi Nasional

Zinc (Zn) is one of the most common heavy metal contaminants found in industrial wastewater and solid residues such as slag, electroplating waste, and metal ash. At excessive concentrations, Zn can cause environmental disturbances, including toxicity to aquatic organisms, disruption of microbial activity, and groundwater contamination. Long-term exposure may also lead to bioaccumulation and potential health risks to humans. This article presents a comprehensive literature review that discusses the chemical properties of Zn, its environmental behavior, and the development of recent treatment technologies within the last five years. Several techniques, including adsorption using modified or composite materials, biosorption utilizing microalgae and agricultural biomass, as well as solidification–stabilization with amendment agents such as biochar or iron-sulfide compounds, are evaluated and compared. The literature indicates that no single treatment method is universally effective for all waste types; therefore, hybrid or integrated treatment systems are considered more efficient and sustainable. Based on the reviewed evidence, this study proposes an engineering concept that emphasizes environmental safety, cost-effectiveness, and industrial applicability.

Hearty Efifania Ose Payon

DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan 2025 International Forum of Researchers and Lecturers

Anemia is a problem of health in young women. Anemia is a condition in the concentration levels of hemoglobin in the blood is low, one of the efforts to improve the levels of Hemoglobin by non Pharmacology given soy edamame. Is a kind of soy beans which the iron content of substance more than other types. In addition to iron, also contained Vit C, B12, and folic acid, which is also a constituent of hemoglobin in the blood. The purpose of this research is to know the effect of granting soy edamame to increased levels of hemoglobin in on young women. The research design used was quasy eksperiment. Population of young women who are experiencing anemia in boarding schools of Tahfiz Hisbah Al Fatih as many as 20 people, with the total sampling techniques. Research instrument is the observation sheet and tool checks digitally Hemoglobin. Results of the study were analyzed using paired t-test Test and independent t Test. The results obtained from this research is the following value mean increased levels of Hb after given Soy edamame was 0.46 gdl and mean increased levels of Hb after administering a local soybean is 0.18 gdl. This indicates that after the granting of the soy edamame tablet better if compared to a local soybean delivery after this. Research analysis of Hb levels after administering a local soybean or edamame soybeans gained ρ-value 0.006 (α = 0 .05), then it can be inferred that H0 is rejected and there is meaning accepted H1 influence awarding of soy edamame to increased levels of Hb teen daughter in boarding schools of Tahfiz Hisbah Al Fatih. For young women in particular are expected to eat green vegetables and legumes, especially soy edamame to prevent as well as treat mild anemia.

Haryanto Haryanto; Ainun Jariyah; Norita Norita; Nia Agustina; Rarah Maulidya Putri +6 more

Jurnal Riset Ilmu Farmasi dan Kesehatan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

The puring plant (Codiaeum variegatum), which has been known as an ornamental plant, apparently has significant therapeutic potential, supported by the presence of secondary metabolites such as flavonoids, tannins, saponins and alkaloids. Various modern studies report the biological activity of croton leaves, including anti-cholesterol, anti-hyperglycemia, antibacterial effects, and their use in biosurfactant formulations. However, studies on how varying extract concentrations influence bioactivity parameters quantitatively are still limited, especially in the context of dose-response relationships involving many biological parameters in one series of research. Therefore, this research was conducted to evaluate eight bioactivity parameters, namely PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA at croton leaf extract concentrations of 1%, 2%, and 4%. This research uses a laboratory experimental approach by extracting croton leaves through a maceration method using ethanol, then formulated in three concentration levels. Each parameter was analyzed quantitatively to observe the pattern of changes in biological response to variations in the dose administered. The results showed that most of the PSM, SSSP, DSSP, SL, and PSL parameters showed an optimum response at a concentration of 2%, which indicates that there is a most effective dose point before a decrease in activity occurs at the highest concentration. In contrast, several parameters such as RO, SM, and ANA showed a more fluctuating response, even the ANA parameter gave the highest value at a concentration of 4%, indicating that certain activities require higher compound levels to be achieved. In general, the response pattern found was not linear, but instead formed an optimum curve typical of the bioactivity of plant extracts. These findings confirm that determining dosage is very important in the use of croton leaf extract, both for pharmacological purposes and for the formulation of natural ingredient-based products.

Amaliyah, Dede Siska; Melinda, Hanna Septia; Majid Majid; Siti Komariah; Al-Aina Mardiah

Jurnal Pengabdian Sosial 2025 Lembaga Pengembangan Kinerja Dosen

This community service activity was carried out to increase students' understanding of the dangers of drug abuse and its impact on academic achievement and the future of the younger generation at SMK Negeri 1 Pagelaran. The problem of low student awareness and limited access to accurate information about drugs was the main background for this activity. The community service program was designed using interactive socialization and education methods that included direct counseling, educational video screenings, group discussions, and the provision of supporting media in the form of leaflets as a means of reinforcing the material. The results of the activity showed an increase in students' knowledge and understanding regarding the risks of drug abuse, particularly its impact on decreased learning concentration, physical and mental health disorders, and weakened motivation and academic achievement. In addition, students showed high enthusiasm during the activity and were able to identify internal and external factors that can encourage and prevent involvement in drug abuse. This activity made a positive contribution to the school as a preventive effort and became the basis for the development of a sustainable and more comprehensive drug prevention program.

Ammalia Shelky Nakwa Jamalika Putri; Khairunnisa Khairunnisa; Sri Wahyuni

Jurnal Ekonomi dan Pembangunan Indonesia 2025 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

The purpose of this study is to evaluate income inequality and poverty as key indicators of uneven economic development in North Sumatra Province in 2024. This study analyzed various secondary sources, including BPS reports, SINTA-indexed national journals, and regional economic policy publications. The results show that regencies in the west coast and mountainous regions of North Sumatra tend to be lagging behind, while urban areas such as Medan and Deli Serdang have the highest concentration of economic growth, meaning that income inequality remains at a moderate-high level. The finding that economic progress remains uneven is reinforced by the fact that the poverty rate remains higher than the national average. From the results of this study, not only economic factors influence inequality and poverty, but also structural factors such as infrastructure access, human labor quality, and regional fiscal inequality. Therefore, more inclusive and integrated policies are needed to address inequality and improve welfare across all provinces.

Nadila Syafa

Inspirasi Dunia: Jurnal Riset Pendidikan dan Bahasa 2025 Universitas Maritim AMNI Semarang

In the context of the influence of social media on the learning concentration of Students in the learning concentration if students in the J-PBSI (Indonesia Language and Literature Education Department) at Lambung Mangkurat University, social media is one of the most influential technological products in the lives of students today. Students in J-PBSI at Lambung Mangkurat University are increasingly dependent on various digital platfroms to support their educational processes. Theses applicantions have become essential tools for socializing and sharing information with other students. The influence of social media use on the learning concentration of J-PBSI students shows that many students experience a lack of focus while studying due to the distracting effects of social media. This distraction often reduces students’ ability to contcentrate, which in turn affects their overall to concentrate, which in turn affects their overall learning performance. This study uses a descriptive qualitative method with in-depth interviem techniques conducted with several students from the Indonesia Language and Literature Education Department. The results of the most students use sosial media on a daily basis. High usage of social media tends to decrease learning concentration because students are often distracted by notifications of the urge to open social media while studying. However, there are also J-PBSI students who use social media effectively, utilizing it as an additional learning resource. Thus, the influence of social media is twofold, depending on the intensity and purpose of ir use. This study aims to determine the extent to which social media affects students’ learning concentration. It is also expected to provide a better understanding of how social media influences the learning process. Students are encouraged to use social media wisely and responsibly so that is does not interfere with their focus on studying, but instead supports their academic activities.

Choirunnisya Choirunnisya; Hanesya Izzah Salsabillah; Siti Aisyah Haramainy; Ratna Pangastuti

Jurnal Pendidikan Anak Usia Dini dan Kewarganegaraan 2025 Asosiasi Riset Ilmu Pendidikan Indonesia

This study aims to analyze in depth the role of drumband extracurricular activities in developing motor and cognitive abilities of early childhood at Aisyiyah Bustanul Athfal 50 Kindergarten, Surabaya. This study uses a qualitative approach with data collection methods through direct observation, in-depth interviews, and the distribution of questionnaires involving teachers, parents, and students as research subjects. The results show that drumband activities provide a positive contribution to the development of gross and fine motor skills of children, especially through rhythmic movement exercises, hand-eye coordination, and body control when playing musical instruments. In addition to motor aspects, drumband activities also play a role in improving children's cognitive abilities, such as concentration, memory, the ability to follow instructions, and understanding musical patterns and rhythms. Children's active participation in drumband activities also helps shape discipline, the ability to work together in groups, and increases children's self-confidence. Thus, drumband extracurricular activities can be used as an effective and enjoyable learning medium to support the motor and cognitive development of early childhood holistically and sustainably.  

Ningsih, Arista Wahyu; Jihan Fahiroh Nur Arifin; Retno Wulan Devitri; Rusdiana Tri Septiarini; Elvira Silvany Zahara +6 more

Jurnal Riset Ilmu Farmasi dan Kesehatan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Extraction is a crucial stage in obtaining bioactive compounds from natural materials that have potential as medicinal, cosmetic, or nutraceutical ingredients. Among the various extraction methods available, maceration remains one of the most widely used techniques due to its simplicity, cost-effectiveness, and ability to maintain the stability of active compounds. The maceration process involves soaking powdered plant material in a suitable solvent at room temperature for a certain period, accompanied by periodic stirring to facilitate the diffusion of active compounds into the solvent. This method is particularly effective for extracting polar and semi-polar compounds such as flavonoids, phenolics, and essential oils that are sensitive to heat. The review shows that the effectiveness of maceration is influenced by several key factors, including the type and concentration of solvent, particle size of the material, duration of soaking, and stirring frequency. The use of ethanol with higher concentrations generally yields greater extract recovery and higher levels of active compounds. In addition, maceration is considered environmentally friendly because it requires no excessive heating and can employ safe, natural solvents. Therefore, despite the development of advanced extraction technologies, maceration remains a relevant, practical, and efficient method for phytochemical extraction, especially in laboratory research and small-scale herbal industries.          

Faridah Hanum Rajagukguk; Nurmaini Nurmaini; Taufik Ashar

International Journal of Health and Medicine 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Acute Respiratory Infections (ARI) in the working area of Mulyorejo Public Health Center, where an aluminum factory is located, rank first among the ten most common diseases. This study aims to analyze the influence of sociodemographic characteristics and PM2.5 exposure on ARI complaints in the aluminum factory area of Payageli Village, Deli Serdang Regency. The cross-sectional observational study involved 160 housewives living within a radius of 10–1500 meters from the factory’s chimney. The analysis included univariate, bivariate, and multivariate methods. Results showed that 58.1% of respondents experienced ARI symptoms in the past month. The average ambient (outdoor) PM2.5 concentration measured from three sampling points was 12.3 µg/m³, which did not exceed the WHO standard (<15 µg/m³). The highest concentration was recorded in the southern direction (15.5 µg/m³). Bivariate analysis indicated that education (p = 0.010), direction of house location (p = 0.001), and indoor PM2.5 concentration (p = 0.006) were significantly associated with ARI. Multivariate logistic regression analysis showed that the most dominant factor influencing ARI was indoor PM2.5 concentration (p = 0.039), followed by education (p = 0.013) and direction of house location (p = 0.001). This study provides a scientific basis for air quality control and housing environment improvement to reduce the risk of environmentally related diseases in industrial zones.

Krisnawati Banja Uru; Erni Yohani Mahtuti

Jurnal Kesehatan dan Kedokteran 2025 Lembaga Pengembangan Kinerja Dosen

Pediculus humanus capitis, according to the WHO, is classified as a skin disease and ectoparasite in the list of neglected tropical diseases. The cause can infect the scalp, leading to many children suffering from iron deficiency and anemia. Its spread occurs through shared items. Therefore, traditional insecticides such as srikaya seeds and kemiri seeds, which contain saponins and flavonoids capable of killing head lice, are required. The obective of this study is to determine the most effective concentration, compare their efficacy, and determine the killing time of both extracts. The experimental research method involved treatments at concentrations of 20%, 40%, and 60% with four repetitions. The results of this study indicate that there is an effect of srikaya seed extract with kemiri seeds in terms of concentration and time on lice mortality, as shown by a two-way ANOVA test with a p-value of 0.000 (P<0.05). In the Tukey test, the average mortality rate for srikaya seeds was 4, and the average mortality rate for kemiri seeds was 3. The concentration of srikaya seed extract killed 50% of head lice LC50 at a dose of 0,14%, while the concentration of kemiri seed extract killed 50% of head lice at a dose of 0,28% with contact times of 30 and 60 minutes. This demonstrates that srikaya seed extract at a dose of 0,14% is effective in causing mortality in head lice (Pediculus humanus capitis)

Istamala, Mar'atus Sholihah

RISOMA : Jurnal Riset Sosial Humaniora dan Pendidikan 2025 Asosiasi Ilmuwan Pendidikan, Sosial, dan Humaniora Indonesia

The advancement of digital technology has transformed children's media consumption patterns, marked by the growing use of short video content such as TikTok, YouTube Shorts, and Instagram Reels. This study aims to explore the psychological impacts of short video addiction on elementary school-aged children, focusing on cognitive, affective, and social aspects. Using a phenomenological qualitative approach, data were collected through in-depth interviews, observation, and documentation involving 10 children, 7 parents, and 4 teachers from two elementary schools. The findings indicate that children who intensively access short videos (more than two hours per day) experience reduced concentration, emotional instability, and social withdrawal. These results were analyzed using theoretical frameworks from Piaget (cognitive), Krathwohl (affective), Erikson and Bandura (social), and Young’s digital addiction model. The main conclusion reveals that short video addiction negatively affects children's developmental tasks, including logical thinking abilities, emotional regulation, and social skills. Therefore, digital literacy-based interventions and active supervision by parents and teachers are essential to prevent the long-term detrimental impacts on children's psychological development.

Ryan Marina; Dimas Prasetya; Arditya Prayogi; Alif Adhar Amatullah; Keisha Kirania Safitri

Jurnal Pengabdian dan Kesejahteraan Masyarakat 2025 Lembaga Pengembangan Kinerja Dosen

Early Childhood Education is a fundamental phase in the formation of a child's character and basic skills. This period, known as the golden age, is crucial for providing appropriate stimulation so that all aspects of a child's development can develop optimally. The limited learning resources at the Bajo Sayang Early Childhood Education on Boleng Island, West Manggarai Regency, drove the need for innovative, simple yet meaningful learning media. This community service activity aims to implement interactive storytelling as a learning medium that can stimulate the cognitive and social-emotional aspects of early childhood. The implementation method used a participatory and interactive approach, where children are actively involved through questions and answers, emotional expression, and supporting activities such as singing and dancing. The results of the activity indicate that the interactive storytelling method can improve children's concentration and courage in expressing opinions. Furthermore, children also demonstrate a better understanding of basic emotions such as happiness, sadness, and anger, as well as increased empathy for the story characters.

Arcita Rizara; Dwi Kusumawardani; Mita Septiani

Proceeding of the International Conference on Global Education and Learning 2025 Asosiasi Riset Ilmu Pendidikan Indonesia

This systematic literature review examines the effectiveness of game-based learning (GBL) interactive e-modules in improving students' learning concentration. The study synthesizes the findings from eight research articles published between 2012 and 2025. The analysis reveals that GBL-based e-modules significantly enhance learning motivation, with validity rates ranging from 90% to 99%. Additionally, the use of interactive platforms such as Wordwall, Gimkit, and other digital tools effectively supports various learning styles, particularly visual and kinesthetic learners. The review highlights that student engagement levels improve significantly, ranging from 67.42% to 87.12%. Furthermore, these e-modules positively impact learning outcomes, providing a more engaging and interactive approach to education. By integrating gamification elements, the e-modules create a dynamic and motivating learning environment that fosters better concentration and focus among students. The review concludes that GBL-based e-modules are an effective educational strategy, particularly in geography education at the high school level. These tools not only engage students in a fun and interactive manner but also improve their ability to focus, leading to enhanced learning experiences. As a result, incorporating GBL-based e-modules in educational practices can contribute to better learning concentration and overall academic performance.

Miftahir Rizqa; Izzatul Aisy; Mifta Yuljannah Pasaribu; Reva Nur Amalya; Reza Alinata

Aljabar : Jurnal Ilmuan Pendidikan, Matematika dan Kebumian 2025 Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Mathematics learning demands optimal student activity, concentration, and participation. However, many students still exhibit a passive attitude during the learning process, resulting in learning outcomes that have not reached the expected level. This article aims to analyze various effective classroom management strategies for fostering enthusiasm for learning and increasing student participation in mathematics learning. This study uses a library research method by reviewing various scientific sources, such as journals, academic books, and relevant research reports. The results of the study indicate that effective classroom management plays a crucial role in creating a conducive, interactive, and student-centered learning environment. Teachers function not only as transmitters of material but also as facilitators and administrators capable of building positive social relationships and motivating students to actively think and participate. Preventive, curative, and repressive classroom management strategies have been proven to improve student focus, motivation, and learning outcomes, especially when integrated with learning approaches such as discovery learning, teacher-centered learning, and the use of creative methods like squad games and block systems. Thus, adaptive and innovative classroom management is key to realizing participatory, enjoyable, and meaningful mathematics learning for the development of students' overall potential.

Alisyah Pratiwi; Hartalina Mufidah; Rian Anggia Destiawan

Jurnal Ilmu Kesehatan 2025 Lembaga Pengembangan Kinerja Dosen

Water plays a fundamental role in sustaining human life, particularly as a source of drinking water. Nonetheless, the consumption of water that does not comply with established health standards can result in illnesses such as diarrhea and vomiting. In the Patrang District, the use of refillable drinking water has gained popularity as an economical substitute for bottled water. Despite its convenience, there are growing concerns about the microbiological safety of refillable drinking water, especially regarding contamination by Coliform and Escherichia coli bacteria, which serve as key indicators of water hygiene and safety. The objective of this research was to determine the contamination levels of Coliform and Escherichia coli bacteria in refillable drinking water. The study utilized a quantitative research design with descriptive analysis and employed the Most Probable Number (MPN) method for testing. Data collection took place from May to June 2024, comprising five water samples labeled X, Y, Z, A, and B, obtained from refillable drinking water depots in Patrang District using a simple random sampling approach. The results indicated that out of the five samples tested, the sample labeled Z was positive for Coliform with an MPN value of 920 cfu/mL, while the sample labeled A was positive for both Coliform and Escherichia coli with an MPN value of 2,000 cfu/mL. From these findings, two samples (Z and A) were identified as contaminated, with the highest bacterial concentration found in sample A, which had an MPN value of 2,000 cfu/mL

La Eddy; Febriyanti Y. Kdise; Amos Killay; Abdul M Ukratalo; Pieter Kakisina

Jurnal Ilmu Kesehatan 2025 Lembaga Pengembangan Kinerja Dosen

The root of Mimosa pudica L. contains mimosine, a toxic alkaloid, as well as tannins that exhibit toxic properties, potentially disrupting pancreatic function. Exposure to sufficiently high concentrations of toxic compounds can impair cellular metabolism, leading to irreversible damage. One of the cellular changes induced by cytotoxic compounds is the reduction in the size of pancreatic Langerhans islets. This study aimed to investigate the effects of ethanol extract of Mimosa pudica roots on the diameter of Langerhans islets and β-cell damage in the pancreas of mice. Twelve mice were randomly divided into four groups, each consisting of three animals. Group I served as a control and did not receive the extract, whereas Groups II, III, and IV were administered root extract at doses of 10 mg/g BW, 100 mg/g BW, and 1000 mg/g BW, respectively, for 14 consecutive days. The results demonstrated that administration of ethanol extract of Mimosa pudica roots reduced the diameter of pancreatic Langerhans islets in a dose-dependent manner, with higher doses causing more severe β-cell damage. These findings highlight the need for caution in the use of Mimosa pudica roots as traditional medicine or dietary supplements.