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Made Laksmi Meiliana; Indah Ana Resti

Jurnal Pengabdian Masyarakat 2026 Lembaga Pengembangan Kinerja Dosen

Antibiotic resistance is a global health problem that requires international efforts to prevent the ineffectiveness of existing antibiotics and support the development of new antimicrobial agents. The increasing use of antibiotics in the community must be accompanied by proper understanding regarding rational antibiotic use to minimize the risk of resistance. This community service activity aimed to provide education on rational antibiotic use and the dangers of antibiotic resistance to undergraduate nutrition students at STIKes Adila, Bandar Lampung. The activity was conducted through educational sessions using flyers, presentation slides, and interactive discussions to encourage active participation and improve understanding of the topic. Evaluation was carried out using pre-test and post-test assessments to measure changes in participants’ knowledge levels. Descriptive analysis showed an improvement in participants’ knowledge, with the high knowledge category increasing from 0% during the pre-test to 85% in the post-test, while the low knowledge category decreased from 35.5% to 0% after the intervention. These findings indicate that educational interventions can effectively enhance awareness and understanding of rational antibiotic use and the prevention of antibiotic resistance. Therefore, continuous educational programs are important to promote responsible antibiotic use and support public health efforts in combating antibiotic resistance.

Rintan Elawati; Lilia Faridatul Fauziah

Inovasi Kesehatan Global 2026 Lembaga Pengembangan Kinerja Dosen

The increased intake of packaged sugar-sweetened beverages among adolescents may affect health status, particularly blood glucose levels, as their high added sugar content can disrupt glucose metabolism when consumed excessively. This study aimed to examine the relationship between the consumption of packaged sugar-sweetened beverages and blood glucose levels among high school students in Tuban District. A quantitative approach with a cross-sectional design was employed, involving 2,092 students from four schools. The sample was selected using a stratified random sampling technique. Data on beverage consumption were collected using a Semi Quantitative Food Frequency Questionnaire (SQ-FFQ), while blood glucose levels were measured using a glucometer. Data analysis was performed using the Spearman Rank correlation test with SPSS version 24. The results indicated a significant relationship between the consumption of packaged sugar-sweetened beverages and blood glucose levels among high school students in Tuban District (p = 0.000). These findings suggest that higher consumption levels are associated with higher blood glucose levels in adolescents.

Asna Safitri; Mulyati Sri Rahayu; Iskandar Albin

Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi 2026 LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Cigarette smoke is a major source of free radicals that can cause various health problems, including disturbances in the male reproductive system. Nicotine and other harmful compounds in cigarettes increase oxidative stress and interfere with spermatogenesis. Gotu Kola (Centella asiatica) is a medicinal plant known for its antioxidant properties that may help neutralize free radicals. This study aimed to determine the effect of Gotu Kola leaf extract on the histopathological features of the testes in male Wistar rats exposed to cigarette smoke. An experimental study using a Post-Test Only Control Group Design was conducted on 24 rats divided into six groups: a normal group, a negative control group exposed to cigarette smoke, a positive control group treated with vitamin E, and three treatment groups receiving Gotu Kola extract at doses of 120, 180, and 240 mg/kg body weight for 28 days. The observed parameters were Leydig cell count and seminiferous tubule diameter. One-way ANOVA analysis showed that Gotu Kola extract significantly increased Leydig cell numbers and seminiferous tubule diameter in all treatment groups compared to the negative control group (p < 0.05). Post hoc analysis demonstrated significant differences in tubule diameter, with the highest improvement observed at the 240 mg/kg body weight dose. These findings indicate that Gotu Kola extract has potential protective effects against testicular damage caused by cigarette smoke exposure.

Stefania Galathzia; Magdalena Silawati Samosir; Nunsio Handrian Meylano

Jurnal Projemen UNIPA 2026 Universitas Nusa Nipa Maumere

This study aimed to: (1) determine the description of hotel booking decisions, social media, and facilities; (2) analyze the effect of social media and facilities on hotel booking decisions both partially and simultaneously. The population in this study consisted of 98 visitors to Hotel Merlin Maumere. As the population is limited, this study was conducted using a census or saturated sampling technique. Data were collected through questionnaires and were analyzed using descriptive methods and inferential statistics, namely multiple linear regression. Hypothesis testing was conducted through the F-test and t-test. The results of the descriptive analysis showed that the variable of hotel booking decisions was in the good category, the social media variable was in the good category, and the facilities variable were in the good category. The statistical results of the t-test showed that, partially, the social media variable had a positive and insignificant effect on hotel booking decisions. Furthermore, the facilities variable had a positive and significant effect on hotel booking decisions. Furthermore, the statistical results of the F-test showed that, simultaneously, the social media and facilities variables had a significant effect on hotel booking decisions. The results of the determination analysis showed that the two independent variables in this study were able to explain the variation in the increase and decrease of hotel booking decisions at Hotel Merlin Maumere by 24.9%. Keywords: Social Media, Facilities, Hotel Booking Decisions

Enggar Enggar; Srigita Dewiyana; Alya Mahira; Kiran Violeta Mamahit; Ghita Melati Putri +1 more

Faedah : Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia 2026 FKIP, Universitas Palangka Raya

Pregnancy complications remain a leading cause of maternal morbidity and mortality in Indonesia. Pregnant women's limited knowledge of pregnancy danger signs and suboptimal participation in antenatal care (ANC) services can increase the risk of delayed detection and management of pregnancy complications. The Kinovaro Community Health Center (Puskesmas) in Sigi Regency is one of the areas requiring maternal health information and activities that can increase pregnant women's participation in health education activities. This community service activity aims to improve pregnant women's knowledge and preparedness in preventing pregnancy complications through mentoring based on Pregnant Women's Classes. The activity involved eight pregnant women in their second and third trimesters. The methods used included health education, interactive discussions, simple pregnancy check-ups, pregnancy exercise demonstrations, and evaluation using pre- and post-tests. The results showed that all participants actively participated in the activity and had a good level of knowledge after participating. The average knowledge score increased from 77.5 to 80.0, an increase of 3.2%. In addition, participants were able to identify pregnancy danger signs, understand the importance of standard ANC visits, and practice pregnancy exercise movements independently. This activity demonstrates that mentoring through the Pregnant Women's Class can strengthen maternal health literacy, increase pregnant women's preparedness in recognizing pregnancy complications, and support the strengthening of maternal health services at the community level.

Muhammad Dzakwan Rafa; Davina Shafa Fellisa; Meisanti Meisanti

Jurnal Pengabdian Masyarakat 2026 Lembaga Pengembangan Kinerja Dosen

This community service activity is motivated by the increasing volume of household plastic waste that has not been optimally managed, thus potentially polluting the environment. Utilizing inorganic waste, especially used plastic bottles, as a planting medium is a simple solution to reduce pollution while increasing community creativity. This activity aims to increase community knowledge and skills in utilizing used plastic bottles as a useful and economically valuable planting medium container. The Women Farmers Group (KWT) participated in this activity on May 1, 2026 in Gempol Sari Village, Sepatan Timur District, Tangerang Regency, Banten Province. Participatory Action Research (PAR) strategies were used to carry out implementation techniques, which included socialization, training, direct practice, mentoring, and assessment. Pre- and post-activity tests were given and evaluated using Paired Sample T-Tests to assess the activity. After participating in the training, the level of participant understanding increased, in accordance with the results of the activity. Participants' knowledge increased significantly through this exercise, as indicated by a significant increase in their average post-test score from 92.86 to 78.57 (p < 0.05). In addition, participants were able to independently practice making simple planting media from used plastic bottles. This activity has positive implications for increasing environmental awareness and community creativity, as well as supporting economic empowerment and sustainable environmental management efforts.

Adi Maulana Putra Hidayat; Dhanar Intan Surya Saputra

Bridge : Jurnal Publikasi Sistem Informasi dan Telekomunikasi 2026 Asosiasi Profesi Telekomunikasi Dan Informatika Indonesia

Public service institutions currently utilize digital technology to improve information accessibility for society. Satres PPA and PPO Polresta Banyumas has an important role in providing services, protection, and education related to violence cases against women and children. However, information regarding services, reporting procedures, and educational materials is still not fully accessible to the public. This study aims to design and develop a service and educational website for Satres PPA and PPO Polresta Banyumas using the Laravel framework. The research method used in this study is the Waterfall method, which consists of requirement analysis, system design, implementation, testing, and maintenance stages. The website was developed using Laravel, MySQL, and Bootstrap to support responsive interface design. The results show that the developed website is able to provide service information, educational articles, reporting procedures, and contact information effectively. System testing results indicate that all website features function properly according to user requirements. The website is expected to improve public access to information and increase awareness regarding the protection of women and children.

Sri Gita Tamai; Tusaban Tusaban; Dewi Shinta Achmad; Nur Jihan Fareranty Piu

Student Scientific Creativity Journal 2026 Pusat Riset dan Inovasi Nasional

Food safety of fresh fish is an important concern because fish is highly perishable and may be misused with hazardous preservatives such as formalin. This study aimed to determine formalin content and analyze the relationship between length and weight of Nile tilapia (Oreochromis niloticus) and formalin levels in traditional markets of Gorontalo City. The study was conducted from January to February 2026 in five traditional markets, namely TPI Tenda, Moodu, Potanga, Andalas, and Sentral. Nile tilapia samples were analyzed using a formaldehyde test kit, and formalin levels were expressed in ppm. Total length and fish weight were measured, and the relationship between physical size and formalin content was analyzed using Pearson correlation. The results showed that all Nile tilapia samples tested positive for formalin, with concentrations ranging from 0.11 to 0.23 ppm. The highest formalin levels were found in TPI Tenda and Moodu, each at 0.23 ppm, while the lowest level was found in Sentral at 0.11 ppm. Fish length ranged from 19.43 to 25.61 cm, while fish weight ranged from 0.17 to 1.78 g. The correlations between length and formalin content and between weight and formalin content were both very strongly negative, with r = -0.97. These findings indicate that smaller fish tended to contain higher formalin levels. Market supervision, trader education, and formalin-free fish handling practices should be strengthened to protect consumer health.

Elsa Mpeana; Nurdiana Nurdiana; Sri Rezeki

Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi 2026 LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Snacks consumed by school children are generally high in sugar, salt, and saturated fat, which may negatively affect health. One effort to improve nutritional intake is developing healthier snacks using local food sources, such as tortilla chips substituted with moringa seed flour (Moringa oleifera). This study aimed to analyze the proximate composition and acceptability of moringa seed flour–substituted tortilla chips as a healthy snack alternative for school children. The study employed an experimental design using a Completely Randomized Design with three formulations: F1 (45%), F2 (50%), and F3 (55%). The acceptability test results showed that F1 was the preferred formulation. The selected tortilla chips contained 13.228% protein, 35.415% fat, 20.311% carbohydrates, 4.283% moisture, and 1.4731% ash. Kruskal–Wallis analysis indicated no significant differences in organoleptic parameters among the formulations (p > 0.05). Therefore, tortilla chips with 45% moringa seed flour substitution demonstrated the highest acceptability and potential as a healthy snack for school children.

Fitria Lestari; Shanti Ariandini; Shinta Purnamasuti; Afthalia Oktavisha; Siti Fauziatu +2 more

Jurnal Pengabdian dan Kesejahteraan Masyarakat 2026 Lembaga Pengembangan Kinerja Dosen

World Health Organization (WHO) reports that immunization is able to prevent approximately 3–5 million deaths each year; however, a number of children still do not receive optimal immunization coverage due to insufficient parental knowledge. This study aimed to analyze the effect of health education on improving mothers’ knowledge regarding early childhood immunization in RW 04, Kertamaya Subdistrict, Bogor City, in 2026. This study employed a pre- experimental design with a one-group pretest–posttest approach involving 30 respondents. Knowledge levels were measured using a questionnaire before and after the health education intervention and analyzed using the Paired Sample T-Test. The results indicated a statistically significant difference in mothers’knowledge levels before and after the health education intervention (p = 0.029). In addition, the proportion of respondents with good knowledge increased from 76.7% in the pre-test to 93.3% in the post-test. These findings demonstrate that health education has a significant effect on improving mothers’ knowledge and can serve as an effective promotive intervention to support the success of community-level immunization programs.

Adam Azmi Fauzi

Jurnal Ekonomi dan Pembangunan Indonesia 2026 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

This study aims to analyze the effect of profitability, company size, and type of public accounting firm on Key Audit Matters (KAM), with audit fees as a moderating variable in manufacturing sector companies listed on the Indonesia Stock Exchange for the 2022–2024 period. This study used a quantitative approach with a purposive sampling method. Data were obtained from audited financial statements and annual reports published on the official Indonesia Stock Exchange website. The study sample consisted of 67 companies, with a total of 201 observations. Data analysis techniques used included descriptive statistical analysis, classical assumption tests, multiple linear regression, and Moderated Regression Analysis (MRA). The results showed that profitability had a significant negative effect on KAM disclosure, while company size had a significant positive effect on KAM disclosure. The type of public accounting firm showed a significant negative effect on KAM disclosure. Furthermore, audit fees did not moderate the relationship between profitability and KAM, but they did moderate the relationship between company size and type of public accounting firm on KAM disclosure. This study demonstrates that company and auditor characteristics play a significant role in determining the disclosure of Key Audit Matters in the independent auditor's report.

Slamet Yuliono; Nofierni Nofierni; Sandra Dewi

International Journal of Management Science and Entrepreneurship 2026 International Forum of Researchers and Lecturers

The completeness of nursing care documentation serves as a primary indicator of hospital service quality and remains a critical component of patient safety, clinical communication, and legal accountability. Despite its importance, empirical evidence from various healthcare facilities indicates that nursing records are frequently suboptimal, incomplete, or inconsistent. This study aims to analyze the complex interrelationships between burnout and coaching on the completeness of nursing care documentation, specifically examining the role of nursing competence as a mediating (intervening) variable at the Dr. Chasbullah Abdulmadjid General Hospital in Bekasi City. Utilizing a quantitative research framework with a cross-sectional design, this study sampled practicing nurses stationed across inpatient and intensive care units. Primary data were gathered through a validated, structured questionnaire designed to measure psychological burnout, the frequency of clinical coaching, perceived professional competence, and the objective completeness of documentation. The data were subjected to rigorous analysis using Structural Equation Modeling–Partial Least Squares (SEM-PLS) to test the hypothesized pathways within the conceptual model. The results demonstrated that burnout exerts a significant negative influence on both nursing competence and the quality of documentation, suggesting that emotional exhaustion hinders professional performance. Conversely, systematic coaching was found to have a significant positive impact, directly improving both competence levels and documentation adherence. Critically, the analysis confirmed that nursing competence acts as a vital intervening variable; it effectively mediates and strengthens the influence of both burnout reduction and coaching interventions on the overall completeness of nursing care records. This study concludes that proactive burnout management and the institutionalization of structured coaching programs are essential strategic priorities. By addressing these factors, hospital management can enhance individual nurse competence, thereby ensuring high-quality, comprehensive nursing documentation that supports patient safety and institutional integrity.

Erika Yuniar; Dewi Sartika

Ebisnis Manajemen 2026 Fakultas Ekonomi & Bisnis, Universitas Nusa Nipa

This study aims to analyze the partial and simultaneous influence of location, product diversity, and store layout on consumer purchasing decisions at Moncheri Hijab in Balikpapan. This research employed a quantitative approach using a survey method by distributing questionnaires to 170 respondents who were consumers of Moncheri Hijab in Balikpapan. The data analysis techniques used included validity testing, reliability testing, multiple linear regression analysis, t-test, and F-test. The results showed that partially, the location variable had a positive and significant effect on consumer purchasing decisions. Product diversity was also proven to have a positive and significant influence on purchasing decisions. Meanwhile, the store layout variable did not show a positive and significant effect on consumer purchasing decisions. However, simultaneously, the three variables, namely location, product diversity, and store layout, had a positive and significant influence on purchasing decisions among Moncheri Hijab consumers in Balikpapan. This study indicates that location and product diversity are the main considerations for consumers in making purchasing decisions, while store layout has not yet become a dominant factor influencing consumer purchasing decisions at Moncheri Hijab Balikpapan.

Kamila KH Djiha; Nuristha Febrianti; Adillah Imansri

Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi 2026 LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Meeting the nutritional needs of pregnant women requires innovative strategies through the provision of healthy snacks with balanced nutritional value. Donuts are popular snack foods; however, they are generally made from wheat flour and have limited nutritional content. This study aimed to analyze the nutritional content and acceptability of donuts enriched with red bean flour and Banggai yam flour as a healthy snack for pregnant women. This experimental study employed a Completely Randomized Design (CRD) consisting of three formulations: F1 (35% red bean flour : 15% Banggai yam flour), F2 (40% : 10%), and F3 (45% : 5%), with two replications. Nutritional analysis included protein using the Kjeldahl method, fat using the Soxhlet method, and carbohydrate using UV-Vis spectrophotometry. Acceptability was evaluated using a hedonic test. Data were analyzed using ANOVA and the Kruskal–Wallis test. The results showed significant differences in protein, fat, and carbohydrate contents among formulations (p<0.05). The highest protein content was found in F3, the highest fat content in F2, and the highest carbohydrate content in F1. Acceptability did not differ significantly among formulations (p>0.05); however, F1 obtained the highest preference score. Donuts enriched with red bean flour and Banggai yam flour have the potential to be developed as a healthy local food–based snack for pregnant women.

Nur Alif Sapoetra; Abd. Rahim; Citra Ayni Kamaruddin; Sri Astuty; Abdul Rajab

International Journal of Economics and Management Sciences 2026 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

This research investigates the effect of the amount of MSMEs, the number of buildings, and GRDP on regional tax revenue in selected cities and regencies in South Sulawesi, driven by the inconsistency between the growth of economic potential and the realization of tax revenue, where increases in MSMEs, buildings, and GRDP are not always followed by higher tax receipts. The study aims to analyze the effect of these variables and identify the most significant factors contributing to regional fiscal capacity. A quantitative approach is employed using panel data that combine time series and cross-sectional data from 2015-2024, analyzed through panel data regression with model selection based on Chow, Hausman, and Lagrange Multiplier test. The results show that partially, MSMEs and the number of buildings do not have a significant effect on tax revenue, while GRDP has a positive significant impact; however, simultaneously, all variables significantly influence tax revenue, as indicated by a high Adjusted R-squared value. These findings suggest that economic growth, as proxied by GRDP, plays a more dominant role in increasing tax revenue compared to the mere increase in the number of MSMEs and buildings, implying that optimizing tax revenue requires not only expanding economic potential but also enhancing tax compliance, administrative efficiency, and the quality of economic growth.

Imas Nurjanah; Rindasari Munir; Sri Dina; Soleha Soleha; Riski Septiani

Jurnal Pengabdian dan Kesejahteraan Masyarakat 2026 Lembaga Pengembangan Kinerja Dosen

Hypertension in pregnant women and Women of Reproductive Age remains a significant health problem in West Java Province. The prevalence of hypertension among pregnant women in West Java is approximately 10.57%, higher than the national rate of 6.18%, while the prevalence among WRA ranges from 25% to 30%. This study employed a pretest–posttest design with health counseling provided to 25 pregnant women and Women of Reproductive Age in RW 05, Kertamaya Subdistrict, Bogor City. Data were collected using knowledge and attitude questionnaires before and after the counseling and analyzed using the Paired Sample T-test. The results showed a significant increase in participants’ average knowledge and attitude scores after the educational intervention (p < 0.05). Based on the Paired T-test, the intervention yielded a p-value of 0.000, indicating a statistically significant improvement in both knowledge and attitudes. These findings demonstrate that health education is effective in increasing knowledge and fostering positive attitudes regarding hypertension among pregnant women and Women of Reproductive Age.

Elia Rossa; Nurasia Natsir

International Journal of Economics and Management Sciences 2026 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

This study examines the effect of working capital on firm performance and sustained growth among consumer non-cyclicals manufacturing companies listed on the Indonesia Stock Exchange (IDX) over the period 2019–2023. Working capital is operationalized through three distinct proxies derived from Akgün and Memiş Karatəs (2021): the Cash Holding Level (CHL), which measures the proportion of cash and cash equivalents relative to total assets; the Cash Interactive Effect (CIE), which captures the efficiency of converting revenue into operating cash flow; and the Gross Working Capital Ratio (GWCR), which reflects the share of current assets within total assets. Firm performance is assessed through Return on Assets (ROA), Return on Equity (ROE), and Tobin’s Q, while sustained growth is measured using the model proposed by Gerson et al. (2025), expressed as SG = b × ROE, where b denotes the earnings retention ratio. Panel data regression analysis is applied to 225 firm-year observations drawn from 45 companies. The study employs the Fixed Effect Model (FEM) for ROA and ROE, and the Random Effect Model (REM) for Tobin’s Q, as determined by the Hausman specification test. The findings reveal that CHL and CIE exert significant positive effects on ROA and ROE, while CIE is the only proxy to produce a statistically significant positive effect on Tobin’s Q. With respect to sustained growth, CHL and GWCR demonstrate significant negative effects, whereas CIE shows a significant positive effect, indicating that operational efficiency dimensions of working capital actively support long-term growth sustainability. These results reinforce the liquidity management theory and contribute empirical evidence that the structure and efficiency of working capital are strategic determinants of both short-term financial performance and long-term growth sustainability in Indonesia’s consumer goods manufacturing sector.

Faneshia Nabil Ayushita; Aulia Jihan Kamila; Lubna Nurul Mumtazah; Nisrina Huwaida Isfaizah; Adriansyah Adriansyah

Journal of Educational Innovation and Public Health 2026 Pusat Riset dan Inovasi Nasional

  Red dragon fruit contains bioactive compounds such as vitamin C, flavonoids, and polyphenols that have antioxidant potential and possess natural pigments that can be used as cosmetic colorants. This study aims to formulate and evaluate a blush-on powder preparation from dragon fruit pulp extract as an alternative natural colorant. The evaluation includes organoleptic testing, homogeneity, pH, irritation, spreadability, fineness, moisture content, and antioxidant activity. The results showed that the formulation met most of the requirements, exhibiting a pink color, a smooth texture, no odor, homogeneity, a pH of 6 suitable for the skin, no irritation, even spreadability within 4 applications, a fineness degree of 97.6%, and a moisture content of 6.91%. Antioxidant activity showed an IC₅₀ value of 0.3036 ppm (very strong), although the relative inhibition percentage was low (18.35%). Thus, dragon fruit extract has the potential as a natural ingredient in blush-on powder that provides both color and antioxidant benefits.

Dwi Nurul Qomariah; Dea Amanda Caressa; Elita Endah Mawarni

Jurnal Ilmu Kesehatan dan Gizi 2026 Pusat Riset dan Inovasi Nasional

Health issues among the elderly are often related to declining bodily functions, digestive disorders, and specific nutritional needs for easily digestible foods. The 60-and-older age group is at high risk for gastrointestinal disorders due to low fiber intake. Therefore, alternative foods are needed that are soft in texture, neutral in taste, safe, and nutritious. One potential solution is the development of food products based on tempeh gembus with the addition of banana hearts, which are rich in fiber, soft in texture, and readily available. This study employed an experimental method using a Completely Randomized Design (CRD) to test three formulation variations (F1, F2, F3). The nutritional content of formulation F1 includes energy 111.575 kcal, carbohydrates 20.185 g, protein 6.91 g, fat 0.355 g, and fiber 6.67 g. Formula F2 contains 88.225 kcal of energy, 14.095 g of carbohydrates, 7.72 g of protein, 0.205 g of fat, 7.3 g of fiber, and 0.0015% flavonoids. Formula F3 has 107.015 kcal of energy, 7.995 g of protein, 0.295 g of fat, 6.88 g of fiber, and 0.0021% flavonoids. In conclusion, the best tempeh with added banana hearts is Formula F2, with its nutritional content, fiber, flavonoids, and BAL >10⁸ CFU/g, which has the potential to serve as a functional food and probiotic source to help improve digestive health in the elderly. Further testing is recommended directly on elderly groups, along with product shelf-life testing.

Renata Amalia Azizah; Callista Luna Sadi Qova Gunawan; Shelfia Putri Chantika; Axelando Carlos Febiyano; Margaret Rianti Martalina

Journal of Educational Innovation and Public Health 2026 Pusat Riset dan Inovasi Nasional

The optimal therapeutic impact of local vaginal drug delivery systems is strongly influenced by the physical characteristics balance of Solid Vaginal Suppositories. A comprehensive review regarding the comparison of mechanical profiles, specifically melting time and crushing strength parameters, from various base classifications constitutes the primary objective of this literature research. The implementation of a Literature Review study design was executed through the extraction of empirical data from twelve experimental journals published within the last ten years. Excessively rapid phase transformation characteristics at physiological basal temperatures and low compression resistance were consistently demonstrated by lipophilic bases such as Oleum Cacao. The risk of structural deformation during the distribution process is highly susceptible to unmodified lipid preparations. High surface elasticity accompanied by a delay in molecular hydration duration reaching 120 minutes was recorded in the utilization of Glycerinated Gelatin Base. Structural rigidity exceeding 4 kgF and disintegration time efficiency under 60 minutes were optimally demonstrated by Polyethylene Glycol (PEG) Base. An enhancement in mechanical resistance against external shocks during the storage period is offered by the thorough modification of the synthetic polymer ratios. Therefore, the determination of the PEG base as the most optimal material is recommended to maintain the quality stability of pharmaceutical products. Compendial regulation standards regarding the physical strength testing of pharmaceutical preparations must be obeyed by every institution to ensure long-term treatment effectiveness. Thus, the alignment between active substance release duration and physical preparation endurance can be realized for absolute patient comfort.