This study examines the effect of personalization-based digital marketing strategies on brand loyalty within cross-cultural contexts, employing A/B testing and multivariate analysis methods. The research is motivated by the critical role of digital marketing in fostering consumer relationships and the challenges of understanding cultural differences that influence consumer responses to marketing strategies. The primary objective of the study is to analyze how cultural dimensions moderate the effectiveness of personalized marketing content in enhancing brand loyalty. The study was conducted through an experiment involving 200 participants divided into two groups: one group received personalized digital content, while the other received standard content. Multivariate Analysis of Variance (MANOVA) was used to evaluate the effects of culture and marketing strategies on brand loyalty, consumer satisfaction, and product recommendations. The results indicate that personalized content significantly increases brand loyalty (M = 4.5, SD = 0.8) compared to standard content (M = 3.8, SD = 1.0; p < 0.05). Additionally, consumers from collectivist cultures demonstrated a more positive response to personalized content, with higher brand loyalty scores (M = 4.6) compared to those from individualist cultures (M = 4.0). This study underscores the importance of cultural sensitivity in digital marketing strategy planning. Integrating personalization elements with an understanding of cultural contexts has been shown to enhance consumer engagement and foster stronger brand loyalty. These results provide both empirical contributions and practical guidance for companies in designing effective marketing campaigns for diverse global markets.