This study was conducted in the laboratories of Samarra Teaching Hospital and some private laboratories in the city of Samarra in salah aldiyn  Governorate for a period from 1/8/2024 to 1/9/2024, where the study included (50) samples of women of reproductive age, ranging in age from (20-40) years, and were distributed into two groups: Patient group: (30) samples were from female patients with PCOS, Control group: (20) samples of healthy women. The pathological cases of women suffering from PCOS were confirmed after conducting clinical examinations and referring them to the specialist doctor and performing an ultrasound examination. after that, blood was taken from both groups (patients and healthy women) and separated using a centrifuge. Then the  sex hormones Luting hormone -LH, Folic stimulating hormone-FSH, and some biochemical variables, which included (Vascular endothelial growth factor-VEGF , Irisin, Copeptin). The results of the this study  showed a significant rise in each of the hormones (LH. FSH, Testosterone ,Copeptin, VEGF) and a significant low in (Irisin) in the blood serum of women infected with PCOS compered a healthy women , with a probability of P ? 0.05.

This study was conducted at the Thalassemia Center of Azadi Educational Hospital, Kirkuk Health Directorate, Iraq, from June 1, 2024, to October 1, 2024. The study sample included 75 individuals, both males and females, aged between 4 and 67 years, divided into two groups: the first group comprised 50 thalassemia patients, while the control group included 25 healthy individuals. The results indicated a significant effect of thalassemia on the studied variables, as the disease led to increased levels of white blood cells, erythrocyte sedimentation rate, total iron-binding capacity, malondialdehyde, iron concentration, and lipoxygenase enzyme, recording values of 10.9 × 103 cells/mL, 25.36%, 321.84 µg/dL, 721.12 mmol/L, 2788.9 ng/dL, and 226.2 IU/L, respectively. In contrast, thalassemia reduced hemoglobin levels to 8.57 g/L. The gender category significantly affected both malondialdehyde and iron concentrations, while the age category significantly impacted white blood cell levels, total iron-binding capacity, serum iron, and lipoxygenase enzyme. Among the interactions, the most influential factor was found in the group of female patients over 30 years old, who recorded the highest significant concentrations of white blood cells and malondialdehyde, reaching 12.26 × 103 cells/mL and 1090 mmol/L. Conversely, female patients under 15 years showed the highest significant averages for the percentage of erythrocyte sedimentation rate and iron concentration, at 28% and 3270 ng/dL, respectively. Meanwhile, female patients aged 15-30 years exhibited the highest significant concentrations for total iron-binding capacity and lipoxygenase enzyme, at 361.8 µg/dL and 234 IU/L, respectively. Male patients aged 15-30 years recorded the lowest significant hemoglobin concentration, which was 7.33 g/L.

In the midst of this developing society, people in Indonesia still use traditional health services, especially baby massage and birth attendants. Massaging babies from traditional healers has been a tradition passed down from generation to generation. This study aims to determine the relationship between attitudes and maternal behavior in carrying out baby massage independently at PMB Lismayani Lubis District. Simalungun. This type of research is an analytical survey. Then analyze the dynamics of correlation between phenomena or between risk factors and consequence factors, which are phenomena that cause consequences (influence). There is a relationship between attitude and mother's behavior in carrying out baby massage independently at PMB Lismayani Lubis Kab. Simalungun with a p value of 0.021.

        Tribulus terrestris L.,Gokshur in Sanskt,  is an annual herbaceous, little prostrate, silky from the Zygophyllaceae family. It is found in extensive, arid, and scorching regions of India. is used in traditional folk medicines as an aphrodisiac, astringent, lithotriptic, diuretic, and urinary disinfectant.     however, uneven, pinnae, elliptical leaves. Sprinkled, round, compressed, five-cornered, transverse partitioned carpel fruits with many seeds ripen in July. Pieces of the cylindrical-fibrous root are 7-18 cm and 0.3-0.7 cm wide. According to reported studies, the investigations indicated the presence of the saponins ;gitogenin, tigogenin, neogitogenin, hecogenin, and flavonoid tribuloside was kaempferol-3-glucoside. Furthermore, Tribulus terrestris plays a vital role in hepatotoxicity and is greatly reduced by Tribulus extracts. Similarly, T.terrestris plays a remarkable role in reducing the elevated level of serum glucose, triglycerides, VLDL, and cholesterol. This study aims to conduct a preliminary analysis of the phytochemicals of Tribulus leaves cultivated in Iraq and to determine the active constituent of the ethanolic extract of the leaves using Gc-Mass. Qualitative detection of herbal leaves in Iraqi soil, investigated by GC-MASS revealed important constituents. The funding shows a new compound; dihydrocoumarin and other major constituents neophytadiene and alpha-tocopherol.

Shina, mai., 2024, test of antibacterial activity of extract, water fraction, ethyl acetate fraction, and n-hexane fraction of chinese petai leaf (leuncaena leucocephala) against staphylococcus aureus atcc 25923, thesis, faculty of health sciences, duta bangsa university, surakarta one of the traditional medicines that currently has the potential to be developed is the chinese petai plant (leucaena leucocephala). Chinese petai leaves are used by the people of indonesia as a remedy for new and swollen wounds. Staphylococcus aureus is a gram-positive coccus bacterium that is the main pathogen in humans. Almost everyone has experienced a wide variety of staphylococcus aureus infections during their lifetime, from severe food poisoning to minor skin infections. The methods used in this study are diffusion and dilution. The purpose of this study was to determine the antibacterial activity of water extracts and fractions, ethyl acetate fractions, and n-hexane fractions of chinese petai leaves (leuncaena leucocephala), to find the most active extracts and fractions based on their inhibitory zones, and to determine the khm and kbm of the most active extracts against staphylococcus aureus atcc 25923. Based on research conducted on ethanol extract, water fraction, ethyl acetate fraction, and n-hexane fraction of chinese petai leaves have antibacterial activity against staphylococcus aureus atcc 25923. The most active extract in inhibiting staphylococcus aures atcc 25923 judging from its inhibition zone value is ethanol extract. Ethanol extract of chinese petai leaves has the same khm and kbm values, namely at a concentration of 25%.
 
 
 

Good logistics management of medicines is one of the factors so that medicines can be managed well. The pharmacy unit of the Kolaka District Health Service has problems with inadequate storage or storage of medicines and delays in the arrival of medicines. The aim of this research is to determine the Analysis of Drug Logistics Management at the Kolaka District Health Service. The research uses qualitative methods through in-depth interviews, observations and observation guides. The results of the research show that at the drug planning stage using the consumption method, drug procurement using an e-catalog system, drug storage is still not good because the warehouse is not large enough for drug storage. Suggestions for the Kolaka District Health Service.

Cross-contamination occurs due to other previously produced products, other rooms or areas producing different products, and particles from machinery or equipment. Quality risk management can be a preventive measure in reducing the potential for cross-contamination that occurs in the pharmaceutical industry. One part of quality risk management is risk assessment. One of the most common and effective methods is the Failure Mode and Effect Analysis (FMEA) method. This risk assessment is carried out using the stages of risk identification, risk analysis, and risk evaluation using categorization based on the Risk Priority Number (RPN). Based on the risk assessment using the FMEA method regarding cross-contamination in the Packaging area in the "XYZ" pharmaceutical industry, it can be concluded that the results of observations and interviews with operators and Packaging Supervisors identified 19 risks which were categorized as low, medium, high, and very high. Based on the results of the risk assessment obtained, the risk of cross-contamination that needs to be controlled is those with an RPN value of 30 ? RPN ? 60 (medium); 75 ? RPN ? 100 (high); RPN ? 150 (very high). Therefore, the "XYZ" pharmaceutical industry needs to determine and implement risk control measures. By adequately controlling the potential risk of cross-contamination, it will ensure the safety and quality of the products produced.

Stroke is a cerebrovascular disease (brain blood vessels) due to the death of brain tissue (cerebral infarction). The cause is reduced blood and oxygen flow to the brain due to blockage, narrowing or rupture of blood vessels. Coping mechanisms are a direct effort in stress management. Cognitive means understanding knowledge or the ability to obtain certain knowledge. The aim of this research is to determine the effect of providing cognitive support on coping in stroke patients. The research population was all inpatients in the neurology room at Piru Hospital, West Seram Regency, with a sample of 30 respondents whose selection was carried out using purposive sampling. The design used was pre-experiment, with a one group pretest-posttest design. The independent variable is cognitive support, the dependent variable is coping mechanisms. Using the Wilcoxon sign rank test with a significance level of p < 0.05. The research results showed that there was an influence in providing cognitive support on coping (p = 0.000). Based on the results of this research, it can be concluded that there is an influence of providing cognitive support on coping in stroke patients at Piru Hospital, West Seram Regency.

Ergonomic exercises can lower blood pressure by restoring the elasticity of blood vessels and improving blood flow. The research method used was a case study involving 2 different respondents. The aim of this research is to analyze the effectiveness of applying ergonomic exercises to reduce blood pressure in hypertensive clients. This type of research is descriptive in the form of a case study. The subjects in this study were two individuals with the same case in two different families with hypertension. Those who were given the same treatment where blood pressure was measured pre and post doing ergonomic exercises. The implementation was carried out 3 times a week for a duration of 30 minutes. The results of the study showed that the blood pressure of the respondents experienced a decrease in blood pressure in systole 14-37 MmHg and diastole 4-15 MmHg. The application of ergonomic exercises is effective in reducing blood pressure in hypertension sufferers.
 
 
 

Preschool children have weak immunity, which causes children to get sick easily and receive hospital treatment which causes anxiety due to hospitalization. Anxiety results in fear of new environments, frequent crying, being spoiled, aggressive, depression and even causing trauma. Playing at preschool age is an important activity, playing by matching pictures can influence a person's feelings by stimulating the nervous system in the brain to regulate emotions. This research uses a descriptive case study. The research subjects were three people, the data collection instrument was carried out using the FIS (Faces Image Scale) scale observation sheet. After being given play therapy, the results were obtained on the first day at F before being given the intervention, the anxiety scale was 4, after being given the intervention, the anxiety scale was 4, A anxiety before 5 and after 4, S anxiety before 4 and after 4. On the second day, F anxiety before 4 and after 3, A anxiety before 4 and after 3, S anxiety before 4 and after 3. The third day F anxiety before 3 and after 2, A anxiety before 3 and after 2, S anxiety before 3 and after 2. After intervention for 3 consecutive days, it can be concluded that providing picture-matching play therapy to preschool children can reduce hospitalization anxiety. Parents should continue to meet children's play needs by inviting children to play and facilitating games according to what the child likes, and nurses are expected to focus on modifying children's play.