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Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

Rebonding is a chemical hair straightening procedure widely popular in Indonesia, involving two-stage redox reactions on keratin disulfide bonds using ammonium thioglycolate and hydrogen peroxide. Although it provides effective hair-straightening results, rebonding potentially causes significant damage to the hair cuticle structure. This study aimed to analyze the morphological changes of hair surface before and after rebonding treatment through a descriptive comparative case study approach using Scanning Electron Microscopy (SEM). The samples consisted of one strand of healthy, chemically untreated hair (control) and one strand of post-rebonding hair that both obtained from a female. Samples were prepared using gold-sputter coating prior to SEM observation. Representative SEM images from each sample were then qualitatively compared based on cuticle morphology parameters. The results showed clear morphological differences between the two samples: the control hair displayed tightly arranged and orderly cuticle scales with a smooth surface, while the post-rebonding hair showed surface erosion and the presence of cracks in multiple areas of the cuticle. These findings confirm that rebonding procedures cause visible and characterizable morphological cuticle damage as identified through SEM, providing a scientific basis for developing more protective post-rebonding hair care products.

Hydrogen-based hybrid microgrid systems have emerged as a promising solution to enhance renewable energy integration and improve energy supply reliability. By combining renewable sources such as solar and wind with hydrogen production and storage technologies, these systems address the intermittency of renewable power while ensuring continuous energy availability. This study evaluates the techno-economic feasibility, environmental impact, and scalability of hydrogen-based hybrid microgrids, with a focus on cost-effectiveness and system performance under varying operating conditions. Simulation tools, including HOMER Pro and MATLAB Simulink, are used to model the system and conduct sensitivity analyses on hydrogen production costs and demand fluctuations. Key performance indicators such as Levelized Cost of Energy (LCOE), Net Present Value (NPV), and CO₂ emissions reduction are assessed. The results show that although the system requires a high initial investment, it becomes economically viable over time due to reduced operational costs and improved efficiency. Additionally, the system demonstrates significant environmental benefits, outperforming conventional fossil fuel-based systems in terms of emissions reduction. Sensitivity analysis further indicates that advancements in hydrogen production technologies could substantially enhance economic feasibility. Overall, hydrogen-based hybrid microgrids offer a reliable and low-carbon energy solution, supporting sustainable energy transitions and reducing dependence on fossil fuels.

Litopenaeus vannamei is a brackish-water aquaculture commodity that is highly favored by the Indonesian community and represents one of the country’s leading aquaculture products, with production continuing to increase in response to rising domestic and export demand. One of the main factors triggering disease in L. vannamei is the presence of Vibrio sp. bacteria, which are recognized as serious pathogens in various aquaculture organisms and serve as causative agents of bacterial diseases. These bacteria naturally inhabit marine environments and are categorized as opportunistic, meaning they become pathogenic when environmental conditions decline and host health is compromised. Disinfectants are chemical substances used to inhibit or eliminate microorganisms such as bacteria, viruses, and fungi (excluding bacterial spores) on non-living surfaces. One disinfectant material is Smart Care (Intracare B.V., The Netherlands), which contains stabilized hydrogen peroxide with a prolonged-release mechanism. This study employed an experimental method using a Completely Randomized Design (CRD) with four treatments and five replications. The treatments included a control (without H₂O₂) and applications of H₂O₂ at concentrations of 1 ml/L, 2 ml/L, 3 ml/L, and 4 ml/L. The results indicated that the addition of hydrogen peroxide at different concentrations did not produce statistically significant differences in suppressing the growth rate of Vibrio sp. Nevertheless, treatment C (3 ml/L H₂O₂) showed the highest inhibitory effect, with no bacterial colony growth observed. Therefore, the application of H₂O₂ at 3 ml/L demonstrates potential in reducing Vibrio sp. growth and supporting sustainable shrimp aquaculture practices.

Vaname shrimp is one of the export commodities with high economic value. Therefore, to meet increasing market demand, it is necessary to improve aquaculture productivity. However, the development of vaname shrimp farming in Indonesia faces several challenges, including the emergence of viral, fungal, and bacterial diseases (Astria et al., 2022). Vibrio sp. bacteria can cause bacterial infections and are opportunistic in nature. Vibrio sp. can attack shrimp at all stages and may lead to decreased production yields (Astria et al., 2022). Generally, farmers control bacterial diseases by adding antimicrobial compounds. However, bacterial disease control in vaname shrimp culture can also be carried out using hydrogen peroxide (Astria et al., 2022). This study examined the effect of different doses of hydrogen peroxide in suppressing Vibrio sp. bacteria using a Completely Randomized Design (CRD). The doses used were 7 ppm, 9 ppm, 11 ppm, 13 ppm, and 15 ppm, with five treatments and five replications. The results showed that the application of different doses of hydrogen peroxide had a significant effect based on the One Way ANOVA test (0.00 < 0.05). The lowest effectiveness was observed in treatment 1 (7 ppm), while the highest effectiveness was found in treatment 5 (15 ppm). Although hydrogen peroxide was able to reduce the number of Vibrio sp. bacterial colonies, the doses used in this study were not able to completely eliminate the colonies (0 cfu/ml).

The development of automotive technology continuously seeks solutions to improve human mobility and address environmental concerns. This study focuses on the Hydrogen Reactor (HHO) technology as an alternative solution for fuel efficiency and emission reduction, specifically examining the legal protection of consumers utilizing this technology at Bengkel Karya Gemilang. The research aims to analyze the legal framework of consumer protection in the context of new energy-saving technologies and to identify the legal responsibilities of business actors (workshops) and the rights of consumers. Employing a normative legal research method with a case study approach, the study analyzes the implementation of Law No. 8 of 1999 concerning Consumer Protection (UUPK) in the utilization of HHO reactors. The findings indicate that while the HHO reactor technology offers a potential 5-15% increase in fuel efficiency and CO emission reduction, its implementation introduces new legal challenges, particularly regarding product safety, standardization, and the obligation for periodic servicing. Consumer protection is primarily ensured through the workshop’s obligation to provide clear product explanations, guarantee product safety, and fulfill the periodic service commitment. The study concludes that the existing UUPK provides a sufficient legal basis, but its implementation requires clear and transparent agreements, especially concerning the technical specifications and long-term maintenance of the HHO reactor, to ensure consumer rights are fully protected against potential risks associated with new, non-standardized automotive technologies.

The transition toward LNG, hydrogen, and ammonia propulsion systems represents a transformative shift in maritime decarbonization, introducing new technical, safety, and operational complexities. This study critically examines the effectiveness of Internet of Things (IoT) monitoring systems in enhancing propulsion efficiency, safety assurance, and regulatory compliance within alternative fuel vessels. Using a qualitative comparative design, data were collected from industry experts, maritime lecturers, and maritime graduates through structured thematic analysis. The findings indicate very high overall effectiveness, with safety assurance scoring highest, followed closely by propulsion efficiency and operational compliance. Cross-group analysis reveals strong consensus regarding IoT’s role in real-time leak detection, predictive engine diagnostics, and emission monitoring transparency. The study contributes by bridging propulsion engineering, digital monitoring technologies, and maritime governance perspectives, highlighting the importance of competency development for deck officers in interpreting IoT-generated data. The research demonstrates that IoT systems are foundational enablers of safe, efficient, and sustainable alternative fuel operations, supporting maritime economic resilience and long-term decarbonization strategies.

This research investigates stakeholder perspectives on alternative maritime fuel adoption barriers, opportunities, and regulatory frameworks within Southeast Asian shipping contexts. Employing qualitative-dominant mixed methods, the study gathered insights through Focus Group Discussions, interviews, and surveys with thirty-eight participants comprising maritime students, lecturers, and veteran practitioners at Sekolah Tinggi Ilmu Pelayaran Jakarta. Thematic analysis revealed substantial adoption barriers dominated by infrastructure inadequacy (28%) and economic competitiveness challenges (26%), with significant regulatory gaps particularly in financial incentive mechanisms (gap score: 2.9/5.0). Comparative fuel pathway assessment identified liquefied natural gas as most viable near-term alternative (overall score: 3.9/5.0) despite limitations as transitional fuel, while zero-carbon alternatives including ammonia (2.7/5.0) and hydrogen (2.5/5.0) face substantial technical, infrastructural, and economic challenges. Overall regulatory adequacy (2.49/5.0) falls substantially below stakeholder-perceived importance (4.55/5.0), producing a regulatory gap of 2.06 points. Findings emphasize need for integrated strategies combining coordinated infrastructure development, substantial financial support mechanisms, regulatory harmonization, and systematic workforce development accelerating fuel transitions toward decarbonization objectives.

Skin is the body's outermost organ, enveloping all parts of the human body. When the water content in the stratum corneum (SC) drops below 10%, the skin can become scaly, rough, and dry. Honey possesses humectant, emollient, and antioxidant properties, making it an effective moisturizer. The humectant properties of honey stem from its high sugar content, particularly glucose and fructose. These  sugars form hydrogen bonds with water, helping to retain moisture in the skin and thus providing a hydrating effect. Additionally, honey contains vitamin C, alpha hydroxy acids, and flavonoids, which contribute to the elasticity and firmness of the skin. Therefore, it is important to conduct a narrative review on the use of honey as a moisturizer in topical preparations, which can serve as a reference for future research. The literature search for this review was conducted using databases such as Google Scholar, Garuda Journal, MDPI, ResearchGate, and Publish or Perish, employing specific inclusion and exclusion criteria. The findings concluded that honey can be used as a moisturizer in various dosage forms, including body scrubs, anti-aging and moisturizing creams, serums, peel-off gel masks, lip moisturizers, and lip scrubs. The concentration of honey used in these formulations depends on the dosage form, its intended function in the formula (whether as an active substance, humectant, or emollient), and the comparison of honey concentration with other ingredients.

The increasing energy demand due to population growth and industrial development has driven the search for clean and renewable alternative energy sources. One promising solution is hydrogen-based energy through water electrolysis, which produces HHO gas (a mixture of hydrogen and oxygen).  The efficiency of the electrolysis process is significantly influenced by the type and concentration of the electrolyte solution used, such as NaCl and KOH, as well as the electrode material here, stainless steel SS316L. This study shows that increasing the mass of the electrolyte solution enhances hydrogen production. NaCl with a mass of 153 grams produced 1,509 ppm of hydrogen at the high-variable setting, while KOH with a mass of 147 grams produced up to 2,320 ppm. However, KOH also caused higher corrosion levels, reaching 0.117 grams in the high-variable setup, compared to NaCl at 0.038 grams. The Cl⁻ and OH⁻ ions in the electrolyte are highly reactive and contribute to electrode surface degradation. Furthermore, the electrode position affects hydrogen productivity, where closer proximity to the power source improves reaction efficiency. Therefore, the selection of electrolyte type and the optimization of the electrolysis system configuration are crucial in the development of efficient hydrogen production technology.

Antioxidants are substances that can inhibit oxidation caused by free radicals. Flavonoids are effective natural antioxidants due to their unique chemical structure. Both have a hydroxyl group (-OH) attached to an aromatic ring. This hydroxyl group can donate hydrogen or electrons to free radicals. Clove stems (Syzygium aromaticum (L.)) are known to possess bioactive compounds, including flavonoids like quercetin and kaempferol, which act as antioxidants in protecting cells from free radicals. Maceration is a commonly used extraction method to obtain therapeutic compounds from plants. The process involves soaking the finely or coarsely ground plant material in a solvent (liquid thinner) in a closed container. Fractionation is a method for separating chemical components in an extract based on differences in their polarity or solubility. This process uses two immiscible solvents. This study is an experimental research aimed at determining the total flavonoid content (TFC) and the IC50​ value of the antioxidant activity present in the ethanol extract and fractions of clove stems (Syzygium aromaticum (L.)) using the ABTS method. The tests utilized maceration extraction with 96% ethanol as the solvent, and liquid-liquid fractionation using N-hexane, ethyl acetate, and water as solvents, along with UV-Vis spectrophotometry analysis. The results showed that the highest flavonoid content was in the ethanol extract, with a TFC value of 51.000 mgQE/g, and the highest antioxidant activity was in the ethyl acetate fraction, with an IC50​ value of 23.716 µg/mL, indicating a strong potential as a source of natural antioxidants.

Inflammation is the body's natural biological response to tissue injury, infection, or other harmful stimuli. Inflammatory processes play an important role in maintaining the body's homeostasis, but excessive or chronic inflammation can trigger various degenerative diseases, including arthritis, cancer, and cardiovascular disorders. One of the main mediators of inflammation is the enzyme cyclooxygenase-2 (COX-2), which is in charge of converting arachidonic acid into pro-inflammatory prostaglandins. Inhibition of COX-2 activity is an important strategy in controlling inflammation. Selective COX-2 inhibitors (Coxibs) have been developed to reduce the gastrointestinal side effects commonly caused by conventional nonsteroidal anti-inflammatory drugs (OAINS). However, the use of Coxibs still poses a significant cardiovascular risk, so the search for alternatives from natural ingredients continues. Flavonoid compounds, which are abundant in fruits, vegetables, teas, and spices, show great potential as natural COX-2 inhibitors. Flavonoids have a polyphenol structure that allows for strong interactions with COX-2 active sites through hydrogen bonding and hydrophobic forces. This study is a literature review that examines the potential of flavonoids from natural ingredients as COX-2 inhibitors based on an in silico approach. This method was carried out through a literature search on the Google Scholar database using the keywords "Flavonoid", "COX-2", "In Silico", "Molecular Docking", and "Anti-inflammatory". The results of the analysis of ten articles showed that compounds such as myricetin, quercetin, rutin, catechin, and epicatechin-3-O-gallate have a high bonding affinity with COX-2, even exceeding in some cases standard drugs such as diclofenac and dexamethasone. Low bond energy values (ΔG) and optimal amount of hydrogen bonds support this potential. The findings indicate that flavonoids from natural ingredients can be developed into candidates for selective anti-inflammatory drugs COX-2 that are safer and more effective than existing synthetic therapies.

Bunga telang (Clitoria ternatea L.) also known as blue pea, is a distinctive flower with single petals, that come in purple, blue, pink, and whote color. This flower is widely used as a natural colorant due to its high anthocyanin content, lemon juice was added to butterfly pea flower to determine antioxidant activity based on the number of hydroxyl groups capable of donating hydrogen atoms to free radical compounds. The color change observed is influenced by the acidity level (pH) of the beverage. Lemon contains a high amount of citric acid, which can flower the pH of the butterfly peaextract solution.  The colot change from blue to purple, redpr even pink indicates reaction anthocyanins to pH changes. Antioxidant activity was teste using the DPPH ( 2,2-diphenyl-picrylhydrazil) method, which measueres the samples ability to scavenge free radical. The lower the IC 150 value obtained, the stronger the antioxidant capacity of the substance. The results showed that the water content in butterfly pea tea was 15,5% and total ash content in butterfly and total ash content was 8%. The IC 50 value obtained was 53,65 which is classified as very strong in antioxidant activity and shows great potential as a natural antioxidant source

Indonesia, as the world's largest archipelagic nation, holds a strategic position while simultaneously facing significant challenges in maintaining the sovereignty and security of its maritime territory. Increasingly complex maritime threats, such as illegal fishing, smuggling, and potential geopolitical conflicts, demand a transformation in maritime defense strategies to be more efficient and sustainable. In an era of increasing global awareness of the climate crisis, the maritime sector, including the defense sector, is being encouraged to decarbonize through the implementation of environmentally friendly ship technology. This research uses a literature review approach by examining various findings related to sustainable propulsion technology innovations relevant to the development of Indonesia's maritime defense fleet. The study results show that a hydrogen- and battery-based hybrid propulsion system can reduce carbon emissions by up to 73% and increase energy efficiency by 35%. In addition, wind-assisted propulsion sistem (WAPS) technology such as Flettner rotors and wing-sails contributes significantly to reducing fuel consumption by up to 30%, while extending ship cruising range without the need for intensive refueling. Meanwhile, the application of Computational Fluid Dynamics (CFD)-based propeller design optimization has been proven to reduce energy consumption by 13.2% and reduce noise levels by up to 15 dB, which greatly supports the needs of stealth operations in military missions. This study concludes that the implementation of environmentally friendly ship technology not only provides benefits in terms of energy efficiency and emission reduction, but also strengthens the operational resilience and strategic competitiveness of the Indonesian naval fleet amidst the dynamics of global maritime security. Thus, the Green Navy concept can be seen as a relevant and urgently needed sustainable defense strategy.

Hypertension, also known as the silent killer, is a serious threat in the world of global health because it causes various vascular diseases to maternal and child mortality during pregnancy. The existence of herb therapy by consuming black garlic has the potential to control and reduce blood pressure. Through this study, it is intended to examine and review the relevant literature and summarized to obtain information about the effectiveness of black garlic consumption on lowering blood pressure in patients with hypertension. The research method uses a literature review based on Google Scholar as a database within the maximum publication range of the last 5 years. The data used is secondary data from previous research results. The results showed that there was a decrease in blood pressure in hypertensive patients after consuming black garlic due to the presence of S-allyl cysteine (SAC), flavonoids, and hydrogen sulfide compounds. Therefore, it has the opportunity to become one of the options in traditional therapy to prevent and treat hypertension conditions.

Diabetes mellitus, especially type 2, is a growing epidemic with almost 90% of cases reported worldwide. Antioxidants are compounds that are in lower concentrations compared to the concentration of oxidizable compounds, can significantly prevent or inhibit the oxidation of the substrate. The formation of more stable oxidant compounds through intramolecular hydrogen bonds in the further oxidation process. Data collection was carried out using Google Scholar, Science Direct and PubMed databases. The literature sources used were in the form of research results that had been published in 2011-2021 in national and international journals. Providing antioxidants is an effort to inhibit the production of intracellular free radicals or increase the ability of defense enzymes against free radicals in order to prevent the emergence of oxidative stress and diabetes-related blood vessel complications. Various supplements containing antioxidants and/or factors that can increase the production of nitric oxide (NO) have the potential to improve endothelial dysfunction and mitochondrial function in cells, as well as reduce the activity of the NAD(P)H oxidase enzyme. 

This study reveals a significant correlation between the phenomenon of underwater rivers discussed in modern oceanographic studies and the scientific signs contained in Surah Al-Furqan verse 53. This verse not only illustrates the difference between two types of water, but also represents physical phenomena that can be explained scientifically, such as the existence of halocline layers and hydrogen sulfide compounds that appear in the transition area between fresh water and sea water. Both classical and contemporary interpretations show that the Qur'an implicitly conveys instructions regarding natural realities that can only be understood through a contemporary scientific approach. The scientific interpretation approach opens up integrative opportunities between divine revelation and empirical knowledge, which not only strengthens the dimension of faith but also stimulates rational, scientific, and spiritual thinking in exploring the meaning of the kauniyah verses. Thus, this study emphasizes the importance of a multidisciplinary approach in understanding the Qur'an in a way that is relevant to the dynamics of science and the challenges of the times.  

Background: The global energy transition requires low-carbon solutions that can be integrated into existing thermal systems without drastic infrastructure changes. Hydrogen blending in conventional combustion systems has emerged as a promising pathway to reduce carbon emissions while maintaining operational flexibility. Objective: This study aims to experimentally evaluate the effect of hydrogen blending ratios (0–100% by volume) on thermal efficiency, CO₂ emissions, and NOx emissions, and to determine the optimal blending range based on technical and economic feasibility. Methods: An experimental thermal system prototype was developed and tested under controlled conditions with three repetitions per operating point. Performance parameters included combustion temperature, fuel consumption rate, and thermal efficiency, while emissions of CO₂ and NOx were measured using a calibrated gas analyzer. Data were analyzed using descriptive statistics, one-way ANOVA at a 0.05 significance level, confidence interval estimation, and linear regression to examine the relationship between hydrogen fraction and emission reduction. Results: The findings indicate that increasing hydrogen fraction significantly improves thermal efficiency, reaching 87.5% at 100% hydrogen, while CO₂ emissions decrease linearly to zero. However, NOx emissions increase with higher hydrogen content due to elevated combustion temperatures. Statistical analysis confirms that hydrogen ratio has a significant effect on efficiency and emissions, with a strong linear correlation between hydrogen fraction and CO₂ reduction. A blending range of 40–60% hydrogen provides the most balanced performance in terms of efficiency improvement, emission reduction, and cost feasibility.

The scarcity of fuel that has an impact on the high selling price of fuel, then there needs to be an effort to save fuel in motor vehicles. The solution to this problem is to use renewable fuel, one of the renewable fuels is hydrogen gas. With the addition of renewable energy in the form of HHO gas (Hydrogen Hydrogen Oxygen) from water electrolysis. The purpose of this study was to determine the effect of the application of an electrolyzer on saving fuel consumption in motor vehicles. By using a quantitative method with an experimental research design to test the effect of two variables whether there is a change in the form of fuel savings before and after the installation of the electrolyzer tube. Based on the trials that the researcher has conducted, the results of the study were obtained, namely that the addition of an electrolyzer has an effect on the fuel consumption of 4-stroke motorcycles, both in static and dynamic tests. So with the addition of an electrolyzer, it will be able to save fuel consumption in motorcycles when compared to without using an electrolyzer    

The modulation of the structures and electronic properties of transition metal complexes by multi-ligands coordination has been widely exploited to enhance the catalytic efficiency in organic transformations. Here, we present synthesis, characterization, and catalytic performance of Cu(II), Ni(II) and Pd(II) complexes of multidentate ligands- EDTA, 1,10-phenanthroline and N-heterocyclic carbenes (NHCs). The Pd-NHC complex displayed the high catalytic activity for hydrogenation as well as small-molecule activation, up to 450 h⁻¹ of turnover frequency (TOF) and total conversion of styrene to ethylbenzene at room temperature, and is higher efficient than Cu-EDTA (TOF =120 h⁻¹), Ni-Phen (TOF= 85 h⁻¹). The DFT calculation with Pd-NHC system showed that the small HOMO-LUMO gap (3.2 eV) and the short Pd–C bond (1.95 Å) of Pd-NHC, which could facilitate the transfer of the growth species, contributed to the low energy of activation (28 kJ/mol). Mathematical model also discussed its high catalytic activity (TOF/Ea = 16.07 h⁻¹·kJ⁻¹·mol) due to the strong σ-donor ligands and proper geometry. These findings underscore the influence of ligand architecture to secure transition states and modulate electron density in designing efficient sustainable catalysis that is industrially relevant.