Publication Search

79,575 articles from 739 journals · 2,111 citations tracked

Showing 1-20 of 270

Analytics

Nur Fadila, Aisyah; Ellya Roziana, Norma; Chauliya Nadina Putri, Rayshya; Muharwati, Marini; Naufarezi, Rayhan +2 more

Journal of Administrative and Sosial Science (JASS) 2026 Sekolah Tinggi Ilmu Administrasi (STIA) Yappi Makassar

The Rumah Padat Karya Program in Surabaya City is one of the local government policies to reduce poverty through job creation and empowerment of low-income communities (MBR). This study aims to evaluate the effectiveness of the Rumah Padat Karya Program in reducing poverty rates in Surabaya and to assess its alignment with the Sustainable Development Goals (SDGs), particularly Goal 1 (No Poverty), Goal 8 (Decent Work and Economic Growth), and Goal 11 (Sustainable Cities and Communities). The study employs a formal evaluation approach with a formative evaluation type, given that the program is still ongoing. Data were collected through interviews, observation, and documentation, and analyzed qualitatively. The evaluation was conducted using William N. Dunn’s (2003) criteria, comprising effectiveness, efficiency, adequacy, equity, responsiveness, and appropriateness. The results indicate that the program is fairly effective in reducing poverty and unemployment through local workforce absorption and the productive utilization of previously idle government assets. However, limitations remain, including budget constraints, inter-district facility disparities, weak inter-agency coordination, and suboptimal business mentoring and market access. Therefore, it is necessary to strengthen the mentoring system, equalize facilities, and enhance cross-sector collaboration so that the program can run more optimally and sustainably.  

Herman Herman; Putra Budi Ansori

JURNAL MANAJEMEN DAN BISNIS EKONOMI 2026 Institut Teknologi dan Bisnis (ITB) Semarang

This paper examines the determinants of income inequality within the SDGs framework in Riau Province. Utilizing BPS secondary data from 2018–2025 across 12 regencies/cities, data were estimated using te random effect modelapproach applied to panel regresiion in EViews 12. F-test finding indicate that-HDI, LN_GRDP, and our jointly and  significant influences on the Gini Ratio (R2 = 39.68%). Partially (t-test), HDI has a significant positive effect due to labor polarization in modern sectors. Conversely, LN_GRDP has a significant negative effect, confirming a trickle-down effect in reducing inequality. Meanwhile, OUR has no significant effect due to high labor absorption in Riau's informal agricultural and plantation sectors.

Aqilla, Rosyida Salsabil; Putro, Raden Kokoh Haryo

JURNAL WILAYAH, KOTA DAN LINGKUNGAN BERKELANJUTAN 2026 Fakultas Teknik Universitas Cenderawasih

Lead (Pb²⁺) is a hazardous heavy metal commonly found in industrial wastewater and poses serious risks to human health and the environment due to its toxic and non-biodegradable nature. Therefore, an effective and environmentally friendly treatment method is required to reduce Pb²⁺ concentration in wastewater. This study aimed to evaluate the effect of pH and initial Pb²⁺ concentration on the adsorption capacity of ramie leaf (Boehmeria nivea) bioadsorbent activated with NaOH. The adsorption process was conducted using a batch system with pH variations of 4, 5, and 7 and initial Pb²⁺ concentrations of 20, 25, and 30 mg/L. The residual Pb²⁺ concentration was analyzed using Atomic Absorption Spectrophotometry (AAS), and the adsorption performance was evaluated based on removal efficiency and adsorption capacity (Qe). The results showed that pH and initial Pb²⁺ concentration significantly affected the adsorption performance. The optimum adsorption condition was obtained at pH 5, with a maximum removal efficiency of 99.20% and a total adsorption capacity of 18.56 mg/g. The increase in pH from 4 to 5 enhanced adsorption performance due to reduced competition between H⁺ and Pb²⁺ ions for active sites on the adsorbent surface. Increasing the initial Pb²⁺ concentration tended to increase adsorption capacity, although removal efficiency remained relatively stable due to the limited number of active adsorption sites. The Relative Standard Deviation (RSD) values ranged from 1.56% to 3.37%, indicating good precision and repeatability of the experimental data. These findings demonstrate that NaOH-activated ramie leaves have considerable potential as an effective, low-cost, and environmentally friendly bioadsorbent for Pb²⁺ removal from wastewater.

Rania Nurlita Sari; Raden Kokoh Haryo Putro; Yerry Kahaditu Firmansyah

Jurnal Sains dan Teknologi 2026 Fakultas Teknik Universitas Cenderawasih

Lead (Pb²⁺) contamination in wastewater is a major environmental concern due to its toxicity, persistence, and ability to accumulate in living organisms. Adsorption using biomass-based materials has been developed as an alternative treatment method because it is efficient, economical, and environmentally friendly. This study aimed to analyze the effect of bioadsorbent dosage and contact time on Pb²⁺ removal efficiency and evaluate Pb²⁺ mass distribution using mass balance analysis in a batch adsorption system. Ramie leaf (Boehmeria nivea) was utilized as a bioadsorbent due to its lignocellulosic content, which provides active sites for metal ion adsorption. The research was conducted experimentally through bioadsorbent preparation, chemical activation, and batch adsorption using artificial Pb²⁺ solutions with variations in bioadsorbent dosage and contact time. Pb²⁺ concentrations before and after adsorption were analyzed using Atomic Absorption Spectroscopy (AAS). The obtained data were used to determine removal efficiency and Pb²⁺ distribution between the liquid phase and bioadsorbent. The results showed that ramie leaf bioadsorbent effectively reduced Pb²⁺ concentration, with the optimum condition obtained at 4 g/L bioadsorbent dosage and 90 minutes contact time, achieving 98.46% removal efficiency. Mass balance analysis indicated that Pb²⁺ ions were successfully transferred from the solution phase onto the bioadsorbent surface. These findings demonstrate that ramie leaf bioadsorbent has potential as a sustainable alternative material for heavy metal removal in wastewater treatment.

Desi Nopiyanti; Zulfanetti Zulfanetti; Helen Parkhurst

JURNAL EKONOMI BISNIS DAN MANAJEMEN (JISE) 2026 CV. ALIM'SPUBLISHING

One key measure of a region's economic growth is the employment rate, as it reflects the ability of the economy to absorb labor and improve community welfare. In Jambi Province, employment opportunities are influenced by several factors, including Gross Regional Domestic Product (GRDP), population growth, and the Human Development Index (HDI). This study aims to analyze the effects of GRDP, population growth, and HDI on employment growth rates across regencies and cities in Jambi Province. The research employs a quantitative approach using panel data regression analysis covering 11 regencies and cities during the period 2017–2023. The findings indicate that GRDP growth, population growth, and HDI simultaneously influence employment levels. Partially, population growth and HDI have significant effects on employment, indicating that improvements in human development and demographic dynamics contribute to labor absorption. Meanwhile, economic growth, as measured by GRDP, has a relatively small negative effect on employment. This suggests that economic expansion does not always generate proportional employment opportunities, possibly due to structural changes and technological developments. Therefore, policies aimed at improving human capital and labor market conditions are essential to support sustainable employment growth in Jambi Province.

Khairul Akhyar; Nurul Jannah; Imsar , Imsar; Muhammad Ikhsan Harahap

JURNAL RISET EKONOMI DAN AKUNTANSI (JREA) 2026 Institut Teknologi dan Bisnis (ITB) Semarang

Poverty is a multidimensional problem that remains a major development challenge in Central Tapanuli Regency. Growth in Gross Regional Domestic Product (GRDP), increased realization of Foreign Direct Investment (PMA) and Domestic Direct Investment (PMDN), and zakat collection should be important instruments in reducing poverty rates. However, data from 2019–2023 shows a discrepancy, where the growth in these macroeconomic and social indicators is not accompanied by a decrease in the number of poor people. This study aims to analyze the influence of zakat, GRDP, PMA, and PMDN on poverty levels in Central Tapanuli Regency. The research method used is qualitative descriptive analysis with secondary data from BPS, BAZNAS, and BKPM as well as interviews with relevant parties. The results show that zakat does contribute to alleviating the burden on mustahik, but its role is still limited because the majority of distribution is consumptive. GRDP increased from Rp9.95 trillion in 2019 to Rp13.67 trillion in 2023, but the resulting economic growth is not yet inclusive. Foreign direct investment (FDI) tends to be oriented towards large capital with limited labor absorption, while domestic direct investment (PMDN) is closer to local needs but still less than optimal in poverty alleviation. Overall, the increase in zakat, GRDP, FDI, and PMDN has not been able to reduce the poverty rate, which actually increased from 376,474 people in 2019 to 489,760 people in 2023. Thus, a more inclusive development strategy, optimization of productive zakat, and investment policies that favor labor-intensive sectors and MSMEs are needed so that economic growth truly impacts poverty reduction.

Annisa Uljannah; Afiqah Divaulhaq

Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan 2026 Asosiasi Riset Ilmu Kesehatan Indonesia

Hydrocephalus is defined as active distension of the brain’s ventricular system, resulting from inadequate flow of cerebrospinal fluid from its site of production to its site of absorption into the systemic circulation. Hydrocephalus can affect anyone at any age; pediatric hydrocephalus affects 1 in 1,000 live births and is the most common cause of brain surgery in young patients. Hydrocephalus is a pathological condition characterized by abnormal accumulation of cerebrospinal fluid (CSF) due to increased production, impaired flow, or reduced absorption. Ventricular enlargement occurs in response to increased CSF volume and can lead to structural damage to the brain parenchyma. This condition can be congenital or acquired. One key point in prenatal diagnosis is the differentiation between fetal hydrocephalus and non-hypertensive ventriculomegaly. The former qualifies for intrauterine treatment with good outcomes. However, the latter can result in either favorable or catastrophic outcomes due to a damaging etiology, as seen in viral infections such as Zika virus. For an accurate diagnosis, fetal MRI is performed to detect brain anomalies, in addition to fetal ultrasound (to detect common complications), karyotype testing, and TORCH testing (toxoplasma, rubella, cytomegalovirus, herpes simplex). Obstetric management of fetal hydrocephalus depends on the gestational age at diagnosis and the presence of other anomalies. Treatment options include termination of pregnancy before the fetus is viable, placement of a ventriculoamniotic shunt, cephalocentesis before delivery, and/or cesarean section.

Agnes Rantesalu; Hardianti Hardianti; Adillah Imansari

Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi 2026 LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Background: The prevalence of Chronic Energy Deficiency (SEZ) of pregnant women nationally is still 16.9%, and anemia reaches 27.7%, so the development of local food-based Supplementary Feeding (PMT) is needed. Brownies with the substitution of red spinach as a source of iron and purple sweet potato flour as an energy source have the potential to be developed as an alternative to PMT. This study aims to determine the acceptability and nutritional content of red spinach brownies with the addition of purple sweet potato flour as an interlude food for pregnant women. Method: Design using the Complete Random Design (RAL) method. The formulation of making brownies consists of three treatments with a comparison between (red spinach pureee and purple sweet potato flour) as follows: F1 (50:50), F2 (60:40), and F3 (40:60). The acceptance test was conducted using a hedonic test of color, aroma, taste, and texture on 30 semi-trained panelists. Analysis of nutritional content includes moisture content (thermogravimetry), ash content (dry ashing), protein (Kjeldahl), fat (Soxhlet), carbohydrates (by difference), and Fe (Atomic Absorption Spectrophotometry). The data were analyzed using the Kruskal-Wallis test. Research Results: The acceptability test showed that there was no significant difference between the formulations. The F3 formulation with a ratio of 40% red spinach pureee and 60% purple sweet potato flour obtained the highest preference value and was determined as the best formulation. The nutritional content of the F3 formulation includes protein 10.447%, fat 8.047%, carbohydrates 1.5579%, Fe 0.0005%, moisture content 20.68%, and ash content 1.4875%. Conclusion: There was no significant effect of each formulation on the acceptability of Brownis Suggestion: It is hoped that the next researcher can improve product formulation and processing processes to maintain and increase iron (Fe) levels in brownies.

Fadilah Balqis; Anwar Sidik

Jurnal Riset Ilmu Pendidikan, Bahasa dan Budaya 2026 Asosiasi Periset Bahasa Sastra Indonesia

The background of this research is driven by the vital importance of strengthening democratic values amidst the challenges of globalization and digitalization, which have begun to erode civic consciousness among the younger generation, particularly in the Pasir Pengaraian region. As the flow of unfiltered information increases, there are significant concerns regarding the decline in understanding the essence of participatory democracy and civic ethics. The primary objective of this study is to analyze in depth the strategic role of civic education as a means to preserve democratic ideals and to identify supporting and inhibiting factors in its implementation within higher education environments. The research method employed is a descriptive qualitative approach, utilizing observations and in-depth interviews with students and academics in Pasir Pengaraian to obtain an objective overview of local political dynamics. Research findings indicate that civic education serves effectively as a pillar of political literacy capable of transforming student perceptions from apathy to active participation, while also serving as a medium for character building that respects diversity of opinion. Furthermore, the integration of local Pasir Pengaraian values with the national curriculum is proven to increase the relevance and absorption of democratic material among students.

Natasya Bethari; Siti Rahima; Annisa Fatia Rizki; Nurul Kamaly; Reza Fahlevi

Jurnal Pendidikan dan Kewarganegara Indonesia 2026 Asosiasi Riset Ilmu Pendidikan Indonesia

Unemployment remains a serious challenge in Aceh, with an Open Unemployment Rate (OUR) of 8.24% (2025) in Lhokseumawe City and 6.54% (2025) in Banda Aceh City. This study compares the implementation and effectiveness of unemployment alleviation policies in the two cities using Van Meter and Van Horn's policy implementation framework with four effectiveness indicators: training absorption, job placement rate, corporate compliance, and community participation. A descriptive qualitative method with a literature study approach was employed, utilizing secondary data from journals, theses, and official documents. The findings show that Banda Aceh focuses on competency-based training through the Job Training Center (BLK) with certification and third-party partnerships. Lhokseumawe prioritizes Qanun Number 1 of 2020 on local labor priority (minimum 40%). Based on the indicators, Banda Aceh is more effective (55% of graduates employed) compared to Lhokseumawe, where local labor priority implementation is weak due to the absence of sanctions and non-existent coordination with PT. PAG. The novelty of this study lies in its systematic comparison of two Acehnese cities using a policy implementation model that integrates demographic bonus and local context. Specific recommendations: Banda Aceh needs to expand BLK capacity, extend training duration (9–12 months with internships), and mandate graduate absorption reports. Lhokseumawe needs to revise the qanun by adding administrative sanctions, recruit permanent instructors, establish a tripartite supervisory team, and establish an energy-sector BLK in the Arun area in collaboration with PT PAG.

Budi Abdullah; Reysya Yusdianingsih; Nandita Saskya; Muhammad Muarif; Juliana Handayani br. Simatupang +2 more

Jurnal Hukum dan Sosial Politik 2026 International Forum of Researchers and Lecturers

This study aims to analyze the unemployment rate in Indonesia during the 2024–2025 period using a linear regression approach based on data from the National Labor Force Survey (Sakernas). The variables used include the labor force, employed population, labor force participation rate (LFPR), and open unemployment rate (OUR). The results show that the labor force increased from 149.38 million in February 2024 to 155.27 million in November 2025, followed by an increase in employed population from 142.18 million to 147.91 million in the same period. Meanwhile, the open unemployment rate decreased from 4.76 percent in February 2025 to 4.74 percent in November 2025. The analysis indicates that the increase in labor force accompanied by higher employment absorption contributes to reducing unemployment, although the decline remains relatively small. Overall, the regression results show that labor market dynamics are influenced by the interaction between labor force growth and the economy’s capacity to absorb labor.

Diah Karina Wibowo; Ervina Damayanti; Ramadhan Triyandi; Muhammad Fitra Wardhana Sayoeti

Jurnal Riset Ilmu Farmasi dan Kesehatan 2026 Asosiasi Riset Ilmu Kesehatan Indonesia

Diarrhea remains a leading cause of mortality among toddlers in Indonesia, with a prevalence reaching 4,9%. In addition to pharmacological management through LINTAS DIARE, non-pharmacological therapies such as baby massage are increasingly being implemented as supportive interventions that families can perform to accelerate recovery. This study aims to examine the effectiveness of baby massage as a complementary therapy in reducing the frequency and intensity of diarrhea in toddlers. The method used involved identifying relevant articles from Google Scholar and Semantic Scholar databases using appropriate keywords. Based on the 6 articles obtained, baby massage significantly (p = 0,000) reduces the frequency and intensity of diarrhea through vagus nerve stimulation, which optimizes intestinal peristalsis and nutrient absorption. Beyond improving defecation patterns, this therapy is proven to significantly increase infant weight, accelerate motor development through central nervous system stimulation, and enhance sleep quality and comfort.

Aditya Hanif Permana; Yuniarti Dewi R; Rifatul Masrikhiyah; Diah Ratnasari

Jurnal Ilmu Kesehatan dan Gizi 2026 Pusat Riset dan Inovasi Nasional

Iron deficiency anemia remains a major public health problem among pregnant women in Indonesia, with a national prevalence of 37.1% and higher rates in regions such as Brebes Regency. Adequate nutritional knowledge and sufficient iron intake are expected to prevent decreases in hemoglobin (Hb) levels during the third trimester. This study aimed to analyze the relationship between nutritional knowledge, iron intake adequacy, and Hb levels among third-trimester pregnant women at Puskesmas Brebes. An analytic observational study with a cross-sectional design was conducted on 62 respondents using total sampling. Data were collected through a nutritional knowledge questionnaire, a Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) to assess iron intake based on the Recommended Dietary Allowance of 27 mg/day, and Hb measurement using a digital device. The prevalence of anemia was 32.3%, with a mean Hb level of 11.25 ± 1.74 g/dL. Most respondents had high nutritional knowledge (72.6%), but 79.0% had inadequate iron intake. Chi-Square analysis showed no significant relationship between nutritional knowledge and Hb levels (p=0.109) or between iron intake adequacy and Hb levels (p=0.426). Other factors, including iron absorption inhibitors, compliance with iron supplementation, nutritional status, and limited sample size, may have influenced the results.

Julfrista Sinlae; Rafael Rape Tupen; Marlyani Anita Seran

Jurnal Riset Rumpun Ilmu Sosial, Politik dan Humaniora 2026 Lembaga Pengembangan Kinerja Dosen

Village institutions play an important role in supporting participatory and sustainable rural development. The Village Law No. 6 of 2014 recognizes village autonomy and emphasizes the importance of community participation through Village Community Institutions (Lembaga Kemasyarakatan Desa/LKD). However, the implementation of these institutions in practice has not always functioned effectively. This study aims to analyze the role of village community institutions in supporting village development and to identify the factors that influence their effectiveness in Oematamboli Village, Lobalain District, Rote Ndao Regency. This research employs an empirical legal research method with a qualitative approach. Data were obtained through interviews and field observations involving village government officials, community institution administrators, and community leaders, while secondary data were obtained from documents and relevant regulations. The results indicate that the functions of LKD, including the Community Empowerment Institution (LPM), Neighborhood Associations (RT), and Community Associations (RW), have not been implemented optimally in supporting village development. This condition is reflected in the limited participation of LKD in development planning, weak absorption of community aspirations, and low community participation in development activities. Several factors influencing this condition include limited human resource capacity, inadequate infrastructure, low community participation, and limited development funding. Therefore, strengthening institutional capacity, improving coordination, and increasing community participation are necessary to enhance the effectiveness of village development.

Muhammad Ramadhani Rahman; Kurnia Putri Dinanti; Nabila Maulidia Fatahillah; Ahmad Zaidan Wahab; Sendi Hendiawan Prayogo

Jurnal Riset Rumpun Ilmu Teknik 2026 Pusat riset dan Inovasi Nasional

The problem of urban flooding is a growing issue due to high population density, increasing volumes of plastic waste, and the reduction of water absorption areas. The use of conventional paving blocks, which are impermeable, further exacerbates flooding conditions because they do not allow water to infiltrate into the soil. This study aims to develop an innovative plastic waste-based paving block incorporating rice straw and sugarcane bagasse, along with the integration of phytoremediation concepts as a solution for urban flood mitigation. The method employed was an experimental approach involving the following stages: material preparation, plastic incineration, material mixing, molding, and testing of water absorption capacity and compressive strength. The results showed that paving blocks with a combination of plastic waste, rice straw, and sugarcane bagasse had the highest water absorption rate of 34% and compressive strength of 21 kg/cm², meeting SNI standards. The addition of natural materials containing silica was proven to enhance the material’s porosity and strength. Additionally, the application of phytoremediation using water hyacinth has the potential to improve the quality of water seeping into the soil. Thus, this phytoremediation-based paving block innovation can serve as an effective alternative solution to reduce flood risks while supporting sustainable waste management and environmental stewardship.

Zahra Safira Yunar; Nur Dwi Wahyu Wibowo; Nia Nurul Imana

Jurnal Riset Rumpun Ilmu Tanaman 2026 Pusat riset dan Inovasi Nasional

The prevalence of non-communicable degenerative diseases in Indonesia continues to rise, particularly affecting adolescents and productive age populations due to unhealthy lifestyle patterns and free radical exposure. Purple sweet potato leaves (Ipomoea batatas L.), a locally abundant resource often regarded merely as agricultural by-product, contain significant bioactive compounds including polyphenols, flavonoids, anthocyanins, and terpenoids demonstrating potent antioxidant properties with IC50 values of 47.99 ppm. This study employs a qualitative descriptive literature review approach, analyzing 28 scientific publications spanning 2018-2025 sourced from Google Scholar and PubMed databases to examine the potential of purple sweet potato leaves as effervescent tablet raw material for degenerative disease prevention. Findings reveal that bioactive constituents effectively neutralize free radicals, prevent lipid peroxidation, and protect cellular structures from oxidative damage linked to diabetes, cancer, and cardiovascular disorders. The effervescent tablet formulation provides strategic advantages including enhanced solubility, accelerated absorption rates due to elimination of disintegration processes, pleasant carbonation sensation masking unpleasant active ingredient taste, and superior gastrointestinal tolerance. This innovation offers promising prospects for degenerative disease prevention through local food resource utilization, though experimental validation regarding optimal formulation, effective dosage determination, and clinical efficacy assessment remains necessary for practical implementation.

Syadzna Malika Maimun; Miswati Furqani; Hafizatun Suardi; Nabila Aini; Shahira Yasmin +1 more

Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam 2026 Pusat riset dan Inovasi Nasional

This study aims to analyze the potential of eupatorin found in Cat’s Whiskers (Orthosiphon stamineus) as an anticancer agent using in silico methods. Eupatorin was selected due to its promising biological activity reported in previous literature. The research employed compound structure data registered in PubChem, analyzed through PASS Online for pharmacological activity prediction, ProTox-II for toxicity evaluation, and pkCSM for ADMET parameters. The results indicated that eupatorin has a high probability of inhibiting cancer cell proliferation with significant pharmacological activity values. Toxicity predictions showed a safe profile with an LD50 supporting its potential therapeutic use. ADMET analysis demonstrated that eupatorin possesses good bioavailability, adequate absorption and distribution, and minimal metabolic interactions, supporting its efficacy as an anticancer compound. These findings suggest that eupatorin could be an important candidate for herbalbased drug development, particularly for cancer therapy, and provide opportunities for further research through in vitro and in vivo experiments to validate anticancer activity comprehensively.

Nilsya Febrika Zebua; Nerdy Nerdy; Lidia Muliani; Dikxi Putri Mulyana; Fathur Raihan Amri +1 more

Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam 2026 Pusat riset dan Inovasi Nasional

This study aims to analyze the in silico profile of the compound orientin derived from the water hyacinth plant (Eichhornia crassipes) as a potential antioxidant candidate. Orientin was selected based on its chemical structure data registered in PubChem, which provides complete information regarding molecular identity, physicochemical properties, and 2D and 3D structural representations. The prediction of biological activity was conducted using PASS Online, which indicated that orientin possesses a promising likelihood of exhibiting antioxidant activity according to relevant probability values. Furthermore, the safety assessment of the compound was carried out through ProTox-II to identify potential toxicity, including toxicity class, possible hepatotoxic effects, and other predicted safety parameters. To determine its pharmacokinetic profile, pkCSM was employed to predict ADMET characteristics such as absorption, distribution, metabolism, excretion, and additional toxicity risks. The results of these analyses show that orientin demonstrates favorable potential as an antioxidant candidate, supported by predicted pharmacological properties and relatively low toxicity levels according to in silico evaluations. Therefore, orientin has promising potential for further development in subsequent in vitro and in vivo studies.

Nerdy Nerdy; Nilsya Febrika Zebua; Andre Aditya; Dea Amelia Adiatma; Ira Eka Fahira +2 more

Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam 2026 Pusat riset dan Inovasi Nasional

This study aims to analyze the phytochemical profile of Sambung Nyawa (Gynura procumbens) leaves as a potential herbal candidate for mild hypertension therapy using in silico methods. Plant samples were examined to identify active compounds documented in the PubChem database. The identified compounds were further analyzed using PASS Online to predict their pharmacological activities, ProTox-II to evaluate toxicity levels, and pkCSM to assess ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics. The findings reveal that several bioactive compounds present in Sambung Nyawa leaves demonstrate strong predicted anti-hypertensive activity accompanied by minimal toxicological risk. PASS Online analysis indicates potential mechanisms of action, including vascular receptor modulation and mild diuretic properties that may support blood pressure regulation. ProTox-II classification places most compounds in the low-toxicity category, while pkCSM predictions confirm acceptable bioavailability and favorable pharmacokinetic properties. Overall, these results provide a preliminary scientific foundation for the development of Gynura procumbens as an alternative herbal therapy for mild hypertension and support the need for further validation through in vitro and in vivo experimental studies.

M. Azmi Ahnaf Tsaqif; Jenny Safira Aulia Wati; Intan Alvatyka; Ulfa Ainunisah; Yusuf Bahtiar

JURNAL RISET MANAJEMEN DAN EKONOMI 2026 Institut Teknologi dan Bisnis (ITB) Semarang

Investment serves as a primary driving force in accelerating regional development and economic growth. This study aims to analyze the influence of investment on development and economic growth in Bandar Lampung City through a literature review approach based on previous research findings. As the center of trade and services in Lampung Province, Bandar Lampung holds strategic potential but continues to face challenges in infrastructure and human resource quality. The findings reveal that private investment, both Domestic Investment (PMDN) and Foreign Investment (PMA), consistently contributes positively and significantly to the growth of Gross Regional Domestic Product (GRDP) and employment absorption in Bandar Lampung. Investment generates a multiplier effect that stimulates productive sectors such as trade, services, and MSMEs. Beyond physical capital, synergy with human capital development is identified as a crucial factor in optimizing the impact of investment on community welfare. In conclusion, fostering a conducive investment climate through supportive policies and infrastructure improvement is essential to achieving sustainable economic development in Bandar Lampung.