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Arumanis mango rind is an organic waste that contains secondary metabolites such as flavonoids. Many flavonoids are found in the rind of the arumanis mango, which acts as a very strong antioxidant and has the potential to heal wounds, including infected wounds. This study aims to determine the effect of arumanis mango (Mangifera indica L.) rind extract ointment on healing infected wounds caused by Pseudomonas aeruginosa bacteria, determine the effective concentration for healing infected wounds, and the histopathological decripstions. This research was an experimental study using male white rats which were divided into 5 groups, namely group I (control), group II (Gentamicin), group III (5% concentration), group IV (10% concentration) and group V (15% concentration). The parameters observed were the percentage of healing of infected wounds, epithelialization time, and histopathology. Then the data were analyzed using the ANOVA test followed by Duncan's further test.The results of the study were based on the group order above, from the parameters the average percentage of infected wound healing on 3rd day  was 29.73%; 48.84%; 45.95%; 42.81%; 42.33%, on 7th day it was 70.96%; 85.79%; 83.25%; 76.95%; 73.87%, and on the 14th day it was 89.89%; 93.32%; 93.87%; 92.67%; 91.48%. Epithecization time is 9; 6; 7; 8; 9 (day), for histopathology of fibroblast cells with a score of 1; 3; 3; 2; 2; for collagen fibers 1; 3; 3; 3; 3; for re-epithelialization 2; 3; 2; 2; 2; for inflammatory cells 0; 3; 2; 2; 2. The conclusion of the research is that arumanis mango peel extract ointment (Mangifera indica L.) has an influence on the healing process of wounds infected by Pseudomonas aeruginosa bacteria in male white mice, the most effective concentration and the best histopathological descriptions at a concentration of 5%.  

Bacterial growth is one processes carried out through binary fission for its reproduction process. Bad bacteria in their growth process must course be inhibited in several ways, one which is through the consumption several herbal or traditional plants, such as torch ginger and kalanduyung extracts. The dangers cigarette smoke can reduce the health individuals. Cigarette smoke can have an impact on reducing the number of spermatozoa caused by decrease in the diameter seminiferous tubules for 45 days. The purpose writing journal is to analyze antibacterial activity of torch ginger and kalanduyung extracts on bacterial growth and the effect of cigarettes on the quality male mouse sperm. The writing method uses qualitative type. The results and conclusions that bacterial growth can be inhibited by consuming several traditional plants such as torch ginger extract and kalanduyung leaf extract. In inhibiting growth of antibacterial activity, torch ginger extract has quite good effectiveness with concentration value 20%. The value inhibition zone formed is 17.22. The use largest concentration, namely 80%, has an effective inhibition of bacterial growth which is known to have an average inhibition zone value of 14.9 mm. Furthermore, the quality male mouse sperm does not have specific effect on the provision control treatment related to provision amount of cigarette smoke.

Clove leaves have the property of overcoming hair growth problems, where the eugenol compound contained in clove leaves is efficacious as a hair growth agent. This research was conducted to formulate a clove leaf extract shampoo preparation. The research method used was the experimental method. Tests were carried out on experimental animals, namely male white mice in various groups. The first group (without treatment), the second group (negative control), the third group (5% clove leaf extract shampoo), the fourth group (10% clove leaf ethanol extract shampoo), the fifth group (15% clove leaf ethanol extract shampoo) and groups sixth (positive control). The shampoo preparations were tested and evaluated, the results of the preparation evaluation test showed that the four shampoo preparations were homogeneous and had a pH ranging from 5.1-5.7, with a viscosity of 1700-3000 cps and a foam height of 9-11 cm. This shampoo preparation also does not irritate the skin. The results of the data analysis obtained showed that all data were normally distributed (p> 0.005) and homogeneous (p> 0.005). The results of the one way ANOVA test show that F1 (5% formula), F2 (10% formula) and F3 (15% formula) have significant differences. This research shows that clove leaf ethanol extract shampoo with a concentration of 15% is the most effective formulation in hair growth in male white rats. However, the ethanol extract of clove leaves shampoo is less effective than minoxidil 5% for hair growth.

Human nature, social life, requires humans to socialize with and interact with other humans for survival. There are the five important elements of socialization: social, cultural, social institutions, social stratification or the final grouping of society: power and authority. The study was done to identify social differences and factors that contributed to social differences. The study used qualitative descriptive methods with an objective approach to literature. Well-illustrated social differences in the background of both mice (country mouse) and (city mouse), they had conflicting backgrounds. The cause of these differences is that they live in different neighborhoods.    

Human nature, social life, requires humans to socialize with and interact with other humans for survival. There are the five important elements of socialization: social, cultural, social institutions, social stratification or the final grouping of society: power and authority. The study was done to identify social differences and factors that contributed to social differences. The study used qualitative descriptive methods with an objective approach to literature. Well-illustrated social differences in the background of both mice (country mouse) and (city mouse), they had conflicting backgrounds. The cause of these differences is that they live in different neighborhoods.    

Analgesics are compounds that in therapeutic doses relieve or suppress pain, without having general anesthetic action. Traditionally, the herb bamboo grass (Lophatherum gracile Brongn.) has been used and proven empirically to reduce pain, so it may have an analgesic effect. This can be caused by the content of secondary metabolite compounds, flavonoids, tannins, alkaloids, steroids/triterpenoids, saponins and glycosides, but this has not been scientifically proven. This research aims to determine the secondary metabolite compounds contained in fresh bamboo grass herbs, simplicia and dekokta and the effectiveness as an analgesic of the bamboo grass herb dekokta in mice.This research was carried out experimentally, including making simplicia and decoction, phytochemical screening and analgesic effectiveness testing. bamboo grass herb dekokta in male mice induced with 0.5% acetic acid intraperitoneally under the stomach, orally administered bamboo grass herb dekokta at a dose of 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, CMC 0.5% (blank), methampirone 65 mg/kgBB. Count the number of animal movements every 5 minutes for 1 hour. From the number of writhes obtained, the percentage of analgesic power and analgesic effectiveness were calculated. Next, the data obtained was analyzed statistically using SPSS ver.20 One Way ANOVA followed by the Tukey test. The results of the phytochemical screening of fresh bamboo grass, simplicia and dekokta contain alkaloids, flavonoids, tannins, saponins, steroids and glycosides. The greater the dose of bamboo grass herb dekokta given, the greater the percentage of reduction in writhing, so that the analgesic power and analgesic effectiveness are greater. . The results of the One Way ANOVA test and the Tukey test showed that the dose of 300 mg/kgBB had the best analgesic power at 50 minutes, not significantly different from administering 65 mg/kgBB of methampirone.

Wounds are a condition where the integrity of the skin is disrupted, often requiring a fast and accurate healing process to prevent infection. Bitter melon (Momordica charantia L) is known to have chemical components that potentially accelerate the wound healing process. This study aims to test the effectiveness of bitter melon extract in accelerating wound healing in mice (Mus musculus). The research method used is an experimental method with a post-test only control group design. This study involved 30 mice divided into five treatment groups: negative control, positive control, and three treatment groups with different concentrations of bitter melon extract. The results showed that bitter melon extract could accelerate wound healing in mice, indicated by a significant decrease in wound length in the treatment groups compared to the control groups. Therefore, bitter melon extract has the potential to be used as an alternative treatment to accelerate the wound healing process.

Dyandra Promosindo is a subsidiary of PT Digital Inisiatif, part of Kompas Gramedia, operating in the MICE (Meetings, Incentives, Conference, and Exhibitions) sector. The event organizer is responsible for determining the theme and overall concept of the event, which serves as the foundation for all event-related aspects. This study aims to understand the role of Dyandra Promosindo Surabaya as an event organizer in organizing an event, namely the Indonesia International Motor Show (IIMS) 2024 in Surabaya. The findings show that Dyandra Promosindo plays a crucial role in promoting products or company brands through various types of events such as expos or exhibitions. The implications of this study highlight the importance of the role of event organizers in the success of events and the satisfaction of all involved parties.

Background: Burns with diabetes mellitus conditions can interfere with the wound healing process. Mesenchymal stem cells have been studied to heal burns, one of which originates from the bone marrow Objective: Determine the effect of human bone marrow mesenchymal stem cells on burn wound healing in the formation of granulation tissue DM rats. Methods: Research is experimental research with post-test only control group design. The research subjects were 30 rats divided into two groups, the control group was given NaCl and the treatment group was given hBM-MSCs. Mice were induced by alloxan to cause hyperglycemia, burns were made using a heated plate. Tissue collection was carried out after termination of the experimental animals on the 3rd, 7th, 14th days and then made histological preparations to assess the formation of granulation tissue. Data were analyzed using Two Way Anova Test. Results: Increase in the number of macrophages, fibroblasts and new blood vessels after hBM-MSCs were given. There were no increase on the 14th day neutrophils and 3rd day lymphocytes. Statistical analysis showed a significant increase in the number of lymphocytes, macrophages, fibroblasts and new blood vessels. Conclusion: The is study concludes that human bone marrow mesenchymal stem cells can increase the formation of granulation tissue by increasing macrophages, fibroblasts and new blood vessels in DM rats.

Advertising is a crucial element in marketing strategies aimed at attracting consumer attention and influencing purchasing decisions. The rapid development of Indonesia's advertising industry, driven by increasing media consumption, has brought about ethical and regulatory challenges. This study examines the ethical violations in the Garnier Micellar Water television advertisement in 2023, which claimed to be the "No 1 Micellar Water in Indonesia" without sufficient evidence, violating the Indonesian Advertising Code of Ethics (EPI). Using a qualitative descriptive method, the research analyzes the content of the advertisement and interviews with advertising experts. Findings reveal that the claim was misleading, lacking valid data support, and driven by commercial pressures and insufficient ethical awareness. Recommendations include stricter enforcement of advertising ethics, enhanced awareness programs, and collaborative efforts among advertising industry stakeholders to uphold honesty and responsibility in advertising practices.

Introduction: Banana peel is an organic waste which is known to have various benefits, especially as an antidepressant for mental health. It inspired to conduct a research on various type of banana peels in Indonesia, particularly on Kepok banana which has been widely studied. This research aimed to prove the effect of Kepok banana peel extract (Musa paradisiaca L.) as an antidepressant in mice (Mus musculus) with acute restraint stress.Method: This research used a laboratory experimental design. The male mice were acclimatized for 3 days. Twenty-four mice were then divided evenly into 4 groups. The first group was given banana peel extract (Musa paradisiaca L.) at a dose of 200 mg / kgBW, the second group was given a dose of 400 mg / kgBB, the third group was given a dose of 800 mg / kgBW and the fourth group was given water as control. Each group was given a dose orally for 14 days and ARS depressed induction for 7 hours. Subsequently, mice were treated to assess depression behavior using the tail suspension test (TST) and forced-swim test (FST) to determine the duration of immobility.Result: The result showed that there was a significant difference (p<0.01) between the control group and the experimental group, at TST there was a significant difference (p<0.01) between two doses of 400 mg / kgBW and 800 mg / kgBW, as well as on the forced-swim test (FST). In addition, there was a significant difference (p<0.01) between two doses of 200 mg / kgBW and 800 mg / kgBW, and between two doses of 400 mg / kgBW and 800 mg / kgBW. Conclusion: These result confirmed that Kepok banana peel extract (Musa paradisiaca L.) was an effective antidepressant in reducing immobility duration with acute restraint stress.

Chinese Betel Plant (Paperomia pellucida) is an herbal plant that has benefits for treating diseases such as acne, ulcers, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antibacterial. The content of bioactive compounds from Chinese betel include alkaloids, flavonoids, steroids, saponins, tannins, triterpenoids, and carbohydrates. The aim The purpose of this study was to determine the effect of steeping Chinese betel and  on reducing blood glucose levels in male mice. This method used is an experimental method at the Pharmacology Laboratory D3 Pharmacy FMIPA Bengkulu University. The test animals used were three groups, namely the positive control treatment group that received glibenclamide, the negative control treatment group received aquadest, and the 2% Chinese betel steeping treatment group. The results showed that Chinese betel curd was reduced from 125 mg/dl to 93 mg/dl and there was no hypoglycemic decrease in blood glucose due to glibenclamide. From the results of the study it can be concluded that the administration of Chinese betel and glibenclamide steeping is effective in lowering blood glucose levels in male mice.

Inflammation is the body's response when it experiences injury, infection, antigen or cell damage, so it is a sign of something that is harmful to the body or disease. Galangal rhizomes (Kaempferia galanga L.) and Srikaya leaves (Annona squamosa L.) are plants that contain flavonoid compounds which have anti-inflammatory potential by inhibiting the enzymes cyclooxygenase and lipooxygenase. The aim of this research was to determine the effectiveness of a combination cream preparation of galangal rhizome extract and srikaya leaf extract as an anti-inflammatory. The various combinations used are a combination of 15 grams of kecur rhizome extract and 10 grams of srikaya leaf extract, 12.5 grams of srikaya rhizome extract and 12.5 grams of srikaya leaf extract, 10 grams of srikaya rhizome extract and 15 grams of srikaya leaf extract. The anti-inflammatory test uses 1% carrageenin induction of 0.1 ml, then the swelling that occurs is measured using a plastinometer. Based on the results obtained, a good anti-inflammatory power value was a combination of 15 grams of kencur rhizome extract with 10 grams of srikaya leaf extract with a value of 21.6216%. The results of the One Way Annova analysis obtained a p-value >0.05, which means there is no significant difference. So it can be concluded that various combinations of galangal rhizome extract and srikaya leaves are effective in mice induced by carrageenin. A post hoc Tuckey test was carried out on the AUC value, obtaining a p-value >0.05, so it can be concluded that there was no significant difference in the positive controls for formulas 1, 2 and 3.

Diarrhea is a condition in which a person defecates with a soft or runny consistency, it can even be water alone and the frequency is more frequent (usually three or more times) in one day. One of the beneficial plants is the Moringa oleifera Lam. Plant. Flavonoids, tannins and steroids in Moringa leaves are thought to be anti-diarrhea. This study aims to determine the antidiarrheal activity of the ethanol extract of Moringa oleifera Lam. Leaves against male white mice (Mus musculus) induced by Oleum ricini. Observations were made for 3 hours. This research is an experimental study divided into 6 groups, namely the normal group, positive control (Loperamid HCl), negative control (Na CMC), and ethanol extract of moringa leaves at a dose of 200 mg / KgBB, 400 Mg / KgBB and 800 mg / KgBB. Numeric data were processed using SPSS with One Way ANOVA test. The results showed that the optimal dose was 200 mg / KgBW in the ethanol extract of Moringa oleifera Lam. Leaves as an antidiarrheal in male white mice (Mus musculus) induced by Oleum ricini.

Insomnia is a sleep disorder that often occurs in teenagers. Insomnia can be treated using sedative hypnotic drugs but this can cause dangerous effects. Therefore, alternative natural ingredients are needed, such as Putri Malu and Secang, which are formulated in the form of jelly drinks as nutrasetikals. This research used 20 female mice as test animals which were divided randomly into 5 grups. The method used was the Traction Test and the data collected was the length of time the mice turned and the time the mice fell. In the positive control grup, Diazepam, distilled water and agar, the average time for mice to fall was 62.5 seconds and the time to turn around was 62.9 seconds. In the negative control grup, Jelly Drink combination of Putri Malu and Secang 0.68 g/kgBW, showed that the time for mice to fall was 106.6 seconds and the time to turn around was 128.5 seconds. In conclusion, the Jelly drink combination of Putri Malu and Secang has a sedative effect and has the potential to prevent insomnia as seen by the need for mice in the Jelly drink grup who had less time to fall and turn around.