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This research discusses the implementation of the Project for Strengthening the Profile of Pancasila Students (P5) in the Independent Curriculum at the UNP Laboratory Development High School. The Merdeka Curriculum emphasizes the character of students with six main dimensions, such as faith, diversity, mutual cooperation, independence, critical thinking and creativity. Implementation of P5 is carried out through project-based activities involving these elements, with a focus on the theme "Local Wisdom." UNP Laboratory Development High School implements P5 every three months, involving all education stakeholders. P5 evaluation does not focus on written grades, but rather on strengthening character, especially local wisdom which describes the culture, identity and ethics of the local community. This program aims to prepare students to face the challenges of globalization while maintaining harmony with Pancasila values ​​and local wisdom. The research method used was qualitative with data collection through observation and interviews with the P5 coordinating teacher. The findings show that P5 involves project-based activities aimed at strengthening students' competencies and character in accordance with the Pancasila Student Profile. The implication of this research is the importance of character education that integrates local wisdom in learning to create a competent and characterful generation.

Abstract. Implementation of the Merdeka Curriculum with a focus on the Project for Strengthening the Pancasila Student Profile (P5) has become a major concern in the world of education since 2022. This research aims to understand the implementation of P5 in the UNP Laboratory Development Kindergarten, focusing on the topics of implementation, objectives, benefits, advantages, and evaluation. The research method involves collecting data through observation, interviews, and documentation studies. The research results show that the implementation of P5 in the UNP Laboratory Development Kindergarten has had a positive impact in increasing understanding of the values ​​of Pancasila, introducing local culture, and forming character and environmental awareness in kindergarten children. Evaluation of P5 activities is carried out through learning management and involving active participation from the surrounding community. In conclusion, the implementation of P5 in the UNP Laboratory Development Kindergarten makes a positive contribution to improving the quality of learning, building student character, and community participation and empowerment. The suggestion proposed is the need for cooperation between teachers, P5 coordinators, and parents of students to better adapt the P5 program.

The influence of the development of Science and Technology (IPTEK) on the world of education, so that both teachers and students are required to always adapt to existing developments. Technology is the result of knowledge originating from the world of education therefore the world of education should utilize technology to increase efficiency in learning. Chemistry among students is still considered material that is difficult to understand. One of its attractions is the abstract nature of chemical material. Chemistry learning does not only include theoretical learning but also includes practical activities. This research was carried out to determine the effect of using a virtual laboratory on students' skills during direct practicum. The method used in this research is a quantitative method that uses a lot of numbers, starting from data collection, interpretation of the data and presentation of the results. A total of 52 students in class XI, Department of Mathematics and Natural Sciences at SMA Negeri 1 Sliyeg. Presenting the results in the form of a representative table will increase the reader's level of understanding and make it easier to access information. Virtual laboratories help students understand the practical process. Based on the results of data analysis obtained from filling out the questionnaire, it was found that 78.8% or the majority of students answered agreeing that the virtual laboratory had an effect on increasing pH testing. This proves that the use of virtual laboratories can be a way out so that when doing direct practicum students do not experience difficulties and the practicum runs more effectively.

Laboratories are uniform in terms of management and availability of complete equipment. Attention is needed to manage the laboratory well. More specifically, the science laboratory includes the fields of Biology, Chemistry and Physics. This research aims to find out how science laboratory services are managed at Ma Annuriyyah Jember. The emphasis of this research is how the head of the laboratory carries out management so that the science laboratory services at Ma Annuriyyah Jember can function well in accordance with the observations that will be made. This research uses qualitative research methods with research data collection instruments using interviews, observation and documentation. The results obtained from this research are that the science laboratory service management process at Ma Annuriyyah Jember is carried out well, both from the ongoing science laboratory program planning and the existing science laboratory management structure, at the Ma Annuriyyah school the science laboratory is not only used for practice. Only, but as a classroom where science laboratory learning takes place.

Drug-resistant tuberculosis (TB) is an escalating global health issue, particularly with the rise of multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), which complicate treatment and control efforts. Resistance to both first-line and second-line drugs weakens the effectiveness of standard WHO-recommended therapies, while alternative drugs can cause severe side effects and reduce patient adherence. This study aims to explore the integration of bioinformatics and pharmacogenomics in supporting personalized TB treatment to improve therapeutic success and reduce the risk of further resistance. The research employed a laboratory-based experimental design with a bioinformatics approach, involving TB patients with clinical evidence of drug resistance. Clinical samples were analyzed through whole genome sequencing to identify gene mutations associated with resistance, followed by pharmacogenomic mapping to predict pharmacological responses based on patients’ genetic variations. The results revealed several specific gene mutations consistently linked to resistance and produced individualized therapeutic recommendations that were more targeted than standard protocols. Effectiveness evaluation demonstrated that genome-based personalized therapy yielded higher treatment success rates, faster recovery times, and lower rates of subsequent resistance. These findings highlight the significant potential of precision medicine in TB management, particularly for resistant cases that are difficult to treat with conventional approaches. In conclusion, the integration of bioinformatics and pharmacogenomics plays an essential role in strengthening TB treatment strategies through a personalized, adaptive, effective, and sustainable approach. Nevertheless, its implementation still faces challenges such as high costs, limited infrastructure, and the need for clear regulations regarding the use of patients’ genomic data.

This research is motivated by the role of the Sharia Investment Gallery (GIS) as a student laboratory for learning about investment. Based on the data, the number of investors in the Islamic Investment Gallery from the inception of GIS from 2016 to 2021 is unstable every year and is still relatively low. Even though the FEBI Faculty has good potential in attracting investors because there are so many enthusiasts in the FEBI departments. Low interest and motivation in investing in Indonesia is due to low knowledge and understanding of the capital market. GIS is expected to help foster student interest in investing in the Islamic capital market. The purpose of this study was to determine the role of Gis, both the constraints and solutions faced by Gis in fostering students' interest in investing in the capital market. This research approach uses descriptive method with a descriptive qualitative approach, namely research that seeks to describe a symptom, event, event that is happening now. The method used in this research is to collect data through interviews, observation, surveys, and documentation. The results of the study show the role of Islamic investment galleries (GIS) in fostering student interest in investing in the capital market by carrying out 4 roles, namely first, socialization as an introduction to the world of investment to students and inviting students to invest, second education, namely providing investment knowledge to students, third motivation, namely motivating students by giving examples of people who are successful in investing, the four integrity, namely the management of GiS applies a commitment attitude among the board, consistently carrying out their duties, being responsible, honest and courageous in conveying educational and motivational socialization to students. The internal constraints for Gis are the difficulty of coordinating administrators to be active in activities and the external constraints are the difficulty in getting students to participate in Gis activities and the lack of awareness of students to invest. The internal solution is to always hold monthly meetings to strengthen relationships between administrators and trigger back responsibilities as GIS administrators and the GIS Management also utilizes social media as a promotional medium so that it can be even wider to convey socialization and education to students. Meanwhile, for external solutions, GIS requests lecturer assistance to direct students to participate in all activities held by GIS. As for these 4 roles, the role most expected by FEBI students is the role of motivation. With good motivation given it can trigger students’ interest in investing.

Triglycerides are fats carried by the lipoprotein system located in the blood, are the main cause of arterial diseases and are usually compared with cholesterol using lipoprotein electrophoresis. Triglycerides consist of glycerol linked to fatty acid groups. The High Intensity Interval Training method is a sport designed to increase metabolism and burn body fat so as to balance triglyceride levels in the body. This exercise is often included in training programs for long-distance runners. This study aims to obtain information about the effect of the High Intensity Interval Training (HIIT) exercise on the interval running model on triglyceride levels in PASI Athletes in Malang City. The research method and design used was an experiment in the form of the one group pretest-posttest design, namely recording the results of triglyceride levels before HIIT training and after HIIT training. This study involved 8 long-distance runners whose blood was taken from the cubital vein before the HIIT treatment. The design of this study was initiated by screening all research subjects according to predetermined inclusion criteria. And all subjects were instructed to fill out a willingness form (informed consent) then proceed with taking a blood sample before the HIIT exercise treatment of ± 10 µL. After taking blood, the HIIT training program is continued with an interval running model, namely by running fast for 2 minutes, then walking for 2 minutes, doing 10 repetitions. After completing the HIIT training treatment, all subjects took blood again as much as ± 10 µL. When all subjects' blood samples have been taken, it is followed by laboratory tests in the clinical pathology laboratory, Faculty of Medicine, Brawijaya University. The results of the study by conducting a paired sample T-test were used to analyze the data obtained with a significant (2-tailed) value of 0.938 greater than the p value of 0.05 (0.938> 0.05) indicating H0 was accepted and Ha was rejected which means that HIIT training has no significant effect on the leukocyte levels of PASI Athletes in Malang City. So it can be concluded that HIIT training has no effect on increasing leukocyte levels in PASI Athletes running long distances in Malang City. The conclusion in this study was that the HIIT training provided had no significant effect on the amount of triglycerides after and after exercise. Triglyceride levels in long-distance runners are at normal levels. This is because there has been regular practice given by the coach as preparation for the match.

This training activity aims to train final year students in Accounting Education Study Program Faculty of Economics, State University of Makassar in the processing of statistical data, which includes simple regression analysis, multiple regression, and correlation. The knowledge and skills acquired by the students are expected to be applied in completing the final task. Implementation of statistical data processing training is running smoothly in accordance with the expected by the implementing team. This is shown by the enthusiasm of the trainees in following the materials as well as the given paracels. The success of this activity is caused by several factors: the students of the trainees are familiar with the implementing team so as to facilitate their directing, the training material is very much needed by the students to improve their understanding and ability in statistical data processing. in preparing the final assignment of students. The limitations felt by the implementing team are the supporting facilities in the form of computer owned by the laboratory is not sufficient in terms of quantity. This resulted in training done by adjusting the laboratory conditions, which of course the delivery of material is not optimal

The covid-19 pandemic has an impact on student learning outcomes in the practicum of the invertebrate systematics course.The aim of this research is to determine the learning outcomes of post-pandemic invertebrate systematics practicum for students in semester 5, academic year 2022/2023. The method used in this research is a descriptive qualitative method. The sample used in this research was 5th semester students with a total of 5 classes totaling 97 students. The sampling technique used was the Population Sampling Technique. Data was obtained from a list of TKP scores, report scores, response scores and student perceptions submitted using a Google Form questionnaire. The results obtained by Biology Education students in the Invertebrate Systematics Practicum were based on TKP scores of 45.4% in the high category, 49.5% medium and 5.2% low. Based on the report value, 96.9% is in the high category, 2.0% is medium and 1.0% is low. Based on the response value, 3.1% were in the high category, 28.9% were medium and 68.0% were low. And based on the results of the student perception questionnaire, it can be interpreted that post-pandemic learning has had a positive impact, including being able to carry out practicums in the laboratory and improving student learning outcomes.

Occupational Health and Safety (K3) training aims to increase students' knowledge of working in the laboratory, identify potential hazards, and take early action if a hazard occurs in the laboratory. The target audience for this activity is class X students majoring in multimedia at SMK Cendekia, Madiun. This training was conducted in the Chemical Engineering Laboratory, Departemen of Chemical Engineering, Faculty of Engineering, Universitas PGRI Madiun. The methods used in the training are lectures, discussions, and practice in the chemistry laboratory. The data obtained from the K3 knowledge questionnaire before and after the training were analyzed descriptively. The results obtained show an increase in the average score of students from 46 to 67, which means that there is an increase in knowledge about OSH in the chemistry laboratory.

This research was motivated by the motivation of students at SMAN 3 Tasikmalaya was not optimal. this is related to optimizing the management of science laboratories. The objectives of this study are: 1) Optimization of science laboratory management in an effort to increase student learning motivation; 2) obstacles faced in optimizing the management of science laboratories in an effort to increase student learning motivation; 3) Obstacle management solutions to optimize the management of science laboratory facilities in an effort to increase student learning motivation. Research data was obtained from informants, namely principals, laboratory heads, science teachers and students. The data collection tools used in this study are interviews, observations, documentation studies, and carrying out triangulation, then the data is processed by data reduction, data presentation, drawing conclusions and verifying data. The results of this study show that the optimization of science laboratory management in an effort to increase student motivation at SMAN 3 Tasikmalaya in terms of planning aspects; organizing; implementation (actuating); and controlling, has been well optimized. However, there is an aspect that needs to be improved, namely the need for an evaluation to be carried out related to the management of the science laboratory, because there are still students who have not shown an increase in their learning motivation

This research was motivated by the motivation of students at SMAN 3 Tasikmalaya was not optimal. this is related to optimizing the management of science laboratories. The objectives of this study are: 1) Optimization of science laboratory management in an effort to increase student learning motivation; 2) obstacles faced in optimizing the management of science laboratories in an effort to increase student learning motivation; 3) Obstacle management solutions to optimize the management of science laboratory facilities in an effort to increase student learning motivation. Research data was obtained from informants, namely principals, laboratory heads, science teachers and students. The data collection tools used in this study are interviews, observations, documentation studies, and carrying out triangulation, then the data is processed by data reduction, data presentation, drawing conclusions and verifying data. The results of this study show that the optimization of science laboratory management in an effort to increase student motivation at SMAN 3 Tasikmalaya in terms of planning aspects; organizing; implementation (actuating); and controlling, has been well optimized. However, there is an aspect that needs to be improved, namely the need for an evaluation to be carried out related to the management of the science laboratory, because there are still students who have not shown an increase in their learning motivation

This study aims to find out and describe how students' perceptions of craft and entrepreneurship subjects in class XI MIPA SMA Laboratory Development UNP. This study took 11 (eleven) respondents consisting of representatives of class XI MIPA students. This research method uses a type of qualitative descriptive research. The data collection method uses observation, interview and documentation techniques. The interview technique is conducted unstructured using interview guidelines. Based on the results of the overall research, it was concluded that students' perceptions of craft and entrepreneurship subjects in class XI MIPA were said to be lacking in the teaching techniques used by teachers so, many students felt less interested in craft and entrepreneurship subjects in class XI MIPA SMA UNP Laboratory Development.

Skin is the largest organ in humans, it functions as the outermost protector of the organs inside. Therefore, the skin is often attacked by various diseases, especially cancer. Skin cancer is divided into two, namely benign and malignant. Malignant has the potential to spread and increase the risk of death. Skin cancer detection traditionally involves time-consuming laboratory tests to determine malignancy or benignity. Therefore, there is a demand for computer-assisted diagnosis through image analysis to expedite disease identification and classification. This study proposes to use the K-nearest neighbor (KNN) classifier and Gray Level Co-occurrence Matrix (GLCM) to classify these two types of skin cancer. Apart from that, the average filter is also used for preprocessing. The analysis was carried out comprehensively by carrying out 480 experiments on the ISIC dataset. Dataset variations were also carried out using random sampling techniques to test on smaller datasets, where experiments were carried out on 3297, 1649, 825, and 210 images. Several KNN parameters, namely the number of neighbors (k)=1 and distance (d)=1 to 3 were tested at angles 0, 45, 90, and 135. Maximum accuracy results were 79.24%, 79.39%, 83.63%, and 100% for respectively 3297, 1649, 825, and 210. These findings show that the KNN method is more effective in working on smaller datasets, besides that the use of the average filter also has a significant contribution in increasing the accuracy.

This research is about fish meatballs using the main raw material of tuna which is proportioned with shrimp to help give more taste and be able to increase the nutritional quality content of the product and the addition of clover puree is expected to be able to increase the nutritional content and also be able to increase the potential for rare local ingredients. used. The purpose of this study was to determine 1) the sensory quality of fish balls with the proportion of tuna and shrimp and the addition of cloverleaf puree 2) the nutritional and non-nutritional content based on laboratory tests including protein, carbohydrates, fat, water, ash, calcium and potassium 3) cost raw material for fish balls. This type of research is an experiment. Observation data collection techniques by means of sensory quality tests were carried out by 35 panelists. The independent variables in the study were the proportions of tuna and shrimp (80%:20%), (70%:30%) and 60%:40%) and clover puree (5% and 10%). The dependent variable of the research is sensory quality including shape, color, texture, elasticity, aroma, and taste. The control variables in this study include the types of materials, equipment and processing techniques. Data analysis used double anova test and Duncan's further test. The results showed 1) there was an effect on the sensory quality of making fish balls with the proportion of tuna and shrimp with the addition of cloverleaf puree including color, aroma and taste. 2) there is no effect on the sensory quality of shape, texture, and elasticity of the meatballs. 3) the selected product contains nutrition equal to or greater according to SNI 2017 including protein content 8.11%/100gr, fat 3.86%/100gr, water 36.58%/100gr, carbohydrates 49.88%/100gr, ash 1 .24%/100gr, calcium 75.80 mg/100 gr, potassium 86.90 mg/100 gr 4) the best product has a raw material cost of IDR 56,450.

Mung bean and sago composite flour cookies are cookies made from the main raw material of wheat flour which is composited with mung bean and sago flour to reduce the use of wheat flour and to increase nutritional content. This experiment aims to determine 1) the sensory quality of mung bean and sago composite flour cookies including shape, color, aroma, crispness, crumb, and taste 2) chemical properties based on laboratory tests which include carbohydrates, protein, fat, ash, and fiber 3) the cost of raw materials for mung bean and sago composite flour cookies. This type of research is a factorial experiment. The independent variable was the proportion of mung bean composite flour (35%, 25%, and 15%) and sago (15%, 25%, and 35%) that had gone through the starch calculation stage. The dependent variable is sensory quality which includes shape, color, aroma, crispness, crumb, and taste. The control variables of this study include the type of materials and equipment. Observation data collection technique by means of sensory quality test conducted by 35 panelists. Data analysis used single anova test and continued with Duncan test.  The results showed 1) there was an influence on the sensory quality of composite flour cookies which included aroma, crispness, crumb, and taste 2) there was no influence on sensory quality in shape and color 3) the best product had a raw material cost of Rp 8,473/250 grams.    

Rolade its a dish that is rarely consumed by the public because the manufacturing process is complicated and cassava leaves are vegetables that have coarse fiber, these two problems are the goal of this research which is an experiment in making cassava leaves and agar-agar as skin for making catfish rolade. This research uses a comparison of the number of cassava leaves and agar-agar with 3 treatments namely (80 grams: 4 grams), (80 grams: 6 grams), and (80 grams: 8 grams). Data collection was carried out by observation method through organoleptic test. Organoleptic test results data were processed by one way ANOVA test and Duncan's advanced test. To determine the content of proximate and vitamin A, laboratory tests were carried out and the selling price was determined for 250 gram packages. The results showed: 1)Catfish rolls with skin made from cassava leaves and agar-agar produced a product with a ratio of the amount of cassava leaves and agar-agar 80 grams: 6 grams. 2)Based on laboratory test results, the best sample per 100 grams contains Vitamin A 119.65 mg, Water 30.55%, Protein 18.05%, Fat 19.52%, Carbohydrates 30.04% and Ash 1.92% . 3)The selling price of catfish rolls with skin made from cassava leaves and agar is known to be Rp. 20,000 per 250 gram pack.

This research is about nastar cakes which have the main raw material as wheat flour substituted with cassava flour to reduce the use of wheat flour and the addition of Moringa leaf powder to increase the nutritional content. The purpose of this study is determine 1) the sensory quality of nastar cake with cassava flour substitution and the addition of Moringa leaf powder 2) nutritional and non-nutritional content based on laboratory tests including protein, carbohydrates, fat, water, ash, vitamin C and antioxidants 3) material costs pineapple cake. This type of research is an experiment. Observation data collection techniques by means of sensory quality tests were carried out by 30 panelists. The independent variables of the research were cassava flour substitution (75% and 100%) and the addition of Moringa leaf powder (3g, 5g and 7g). The dependent variable of the research is sensory quality including shape, color, texture, aroma, and taste. The control variables in this study include the types of materials, equipment and processing techniques. Data analysis used two way anova and Duncan. The results showed 1) there was an effect on the sensory quality of making nastar cakes with substitution of cassava flour and the addition of Moringa leaf powder including color, texture, aroma and taste. 2) there is no effect on the sensory quality of the nastar cake shape because it is influenced by the mold. 3) product that are said to be good may contain nutrition equal to or greater according to SNI 2011 including ash content 1.12%, moisture content 4.93%, protein 6.08%, fat 3.81%, carbohydrates 53.10%, vitamin C 16.55 mg/100g and antioxidants 123.60 mg/100g. 4) the best product has a material cost price of IDR 32,806.

Pukis cake is a typical Indonesian wet cake with the basic ingredients of wheat flour. The low consumption of local food ingredients by the community, it is necessary to make pukis cakes by utilizing local food ingredients. Wheat can be replaced with local foodstuffs that have a high starch such as purple sweet potato and taro potato. This problem is the aim of this study to determine the sensory quality of purple sweet potato puree pukis cake and taro sweet potato puree which includes color, shape, aroma, texture, taste. Knowing the nutritional and non-nutritional content which includes antioxidants, protein, fat, carbohydrates, ash, and vitamin C, laboratory tests are carried out, and material costs are calculated. Data collection uses the observation method through sensory tests. The result data were processed with the Anova test followed by the Duncan test. The results showed: 1)The sensory quality of purple sweet potato puree pukis and taro sweet potato puree produced products categorized as good (40%:20%). 2)The nutritional and non-nutritional contents of the product are Antioxidants 8.16%, Protein 6.15%, Fat 3.10%, Carbohydrates 56.01%, Ash 1.39% and Vitamin C 16.88 mg. 3) The material cost of purple sweet potato puree pukis cake and taro pure potato cake is known to be IDR 30,920. Research conclusions 1)The product is expressed well in color, aroma, texture, taste. 2)The use of local food ingredients has an effect on adding product nutrition. 3)The cost of making the product is IDR 30,920.

aboratorium memainkan peran penting dalam dunia kesehatan dengan memberikan informasi diagnostik yang akurat dan tepat waktu. Mutu pelayanan laboratorium secara langsung mempengaruhi perawatan pasien dan keputusan pengobatan. Dalam beberapa tahun terakhir, implementasi Sistem Informasi Laboratorium (LIS) telah secara signifikan berkontribusi dalam meningkatkan efisiensi dan efektivitas operasional laboratorium. Penelitian ini bertujuan untuk mengeksplorasi peran LIS dalam meningkatkan mutu pelayanan laboratorium.Studi ini difokuskan pada tinjauan literatur yang terkait dengan dampak LIS pada operasional laboratorium dan pengaruhnya terhadap berbagai aspek mutu pelayanan. Temuan menunjukkan bahwa LIS memiliki peran penting dalam meningkatkan efisiensi proses laboratorium melalui otomatisasi, pengelolaan alur kerja yang terstruktur, dan pengelolaan sumber daya yang lebih baik. Sistem ini juga berkontribusi secara signifikan terhadap akurasi hasil pengujian melalui pencatatan data elektronik dan mekanisme validasi otomatis.   Selain itu, LIS memungkinkan pengelolaan data terintegrasi, memfasilitasi akses cepat ke informasi pasien, hasil pengujian, dan data terkait laboratorium lainnya, sehingga meningkatkan analisis data dan proses pengambilan keputusan.Selain itu, LIS memfasilitasi pengelolaan alur kerja yang efisien, mengurangi waktu respons, dan memastikan pengiriman hasil pengujian tepat waktu. Sistem ini juga meningkatkan praktik pengendalian kualitas dengan menyediakan alat untuk pemantauan kualitas rutin, analisis tren, dan identifikasi penyimpangan dari standar mutu secara tepat waktu. Implementasi LIS membutuhkan pelatihan dan dukungan yang tepat untuk memaksimalkan potensinya dalam meningkatkan mutu pelayanan laboratorium.Sebagai kesimpulan, integrasi Sistem Informasi Laboratorium dalam pengaturan laboratorium memiliki peran krusial dalam meningkatkan mutu pelayanan laboratorium. LIS meningkatkan efisiensi operasional, akurasi hasil pengujian, pengelolaan data, alur kerja, dan praktik pengendalian kualitas. Disarankan agar laboratorium mempertimbangkan adopsi dan optimalisasi LIS untuk memaksimalkan manfaatnya dan memberikan pelayanan laboratorium berkualitas tinggi.