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Low Birth Weight (LBW) remains a critical global health issue that significantly contributes to neonatal morbidity and mortality, particularly in developing countries such as Indonesia. The main challenge in addressing LBW lies in its complex and multifactorial risk profile, which involves biological, social, environmental, and healthcare-related determinants. This study aims to analyze and synthesize the risk factors associated with LBW based on recent scientific literature. A literature review method was applied by searching articles from Portal Garuda, DOAJ, PubMed, and Google Scholar published between 2020 and 2025 using relevant keywords. The findings indicate that maternal age, interpregnancy interval, nutritional status, anemia, preeclampsia, infections, socioeconomic conditions, environmental exposure, and the quality of antenatal care are significant determinants of LBW. The synthesis of evidence confirms that LBW is influenced by the interaction of multiple individual and healthcare system factors rather than a single cause. In conclusion, this study highlights the urgent need to strengthen antenatal care services, improve maternal nutritional status, control maternal diseases during pregnancy, and implement community-based promotive and preventive strategies as key efforts to reduce the incidence of LBW.

Quality control is a crucial aspect in various fields, such as education, the food industry, and manufacturing, as it functions to maintain the consistency of service or product quality. Inaccuracy in managing quality can cause financial losses, damage an institution's reputation, and reduce stakeholder trust. Based on this urgency, this study reviews recent literature to answer the main question of how quality control strategies can be effectively applied in diverse organizations. The review was conducted through a qualitative literature review approach by exploring scientific publications via Google Scholar and the Publish or Perish (PoP) application. Article selection was based on the relevance of keywords related to quality control and was limited to publications from 2020–2025. Out of 24 articles found, filtering was done until 5 of the most relevant articles remained for in-depth analysis. The analysis reveals three main findings. In higher education, a strong internal quality system and a sustainable quality culture are needed. The food industry emphasizes the standardization of raw materials and optimization of production processes. Meanwhile, the manufacturing sector makes extensive use of statistical techniques and tiered inspections. Overall, the effectiveness of quality control requires a combination of technical, managerial, and organizational culture aspects. Future research is recommended to explore the integration of digital technology and sustainability principles in quality control practices.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder whose prevalence continues to rise, making it a major challenge for health systems worldwide. This disease results from a combination of insulin resistance and impaired pancreatic β-cell function, leading to persistent hyperglycemia and increased risk of long-term complications affecting the kidneys, cardiovascular system, nervous system, and eyes. This report describes the case of a 52-year-old woman diagnosed with T2DM for approximately ten years. The patient presented with fatigue, nocturnal polyuria, nausea after meals, significant weight loss, and tingling in her extremities. Laboratory findings revealed an HbA1c level of 12%, reflecting very poor glycemic control. A family medicine approach was applied through detailed history taking, physical and laboratory examinations, home visits, and completion of a family folder to assess clinical, personal, social, and functional aspects. Interventions included counseling on balanced diet, encouragement of regular physical activity, education on diabetic foot care, and pharmacological treatment with metformin and insulin. The family received counseling about hereditary risk factors, the importance of emotional support, and the need for consistent monitoring of health status. The patient was still capable of light daily activities, supported by a highly functional family environment with an APGAR score of 10. A holistic family medicine–based approach was shown to improve treatment adherence, patient knowledge, and overall quality of life. Therefore, management of T2DM requires a comprehensive strategy that integrates promotive, preventive, curative, and rehabilitative components, emphasizing the active involvement of family and community at the primary care level to reduce complications, slow disease progression, and enhance patient well-being.   Keywords: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder whose prevalence continues to rise, making it a major challenge for health systems worldwide. This disease results from a combination of insulin resistance and impaired pancreatic β-cell function, leading to persistent hyperglycemia and increased risk of long-term complications affecting the kidneys, cardiovascular system, nervous system, and eyes. This report describes the case of a 52-year-old woman diagnosed with T2DM for approximately ten years. The patient presented with fatigue, nocturnal polyuria, nausea after meals, significant weight loss, and tingling in her extremities. Laboratory findings revealed an HbA1c level of 12%, reflecting very poor glycemic control. A family medicine approach was applied through detailed history taking, physical and laboratory examinations, home visits, and completion of a family folder to assess clinical, personal, social, and functional aspects. Interventions included counseling on balanced diet, encouragement of regular physical activity, education on diabetic foot care, and pharmacological treatment with metformin and insulin. The family received counseling about hereditary risk factors, the importance of emotional support, and the need for consistent monitoring of health status. The patient was still capable of light daily activities, supported by a highly functional family environment with an APGAR score of 10. A holistic family medicine–based approach was shown to improve treatment adherence, patient knowledge, and overall quality of life. Therefore, management of T2DM requires a comprehensive strategy that integrates promotive, preventive, curative, and rehabilitative components, emphasizing the active involvement of family and community at the primary care level to reduce complications, slow disease progression, and enhance patient well-being.

The production of pharmaceutical sterile products requires strict procedures to minimize the risk of microbial, particulate and pyrogen contamination that can be harmful to the user's health. The selection of the right sterilization method is the key to achieving the desired stability of the final product. Filtration sterilization is one of the oldest methods used for pharmaceutical sterile products. There are two types of feed flow in the method, namely through flow filtration and tangential flow filtration. This review article is prepared through literature search and download of national or international journals with inclusion or exclusion criteria that have been set. Literature sources are accessed online from various sites such as Google Scholar and Pubmed in the range of 2014-2024. The keywords used for journal searches are sterilization, through flow filtration, and tangential flow filtration. This review article reviews and compares the two methods to understand the differences, mechanism of action, and research objectives based on the review article on membrane filtration sterilization. This review aims to provide a better insight into the advantages and disadvantages of each membrane filtration sterilization method, as well as guidance in choosing the appropriate method based on the characteristics of the product to be sterilized. The results showed that through flow filtration is more commonly used in small volume and batch processes because of its simple design, but has limitations in reducing membrane fouling. In contrast, tangential flow filtration allows for continuous processing of larger volumes, with the advantage of minimizing particle build-up on the membrane surface, thus extending membrane life. The choice of method is also influenced by factors such as particle size, viscosity of the solution, sensitivity to heat, as well as operating costs. An in-depth understanding of the Working Principle and application of each method is essential for the pharmaceutical industry to ensure the quality, safety and efficiency of the production process. Thus, this review is expected to be a reference for researchers and practitioners in determining the optimal filtration sterilization strategy according to product needs.

Hazard Analysis and Critical Control Points (HACCP) is a food safety management system designed to identify, analyze, and control physical, chemical, and biological hazards throughout the food production process. In the context of Small, and Medium Enterprises (SMEs) in Indonesia, HACCP implementation is essential to ensure food safety, improve product quality, and enhance access to modern and export markets. This study is a literature review that analyzes 14 scientific articles published between 2000 and 2025, sourced from Scholar and Sinta databases. The analysis focused on abstract keywords to identify key concepts, findings, and research gaps regarding HACCP implementation in SMEs food businesses. The review findings indicate that HACCP offers positive impacts such as improved production efficiency, extended shelf life, and reduced contamination risks. The establishment of Critical Control Points (CCPs) in stages like grinding, packaging, and storage has proven effective in preventing potential hazards. However, several challenges hinder effective implementation, particularly in SMEs. Common obstacles include limited human resources, lack of technical knowledge, inadequate basic sanitation infrastructure, and weak documentation and monitoring systems. Several studies also emphasize that successful HACCP implementation relies heavily on intensive mentoring and strong support from government bodies, academia, and business partners. Therefore, a collaborative and strategic approach is essential to optimize HACCP implementation within the SMEs sector, contributing to an inclusive, adaptive, and sustainable national food safety system.

Sustained-release tablets are pharmaceutical preparations designed to gradually release the active substance over a specific period, thereby maintaining a constant concentration of the drug in the circulatory system and enhancing therapeutic effectiveness.The development of sustained-release tablets aims to extend the duration of drug action, reduce the frequency of dose administration, and minimize fluctuations in drug levels in the plasma, which ultimately enhances patient compliance and treatment effectiveness, especially in chronic diseases.The purpose of this review is to identify various formulation methods and innovations in the production of sustained-release tablets, as well as to examine the factors that influence the success of these formulations.The method used in this study is a literature review that collects data from various scientific publications over the past five years through online platforms such as Google Scholar, using keywords related to matrix sustained-release tablets and pharmaceutical formulations.The results of the review indicate that various techniques, such as formulating polymer matrices, coating, and encapsulation, have been applied with varying degrees of success depending on the type of active ingredients and excipients used. Some formulation innovations, such as the use of natural polymer matrices and matrix modifications, have proven effective in achieving controlled, stable, and quality-standard-compliant drug release.

Postural balance is a crucial aspect of daily life that enables individuals to move with stability and safety. Children with Down Syndrome (DS) often experience balance disorders due to cognitive function limitations that affect their motor abilities. This study aims to explore the relationship between cognitive function and balance in children with DS. Cognitive impairments, including memory deficits, attention difficulties, and executive function challenges, can impact a child's ability to control posture and perform motor activities effectively. Additionally, difficulties in movement coordination and sensorimotor responses contribute to poor balance abilities. Understanding the connection between cognitive function and balance can facilitate the implementation of appropriate interventions, such as physical therapy and cognitive stimulation, to improve the quality of life of children with DS. A holistic approach is essential in supporting the development of children with DS to help them achieve greater independence. Parents and families play a vital role in actively participating in the growth and development of children with DS, ensuring that their cognitive function and balance are maintained and enhanced. Consequently, children with DS can become more independent and socially engaged, enabling them to interact with others and build healthy social relationships. Keywords: Down Syndrome, cognitive function, postural balance, parents, family

The learning and teaching system at the Postgraduate level of higher education greatly contributes to the development of society and the state. Postgraduate class must certainly have a good strategy in improving the quality of education. so that the results obtained are in accordance with the goals that have been outlined. Likewise, the Postgraduate Program system at the Tribakti Islamic University Lirboyo Kediri. no exception to the Education. However, efforts to realize Quality in the Study Program play an important role in making it happen. This study aims to determine the form of caprodi strategy in realizing the quality of PAI Study Program at the Postgraduate Program of Tribakti Islamic University, knowing the procedures of each Kaprodi strategy in Realizing the Quality of PAI Study Program at the Postgraduate Program of Tribakti Islamic University. The method used in this research is descriptive qualitative with the type of field research approach. This research was conducted at Tribakti Islamic University (UIT) Lirboyo Kediri, Lirboyo Darussalam Islamic Boarding School, Kediri. The results of this study are: 1) The form of Kaprodi's Strategy in realizing the Quality of PAI Study Program at the Postgraduate Program of Tribakti Islamic University has several forms, namely by Achieving Accreditation-Based Quality, Preserving Excellent Programs and International Proceedings Seminars. 2) Quality planning, quality control and quality improvement.  The procedure includes three activities, namely opening activities such as debriefing and grouping students with lecturers. In this core activity is carried out while the activity is in progress such as making observations. for closing activities carried out at the end of the activity and after activities such as making final reports in the form of journals and articles which are used as a condition for the completion of the activity. Of the three contain Quality Planning, Quality Quality and Quality Improvement.