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One of the impacts of the growth of activities in the transportation sector is the disposal of rubber tire waste. The increasing number of motorized vehicles in society has caused an increase in tire waste. Especially in developing countries, the use of plastic bottles has become an inevitable and unavoidable necessity for society. Inadequate waste management and handling causes negative impacts on the environment, such as hazards to human health, to animal life, soil, water, and air pollution. The purpose of this study was to reduce environmental pollution by testing the compressive strength of concrete made with a mixture of waste. Experiments were conducted in the laboratory with concrete cylinder test objects with a diameter of 150 mm and a height of 300 mm. The proportion of waste mixture, Polyethylene Terephthalate (PET), Rubber Powder, Waste Metalized Film Food Packaging (WMFFP) to fine aggregate was 0%, 5%, and 10%, each variation. The test results showed a compressive strength of 17.62 MPa, 15.29 MPa, and 14.83 MPa at the percentage of waste mixture. From this data, it can be concluded that waste materials can be used as a substitute for sand in concrete.

Mrs. Km visited the Integrated Health Post (Posbindu) in Alue Keureunyai Village with complaints of throbbing neck pain that had occurred intermittently over the past two weeks and worsened in the last day. The pain intensified after consuming fatty or coconut milk-based foods and improved with rest or cholesterol-lowering medication. She also experienced a persistent, heavy, throbbing headache for two weeks and ongoing fatigue for the past three weeks, despite minimal physical activity. These symptoms led to reduced motivation in daily activities. Physical examination showed: BP 160/100 mmHg, HR 88 bpm, RR 20 breaths/min, T 36.8°C. Laboratory results revealed a total cholesterol level of 250 mg/dL. Data were gathered through auto-anamnesis, physical and laboratory examinations, home visits, completion of the family folder, and patient documentation. Assessment was based on holistic diagnosis at the initial, ongoing, and final stages of the visit, using both qualitative and quantitative approaches. Interventions included education on the causes of hypercholesterolemia, the importance of taking medication regularly, and awareness of complications due to high cholesterol levels.

The Snail Canning Industry has the potential to impact the environment if wastewater with high organic compound content is not treated first. This study aims to analyze the performance of the Snail Canning Industry Wastewater Treatment Plant (WWTP) based on BOD, COD, and TSS parameters. The method used is descriptive, with primary data obtained through interviews and secondary data from laboratory test results. Measurements were taken at the inlet and outlet points of the WWTP, then compared with the quality standards based on the Regulation of the Minister of Environment No. 5 of 2014. The results showed that the WWTP succeeded in reducing the concentration of BOD from 201 mg/L to 6 mg/L, COD from 315 mg/L to 24 mg/L, and TSS from 25 mg/L to 6 mg/L. The reduction efficiency of each parameter was 97.01% for BOD, 92.38% for COD, and 76% for TSS. All outlet results met the established quality standards. This indicates that the wastewater treatment process at the IPAL functions effectively in reducing the levels of pollutant parameters in wastewater.

Irritant contact dermatitis is a skin disease that often occurs in rubber company workers due to contact with irritant materials. Irritant materials in the work environment can damage the skin, cause inflammation, and cause irritation. If not treated immediately, this condition can interfere with comfort and reduce work efficiency. This study aims to determine the factors associated with complaints of irritant contact dermatitis in production and laboratory workers at PT. X. This study uses a quantitative approach with an observational cross-sectional design. The study population was 64 workers, with 38 people as samples taken using a purposive sampling technique. The variables studied included the dependent variable (complaints of irritant contact dermatitis) and independent variables (length of service, exposure to chemicals, duration of exposure, personal hygiene, and use of PPE). Data analysis was carried out univariately and bivariately using the Chi-Square statistical test with a 95% confidence interval. The results showed that complaints of irritant contact dermatitis with moderate and severe categories were 44.7%, and the mild category was 55.3%. There was a significant relationship between length of work (p=0.031), length of exposure (p=0.032), personal hygiene (p=0.011), and use of PPE (p=0.024) with complaints of irritant contact dermatitis.   Keywords:, , 

Chronic disease caused by increased blood sugar levels and potentially causing many complications especially when uncontrolled conditions are known as diabetes mellitus. Glycosylated hemoglobin examination is a reliable method in evaluating long-term glycemic control because it is not affected by daily fluctuations and reflects glucose levels for 120 days. The province with the 10th highest number of diabetes mellitus cases in 2018 was Aceh. One of the districts in Aceh, namely North Aceh, is the area with the highest incidence of cases. This study aims to describe HbA1c levels and characteristics of type 2 diabetes mellitus patients at Cut Meutia Regional Hospital, North Aceh in 2023. Using a descriptive cross-sectional design, 77 patients were selected through purposive sampling. Data were collected from laboratory results and MMAS-8 and MIAS-8 questionnaires. The results showed that most patients had uncontrolled HbA1c levels (90.9%), uncontrolled HbA1c men (91.7%), 56–65 years old (40.3%), had pre-hypertension blood pressure (83.1%), and medication compliance in the moderate category (54.5%). This can be concluded that cases of diabetes with uncontrolled glycosylated hemoglobin levels are men.

Using a descriptive method with a triangulation approach including observation, document analysis, and interviews this study ensures data reliability. Daily monitoring is conducted on wastewater flow and pH levels, while monthly laboratory analysis covers eight key parameters: Total Suspended Solids (TSS), iron (Fe), copper (Cu), zinc (Zn), total chromium (Cr), phosphate (PO³), oil and grease, and pH to evaluate the perfomance of the treatment system. The treatment process begins with the inflow of 960 m³ of wastewater per day into the storage pond, where aeration is applied to ensure homogenization before being transferred to the neutralization unit. pH adjustment is carried out by adding NaOH or HCl before the wastewater undergoes coagulation and flocculation stages. The study’s findings indicate that the WWTP meets the environmental quality standards established in accordance with the Decree of the Head of the Investment Coordinating Board of the Republic of Indonesia (2020), Number SK.214/1/KLHK/2020 concerning the Permit for Wastewater Disposal into the Sea on Behalf of PT Pembangkit Jawa Bali Unit Pembangkitan Gresik. This study emphasizes the importance of systematic monitoring and treatment in wastewater management.

This study aims to evaluate the performance of the Sewage Treatment Plant (STP) at PT PLN Nusantara Power Unit Pembangkitan Gresik in reducing pollutant loads from domestic wastewater. The evaluation involves analyzing water quality parameters including pH, BOD, COD, TSS, oil and grease, total ammonia, and total coliform at both inlet and outlet of the STP. Additionally, the actual daily discharge was observed and compared to the design capacity to assess operational efficiency. The method used was descriptive qualitative, involving field observation, documentation, and laboratory test data analysis during the January–March 2025 period. The results show that all outlet parameters met the effluent standards set by Regulation No. 68/2016 of the Ministry of Environment and Forestry. However, the actual flow rate, which is only 1.6–3.3% of the design capacity, indicates potential inefficiencies in energy use and biological processes. Therefore, operational adjustments and optimization of STP capacity utilization are necessary for more efficient and sustainable system performance.

Pressure vessels are critical components in the energy industry, used to store and process high-pressure fluids. The structural reliability of these vessels plays a pivotal role in ensuring operational safety and system efficiency. This study aims to analyze the design and reliability of pressure vessels using both numerical and experimental approaches to optimize performance and enhance safety factors. The numerical method was conducted through Finite Element Analysis (FEA) using ANSYS software to evaluate stress distribution, stress concentration, and potential failure modes under various operational load scenarios. Meanwhile, the experimental method involved hydrostatic pressure testing, strain measurements using strain gauges, and displacement analysis to validate the numerical simulation results. Data were collected from simulations and laboratory experiments, then analyzed quantitatively by comparing key parameters such as stress distribution, deformation patterns, and safety factors against industry standards. The results indicate that combining numerical and experimental approaches improves the accuracy of pressure vessel behavior predictions, enables more efficient design optimization, and enhances structural reliability. In conclusion, the methods applied in this study can serve as a reference for developing safer, more efficient pressure vessel designs that comply with industrial standards, thereby supporting improved safety and operational efficiency in the energy sector.

This study aims to examine the problem of the lack of implementation of experiment-based learning in Biology subjects at SMA Nahdlatul Ulama Padangsidimpuan. The method used is descriptive qualitative with a case study approach, with data collection through interviews with Biology teachers and literature studies. The results showed that limited laboratory facilities, lack of practicum tools and materials, and limited learning time allocation were the main obstacles in the implementation of practicum. Although teachers realize the importance of experimental activities in improving students' understanding and science process skills, structural support from schools is still very limited. In response to these obstacles, several alternatives such as the utilization of virtual laboratories, the use of experimental videos, and simple experiments based on local resources have been attempted. This research recommends strengthening educational policies that support practicum-based learning through the provision of adequate infrastructure, continuous training for teachers, and development of alternative learning media. Thus, Biology learning can be more effective in fostering students' scientific skills and critical thinking according to the demands of the 21st century.

Fever is a condition characterized by an increase in body temperature as a response to infection or inflammation, and it is one of the most common clinical symptoms in various diseases. The excessive use of synthetic antipyretics such as paracetamol can lead to side effects; therefore, safer and natural-based alternatives are needed. This study aims to determine the antipyretic activity of betel leaf and to compare its effectiveness with that of paracetamol.This research was conducted using an experimental laboratory method with a completely randomized design. The test subjects were male white rats (Rattus norvegicus) of the Wistar strain, induced with fever using a 20% yeast suspension. The rats were divided into five groups: negative control, positive control (paracetamol), and three treatment groups with low, medium, and high doses of the extract. Body temperature was measured every 30 minutes for 180 minutes after treatment. The data were statistically analyzed using one-way ANOVA followed by Tukey's post hoc test.The results showed that the [plant extract] exhibited significant antipyretic activity (p < 0.05) compared to the negative control, especially at medium and high doses. The effectiveness of the highest dose was comparable to that of paracetamol. This antipyretic effect is presumed to be associated with the presence of flavonoids and tannins that may inhibit the synthesis of prostaglandin E2 (PGE2), a key mediator in the fever response.In conclusion,betel leaf has potential as an effective natural antipyretic agent and may be developed as a safer herbal-based alternative for fever treatment.

Pneumonia is a lung infection that causes inflammation in the lung parenchyma. Pneumonia is the third leading cause of death globally. In Indonesia, in 2018, the prevalence of pneumonia among all age groups reached 2.21%. This case report was obtained from primary data through anamnesis, physical examination, and supporting tests. The patient complained of shortness of breath. The shortness of breath occurred during moderate physical activity and improved with rest. The shortness of breath was not affected by the weather. The patient also complained of left chest pain, productive cough, fever, diarrhea, and weakness. Upon physical examination, the general status showed vesicular breath sounds and rhonchi in the left lung field. Chest X-ray revealed diffuse consolidation in the bilateral paracardial pulmonary areas, suggesting pneumonia. Laboratory tests showed elevated white blood cell count. The patient was given pharmacological and non-pharmacological management in the form of respiratory fluoroquinolone.

Current water safety issues in society are very diverse. Water quality safety issues are closely related to the bioethics of water testing, because water testing involves protecting human health and the environment. Water quality testing is an important part of ensuring that the water consumed is safe for human health. The purpose of this study was to evaluate the application of bioethical principles in water quality testing (Pb and Cd). This study was conducted in March 2025 at the UPT Food Security Laboratory of Medan City. The data analysis used in this study used qualitative descriptive methods to see the pattern of observation responses. The results of the study showed that in the bioethical aspect of sample testing, analysts who conducted the testing had implemented bioethics or SOPs that apply in food quality and safety testing laboratories. In conducting water testing for lead and cadmium examination, the procedures used were in accordance with applicable requirements using testing procedures from SNI (Indonesian National Standard).

Background: Preterm labor (PTL) remains a major global health concern, contributing significantly to neonatal morbidity and mortality. Asymptomatic bacteriuria (ASB), has been implicated as a predisposing factor to PTL. This research investigates association between ASB and PTL, emphasizing inflammatory mediators such as high-sensitivity C-reactive protein along with tumor necrosis factor- α. Methods: This observational case-control study was conducted at Tikrit Teaching Hospital, Iraq, involving 100 pregnant women (50 PTL cases and 50 full-term controls). Demographic, clinical, and laboratory data were collected. Urine cultures identified bacterial isolates. In addition, levels of TNF-α and hs-CRP in serum were measured using ELISA. Statistical analyses were performed using SPSS.  Results: ASB was significantly associated with PTL, with 30% from PTL cases having a positive urine culture compared to 8% in controls (p = 0.009). Escherichia coli was the predominant pathogen (53%). TNF-α and hs-CRP levels were significantly elevated in PTL cases (p < 0.001), suggesting an inflammatory pathway in PTL pathophysiology. Conclusions: ASB is a significant risk factor for PTL, likely mediated by systemic inflammation. Routine ASB screening and targeted antimicrobial therapy may reduce PTL risk. Further study is required to explore the mechanistic connections amongst microbial infection and inflammatory responses in PTL. 

The ultimate goal of predicting preeclampsia that can enhance early detection and risk stratification in pregnant women, by leveraging the diagnostic potential of ECG patterns, we hope to improve maternal and fetal outcomes and contribute to the development of personalized care strategies for preeclamptic patients. Current diagnostic methods for preeclampsia rely primarily on routine blood pressure monitoring and proteinuria assessment, which have limited sensitivity and specificity. The aim of this study is to investigate the predictive role of P wave duration, amplitudes and morphology in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of  twenty (20) normotensive  and twenty (20) preeclamptic pregnant women in their  third trimester of pregnancy. After the subjects were  identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. Results from this present study show statistically significant increases in P wave duration, amplitude and abnormal M pattern among preeclamptic compare to normotensive pregnant women, consistent with prior research, abnormal M pattern in P wave morphology is linked to atrial pathology in preeclampsia. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection, risk stratification, and management of the condition.

Early detection and prediction of preeclampsia are crucial to prevent severe complications and ensure timely interventions, Specific ECG patterns, including PR segment, Q wave duration and amplitude, ST segment, U wave, and sinus rhythm were under study for their potential indicators of preeclampsia. This study aims to investigate the predictive role of these ECG patterns in preeclamptic pregnant women in the third trimester of pregnancy. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of  twenty (20) normotensive  and twenty (20) preeclamptic pregnant women in their  third trimester of pregnancy. After the subjects were  identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. results from this present study show no significant differences were observed in the P-R segment, R-R interval, Q wave duration, Q wave amplitude The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection, risk stratification, and management of the condition, despite  parameters showing no significant differences. However, PR Segment, Q Wave duration and amplitude, ST Segment , U wave and Sinus rhythm cannot be used to predict preeclampsia  

The use of ECG patterns as predictors of preeclampsia offers a promising approach, as it is a widely available and cost-effective tool. Specific ECG patterns, including angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes as a potential tool for predicting preeclampsia. The aim of this study is to investigate the predictive role of angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of  twenty (20) normotensive  and twenty (20) preeclamptic pregnant women in their  third trimester of pregnancy. After the subjects were  identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. Results from this present study show no significant differences were observed in QRS complex angles related to right ventricular hypertrophy (RVH) between normotensive and preeclamptic pregnant women. Notably, there was a significant increase in QRS complex related to left ventricular hypertrophy (LVH) in preeclamptic pregnant women, indicating left ventricular remodeling's importance. Moreover, there was a significant increase in T wave amplitude, this suggests underlying myocardial electrical remodeling or dysfunction in preeclampsia, emphasizing the need for cardiovascular monitoring. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection.

Carcinoembryonic antigen (CEA) is a glycoprotein normally produced during fetal development, but presence of tissue damage and inflammation, its levels increase and this may be linked to  Carcinoembryonic antigen in the pathophysiology of preeclampsia. This study aims to assess the  level  of Carcinoembryonic antigen (CEA) in preeclamptic pregnant women in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. After the subjects were  identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and 10 milliliters (10 ml) of venous blood was drawn from consenting participants and placed in a lithium heparin sample bottles analyzed for Carcinoembryonic antigen (CEA) levels  by fluorescence immunoassay. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in the level of Brain injury marker (CEA) was observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as Brain injury in preeclampsia.

Sterilization is a process that aims to remove all forms of microbial life, including bacteria, viruses, fungi, and spores, from an object or surface. This process is very important in various fields, such as medicine, laboratories, food industry, and pharmaceuticals, to prevent infection and contamination. This article was written through a literature review of articles originating from international and national journals. Data searches were carried out through scientific-based websites and databases, namely Google Scholar, Science Direct, and PubMed. The results show that of various sterilization methods such as autoclave, oven, ozone, filtration, steam, 70% alcohol, UV radiation and gamma rays, each has different effectiveness in killing microorganisms, and each method has advantages and disadvantages. . The conclusion of this article provides a comprehensive evaluation of the effectiveness of various sterilization methods used in laboratory and industrial contexts. Various techniques, such as autoclave, oven, ozone, filtration, steam, 70% alcohol, UV radiation and gamma rays.  

Modern cellular tissues have evolved into cell tensegrity structures, where cell strength and stability are established through supportive interactions. Tensegrity improves the efficiency of frequency spectrum use and signal quality in cellular networks. Research shows miRNAs play an important role in the regulation of gene expression in the immune system, providing new insights into the complexity of modern biological systems. Structural Design of Cellular Tissues involves computer simulation studies and laboratory experiments on cell tensegrity. Immune Regulation by MicroRNAs includes analysis of MiRNA gene expression and functionality using technologies such as microarrays and high-throughput sequencing. Data Integration includes identifying microRNA gene targets and understanding transcriptional regulation through methods such as reporter gene assays and Chromatin Immunoprecipitation to predict cellular responses in clinical scenarios. The complex interplay between cellular tensegratas mechanisms and immune regulation by microRNAs shows how widespread their interactions are in human biological systems. The cellular tensegratas structure helps improve intercellular communication, while immune regulation by microRNAs ensures the body's proper response to pathogens. Recent research on microRNAs has exposed their role in the development and function of mammalian immune cells. MiRNAs play an important role in the development and function of mammalian immune cells. The complex interactions between cellular tensile mechanisms and immune regulation by microRNAs demonstrate how structural and functional integration can improve the performance of human biological systems. Integration of these data provides a complete picture of the complexity of modern biological systems and their clinical implications in the diagnosis and treatment of immunological diseases.

With the increasing development of society, information is an important tool today. Information forces every person, both individuals and groups, both private and government, to calculate the information system that will be implemented in order to remain competitive in the era of globalization. In this case, the implementation of the right strategy allows every government agency to further improve services. In addition, the rapid advancement of information technology, but the lack of proper utilization. In general, the problems faced in the Information Technology Study Program Laboratory of Aisyiyah Pontianak Polytechnic are the suboptimal service of the inventory system where laboratory data is still manual so that the search time for equipment takes a long time. In instrumentation maintenance if it is still manual, it will be difficult to find out how many hours the equipment has been used and how many times it has been damaged. Along with the progress of Information Technology development, globalization is also becoming increasingly rapid. The specific objective of implementing the use of applications related to the theory of the concept of the course given to students. Analytical survey method with a Cross Sectional approach. The qualitative research design used is Phenomenological Research. The results of this study can improve the knowledge and skills of students, in improving knowledge in the field of Information Technology. Promoting the information technology study program at the Aisyiyah Pontianak Polytechnic.