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Allergic rhinitis (AR) is a chronic inflammatory disorder of the nasal mucosa mediated by immunoglobulin E (IgE) in response to allergen exposure. This condition has become a significant global health concern because of its increasing prevalence and substantial impact on quality of life, sleep, cognitive function, and work productivity. AR is also commonly associated with other atopic diseases, including asthma and atopic dermatitis. This article aims to review the current understanding of allergic rhinitis, focusing on epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, and evidence-based management strategies. This study used a narrative literature review method by analyzing scientific articles, clinical guidelines, and peer-reviewed journals published between 2015 and 2025. Literature sources were obtained from PubMed, Google Scholar, and relevant medical databases using keywords related to allergic rhinitis, IgE, diagnosis, and immunotherapy. The findings indicate that allergic rhinitis involves complex immune mechanisms characterized by Th2 lymphocyte activation, IgE production, and inflammatory mediator release. Diagnosis is primarily established clinically and supported by allergy testing such as skin prick tests or serum-specific IgE measurement. Intranasal corticosteroids remain the first-line therapy for moderate to severe cases, while antihistamines and leukotriene receptor antagonists are used as adjunctive therapies. Allergen immunotherapy has shown effectiveness in modifying disease progression and improving long-term outcomes. In conclusion, allergic rhinitis is a manageable chronic disease that requires a comprehensive and individualized treatment approach involving environmental control, pharmacotherapy, and immunotherapy.

Knee septic arthritis is an orthopedic emergency that requires prompt and appropriate management to prevent permanent joint damage and systemic complications. Inflammatory markers such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are commonly used for diagnosis and monitoring of treatment response; however, their prognostic value after surgical debridement remains variable. This systematic review aimed to evaluate the role of ESR, CRP, and platelet count as prognostic indicators following irrigation and/or surgical debridement in patients with knee septic arthritis. A literature search was conducted in January using PubMed, Google Scholar, ScienceDirect, Wiley Online Library, SpringerLink, and Semantic Scholar, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Study quality was assessed using the National Heart, Lung, and Blood Institute (NHLBI) tools. Fifteen studies meeting the inclusion criteria were qualitatively analyzed. The findings indicate that elevated preoperative CRP levels and delayed postoperative CRP reduction are associated with unfavorable clinical outcomes, including failure of infection eradication and the need for repeat debridement. Although ESR is consistently elevated during the acute phase, its slower decline limits its short-term prognostic utility. Platelet count may increase as part of the systemic inflammatory response but shows inconsistent prognostic value.

The quality of rice that is suitable for consumption, one of which is determined by the absence of associated components when the rice is in storage. Rice storage is carried out by means of long shelf life and good rice quality. Damage to rice due to pest attacks causes a decrease in quality and quantity. Environmentally friendly efforts are needed to control the rice weevil Sitophilus oryzae using vegetable materials. This study sought to ascertain the death rate of rice weevils treated with lemongrass stem (Cymbopogon citratus), bay leaves (Syzygium polyanthum), and pandan leaves (Pandanus amaryllifolius). The study employed a fully randomized design with three treatments in the form of simplicia plant components. There were 21 study units because each treatment included seven repetitions. Each treatment used 20 rice weevil imago breeding results which were infested in a jar containing 200 g of rice for 4 weeks in the laboratory. The use of pandan leaf, bay leaf, and lemongrass simplicia at 7 days after treatment showed the proportion of rice weevil mortality was 59,29%, 39,29%, and 50,00%, respectively. As for the observations of 14 day after treatments, 21 day after treatments, and 28 day after treatments showed that the mortality rate of all rice beetles was above 50%. Regarding the percentage of rice powder, hollow rice, and rice weight loss, the findings of observations on rice weevil mortality did not reveal any significant variations across all treatments.

Background: Acne vulgaris is one of the most common skin problems and is closely associated with the activity of Propionibacterium acnes. Long-term use of antibiotics may lead to bacterial resistance; therefore, alternative antibacterial agents derived from natural products are needed. White rice (Oryza sativa L.) is known to contain bioactive compounds such as flavonoids, alkaloids, terpenoids, tannins, and saponins, which potentially exhibit antibacterial activity. Objective: This study aimed to evaluate the antibacterial activity of ethanol extract of white rice against the growth of Propionibacterium acnes. Methods: This research was conducted as a laboratory experimental study using a post-test only control group design. The ethanol extract of white rice was prepared by maceration using 70% ethanol. Antibacterial activity was evaluated using the disc diffusion method with extract concentrations of 100%, 50%, 25%, 12.5%, and 6.25%. Clindamycin was used as a positive control, while sterile distilled water served as a negative control. The parameter observed was the diameter of the inhibition zone. Result: The results of phytochemical screening showed that the ethanol extract of white rice (Oryza sativa L.) contains flavonoids, alkaloids, and terpenoids. Antibacterial activity test showed that the ethanol extract of white rice at concentrations of 100%, 50%, and 25% was able to inhibit the growth of Propionibacterium acnes by forming an inhibition zone, while at concentrations of 12.5% and 6.25% no inhibition zone was formed. The highest inhibition zone diameter was found at a concentration of 100%. The ethanol extract of white rice at concentrations of 100% (7.65 mm), 50% (6.77 mm), and 25% (6.15 mm) was able to inhibit the growth of Propionibacterium acnes, and was classified as having moderate inhibition. In contrast, at concentrations of 12.5% and 6.25%, the ethanol extract of white rice did not show any inhibitory activity detected in vitro using the disc diffusion method. The results of statistical analysis showed a p value <0.001, which means there was a significant difference in the diameter of the inhibition zone between the treatment groups. Conclusion: In conclusion, the ethanol extract of white rice exhibits antibacterial activity against Propionibacterium acnes in a concentration-dependent manner; however, its inhibitory effect remains lower than that of clindamycin.

This study examines the performance of student administrative services in the Society 5.0 era at the Bureau of Academic Affairs, Student Affairs, and Planning of Gorontalo State University, focusing on scholarship services. It addresses the need for accessible, responsive, transparent, inclusive, and student-centered administrative services in higher education. A descriptive qualitative approach was employed through in-depth interviews, participatory observation, and document analysis. Informants included bureau leaders, scholarship and financial aid administrators, operational officers, and students receiving various scholarship schemes. Thematic analysis was conducted through data reduction, data display, and conclusion drawing, while validity was ensured through source triangulation, method triangulation, and member checking. The findings show that accessibility has improved through service counters, websites, social media, WhatsApp, online forms, SIMPEL BAKP, and coordination with faculties and study programs. However, information remains fragmented, digital standard operating procedures are not uniform, and disability-inclusive access is limited. Responsiveness is supported by direct and digital communication, but it lacks a dedicated complaint system, automatic notifications, selection-status dashboards, and real-time disbursement tracking. Service quality is perceived as fairly good because students experience professional, friendly, and fair treatment. Nevertheless, service documentation, procedural standardization, staff training, and humanistic technology integration need strengthening. The study concludes that scholarship administration should be transformed into a centralized, inclusive, responsive, transparent, and student-centered digital-humanistic service model.

Rheumatoid arthritis (RA) is a daily disease seen in rheumatology clinics. It predominantly involves the appendicular skeleton. The axial skeleton is mostly spared except for the cervical spine where instability can occur and can be carefully assessed with cervical spine radiographs in flexion and extension. Radiographs may show erosion at the C1-C2 level with destruction of the transverse ligament that can result in atlantoaxial subluxation. Diagnosis is based on clinical, laboratory, and radiographic findings. Conventional radiography has been the mainstay for diagnosis of joint damage and subsequent follow-up. Radiography can provide only indirect information on synovial inflammation, however, and the technique is insensitive to early bone damage. Hand radiographs are frequently ordered as the first imaging modality in the assessment of patients presenting with peripheral arthritis. They can provide invaluable information about the bones, joints, mineralization, soft tissues and the distribution of abnormalities. Given the wide spectrum of rheumatic diseases, it might be challenging to make the diagnosis solely based on the clinical findings and imaging plays an important role in narrowing the differential diagnosis. Having the knowledge of the common radiographic manifestations of inflammatory arthritis is of paramount importance for clinicians and radiologists to diagnose the underlying disease in early stages of disease in order to start treatment. The purpose of the article is to review the key radiographic findings of common rheumatic diseases in the hands.

Hydrocephalus is defined as active distension of the brain’s ventricular system, resulting from inadequate flow of cerebrospinal fluid from its site of production to its site of absorption into the systemic circulation. Hydrocephalus can affect anyone at any age; pediatric hydrocephalus affects 1 in 1,000 live births and is the most common cause of brain surgery in young patients. Hydrocephalus is a pathological condition characterized by abnormal accumulation of cerebrospinal fluid (CSF) due to increased production, impaired flow, or reduced absorption. Ventricular enlargement occurs in response to increased CSF volume and can lead to structural damage to the brain parenchyma. This condition can be congenital or acquired. One key point in prenatal diagnosis is the differentiation between fetal hydrocephalus and non-hypertensive ventriculomegaly. The former qualifies for intrauterine treatment with good outcomes. However, the latter can result in either favorable or catastrophic outcomes due to a damaging etiology, as seen in viral infections such as Zika virus. For an accurate diagnosis, fetal MRI is performed to detect brain anomalies, in addition to fetal ultrasound (to detect common complications), karyotype testing, and TORCH testing (toxoplasma, rubella, cytomegalovirus, herpes simplex). Obstetric management of fetal hydrocephalus depends on the gestational age at diagnosis and the presence of other anomalies. Treatment options include termination of pregnancy before the fetus is viable, placement of a ventriculoamniotic shunt, cephalocentesis before delivery, and/or cesarean section.

Introduction: Ramadan fasting is a religious practice observed by Muslims by abstaining from food and drink from dawn until sunset. These changes may increase the need for oral and dental healthcare. However, some Muslims still perceive that undergoing dental treatment while fasting may invalidate the fast, leading many patients to delay or avoid dental visits during Ramadan. Objective: This study aims to review and analyse various scientific literature regarding the safety and permissibility of dental procedures for patients who are observing fasting during Ramadan. Methods: This study used a narrative review method by searching scientific articles through PubMed, ScienceDirect, and Google Scholar databases using keywords relevant to the research topic. Articles were selected based on predetermined inclusion and exclusion criteria. Results: The review findings indicate that most dental procedures, such as local anaesthesia administration, scaling, restorative treatment, and tooth extraction, generally do not invalidate fasting as long as no material or fluid is intentionally swallowed. The use of suction devices, isolation of the treatment area, and proper scheduling of dental procedures are important factors in minimizing the risk of swallowing fluids during treatment. Conclusion: Most dental procedures can be safely performed on fasting patients while still considering both medical aspects and Islamic principles. Patient education regarding the safety of dental procedures during fasting should be improved to prevent delays in treatment and complications in oral health.

Breast cancer has a high global incidence and is the most prevalent cancer among women. Chemotherapy is a primary treatment option, but it may cause various physical and psychological side effects that can reduce patients’ quality of life. This study aimed to describe the characteristics of breast cancer patients undergoing chemotherapy and examine the relationship between chemotherapy side effects and quality of life at the outpatient unit of Ciremai Hospital. A cross-sectional analytical observational design was applied, with 30 patients receiving chemotherapy between May and July as the sample. Data were collected from medical records and the Indonesian version of the WHOQOL-BREF questionnaire, then analyzed using Spearman rank correlation. Most patients were aged 40–60 years, had a senior high school education, were housewives, and were in the 2nd or 5th chemotherapy cycle. Frequently reported side effects included nausea, vomiting, decreased appetite, early satiety, dizziness, sleep disturbances, body pain, and alopecia, mostly categorized as moderate. Most patients had a relatively poor quality of life. The analysis indicated a strong positive correlation between chemotherapy side effects and patients’ quality of life, with a Spearman correlation coefficient of 0.604 (p = 0.000 < 0.05), demonstrating a significant and strong relationship.

Breast cancer has a high global incidence and is the most prevalent cancer among women. Chemotherapy is a primary treatment option, but it may cause various physical and psychological side effects that can reduce patients’ quality of life. This study aimed to describe the characteristics of breast cancer patients undergoing chemotherapy and examine the relationship between chemotherapy side effects and quality of life at the outpatient unit of Ciremai Hospital. A cross-sectional analytical observational design was applied, with 30 patients receiving chemotherapy between May and July as the sample. Data were collected from medical records and the Indonesian version of the WHOQOL-BREF questionnaire, then analyzed using Spearman rank correlation. Most patients were aged 40–60 years, had a senior high school education, were housewives, and were in the 2nd or 5th chemotherapy cycle. Frequently reported side effects included nausea, vomiting, decreased appetite, early satiety, dizziness, sleep disturbances, body pain, and alopecia, mostly categorized as moderate. Most patients had a relatively poor quality of life. The analysis indicated a strong positive correlation between chemotherapy side effects and patients’ quality of life, with a Spearman correlation coefficient of 0.604 (p = 0.000 < 0.05), demonstrating a significant and strong relationship.

High-quality forage selection is a central factor in improving Bali cattle performance, particularly in smallholder systems that rely heavily on local feed resources. This study evaluated the effects of odot grass (Pennisetum purpureum cv. Mott) and pakchong grass (Pennisetum purpureum cv. Thailand) on feed intake, average daily gain, and feed conversion ratio of male Bali cattle. The experiment was conducted for 30 days from February to March 2026 at CV. RnB Farm, Gorontalo Regency. Nine male Bali cattle with relatively homogeneous initial body weights of 150–200 kg was assigned to a completely randomized design with three treatments and three replications. The treatments were P0, field grass as the control; P1, 100% odot grass plus concentrate; and P2, 100% pakchong grass plus concentrate. Dry matter intake did not differ significantly among treatments, with values of 6.47 ± 0.19, 6.52 ± 0.19, and 6.55 ± 0.16 kg/head/day for P0, P1, and P2, respectively. In contrast, average daily gain differed significantly, with the highest value observed in P2 at 0.56 ± 0.08 kg/head/day, followed by P1 at 0.52 ± 0.09 kg/head/day and P0 at 0.45 ± 0.06 kg/head/day. Feed conversion ratio also differed significantly, with the most efficient value recorded in P2 at 11.98 ± 2.10. These findings indicate that pakchong grass combined with concentrate provides the best feed efficiency and growth performance, while odot grass remains a promising alternative forage for improving Bali cattle productivity.

Pneumonia is one of the leading causes of morbidity and mortality among children aged 0–18 years worldwide. Appropriate treatment is crucial for improving treatment outcomes and preventing complications and antibiotic resistance. This literature review aims to analyze treatment options for pneumonia in pediatric patients based on articles published in PubMed from 2024 to 2025. The method used involved searching for articles with the keywords “(Case Reports) AND (pneumonia) AND (in children)” using filters for free full text, case reports, English language, human subjects, and the 0–18-year-old age group. Of the 71 articles identified, 10 met the inclusion criteria. The review results indicate that pneumonia treatment in children is dominated by the use of antibiotics and supportive care. In cases of severe pneumonia and necrotizing pneumonia, intensive antimicrobial therapy, close monitoring, and management of complications are required. Modern diagnostic tests such as bronchoalveolar lavage fluid (BALF), rapid syndromic arrays, and metagenomic next-generation sequencing (mNGS) help identify pathogens more quickly and accurately, thereby allowing for more targeted therapy. Additionally, corticosteroids and immunoglobulins are used as adjunctive therapies in cases of severe inflammation. Accurate diagnosis and individualized therapy selection play a crucial role in improving clinical outcomes for pediatric pneumonia patients. 

This study was motivated by the low basic multiplication skills of third-grade elementary school students, particularly in conceptual understanding, calculation accuracy, and problem-solving abilities. The objective of this study was to determine the effect of the Jarimatika method combined with the Problem Based Learning (PBL) model on students’ basic multiplication skills. This study employed a quantitative approach using a one-group pretest-posttest design. The participants were 30 third-grade students of SD Negeri Sukanegara. Data were collected through pretest and posttest instruments that had been tested for validity and reliability. The results showed a significant improvement in students’ multiplication skills after the treatment, as indicated by the increase in the mean score from 55.17 in the pretest to 80.00 in the posttest. The paired sample t-test analysis revealed a significant difference between pretest and posttest scores (t = -10.951, p = 0.000 < 0.05). The findings indicate that the implementation of the Jarimatika method combined with the Problem Based Learning (PBL) model effectively improves students’ basic multiplication skills and supports more active and meaningful mathematics learning.

Diabetes mellitus (DM) is one of the global, national, and regional health problems. DM often requires complex medications and lifestyle management that can impact patients’ daily life, including spiritual practices such as fasting during Ramadhan. For Muslims with DM, fasting during Ramadhan can be challenging due to the need to modify the treatment regimens and risk of hypoglycemia.  This study aimed to analyze the effects of education intervention regarding Ramadhan fasting on knowledge improvement and blood glucose of patient with DM type 2. This study used a case study design involving three patients with DM type 2. All three respondents received education from the researchers. The patients’ knowledge and fasting blood glucose were measured before and after the intervention. The results of this study showed an improvement in knowledge in DM patients after the intervention, while fasting blood sugar results remained unchanged. Based on the results of the study, diabetes mellitus (DM) management education during fasting has been potentially effective in improving respondents' knowledge and prevent hypoglycemia during Ramadhan fasting. In conclusion, education alone is benefit in increasing patient’s knowledge and may prevent hypoglycemia during Ramadhan fasting.

Rebonding is a chemical hair straightening procedure widely popular in Indonesia, involving two-stage redox reactions on keratin disulfide bonds using ammonium thioglycolate and hydrogen peroxide. Although it provides effective hair-straightening results, rebonding potentially causes significant damage to the hair cuticle structure. This study aimed to analyze the morphological changes of hair surface before and after rebonding treatment through a descriptive comparative case study approach using Scanning Electron Microscopy (SEM). The samples consisted of one strand of healthy, chemically untreated hair (control) and one strand of post-rebonding hair that both obtained from a female. Samples were prepared using gold-sputter coating prior to SEM observation. Representative SEM images from each sample were then qualitatively compared based on cuticle morphology parameters. The results showed clear morphological differences between the two samples: the control hair displayed tightly arranged and orderly cuticle scales with a smooth surface, while the post-rebonding hair showed surface erosion and the presence of cracks in multiple areas of the cuticle. These findings confirm that rebonding procedures cause visible and characterizable morphological cuticle damage as identified through SEM, providing a scientific basis for developing more protective post-rebonding hair care products.

Diabetes mellitus (DM) is one of the global, national, and regional health problems. DM often requires complex medications and lifestyle management that can impact patients’ daily life, including spiritual practices such as fasting during Ramadhan. For Muslims with DM, fasting during Ramadhan can be challenging due to the need to modify the treatment regimens and risk of hypoglycemia.  This study aimed to analyze the effects of education intervention regarding Ramadhan fasting on knowledge improvement and blood glucose of patient with DM type 2. This study used a case study design involving three patients with DM type 2. All three respondents received education from the researchers. The patients’ knowledge and fasting blood glucose were measured before and after the intervention. The results of this study showed an improvement in knowledge in DM patients after the intervention, while fasting blood sugar results remained unchanged. Based on the results of the study, diabetes mellitus (DM) management education during fasting has been potentially effective in improving respondents' knowledge and prevent hypoglycemia during Ramadhan fasting. In conclusion, education alone is benefit in increasing patient’s knowledge and may prevent hypoglycemia during Ramadhan fasting.

High feed costs remain a major constraint in Nile tilapia (Oreochromis niloticus) aquaculture, requiring alternative feed formulations based on local ingredients with adequate nutritional quality. This study aimed to evaluate the proximate composition of fish feed formulated from snail meal, Azolla meal, and turmeric as a phytobiotic supplement. The study used an experimental method with a Completely Randomized Design consisting of three treatments and three replications. The feed formulations were P1, consisting of 55% snail meal, 25% Azolla meal, 5% turmeric, 10% corn flour, and 5% tapioca flour; P2, consisting of 39% snail meal, 39% Azolla meal, 7% turmeric, 10% corn flour, and 5% tapioca flour; and P3, consisting of 25% snail meal, 51% Azolla meal, 9% turmeric, 10% corn flour, and 5% tapioca flour. The analyzed parameters included protein, moisture, fat, ash, crude fiber, and carbohydrate contents. Data were analyzed using analysis of variance followed by the Least Significant Difference test. The results showed that feed formulation significantly affected all proximate parameters. P3 produced the highest protein content of 43.87%, fat content of 3.68%, crude fiber of 3.11%, and carbohydrate content of 7.28%, while also producing the lowest ash content of 28.46%. Moisture content ranged from 1.11% to 1.30%, indicating good feed storage stability. These findings demonstrate that the integration of snail meal, Azolla, and turmeric can improve the nutritional quality of alternative Nile tilapia feed and support locally based sustainable aquaculture feed development.

Odot grass (Pennisetum purpureum cv. Mott) is an important ruminant forage because of its high palatability, adaptability to tropical environments, and potential for high biomass production. This study aimed to evaluate the effect of solid organic fertilizer on the growth and production of odot grass as a basis for developing productive and sustainable forage cultivation. The experiment was conducted in Pangi Village, Dulupi District, Boalemo Regency, from February to March 2026 using a completely randomized design with five treatments and three replications. The treatments consisted of P0 without solid organic fertilizer, P1 at 10 t/ha, P2 at 20 t/ha, P3 at 30 t/ha, and P4 at 40 t/ha. Observed variables included plant height, leaf number, tiller number, and fresh weight production. Data were analyzed using analysis of variance followed by Duncan’s multiple range test at the 5% significance level. The results showed that P4 produced the best response for all measured parameters. The highest plant height was 77.83 ± 43.80 cm, with 18.83 ± 3.67 leaves, 2.42 ± 1.38 tillers, and fresh weight production of 52.33 ± 10.12 t/ha. These improvements indicate that 40 t/ha solid organic fertilizer enhanced nutrient availability and supported biomass formation. Solid organic fertilizer is therefore a promising locally based cultivation input for improving ruminant forage productivity.

Pneumonia is one of the leading causes of morbidity and mortality among children aged 0–18 years worldwide. Appropriate treatment is crucial for improving treatment outcomes and preventing complications and antibiotic resistance. This literature review aims to analyze treatment options for pneumonia in pediatric patients based on articles published in PubMed from 2024 to 2025. The method used involved searching for articles with the keywords “(Case Reports) AND (pneumonia) AND (in children)” using filters for free full text, case reports, English language, human subjects, and the 0–18-year-old age group. Of the 71 articles identified, 10 met the inclusion criteria. The review results indicate that pneumonia treatment in children is dominated by the use of antibiotics and supportive care. In cases of severe pneumonia and necrotizing pneumonia, intensive antimicrobial therapy, close monitoring, and management of complications are required. Modern diagnostic tests such as bronchoalveolar lavage fluid (BALF), rapid syndromic arrays, and metagenomic next-generation sequencing (mNGS) help identify pathogens more quickly and accurately, thereby allowing for more targeted therapy. Additionally, corticosteroids and immunoglobulins are used as adjunctive therapies in cases of severe inflammation. Accurate diagnosis and individualized therapy selection play a crucial role in improving clinical outcomes for pediatric pneumonia patients. 

The use of local raw materials in Nile tilapia feed formulation needs to be developed to reduce dependence on increasingly expensive conventional feed ingredients. This study aimed to analyze the effect of different formulations of chicken feather meal and moringa leaf meal with turmeric addition as a phytobiotic on the chemical composition of Nile tilapia (Oreochromis niloticus) feed. The study used a completely randomized design with three treatments and three replications. P1 consisted of 55% chicken feather meal, 25% moringa leaf meal, 5% turmeric, 10% corn flour, and 5% starch; P2 consisted of 40% chicken feather meal, 40% moringa leaf meal, 5% turmeric, 10% corn flour, and 5% starch; and P3 consisted of 25% chicken feather meal, 55% moringa leaf meal, 5% turmeric, 10% corn flour, and 5% starch. The parameters analyzed were crude protein, moisture, ash, crude lipid, crude fiber, and carbohydrate. Data were analyzed using analysis of variance followed by the least significant difference test when significant differences occurred. The results showed that P3 produced the highest protein content (22.60%), ash content (6.65%), crude fiber (6.55%), and carbohydrate (8.45%), whereas P2 produced the highest lipid content (6.54%). Based on chemical analysis, P3 was the most prominent formulation for most proximate parameters. However, this formulation cannot be directly concluded as the best feed for fish growth because digestibility, palatability, feed conversion ratio, growth, survival, and health responses were not evaluated. Further biological testing is therefore required to confirm its feasibility for Nile tilapia culture.