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Type 2 diabetes mellitus represents a persistent metabolic dysfunction marked by elevated blood glucose levels attributable to insulin resistance. Geriatrics pertains specifically to individuals aged 60 years and older. Managing diabetes mellitus necessitates intricate therapeutic interventions, often comprising single or combined pharmacological agents aimed at achieving euglycemia. The concurrent administration of multiple medications, termed polypharmacy, amplifies the likelihood of pharmacological interactions. This investigation endeavors to delineate potential drug interactions observed in geriatric inpatients afflicted with type 2 diabetes mellitus at Dr. Moewardi Regional General Hospital in Surakarta throughout the calendar year 2023. The study adopted a descriptive observational design employing a cross-sectional approach. Data collection was conducted retrospectively through purposive sampling based on the medical records of geriatric patients at Dr. Moewardi Regional General Hospital in Surakarta. Inclusion criteria encompassed patients aged 60 years and older diagnosed with type 2 diabetes mellitus who had been hospitalized. Exclusion criteria included incomplete or illegible medical records, patients diagnosed with anemia and hemoglobinopathies, and those who expired during treatment. The findings revealed that out of 100 patients, 96 experienced drug interactions. Most patients (47.00%) were aged between 66 and 74 years. Females constituted a larger proportion (51.00%) of the patient cohort. Among hospitalized patients, 83 (83.00%) were admitted for 2-6 days. A total of 70 patients (70.00%) were prescribed between 4 and 13 medications. The predominant severity level of drug interactions was moderate, comprising 1,017 cases (74.60%). Pharmacodynamic mechanisms accounted for most drug interactions observed, totaling 1,054 cases (77.30%).  

A clot or bleeding in the brain causes a stroke or a cerebral vascular disease that damages the nervous system. Patients suffering from strokes may have physical, mental, sensory, and intellectual disabilities that impede their interaction with the environment and prevent them from performing daily activities and quality of life. This research determines the correlation between the disability level and the quality of life of patients suffering from stroke treated at the Kedungmundu Public Healt Care. The quatitative research applied a cross sectional approach and collected the samples from 67 respondents using proposive sampling. The applied measuring tools were mRS and SSQOL. The Spearmen Rank statistical test obtained a p-value of 0,000. The result accepts Ha, indicating a significant  correlation between  the disability level and the quality of life of the post-stroke patient with a value of r = -0,542. The value indicates a moderate and negative correlation between the level of disability and the life quality of post-stroke patients. The research result suggest the implementation of the intervention to lower the disability level because it influences post-stroke patients with low quality life.

Jati Village has a unique potential in processing organic waste into Liquid Organic Fertilizer (POC). The waste processing is an effort to preserve the environment and also provide added economic value to the local community. However, in making sales, the community in Jati Village has not implemented the right marketing strategy. Digital marketing offers various tools and platforms that can be used to promote POC. Digital marketing strategies that can be applied include the use of social media such as Instagram, Facebook, Tiktok and Youtube to promote POC through interesting and educational visual content, as well as direct interaction with consumers. By implementing digital marketing strategies, Jati Village can increase the visibility of their POC products, expand their customer base, and increase revenue. This can support the SDGs program, especially point 8, namely Equitable Village Economic Growth. Utilizing technology for marketing can help POC sales sell evenly.

The phenomenon of inner child or childhood experiences is one of the factors that shapes a person's character. Everyone experiences their own inner child to varying degrees and with different impacts. Family conflicts experienced during childhood, harsh treatment or words received by parents during childhood can have the impact of painful emotional wounds on a child who becomes an inner child. Parenting style is an important factor in the formation of an inner child. Parenting is the interaction between parents and children, what is the attitude or behavior of parents when interacting with children, for example how to set rules, teach normative values, provide attention and affection and show good attitudes and behavior so that they become role models and role models for children. -his son. The research aims to review one of the factors causing mental health disorders, namely the inner child and how the book of Isa reconciles and escapes the negative influence of the inner child based on research journals that have been conducted previously. The method used in this research is the Literature Review research method.. The result requires self-awareness of the inner child within oneself and this will help to reprogram one's conscious mind to be more adaptable to current life. Try to make peace with the existence of your inner child so you can live a more positive and happy life. This inner child cannot be considered trivial because it can have a negative impact on the person's personality and a solution needs to be found, so that it doesn't happen again in future generations, because if this inner child is not cured it will become a chain of inner children that will continue to repeat itself in the next generation..  

The learning process at the Merdeka Campus is one manifestation of student-centered learning which is very essential. Learning on the Independent Campus provides challenges and opportunities for developing innovation, creativity, capacity, personality and student needs, as well as developing independence in seeking and finding knowledge through the realities and dynamics of the field such as ability requirements, real problems, social interaction, collaboration, self-management, performance demands, targets and achievements. Through a well-designed and implemented independent learning program, students' hard and soft skills will be strongly formed.In the series of introductions to new students, the MBKM team was asked to be a resource for introducing MBKM to new students. The aim of this activity is to provide knowledge to new students regarding MBKM. There are several benefits that students can get by participating in MBKM activities, one of which is additional competency skills outside campus, learning experiences outside campus and recognition of a maximum of 20 credits for MBKM activities so that they can speed up graduation. Students and students have the skills desired by industry.

Drug interaction is a change in the effect of a drug due to the presence of other drugs taken simultaneously, which will cause a decrease in the therapeutic effect of the drug and toxicity in the body can increase. Changes in drug effects due to drug interactions vary greatly between individuals because they are influenced by various factors such as dose, drug levels in the blood, route of drug administration, drug metabolism, duration of therapy and patient characteristics. The potential for drug interactions can occur, one of which is in patients who take a large number of drugs simultaneously or Polypharmacy. Therefore, this study is related to the problem of drug interactions that occur due to Polypharmacy Prescriptions from internal medicine specialists at One of the Pharmacies in Bandung City which really needs to be considered, especially by a pharmacist. The results can be concluded that there are 22 drug interactions originating from 69 prescriptions with details of 10 minor interactions, 11 moderate interactions, and 1 major interaction. This shows that of the 69 prescriptions that have been studied, only 31.88% have interactions with minor, moderate, and major categories.

Word Health Organization defines a cause of death as an illness, disease or injury that causes or contributes to death. Diabetes mellitus is a major comorbidity and cardiac arrest is the highest cause of death. Cardiovascular disease is more common in men with an average age of 57 years. There are many types of cardiovascular disease, but the most common and well-known are coronary heart disease and stroke. Basic Health (Riskesdas) in 2018 reported that the incidence of heart and blood vessel disease is increasing from year to year. The main factor in heart disease is uncontrolled blood sugar, while the most common macrovascular complication of diabetes mellitus is coronary heart disease. Causative factors The prevalence of type 2 diabetes mellitus is caused by the interaction between gene susceptibility factors and environmental exposure as follows Genetics and Environment The occurrence of coronary heart disease is closely related to the presence of disorders affecting the blood vessels called atherosclerosis. This research uses a systematic review based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). with inclusion and exclusioncriteria, the risk of cardiovascular death and myocardial infarction was higher with increasing values ​​of lysis time and maximum turbidity.

The purpose of this study was to determine the care skills of nurses. In carrying out their profession, care is required to improve skills which is a process that leads to professionalism. The process begins with the perception of nurses in seeing conditions and solving problems, one of which is carrying out the application of nursing care to clients. The application of nursing care provided by nurses cannot be separated from spiritual aspects which are an integral part of the nurse's interaction with clients. Nurses together with special spiritual officers in the hospital try to help meet the spiritual needs of clients as part of the client's overall needs, among others by facilitating the fulfillment of these client needs, even though nurses and clients do not have the same beliefs and religions. In the application of spiritual nursing care is influenced by several factors, namely intellectual skills where the nurse's intellect will be very influential in the application of care. With data collection methods, namely observation, documentation and questionnaires. The population and sample are Samples In this study, the sampling technique used was purposive sampling, namely the sample taken was 50 nurses who served in four rooms of the Inpatient Hospital Labuang Baji Makassar.

ARI is an acute respiratory disease characterized by signs of cough, runny nose, hoarseness, fever and discharge of mucus or mucus that lasts up to 14 days. The impact of ARI begins with the interaction of the virus with the body, viral irritation that causes damage to the structure of the lining of the respiratory tract which results in increased activity of the mucus glands in the walls of the respiratory tract, resulting in the release of mucosal fluid that exceeds normal and the problem that arises is ineffective airway clearance. The application of simple inhalation using eucalyptus oil can improve airway clearance in ARI patients. The purpose of this study was to analyze the effect of simple inhalation on improving airway clearance in children with ARI. The research method is experimental with a pre-post test design. The study was conducted by assessing airway clearance before and after simple inhalation therapy. The sample size in the study was 30 respondents determined by purposive sampling. The results of the study to be achieved in the form of a textbook integrated with the learning outcomes of the Pediatric Nursing course, HAKI, and national publications. The TKT target of this study is at level 2. The results of this study indicate that there is an effect of simple steam inhalation in improving airway clearance in children with ARI with a p value of 0.000. The conclusion of this study shows that simple steam inhalation can improve airway clearance in children with ARI. The suggestion of this study can be used as a guide for mothers at home who have children who experience ineffective airway clearance due to ARI.

Background: Stress is a mental feeling disorder that often occurs in society. Starting from unhandled stress can turn into more serious. Stress can occur at all ages, especially in the elderly, the elderly are a group that is vulnerable to physical and psychosocial changes. Objective: For this reason, this community service activity aims to socialize about handling in reducing stress/stress by using United Kingdom music therapy. Method: This community service activity uses the lecture and question and answer method. The lecture method was carried out by delivering material on stress and music therapy in United Kingdom. Meanwhile, the question and answer method is carried out by asking participants about the material that has been presented. Results: The results of this community service activity were obtained that participants were able to understand and apply the material that had been delivered. Conclusion: Based on the community service activities that have been carried out, many of the participants enthusiastically received the entire series of events ranging from material presentations to question and answer interactions.

The growth of new innovations makes snacks rich in iron and protein in the form of cookies using red bean flour substitution and the addition of moringa flour. This study aims to determine the effect of red bean flour substitution, the addition of moringa flour, and the interaction of the two factors on the acceptability of cookies (color, aroma, taste, and crispness), as well as the protein and iron content contained in the best cookie formula. The study was conducted in Surabaya on adolescent girls. This type of research is experimental with a two-factor randomized complete block design (RAL). The study used descriptive analysis of nutritional content (protein and iron) obtained from the laboratory. Acceptability will be tested parametric statistics using Two-ways Anova statistics. The results showed that red bean flour affects the color and crispness of cookies (<0.05); Moringa leaf flour affects the color, aroma and crispness (<0.05); the interaction between the two only affects the crispness (<0.05); and protein and iron in accordance with SNI dan Nutritional Adequancy Rates.  

Government policy changes and drug price fluctuations related to e-catalog can affect drug costs and types purchased between 2022 and 2023. This research aimed to analyze the differences in drug procurement using the e-catalog system and its interaction with hospital financial and operational variables. The study employed a mixed-methods approach to understand the dynamics of drug procurement at Pharmacy Department of X Hospital through the e-catalog system between 2022 and 2023. This research evaluated changes in purchasing volume, costs, cost efficiency, and service speed. Quantitative data were obtained from e-catalog documentation, focusing on the types, volumes, and prices of chronic medications, as well as BPJS claims. Statistical analysis was used to compare the study periods, while qualitative data from in-depth interviews with 15 respondents, observations and document analysis enriched the understanding of procurement process changes through data triangulation analysis.  The results demonstrated an increased use of e-catalog, with policy changes leading to supplier diversification and price flexibility. Quantitative findings indicated a 25% increase in the volume of drug purchases through the e-catalog from 2022 to 2023, accompanied by a 15% reduction in average drug prices due to heightened competition among suppliers. Additionally, procurement efficiency improved by 30%, as reflected in the reduction of the procurement cycle time from 45 days to 31 days. These findings indicated shifting needs and procurement strategies, affecting budget efficiency and the speed of fulfilling drug requirements. In conclusion, strategic adaptations and ongoing evaluations in managing e-catalog are essential to address financial and logistical challenges, ensuring patient satisfaction and drug availability.    

Medications used for gastrointestinal (GI) disease therapy are widely prescribed or over-the-counter, ranking among the top 10 prescribed and sold globally. These drugs are often concurrently used with other medications, leading to potential drug interactions that can impact their effectiveness. However, the identification of potential interaction severity remains limited. This study focuses on identifying drug interactions in patients with digestive disorders through common prescriptions in Bandung city in November 2023. Out of 50 analyzed prescriptions, 20 potential drug interactions were identified, comprising 8 minor and 12 moderate interactions, with no major interactions. The findings underscore the pharmacist's crucial role in counseling and providing drug information to enhance therapy effectiveness and patients' quality of life.

This paper examined the role of social media on mental health amidst the acceleration of digital transformation. The increasing engagement of young people in social media platforms has raised major concerns regarding its impact on psychological well-being. This study investigates that there is a strong correspondence of social media consumption and the emergence of mental health issues such as depression and anxiety and social isolation among adolescents. Data shows a significant increase in screen/mobile time among Indonesian adolescents, with average daily use exceeding global recommendations and correlating with high incidence of mental health disorders. This study utilized a comprehensive review of the existing literature, as well as engaging multiple academic sources to assess the cumulative impact of the digital Effect. Key findings suggest that excessive interaction with digital platforms potentially increases risk of cyberbullying, body image problems, depression, anxiety, self-harm, suicidal tendencies and substance consumption. Another finding, that exposure to sexual content or pornographic sites on the internet, is a predictor of increased sexual activity and premarital sex. This is an important concern, highlighting the adverse impact of prolonged digital effects on adolescents' mental resilience and life satisfaction. This research underscores the urgent need for strategic interventions and policy frameworks to mitigate the negative effects of social media on mental health holistically.

This community service focuses on participatory planning of thematic parks at the Kampoeng Semawis Housing Complex, Semarang. This area has great potential to be developed into a useful public space, but currently the existing green open space is still less than optimal in its use. The focus of this service is to create a thematic park that not only functions as a green open space, but also as a place for social interaction and education for residents. The main issue faced is the lack of community involvement in planning and managing public spaces, which results in a lack of sense of ownership and concern for existing facilities. Through a participatory approach, this program aims to increase citizen participation in planning and managing public spaces. It is hoped that with this thematic park, the level of citizen participation in maintaining and utilizing public spaces will increase, which will ultimately improve the quality of life for the residents of Kampoeng Semawis. This community service aims to examine the participatory planning process for thematic parks in Kampoeng Semawis and its impact on community participation and the quality of life of local residents. It is hoped that the results of this program can become a model for the development of public space in other residential areas in Semarang.

A novel compound called 3-chloro-4-(4-(dimethylamino)phenyl)-1-(6-methoxybenzo[d]thiazol-2-yl)azetidin-2-one (3-CDBA), derived from beta-lactams, was investigated for its effects on human leukemia (HL-60) cells, pancreatic cancer (TCP-1026) cells, and healthy cells (WRL68) for comparison. The compound showed an inhibitory concentration (IC50) of 91.55 µg/ml on the leukemia cells, 141.3 µg/ml on the pancreatic cancer cells, and 353.8 µg/ml on the healthy cells. This indicates that the compound selectively kills cancer cells while having minimal effect on healthy cells, as higher concentrations are required to kill half of the healthy cells. These findings suggest that the compound has the potential to inhibit the growth of cancer cells. In comparison to conventional antioxidants like ascorbic acid (vitamin C), the beta-lactam derivative (3-CDBA) exhibited a higher percentage of inhibition at the highest concentration, with a value of 72.95% and an IC50 of 42.67 µg/ml. Furthermore, the compound's effects were studied on two types of pathogenic bacteria, specifically Staphylococcus aureus (positive) and Escherichia coli (negative), as well as various Penicillium species. The compound showed the greatest inhibitory effect at a concentration of 1000 µg/ml. In a theoretical examination, molecular docking was employed to design and synthesize a drug using the beta-lactam derivative and a target associated with cancer cells from a protein database. The compound demonstrated a strong and close interaction with amino acids and different sites within the active pocket, resulting in a higher binding energy. This indicates that the compound has the potential to inhibit the growth of cancer cells by disrupting their metabolic processes.  To determine the lethal dose (LD50), the beta-lactam derivative (3-CDBA) was administered to half of the animals in the study.

This research was motivated by the relatively limited understanding of students in grades 3, 4 and 5 at SDN 15 Sutijo regarding PAI material. Many students have not demonstrated attitudes and behavior that reflect religious teachings well. Then, most students experience difficulties in achieving the expected competency standards in Islamic Religious Education subjects, including from the emotional and spiritual aspects of students. Many students lack motivation and feel anxious during the learning process, which has a negative impact on learning outcomes. Then some students also show apathy and lack motivation in taking religious lessons. This can be seen from the low average test scores and the results of observations of student interactions in class. So this research aims to determine the influence of IQ, EQ and SQ on students' PAI learning outcomes. This type of research is quantitative correlation. The population was 30 students and the sample used a total sampling technique. Data was collected through questionnaires and documentation and analyzed using simple and multiple linear regression tests. The research results show that IQ, EQ and S1 influence students' PAI learning outcomes. IQ has an effect of 14.4%, EQ of 14.3%, SQ of 27.2%. Then IQ, EQ and SQ together also influence students' PAI learning outcomes, namely 27.4% and the rest is influenced by other factors not examined in this research.

Hypertension is a non-communicable disease characterized by an increase in blood pressure above normal limits. Hypertension is a disease that increases every year and can cause complications. Hypertension can be prevented from complications by doing good self-care to control blood pressure. Self-care is an action taken independently to improve health, prevent disease and maintain health. Here are 5 components of self-care for people with hypertension, namely self-integration, self-regulation, interaction with health workers and others, monitoring blood pressure, and adherence to recommended rules. The purpose of this study was to determine the description of self-care in hypertensive patients at Puskesmas Kalijati Subang. This research design is descriptive with cross sectional design. The population in this study was 921 people, where the research sample was 91 people. The sampling technique used purposive sampling. The results of this study found that self-care in hypertensive patients at Kalijati Subang Health Center was 61.5% in the bad category and 38.5% in the good category. The conclusion is that most of the self-care in hypertensive patients at Puskesmas Kalijati Subang is in the bad category. It is hoped that future researchers can develop related factors that affect self-care in hypertensive patients.

This research aims to improve the English language skills of class 2 students at MIS Fathul Jannah using flipchart media, carrying out interactive learning methods, and evaluating the impact of using flipcharts on student understanding. The results show that using flipcharts effectively improves students' understanding, although it requires time preparation and reliance on teacher explanations. The advantages are material visualization, interaction, and flexibility. Disadvantages include time-consuming preparation, reliance on explanations, and space limitations. In conclusion, using flipcharts can improve students' English skills, but requires careful preparation and training for teachers. Integration with digital learning tools is also needed to increase its effectiveness. Although recommended as an effective learning method for elementary schools, further research is needed to improve the quality of its use.

Al-Qur'an recitation assistance at TPQ Saroja Kutisari Tenggilis Mejoyo, Surabaya, is key in improving the quality of Al-Qur'an recitation among students. This research explores the implementation of Tahsin Tilawah Al-Qur'an activities as a step to perfect the recitation of the Al-Qur'an in the neighborhood. Through a qualitative method with participatory observation, the results show that this activity is effective in improving the recitation of the Qur'an of the students. Factors such as direct guidance from the ustadz, a conducive learning atmosphere, and interaction between fellow students play an important role in the success of this program. This research provides an in-depth understanding of the role of Qur'an recitation mentoring in religious education in Indonesia, as well as making important contributions to the development of similar programs in the future.