Isolasi dan Identifikasi Bakteri Endofit Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) sebagai Penghasil Senyawa Antifungi terhadap Candida Albicans

Suci Tri Ramadhani ; Ardi Mustakim
Intellektika : Jurnal Ilmiah Mahasiswa 📅 2025 Vol 3, No 4 🔗 DOI: 10.59841/intellektika.v3i4.3038
Abstract
Opportunistic fungal infections caused by Candida albicans pose increasing global health challenges, especially in immunocompromised patients. Resistance to conventional antifungal agents such as azoles and echinocandins has driven the search for alternative natural sources of antifungal compounds. This study reviews the isolation and identification of endophytic bacteria from Curcuma xanthorrhiza rhizomes and their potential to produce antifungal metabolites against C. albicans. Literature from the past ten years was analyzed, focusing on bacterial endophytes isolated from temulawak, their identification methods, and antifungal activities. Dominant endophytes such as Bacillus subtilis, B. amyloliquefaciens, and Pseudomonas fluorescens demonstrated significant inhibition of C. albicans growth, with inhibition zones ranging from 10 to 25 mm and minimum inhibitory concentrations (MIC) between 62.5 and 250 µg/mL. Antifungal activity is attributed to bioactive secondary metabolites, particularly lipopeptides produced by Bacillus species. Molecular identification via 16S rRNA sequencing confirms bacterial taxonomy, supporting further biotechnological exploration. This review highlights the promising potential of temulawak endophytic bacteria as a natural source for new antifungal agents to address drug resistance issues.
Keywords
Antifungal Activity; Bacillus; Candida Albicans; Curcuma Xanthorrhiza; Endophytic Bacteria
How to Cite

Suci Tri Ramadhani & Ardi Mustakim (2025). Isolasi dan Identifikasi Bakteri Endofit Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) sebagai Penghasil Senyawa Antifungi terhadap Candida Albicans. Intellektika : Jurnal Ilmiah Mahasiswa, 3(4). https://doi.org/10.59841/intellektika.v3i4.3038

Suci Tri Ramadhani; Ardi Mustakim, "Isolasi dan Identifikasi Bakteri Endofit Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) sebagai Penghasil Senyawa Antifungi terhadap Candida Albicans," Intellektika : Jurnal Ilmiah Mahasiswa, vol. 3, no. 4, 2025.

Suci Tri Ramadhani; Ardi Mustakim. "Isolasi dan Identifikasi Bakteri Endofit Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) sebagai Penghasil Senyawa Antifungi terhadap Candida Albicans." Intellektika : Jurnal Ilmiah Mahasiswa, vol. 3, no. 4, 2025.

Suci Tri Ramadhani; Ardi Mustakim. "Isolasi dan Identifikasi Bakteri Endofit Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) sebagai Penghasil Senyawa Antifungi terhadap Candida Albicans." Intellektika : Jurnal Ilmiah Mahasiswa 3, no. 4 (2025).

Suci Tri Ramadhani & Ardi Mustakim (2025) 'Isolasi dan Identifikasi Bakteri Endofit Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) sebagai Penghasil Senyawa Antifungi terhadap Candida Albicans', Intellektika : Jurnal Ilmiah Mahasiswa, 3(4). doi: 10.59841/intellektika.v3i4.3038.

Suci Tri Ramadhani; Ardi Mustakim. Isolasi dan Identifikasi Bakteri Endofit Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) sebagai Penghasil Senyawa Antifungi terhadap Candida Albicans. Intellektika : Jurnal Ilmiah Mahasiswa. 2025;3(4).

Artikel Terkait

Analisis Pencemaran Lingkungan sebagai Penyebab Banjir di Kawasan Jalan Pekapuran Kota Depok

Syamsa Azilla; Aprillia Intan Nur Cahya; Adrianus Rebon Piran

Pemanfaatan Media Multimodal dalam Pembelajaran Keterampilan Membaca Teks Berita

Asra Fania; Syahrul Ramadhan

Simbol Relegius Spiritual dalam Film “Titip Surat Untuk Tuhan” Analisis Semiotika Roland Barthes

Dinar Thahira Handatika; Salma Rosyida Nur Hanifah; Ulul Fadli Zakiyatul Badriyah

Eksplorasi Media Loose Parts dari Bahan Alam Dalam Menstimulus Kreativitas Anak Usia Dini di Pos Paud Pelita Mandiri Kertek

Dina Zuhda Syauqia; Siti Rohmatun; Ani Sofiana Istiqomah; Fatiatun Fatiatun

The Massuru' Tondok Ritual as a Space for Encountering the Transcendent: An Analysis Based on the Thought of Ninian Smart

Agustinus Abraham

Analisis Efektivitas Penerapan A/B Testing dalam Meningkatkan Performa Website pada PT Pamor Putra Mandiri

Hari Noer Fazri; Ina Najiyah
Tren Sitasi Jurnal