Soursop leaves contain active compounds annonaceous acetogenins which are known to have cytotoxic activity against cancer cells. This study aims to evaluate the effect of soursop leaf methanol extract (EMDS) on the viability and growth inhibition of PC3 prostate cancer cells. The research method used was an in vitro experiment with subjects in the form of PC3 cell lines divided into five groups, namely the cell control group, the treatment group with EMDS at concentrations of 6.25; 12.5; and 25 mg/mL, and the group given doxorubicin as a positive control. Cell viability was analyzed using the MTT assay method after incubation for 0 and 24 hours, and cell morphology was observed. Data analysis was carried out using the ANOVA test. The results showed that the EMDS group with concentrations of 6.25 and 12.5 µg/mL experienced a decrease in OD values, although statistically there was no significant difference. The concentration of 12.5 µg/mL had the highest inhibitory effect on cell viability with an OD value of 0.94. Observation of cell morphology indicates the presence of cytotoxic effects. Conclusion: methanol extract of soursop leaves has potential as an anticancer agent against PC3 prostate cancer cells, although the inhibitory effect is relatively small.

Health problems in the elderly are increasingly becoming a major concern at global and national levels, along with increasing life expectancy. One of the most common health problems faced by the elderly is musculoskeletal disease, including rheumatism. This study aimed to determine the effect of rheumatic exercise on the ability of elderly individuals to perform daily activities. This study is a quantitative study using a quasi-experimental one-group pre-test and post-test design. The results showed that The results of the Wilcoxon rank test were p = 0.000, which was smaller than ? = 0.05. This study shows the effect of rheumatic exercise on the ability of the elderly to perform daily activities. This shows that rheumatic exercise is an effective intervention to support the ability of the elderly to face physical and psychological challenges due to aging and chronic diseases, such as rheumatoid arthritis.

The rapid development of information technology has provided great opportunities for the service sector to improve efficiency and convenience, including in vehicle washing services. This research aims to develop a web-based system using the Laravel framework, which is designed to simplify the online ordering process and overcome queuing problems. The system features user authentication, location-based booking, payment gateway integration for real-time transactions, and an interactive dashboard for service providers. The case study was conducted at Carenmore, a vehicle wash service in Krian. The implementation results show that the system is able to reduce customer waiting time, provide a better user experience, and improve service efficiency. Further development is recommended to add a variety of features, improve interface design, and increase the system's ability to handle larger user loads.

This study aims to describe: (1) the meaning of utterances containing conventional implicatures in the novel ‘The Years of The Voiceless’ by Okky Madasari, (2) define the function of utterances containing conventional implicatures in the novel ‘The Years of The Voiceless’ by Okky Madasari, and (3) describe the types of utterances containing conventional implicatures in the ‘The Years of The Voiceless’ by Okky Madasari based on Grice’s theory about implicature. The research method was descriptive qualitative method. The data in this study are sentences in utterances containing implicature. The data in this study were obtained by reading, recording and note-taking techniques. The findings are as follows. There are 8 forms of conventional implicature found. Based on the results of the classification that has been done, there are four intentions, 1 utterance of the intention of commanding, 1 utterance of the intention of pride, 1 utterance of the intention of giving information. Types of utterances that contain conventional implicatures in the novel 'The Years of The Voiceless'. Each implicature has a function. The function of conventional implicatures in the novel can be categorized into three functions, namely 1. implicatures that function as persuasive or persuade, 1 implicature that functions as directive, namely giving advice, 1 implicature that functions as expressive, namely showing hatred. Based on the results of the classification that has been done, there are two classifications, 1 type of declarative speech (statement), 1 type of imperative speech (command).

This research examines the use of *amtsal* (parables/analogies) in the Quran from an Arabic sociolinguistic perspective. The main focus of the research is to analyze the forms of amtsal, their sociolinguistic functions, and the influence of socio-cultural context in the selection of Quranic amtsal. The research method uses a qualitative approach with descriptive analysis through literature study of primary and secondary sources. The research results show that amtsal in the Quran has three main forms: *musharrahah* (explicit), *kaminah* (implicit), and *mursalah* (free). The sociolinguistic functions of amtsal include educational functions in facilitating understanding of abstract concepts, persuasive functions in influencing attitudes and behavior, and communicative functions in bridging divine messages with socio-cultural contexts. The selection of amtsal is heavily influenced by the socio-cultural context of Arab society, including traditions, social conditions, and psychological aspects. This research contributes to a deeper understanding of the Quran's communication methods and can serve as a reference in developing contemporary learning and da'wah methods.
 

This research examines the potential of Epoxy-HGM-Carbon Fibre and Epoxy HGM Sical Woven Fibre composites as alternative materials for bulletproof vests. These two materials were chosen because they have similar ballistic protection capabilities to kevlar but with lighter weight and more economical cost. Using the finite element method, this study simulates the resistance of each composite to the penetration and impact energy of projectiles in accordance with the NIJ 0101.06 standard to protect users from ballistic threats. The simulation results show that the Epoxy-HGM-S Sisal Woven Fibre specimen at an optimum thickness of 30 mm as well as Epoxy-HGM-Carbon Fibre at a thickness of 18 to 30 mm are able to meet the penetration, Back Face Signature (BFS), and residual kinetic energy criteria that comply with the safe limits for users. This research makes an important contribution to the identification of alternative materials that not only improve user comfort and mobility, but also maintain ballistic protection effectiveness for military and security applications, especially for personnel who need protection against ballistic projectiles.

The rapid development of social media has significantly impacted the management of Islamic education, presenting both opportunities and challenges. This study aims to analyze the influence of social media on Islamic education management by employing a Systematic Literature Review (SLR) approach. The research method involves identifying, evaluating, and synthesizing relevant literature from the past ten years to understand trends, benefits, and obstacles in utilizing social media for educational purposes. A total of 50 studies were reviewed, focusing on various aspects such as communication effectiveness, student interaction, and access to learning resources. The findings indicate that social media facilitates communication efficiency, enhances student engagement, and broadens access to Islamic educational resources. It has become an essential tool in delivering content, connecting students and educators, and fostering collaborative learning. However, challenges such as misinformation, lack of regulatory policies, and student distractions require strategic solutions. The study suggests implementing internal policies, providing teacher training, and utilizing social media analytics to optimize its use. In addition, integrating social media strategies with traditional Islamic teaching methods can enhance educational outcomes. These findings contribute to a deeper understanding of the role of social media in Islamic education management and offer recommendations for its effective implementation. Furthermore, the study highlights the need for further research to explore the long-term impacts of social media on Islamic education.

This study aims to analyze the different types of characters in Agatha Christie's Mengungkit Murder. By adopting a qualitative approach and descriptive analysis method, this study identifies the characters in the novel and their roles and relationships in the storyline. The research data were obtained through literature study and text analysis, which were then analyzed using content analysis techniques. The results show that the characters in the novel not only serve as plot drivers, but also reflect broader themes, such as justice and betrayal. This research is expected to make a significant contribution to literary studies, especially in understanding characterization in Agatha Christie's works.

Knitting craft training at the Darul Khuldi Islamic Boarding School aims to increase the creativity and independence of students in Sri Mulya Village. This activity involved 36 students divided into six groups, where they learned basic knitting techniques and made knitted products that were of marketable value. The method used is participatory, with a direct approach through training sessions and discussions. The results of the training show that students are able to understand basic knitting techniques well, improve collaboration skills and creativity. Apart from that, this training also strengthens social ties between students and gives them confidence in creating products. Even though there are challenges in the availability of raw materials and learning time, it is hoped that this program can provide initial capital for students to develop handicraft skills and contribute to the development of the local economy.

The healing process of a tooth socket after extraction involves various stages, including the proliferation of fibroblasts that play a role in the formation of new tissue. Natural ingredients have long been used in accelerating wound healing, but their effectiveness in increasing the number of fibroblast cells still needs to be studied further. To determine the effectiveness of natural ingredients in increasing the number of fibroblast cells in the tooth socket of Wistar rats after tooth extraction. Methods: This is a literature review that collects and analyzes scientific articles from various databases such as PubMed, Google Scholar, DOAJ, Garuda Portal, and CrossRef. The selected articles met the predetermined inclusion criteria, including studies conducted on Wistar rats and using natural ingredients as interventions. Red ginger extract at 10% concentration was found to be the most effective ingredient in increasing the number of fibroblasts and accelerating wound healing. Red ginger extract (Zingiber officinale var. rubrum) is the most effective natural ingredient in increasing the number of fibroblast cells in the tooth socket of Wistar rats after tooth extraction.