Cancer is one of the leading causes of death in the world, with the incidence rate continuing to increase every year. Conventional treatments such as chemotherapy and radiotherapy often have limitations, especially related to selectivity towards cancer cells and toxic side effects caused to normal cells. Therefore, an alternative approach that is more effective and safe is needed. One promising approach is the utilization of bioactive compounds from natural materials that are optimized through a medicinal chemistry approach. This study aims to examine the potential of natural compounds such as epigallocatechin gallate (EGCG) from green tea, berberine from Berberis vulgaris, curcumin from turmeric (Curcuma longa), and cardiotonic steroids (CTS) from Digitalis purpurea and Nerium oleander as anticancer agents, as well as their optimization strategies through structural modification, increased stability, and modern delivery technology. The method used is a systematic literature review of scientific articles from 2020 to 2025 obtained through the PubMed, ScienceDirect, and Google Scholar databases. The results of the study indicate that these compounds have various anticancer mechanisms of action, such as apoptosis induction, cell cycle inhibition, and activation of specific signaling pathways such as PI3K/Akt, MAPK, and ferroptosis. However, challenges such as low bioavailability, poor stability, and toxicity are still obstacles in their application. Through a medicinal chemistry approach, these compounds can be structurally modified or reformulated to improve their clinical effectiveness. In conclusion, the combination of natural wealth with medicinal chemistry innovation opens up great opportunities in the development of more selective, effective, and safe anticancer therapies in the future.
 
 

This article aims to conduct a systematic literature review of empirical and theoretical studies of the last five years (2020–2024) that discuss the relationship between financial performance and company value in various countries. The study summarizes the most commonly used financial performance indicators, such as ROA, ROE, EPS, and NPM, and evaluates their contribution to a company's value. In addition, this article analyzes the consistency and variation of research results based on methodology, geographic location, industry type, and theoretical approaches such as signal theory, agency, and stakeholders. The literature selection process is carried out through reputable databases (Scopus, Web of Science, ProQuest) with certain inclusion criteria. The results of the review show that internal factors such as CSR, ESG, green innovation, and risk management generally have a positive effect on the company's performance and value, depending on the context of implementation. This article is expected to be a critical and useful reference for future researchers in developing similar studies.

Performance implementation is a key component of human resource management that not only plays a role in achieving organizational goals but also directly influences employee attitudes and behavior. This study aims to analyze how performance implementation affects job satisfaction and employee motivation. A quantitative method was used by distributing questionnaires to 32 employees at an institution. The analysis results indicate that performance implementation significantly influences both job satisfaction and work motivation. These findings emphasize the importance of fair and participatory performance evaluations in boosting employee morale and loyalty to the organization.

Chronic Energy Deficiency (CED) is a manifestation of malnutrition characterized by an inadequate energy intake over a prolonged period in pregnant women, resulting in adverse health outcomes due to a relative or absolute deficiency of one or more essential nutrients. The 2023 SKI results indicate that malnutrition among pregnant women remains a problem, with nearly 3 out of 10 pregnant women experiencing anemia and 17% at risk of CED. According to data from the Jambi City Health Office, Putri Ayu Public Health Center (Puskesmas Putri Ayu) has the highest number of CED cases, with 67 affected pregnant women. The main objective of this study is to explain the underlying factors contributing to the high prevalence of Chronic Energy Deficiency (CED) and to inform the development of evidence-based health interventions aimed at reducing this condition. This study employed a quantitative research method with a case-control design. The sampling technique used was purposive total sampling, involving 78 pregnant women in the Putri Ayu Public Health Center area, Jambi City. Data collection was conducted in October 2024, using a questionnaire as the research instrument. Data were analyzed using the chi-square test. The results showed a significant relationship between CED and parity (p=0.034), anemia (p=0.013), attitude (p=0.000), and the role of health workers (p=0.000). No significant relationship was found between CED and age (p=1.000), pregnancy spacing (p=0.615), and knowledge (p=0.359) in pregnant women. The findings indicate that parity, anemia, attitude, and the role of health workers are significantly associated with the occurrence of CED in pregnant women, while age, pregnancy spacing, and knowledge are not significantly associated.

Dynamic business markets require Micro, Small and Medium Enterprises (MSMEs) to continuously innovate in order to maintain competitiveness and increase business growth. This article discusses the product and service innovation strategies implemented by Bakso Simas Business in facing the challenges of a rapidly changing market. This research uses a qualitative method with a case study approach, where data is collected through interviews, observation, and documentation analysis. The results show that innovation in product variants, improving service quality, and utilizing digital technology are the main factors in increasing customer attractiveness and loyalty. In addition, differentiation strategies and adaptation to consumer trends play an important role in maintaining business sustainability. This study provides insights for MSME players in developing effective innovation strategies to face competition in a dynamic business market.
 
 

Hypertension is one of the major health problems frequently experienced by the elderly and can lead to serious complications if not properly managed. Simple physical activities such as massage can serve as a non-pharmacological intervention to help reduce blood pressure. This study aimed to determine the effect of physical activity in the form of massage on reducing blood pressure in elderly individuals with hypertension at PSTW "Meci Angi" in Bima City. This research employed a quasi-experimental design with a pre-post test control group design. The sample consisted of 20 elderly people divided into two groups, an experimental group and a control group, with 10 respondents in each group. Data were collected using an observation sheet to measure blood pressure before and after the intervention. The t-test analysis showed a significance value (2-tailed) of 0.009, which was less than α = 0.05, indicating a significant effect of physical activity on lowering blood pressure among the elderly. Therefore, massage as a simple form of physical activity can be considered an alternative intervention in managing hypertension among the elderly in social care institutions.

Generators are an important component in electrical generation. One of the disturbances that occurs in the generator is a short circuit fault. PT Oki Pulp and Paper has a Diesel Generator which is equipment that can be used as an alternative electrical generator to meet backup electricity needs, when a trip / shutdown occurs, the diesel generator will become backup power. The diesel generator observed is YCSR with a capacity of 3875 KVA/380 Volts. The purpose of this research is to analyse the Short Circuit Disturbance of Diesel Generator YCSR 3875 KVA and analyse the calculation of the time required for Over Current Protection on short circuit disturbance of Diesel Generator YCSR 3875 KVA. The research was conducted at the DG House of PT Oki Pulp and Paper in December 2024. The results of the short circuit fault analysis obtained are 17,042.40 A. The time required for the relay to disconnect the electricity during a short circuit is 4.09 seconds. The time obtained from the calculation is quite short, it can be seen that the short circuit fault that occurred was 17,042.40 A. To get the results of the relay working time, there is a calculation to find out how much TMS is determined through calculation, from the calculation getting the TMS result of 1,007 seconds. With TMS = 1.007 seconds, calculations are carried out to find the time required for the overcurrent relay to send a signal to the circuit breaker.

Nowadays, the number of cyber terrorists that using Internet as a medium keep increasing around the world are really worrying. Even though the cyber terrorist is publishing their post openly and public, there are quite difficult to recognize their main communication media. This happen because the cyber terrorist might hide their agenda through any sympathetic base website. Therefore, the aim of this project is to formulate tracing and linking algorithm using data mining technique in order to identify the relationship between each cyber terrorism components that may result to cyber terrorism website.
 
 
 

One of the negative impacts of the mining process is acid mine drainage which is formed from the oxidation of minerals containing iron sulfur, such as pyrite (FeS2) and pyrothite (FeS) by oxidizers such as water and oxygen. To handle or control acid mine drainage, one way is to use activated carbon or often referred to as activated charcoal, which is a type of carbon that has a very large surface area. Charcoal is a porous solid that contains 85% to 95% carbon, produced from materials containing carbon by heating at high temperatures without oxygen (pyrolysis). Activated carbon made from palm shells is an adsorbent that can be used to treat coal mine acid water, so that the water meets standards for flowing into the environment. This study used concentration variants of 4 grams, 6 grams, 8 grams and contact times of 30 minutes, 60 minutes and 150 minutes. The results of this study show that the concentration of palm oil shell activated carbon adsorbent influences the reduction of iron (Fe) and manganese (Mn) metal levels as well as the pH conditions in acid mine drainage water. The higher the concentration and the longer the contact time, the more heavy metals are adsorbed, the contact time is the highest. The optimal concentration in this study was 150 minutes and the optimal concentration was 8 grams with physical activation.

This study analyzes speech acts used by students in academic and social interactions. Speech acts are part of pragmatic studies that describe how language is used in everyday communication. This study aims to identify the forms, functions, and differences in the characteristics of speech acts in both contexts. The methods used in this study include observation, interviews, recording, transcription, and literature review by analyzing various relevant literature. The results of the study indicate that in academic interactions, students more often use representative and directive speech acts to convey information and give instructions, while in social interactions, they use more expressive and commissive speech acts to build relationships and express emotions. Factors that influence these differences include the context of the situation, relationships with interlocutors, the influence of media and technology, and cultural background. The conclusion of this study confirms that understanding speech acts is very important in improving the effectiveness of student communication in both academic and social environments. The implications of this study can be used to develop better communication strategies in higher education environments and increase students' awareness of the use of appropriate language in various contexts.