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Global Health Journal of Health Sciences, Public Health and Pharmacy

Identitas Jurnal

Judul Terbitan Global Health Journal of Health Sciences, Public Health and Pharmacy
Sub Judul International Journal of Health Sciences, Public Health and Pharmacy
Nama Institusi International Forum of Researchers and Lecturers
Jenis Jurnal Penelitian
Akreditasi Jurnal International tidak bereputasi
Terbitan 4x Setahun (Maret, Juni, September, Desember)
Bidang Ilmu Health Professions
P-ISSN 3063-7465
E-ISSN 3062-8687
Biaya APC Rp 350.000
Artikel Per Tahun 40 Artikel
Lama Waktu Terbit 10 Hari
Prosentase Penerimaan 10%
Indeksasi

Deskripsi

(Global Health: International Journal of Health Sciences, Public Health and Pharmacy) [e-ISSN : 3062-8687, p-ISSN : 3063-7465] is an open access Journal published by the IFREL (International Forum of Researchers and Lecturers). GlobalHealth accepts manuscripts based on empirical research results, new scientific literature review, and comments/ criticism of scientific papers published by GlobalHealth. This journal is a means of publication and a place to share research and development work in the field of Health Sciences, Public Health and Pharmacy. Articles published in GlobalHealth are processed fully online. Submitted articles will go through peer review by a qualified international Reviewers. Complete information for article submission and other instructions are available in each issue. GlobalHealth publishes 4 (four) issues a year in March, June, September and December, however articles that have been declared accepted will be queued in the In-Press issue before published in the determined time.

Article indexed DOI

Global Health Journal of Health Sciences, Public Health and Pharmacy

Phytochemical Screening of Balinese Traditional Herbal as Anticancer Candidates Using GC-MS and Molecular Docking Analysis (Ni Luh Putu Eka Kartika Sari, Putu Nia Calista Santoso, Ni Putu Diah Witari, I Gusti Ngurah Agung Adi Primantara, I Putu Bhujangga Pratama Kusuma Artana, Putu Deninta Swari Cahya Winata, Kennedy Winartan)
DOI : 10.70062/globalhealth.v2i2.201 - Volume: 2, Issue: 2, Sitasi : 0
30-Jun-2025 | Abstrak | PDF File | Resource | Last.06-Aug-2025

Abstrak:

Indonesia's biodiversity holds great potential for drug development, including through the use of traditional medicinal plants such as tapak liman (Elephantopus scaber L.), suruhan (Peperomia pellucida L. Kunth), and temu ireng (Curcuma aeruginosa Roxb.). These plants have been used in traditional medicine and are known to contain bioactive compounds with potential anticancer properties. Tapak liman contains compounds capable of inducing apoptosis in cancer cells. Suruhan is known to have cytotoxic and immunomodulatory effects, while temu ireng contains compounds with antioxidant and anticancer activity. This study aims to identify and quantify the bioactive compounds in these three plants using Gas Chromatography-Mass Spectrometry (GC-MS) and to explore their therapeutic potential in cancer treatment. The results of GC-MS analysis successfully identified six main compounds that have potential as anticancer agents, namely Phytol, Caryophyllene, Apiol, Germacrone, Germacrene B, and one additional compound. Temu ireng contains Germacrone, Germacrene B, and Caryophyllene, while suruhan contains Caryophyllene, Apiol, and Phytol. Meanwhile, tapak liman shows the presence of bioactive compounds that support cytotoxic activity. The focus of this study is on the interaction of bioactive compounds with the Bcl-2 protein, which plays a role in inhibiting apoptosis in cancer cells. Additionally, molecular analysis revealed that Germacrone, Germacrene B, Caryophyllene, and Apiol can also bind to the p53 protein, known as a guardian of the genome and a trigger for apoptosis. These findings suggest that the three plants have high potential as natural sources of anticancer agents. Further in vitro and in vivo studies are recommended to test the biological efficacy of these compounds in the context of cancer therapy, thereby bridging traditional knowledge with modern scientific approaches in the development of natural-based medications.

Global Health Journal of Health Sciences, Public Health and Pharmacy

Identitas Jurnal

Deskripsi

Article indexed DOI

Global Health Journal of Health Sciences, Public Health and Pharmacy

Artikel PerTahun

Artikel PerVolume

Sitasi Per Tahun

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