Liver damage induced by hepatotoxic compounds such as N-acetyl-p-aminophenol (N-APAP) remains a significant global health concern. Hepatotoxicity caused by N-APAP, particularly in cases of overdose or prolonged use, can lead to a reduction in glutathione levels in the liver, resulting in oxidative stress and cellular damage. This condition contributes to an increased incidence of liver diseases, including toxic hepatitis and acute liver failure, which can lead to serious complications and even death. Although various pharmacological therapies, such as N-acetylcysteine (NAC), are available to address N-APAP-induced liver damage, limitations such as side effects, high costs, and variable efficacy have driven the search for safer and more affordable therapeutic alternatives. Therefore, research on natural hepatoprotective agents, such as extracts from the rhizomes of fingerroot (Boesenbergia rotunda), has become increasingly relevant in addressing this issue. The aim of this study was to evaluate the hepatoprotective potential of ethanol extract from fingerroot rhizomes (Boesenbergia rotunda) in protecting the liver from N-acetyl-p-aminophenol (N-APAP)-induced damage. Specifically, this research focuses on measuring glutathione levels as a key indicator of the liver's protective mechanism against oxidative stress. In this study, 30 male White rats were randomly divided into six groups, each consisting of five rats. All rats were orally administered the extract at predetermined doses for 10 consecutive days, except for the negative and positive control groups. On the 10th day, all groups (except group 1) were treated with paracetamol (800 mg/kg body weight) to induce liver damage. Twenty-four hours after induction, the rats were sacrificed and liver samples were collected. Glutathione levels were measured using the ELISA immunosorbent assay. Statistical analysis showed that administering the ethanol extract of Fingerroot rhizomes (EERTK) for 10 days prior to N-APAP induction significantly increased the average antioxidant enzyme GSH-Px levels in the liver homogenate of rats in the EERTK 250 mg/kg BW (43.36 ± 1.34 U/mg protein), EERTK 500 mg/kg BW (55.70 ± 2.15 U/mg protein), and 750 mg/kg BW (53.14 ± 2.57 U/mg protein) group compared to the negative control group (N-APAP 800 mg/kg BW), which had the lowest average antioxidant enzyme GSH-Px level (33.86 ± 3.52 U/mg protein).

The use of ECG patterns as predictors of preeclampsia offers a promising approach, as it is a widely available and cost-effective tool. Specific ECG patterns, including angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes as a potential tool for predicting preeclampsia. The aim of this study is to investigate the predictive role of angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of  twenty (20) normotensive  and twenty (20) preeclamptic pregnant women in their  third trimester of pregnancy. After the subjects were  identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ? 0.05 were considered statistically significant. Results from this present study show no significant differences were observed in QRS complex angles related to right ventricular hypertrophy (RVH) between normotensive and preeclamptic pregnant women. Notably, there was a significant increase in QRS complex related to left ventricular hypertrophy (LVH) in preeclamptic pregnant women, indicating left ventricular remodeling's importance. Moreover, there was a significant increase in T wave amplitude, this suggests underlying myocardial electrical remodeling or dysfunction in preeclampsia, emphasizing the need for cardiovascular monitoring. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection.

The purpose of this study was to determine: (1) The difference in the effect of plyometric training methods between double leg bound training and double leg vertical power jump training on 100-meter running ability, (2) The difference in the effect between high balance and low balance on 100-meter running ability, (3) Interaction between plyometric and balance training methods on 100-meter running ability. The instruments used to collect data were: (1) Balance test (Modified Bass Test of Dynamic Balance), (2) 100-meter running ability test with time test, (3) Training program as a guideline that will be used in providing treatment . The data analysis technique used was Analysis of Variance (ANOVA) at a significance level of ? = 0.05. The results of the hypothesis testing proved that: (1) There is no difference in the influence between double leg bound training and double leg vertical power jump training on 100-meter running ability. By looking at the similarity of the movements that both jump use both legs, it seems that these two exercises are variations in training, as a result the two plyometric training methods are not significantly different. (2) There is a difference in the influence between high balance and low balance on 100-meter running ability. The results of the data analysis showed that high balance has a significant difference in influence with low balance. (3) There is no interaction of influence between plyometric and balance training methods on 100-meter running ability. Related to the interaction hypothesis, it turns out that the results of the hypothesis testing have proven that there is no interaction between plyometric and balance training methods on 100-meter running ability where the calculated F value = 0.006 < than the F table value = 2.82 at a significance level of ? = 0.05. Conclusion of the study: 1) There is no significant difference in influence between double leg bound training and double leg vertical power jump training on 100-meter running ability. 2) There is a significant difference in the influence of high balance and low balance on 100-meter running ability. 3) There is no interaction between plyometric training methods and balance on 100-meter running ability.

One of the cardiovascular diseases that can cause death is Unstable Angina Pectoris (UAP) Benson relaxation is a passive relaxation technique without using muscle tension so it is very appropriate to reduce pain. Benson relaxation is a development of the relaxation response method by involving the patient's belief factor, which can create a calm internal environment that can help patients achieve higher health and well-being. Method:Descriptive method in the form of case studies. Nursing care approach consisting of
from assessment, nursing diagnosis, planning, implementation, evaluation and documentation nursing. The subject of this study was one person. Results:Benson relaxation is a passive relaxation technique without using muscle tension so it is very appropriate to reduce pain. Conclusion: Benson Relaxation therapy in patients with Unstable Angina Pectoris (UAP) was carried out for 3 days. It was found that there was a decrease in the pain scale. This is evidenced by the results of the evaluation on the first day, March 1, 2024, the pain scale was 7 to 7. The second day, March 2, 2024, the pain scale was 7 to 5. The third day, March 3, 2024, the pain scale was 5 to 3.

This systematic review examines the effectiveness of antenatal classes in improving pregnant women's attitudes towards stunting prevention. The review analyzed 28 studies published between 2018 and 2023, focusing on developing countries, particularly in Southeast Asia. The methodology followed PRISMA guidelines, utilizing multiple academic databases. The analysis revealed that structured antenatal classes significantly improved maternal knowledge about stunting (68% increase in knowledge scores) and led to positive behavioral changes in nutritional practices. Regular attendance at comprehensive antenatal classes was associated with better pregnancy outcomes, with participants showing 75% higher rates of implementing recommended nutritional guidelines. Key success factors included regular class frequency, interactive teaching methods, cultural sensitivity, and strong community support. However, significant challenges were identified, including resource limitations, access barriers, and cultural resistance. The review highlighted successful adaptations such as hybrid learning models and community-based approaches. Recommendations include strengthening program design through evidence-based approaches, enhancing community engagement, developing sustainable funding mechanisms, and implementing robust monitoring systems. This review underscores the vital role of antenatal classes in stunting prevention while emphasizing the need for continued research to address existing challenges and enhance program effectiveness across diverse settings.

Purple sweet potato is one type of tuber. Organoleptic test is a test of a food ingredient based on the level of preference. Shelf life is a time span on a product. Objective: To determine the level of consumer preference and shelf life of pia cake skin with the addition of purple sweet potato (Ipomea Batatas L). Methods: Quantitative research with a completely randomized experimental design (CRD). Panelists in this study were 30 untrained panelists, 15 moderately trained panelists. Results: It is known that the results of research conducted on pia cake skin added purple sweet potato (Ipomea Batatas L) have an effect on the taste p-value 0.01 (<0.05), there is an effect on the aroma p-value 0.02 (<0.05), there is an effect on the color p-value 0.00 (<0.05), there is an effect on the texture p-value 0.00 (<0.05), for the shelf life of pia cake skin in treatments X, Y, V and Z at cold temperature and room temperature there is a relationship p-value <0.05. Conclusion: Based on the results of the study, it can be concluded that there are differences in the variables of taste, aroma, color, texture and shelf life of pia cake skin with the addition of purple sweet potato (Ipomea Batatas L) in Kimi Village, which obtained p-value <0.05. Suggestion: There is a need for skills, knowledge related to purple sweet potatoes to increase creativity and the economy of the community.

This research examines the relationship between air quality and respiratory health in urban populations. By analyzing data on air pollution levels and health outcomes such as asthma and chronic obstructive pulmonary disease (COPD), the study identifies significant correlations between poor air quality and increased respiratory issues. The findings underscore the need for policy changes aimed at improving air quality to enhance public health in urban settings.

Health education is a crucial aspect of guiding learners about health in a broad range, encompassing physical, mental, and social well-being. Schools, being environments where students are exposed to various hazards, are particularly vulnerable to accidents. First aid education is essential in preventing injuries and ensuring that students are equipped with the necessary skills to respond effectively in emergency situations. This study aims to evaluate the effect of Augmented Reality (AR) based First Aid health education on the knowledge of Youth Red Cross (PMR) members at Titian Teras State Senior High School, Jambi City. This study employed a quasi-experimental design with one pretest-posttest group without a control group. A total of 50 PMR members were involved, divided into an intervention group (n=25) and a control group (n=25). The intervention group received AR-based First Aid health education, while the control group received conventional methods. Data collection was conducted using a knowledge assessment tool, and pre- and post-test analyses were performed to evaluate the effectiveness of the intervention. The results showed a significant increase in the intervention group's knowledge. After the intervention, 80% of respondents in the intervention group achieved the "good" category, compared to only 36% in the control group. The Mann-Whitney test confirmed the significant difference between the two groups (p<0.05), indicating that the AR-based First Aid health education was more effective in improving PMR members' knowledge compared to conventional methods. This study concludes that AR-based First Aid health education is more effective in improving PMR members' knowledge compared to conventional methods. The integration of AR technology in health education highlights its potential in enhancing learning outcomes and improving the preparedness of students in responding to emergencies. The findings suggest that AR can be a valuable tool in health education, particularly in first aid training, by providing an immersive and interactive learning experience that enhances both knowledge and skills acquisition.

A child's life is very important, and parental attention is also important. Babies need to get nutrition from food every day in the right amount and good quality every day. One way to optimize child growth and development is by giving formula milk. Objective: To determine the effect of formula milk consumption on the nutritional status of toddlers in the Working Area of ??the Yaro Health Center UPTD, Jaya Mukti Village, Nabire Regency. Method: This type of research is quantitative research using observational analysis research design and cross-sectional study design. The population in the study was 65 toddlers and the selected sample consisted of 65 toddlers using total sampling. The research instruments included questionnaires, anthropometric measuring instruments (digital scales and length boards), stationery and documentation tools. The analysis used the Release Statistical Program For Science (SPSS) type 16.0 application. Results: The study showed that the BB/TB index p-value was 0.00 (<0.05), the BB/A index p-value was 0.00 (<0.05) and the TB/A index p-value was 0.00 (<0.05). Conclusion: There is an effect of giving formula milk on the nutritional status of toddlers based on anthropometric measurements using the Body Weight/Height (BW/TB), Body Weight/Age (BW/U) and Height/Age (BH/U) indices. Suggestion: For parents to pay attention to the appropriateness of the dosage, frequency of giving and sanitation of serving formula milk to achieve optimal nutritional status.

The study was to describe the nutritional status of participants in the Integrated Development Post for Non-Communicable Diseases. The method used was descriptive quantitative with 35 respondents. Respondents were measured anthropometrically including weight, height, waist circumference and body mass index (BMI) then descriptive analysis was carried out using SPSS. The results showed that respondents who had BMI in the obesity category were 15 (42.90%), normal 14 (40%) and obese 6 (17.10%) and based on the measurement of waist circumference, respondents who experienced central obesity were 30 (85.70%) and not central obesity were 5 (14.30%). Conclusion: Maintaining nutritional status is very beneficial because someone who is overweight is at risk of experiencing several diseases such as hypertension, diabetes mellitus and heart disease.