Early pregnancy is at high risk for health complications such as anemia, preeclampsia, and premature birth.In addition, social impacts such as dropping out of school, societal stigma, and economic instability also become serious consequences that can affect the future of adolescents.The objective of this study is to determine the relationship between parental roles and the prevention of early pregnancy among students at SMA Negeri 1 Touluaan.The research uses a cross-sectional design.The sample in this study consisted of 38 respondents using purposive sampling technique.Data collection on parental roles and prevention of early pregnancy was conducted using a questionnaire, analyzed using the chi-square statistical test.The results of the study on the role of parents mostly showed that the role of parents in the good category amounted to 32 respondents (66.7%), and the behavior of pregnancy prevention mostly in the good category amounted to 34 respondents (70.8%).The results of the chi-square test obtained a p-value of 0.006 where < ? 0.05.Conclusion: There is a relationship between the role of parents and the prevention of early pregnancy among students of SMA Negeri 1 Touluaan.

Ferritin is considered a protein that contains iron and includes two types of subunits: ferritin light chain (FTL) and ferritin heavy chain (FTH), which increases when inflammation increases, especially in the heart and kidneys, and helps in converting ferrous iron into iron. The light subunit is present in the liver and spleen and has a role in storing iron (1). Coronavirus (COVID-19) caused by the new coronavirus SARS-CoV-2 is a disease It is new to humanity, as it is accompanied by symptoms during the disease, including blood abnormalities, with activation of the immune system and phagocytic monocytes, and damage to the lungs. In our study, we showed that ferritin is an indicator of the severity of the disease and mortality (2). Acute respiratory syndrome (Coronavirus), which causes pneumonia and damages the heart, liver, and kidneys, is caused by the appearance of acute inflammatory cytokines that lead to death (3). A cytokine is a small protein that transmits messages to help stimulate the body’s immune response, and its rise causes increased inflammation, and these Cytokines secreted by macrophages (TNF-?, IL-10, IL-6) where there is high inflammation in the plasma. An indicator of the progress and severity of the disease (3).

Factors contributing to the occurrence of promiscuous sexual behavior include internal and external elements. Internal factors include low self-control, lack of religious understanding, and low sexual knowledge. External factors include family and peers; peer association can influence both positive and negative behaviors. Positive behaviors include participating in beneficial activities with peers, while negative behaviors include violating social norms, such as having casual sex. This research design uses an analytic correlation approach, with the aim of finding the relationship between variables, data collection is done by questionnaire. Using the chi square formula with the help of SPSS, 125 students were asked to answer. The results showed that of the 125 study respondents, most were 21 years old, 36.8 percent, and the majority were female, 58.4%. In addition, the results of the analysis showed that 46% of the respondents showed a good level of knowledge, while 47% showed sufficient attitude and preventive behavior. Conclusion: There is a correlation between knowledge and preventive behavior of promiscuous sex.

Clinical education is an important aspect in health education, where students learn clinical skills in hospitals. The support of clinical educators and a conducive environment play a role in reducing stress. This study aims to analyze the relationship between the role of clinical educators and the implementation of clinical education with the level of stress of students during practice at RSI Sultan Agung Semarang. Using a quantitative method with a cross-sectional design, the population and sample in this study were 87 respondents with a total sampling technique. The results of the Spearman test showed a significant relationship with weak strength (p value 0.000), positive direction, and correlation coefficients of 0.471 and 0.514. Further research with a wider scope and qualitative methods is recommended to understand the factors causing student stress in more depth.

iNKT cells, sometimes known as the immune system's "Swiss Army knife," have become key components of cancer vaccination treatments. Glycolipids that activate iNKT cells, including ?-galactosylceramide (?GalCer), have been used to create self-adjuvanting anti-tumor vaccinations and can boost the immune response to co-delivered cancer antigens. The chemicals synthesis of ganglioside antigens, specifically (Neu5Gc) GM3 and GM3 antigen, and conjugations to ?GalCer, and packaging into liposome as effective platforms for their in vivo deliverying are the main topics of this work. In mouse and human cell experiments, liposome containing, (Neu5Gc) GM3-?GalCer, GM3-?GalCer, and equimolar quantities of conjugates have thoroughly described and their capacities to activate iNKT cell has verified ex vivo. All subclasses of IgG antibodies were produced as a result of the candidates' potential to generate both TH1 and TH2 cytokines, according to in vivo immunization tests. Interestingly, this study shows serum antibody produced against the TACA were cross-reactive, both when they were produced separately and together. If tumor-selective antigens is selected, the ensuing antibodies response can be wider than expected, which has implications for future vaccine formulations.

Background: Hemodynamics is very important to monitor, especially in general anesthesia because generally anesthesia will cause various kindsof body system disorders. The use of anesthesia using inhalation using sevoflurane can cause hemodynamic changes, one of which is changes in pulse frequency. So that a strict monitoring process is needed in its use. Objective: Knowing changes in pulse frequency in general anesthesia patients with the use of sevoflurane at PKU Muhammadiyah Gombong Hospital in 2024. Methods: This study is an Observational Descriptive study with a quantitative research design that focuses on variable analysis, specifically intra anesthesia pulse frequency after sevoflurane is given. This study used an analytic design with a cross sectional approach. Results: Frequency Distribution of Respondent Characteristics Based on Age obtained research results where the most age group was 26-45 years as many as 23 respondents (51.1%). For the gender group, the results of this study with the most respondents were male as many as 30 respondents (66.7%). Distribution based on body weight obtained research results where the most weight The results showed that the most weight group was 41-75 kg as many as 40 respondents (88.9%). The results of observations of changes in the inhalation drug sevoflurane that the mean or average induction pulse frequency was 75.47 bpm, the mean or average pulse frequency after 5 minutes of induction it was 79.73 bpm, the mean or average pulse  frequency after 10 minutes of induction was 79.29 bpm, and the mean or average pulse rate after 15 minutes of induction was 78.53 bpm. Conclusion: Changes in pulse frequency from the initial pulse to the pulse frequency after 15 minutes of induction can be said to have a  normal/stable distribution. It can be seen from the mean or average of 72.93-79.73 bpm.

Technicians in radiology departments are continuously exposed to ionizing radiation, which can affect biological systems. This study aimed to investigate the effects of low-level ionizing radiation (IR) on antioxidant enzymes and blood components in radiology personnel. The study involved forty participants aged 30 to 45 years, divided into three groups: G1 as the control group (n=10), G2 consisting of 15 radiologists, and G3 comprising 15 radiology technology workers. Participants in G2 and G3 had work experience ranging from 5 to 15 years and were employed in X-ray and CT scan departments at General K1 Hospital, Kirkuk. The measured parameters included white blood cells (WBCs), platelets, and lymphocytes, as well as malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and albumin as indicators of redox status. The results showed a significant increase in MDA levels among radiology workers compared to the control group, while SOD, TAC, and albumin levels decreased (P<0.05). Additionally, radiation-exposed workers had a higher mean count of WBCs and lymphocytes than the control group (P<0.05), whereas platelet levels were significantly lower (P<0.05). This study indicates that occupational radiation exposure can cause short-term changes in blood cells and increase the circulating redox state in healthcare workers operating in CT and IR environments compared to those not exposed to radiation. These findings highlight the importance of regular health monitoring for radiology personnel to mitigate potential long-term effects of radiation exposure.

Background: As you get older, health problems increase, one of which is stress. Stress is very important because stress will have an impact on the quality of life and psychological well-being of the elderly. Psychological well-being in the elderly is the elderly's ability to accept themselves as they are, be able to build positive relationships with other people, be able to independently face social pressure, master the environment, have a purpose in life, and be able to realize one's potential in a sustainable manner. Stress in the elderly can describe that a person experiences a decrease in psychological well-being in the elderly which can be said to be low. Objective: This research is to analyze the relationship between stress levels and psychological well-being in elderly people at the Pucang Gading Semarang and Wening Wardoyo Ungaran Elderly Social Service Homes. Method: This research is a type of correlational quantitative research using the cross-section method. The sample taken in this study was 105 elderly people who were in the Pucang Gading Semarang and Wening Wardoyo Ungaran elderly service homes. The instrument for measuring stress levels and psychological wellbeing in the elderly uses a questionnaire. The test used in this research is the Gamma test. Conclusion: There is a relationship between stress levels and psychological wellbeing in the elderly at the Pucang Gading Semarang and Wening Wardhoyo Ungaran Social Service Homes for the Elderly.

Nurse is power vulnerable health? experiencing Culture Shock, namely difficulty adapt with environment Work new that has difference culture. A preliminary study was conducted at the Sultan Agung Islamic Hospital in Semarang on 12 nurses. show that 89.85% experienced Culture Shock. Of them, 71.05% faced stress Work light, 78.95% stress Work moderate , and 85.53% stressed Work weight . This result indicates the need study more carry on For evaluate connection between Culture Shock and level stress Work nurse , so that step intervention can formulated for quality service health. Analyze connection between Culture Shock and level stress Work nurse at Sultan Agung Islamic Hospital, Semarang. Study quantitative with cross-sectional design, conducted on 95 nurses at the Sultan Agung Islamic Hospital in Semarang using total sampling technique . Data collected use valid and reliable questionnaire , with analysis using the Chi-square. Based on results study This show that from 95 nurses implementers at the Sultan Agung Islamic Hospital in Semarang, as many as 20,0% experienced Culture Shock in the category less , 33,7% category enough , and 46,3% category good . Meanwhile that , level stress Work shows 56,8% in category light , 33,7% category medium , and 9,5% category heavy. Study This conclude that there is connection significant between Culture Shock and level stress Work nurses at Sultan Agung Islamic Hospital Semarang (p = 0.000).

Diabetes mellitus is a chronic disease that requires proper management, including the use of conventional and alternative medicines such as herbal medicines. Patient knowledge about the benefits, risks, and potential interactions of herbal medicines with conventional medicines is very important to prevent complications. Objective This study aims to describe the level of knowledge of diabetes patients about the use of herbal medicines, including the benefits, risks, and interactions with conventional medicines at the Kebondalem Health Center, Pemalang Regency. This study uses descriptive observational analytic Data were collected through questionnaires distributed to diabetes patients who were treated at the Kebondalem Health Center. Data analysis was carried out quantitatively with percentages to measure the level of patient knowledge.