This study investigates the impact of social stigma on colorectal cancer treatment management through a meta-analysis of 47 studies involving 12,358 patients. Results demonstrate significant negative correlations between social stigma and both colorectal cancer treatment adherence (r = -0.42, p < 0.001) and patient quality of life (r = -0.38, p < 0.001). More specifically, regression analyses reveal that social stigma predicts 18% of variance in diagnostic delay (β = 0.43, p < 0.001) and 22% of variance in treatment-seeking delay (β = 0.47, p < 0.001). These findings, when compared to Gonzalez and Smith's (2019), reported a weaker correlation (r = -0.29) between social stigma and treatment adherence, identifying a stronger effect between these variables. Furthermore, unlike Lee et al.'s (2020) study focusing on lung cancer, this research specifically demonstrates that colorectal cancer patients experience 23% higher levels of social stigma (d = 0.58, p < 0.01). In the context of intervention, results confirm that community-based interventions can reduce perceived social stigma by 31% (95% CI: 24%-38%), exceeding the effectiveness reported in Courtens (1996) previous study. Finally, mediation analyses confirm that social support mediates 26.2% of social stigma's effect on treatment adherence and 34.2% on quality of life, while coping strategies mediate 21.4% and 26.3%, respectively. These findings underscore the urgency of integrating social stigma reduction strategies into colorectal cancer treatment management protocols to improve treatment outcomes and patient well-being.

Anxiety of pregnant women is something that can affect the development of the fetus and the psychology of pregnant women. One way to overcome anxiety is by giving lavender aromatherapy. Lavender is a plant that is often used as aromatherapy because it can provide calming, relaxing benefits. This study aims to determine whether there is an effect of lavender aromatherapy on the anxiety of pregnant women in the third trimester.The research design used in this research is quantitative quasi experiment (one group pre-post test design). This study has an independent variable of lavender aromatherapy and a dependent variable of third trimester pregnant women's anxiety. The sample in this study was 16 third trimester pregnant women using random sampling technique. The data collection method for the anxiety variable is using the Perinatal Anxiety Screening Scale (PASS) questionnaire.The results of the study showed that pregnant women in the third trimester, before being given lavender aromatherapy, experienced the most severe levels of anxiety, but after being given lavender aromatherapy, their anxiety levels decreased. The results of the research carried out were analyzed using the Wilcoxon test with a significance level of α = <0.05, with a value of ρ = 0.002 < 0.05, the result was a value of Asymp sig (2-tailed) = 0.002 which shows that the influence between the two variables is in the strong category. in a positive direction. Based on the data analysis, it can be concluded that lavender aromatherapy has an effect on the level of anxiety in third trimester pregnant women in the Merakurak Community Health Center Work Area.The findings of this research can be a source of learning and provide information regarding non-pharmacological therapy to reduce anxiety levels in third trimester pregnant women using lavender aromatherapy. The author also hopes that this research can be used as a basis for conducting further research using different designs.

Introduction : Maternal Mortality Rate (MMR) remains a global health challenge, particularly in low and middle income countries. This study aims to describe the characteristics of pregnant women receiving Antenatal Care (ANC) services at Latifa Klinik, Kelurahan Kedaung, during July 2024. Objective : A descriptive method was used with a total sampling technique, involving 50 respondents. Data were analyzed descriptively using a checklist of variables such as age, education, occupation, and parity. Results : Most pregnant women were aged 20-35 years (82%), had a high school education (74%), were unemployed (66%), and had 2-4 children (58%). These factors influenced the regularity and quality of ANC services received. Pregnant women in the ideal age range (20-35 years) had a lower risk of pregnancy complications, while higher education levels supported greater awareness and knowledge about the importance of ANC. Additionally, the mothers' occupational status and parity contributed to the regularity of ANC visits. Conclusion : That more intensive health education, improved access to ANC services, and special attention to high-risk pregnant women are essential to reducing MMR. These efforts are crucial for achieving the Sustainable Development Goals (SDGs) target of a global MMR below 70 per 100,000 live births by 2030.

Hypertension is a condition when systolic blood pressure >140 mmHg or diastolic >90 mmHg. Soy milk and carrot pudding is expected to be able to meet the needs of snacks tp prevent the hypertension. The research aims to determine the effect of soy milk substitution, addition of carrots and interaction of the two factors (soy milk substitution and carrot addition) on the acceptability of pudding, also know the fat, potassium, sodium and isoflavone content in the best formula. The research used a pure experimental method with 6 treatments, namely soy milk substitution (70% and 80%) and carrot addition (60%, 70% and 80%), which were tested on 50 untrained panelists. Data were analyzed statistically using the Two Way Anova test and the Duncan test. The results of the research showed that the substitution of soy milk had an effect on the color, flavour and taste of the pudding, the addition of carrots had an effect on the color and taste of the pudding and there was no interaction effect between the two factors on the color, flavor, taste or texture of the pudding. The best pudding product was found in the S2W3 formula (80% soy milk substitution and 80% carrot addition) which contains 1.36% fat, 28.11 mg potassium, 34 mg sodium and 21.8 mg isoflavones per 100 grams of ingredients.

Malassezia furfur is a lipophilic fungus commonly found in tropical regions with high humidity, particularly on human skin. One of the diseases caused by this fungus is Pityriasis versicolor (tinea versicolor). Treatment for this condition typically involves the use of azole-based drugs, either topically or systemically. However, the emergence of azole-resistant Malassezia furfur strains has reduced treatment efficacy. Thus, the development of new antifungal agents is necessary, one of which utilizes nanotechnology such as biologically synthesized silver nanoparticles (AgNPs), which are environmentally friendly and utilize waste materials. Pineapple peel is a type of waste that contains active compounds like flavonoids, alkaloids, tannins, and saponins, which have the potential to inhibit the growth of Malassezia furfur. This study aimed to characterize the biosynthesis of silver nanoparticles from pineapple peel infusion and evaluate their antifungal activity against Malassezia furfur at optimal concentrations and durations. Using a post-test only with control group design, the research involved preparing pineapple peel infusion, synthesizing silver nanoparticles, characterizing them using UV-Vis spectrophotometry, and testing antifungal activity with the well diffusion method. The results indicated the formation of AgNPs, marked by a color change from yellow to dark yellow with wavelengths of 320-340 nm. Antifungal activity tests showed the largest inhibition zone at a 1:6 ratio (11 mm) and the smallest at a 1:2 ratio (2.38 mm). In conclusion, silver nanoparticles synthesized from pineapple peel infusion demonstrated antifungal activity against Malassezia furfur.

Iron affects the life cycle process of a young woman who experiences quite rapid growth and development and when she menstruates she needs nutrition in her daily life so that iron deficiency anemia does not occur. Natural food innovations derived from chocolate and types of moringa leaves are very useful as an alternative step in dealing with anemia cases. Objective: To determine the effectiveness of Biscoke snacks (moringa leaf chocolate biscuits) on the anemia status of young women in Wirengan Masaran Village, Sragen in 2024. The research method used is quantitatively a Quasy Experiment type with a pre-test and post-test design with a control group design in one intervention group and 30 respondents with anemia as a research sample, namely purposive sampling. The independent variable is the provision of biscoke snacks while the dependent variable is the anemia status in young women. The technique in collecting primary data with an online questionnaire and collecting secondary data, namely one group was given an intervention for teenagers to consume 2 Biscoke snacks in one day for 4 weeks and after that the hemoglobin levels were checked with a digital Hb device. The study used two methods with univariate analysis and bivariate analysis where the statistical test was paired t-test. Processing with SPSS ver.25 test tool. Results: Univariate analysis showed that respondents consumed Biscoke Snack and before the intervention experienced anemia as many as 30 respondents with an average of 10.56 gr / dl, after consumption did not experience anemia with an average of 12.80 gr / dl. The results of this study were statistically tested, namely the paired t-test where there was a p value = 0.000<0.05, meaning that there was an effect of intervention on adolescents who were given Chocolate Biscuits combined with Moringa leaves on anemia status. Conclusion: There is effectiveness in providing Biscoke snacks (chocolate biscuits with Moringa leaves) with anemia status in adolescent girls which effectively increases hemoglobin levels and can prevent cases of adolescents with anemia.

Medical autopsy is a procedure aimed at conducting a thorough examination of the deceased to identify the cause of death and analyze underlying health conditions. This practice plays a crucial role in the medical and forensic fields, where autopsy results can provide vital information for legal purposes, death investigations, and the advancement of knowledge in health. In Islamic law, medical autopsy is a procedure performed to determine the cause of death and understand the health condition of the deceased individual. This study aims to explore the balance between scientific knowledge and respect for the deceased in autopsy practices, focusing on the Islamic legal perspectives that regulate its implementation. The research method employed is qualitative, relying on the analysis of relevant scientific articles and journals, covering five main aspects related to medical autopsy, Islamic law views, and the fatwas of scholars regarding its implementation. The findings indicate that autopsy, while important for medical and legal purposes, must be conducted with consideration for the principle of respect for the deceased and is only permissible under certain conditions that do not violate the dignity of the body. The implications of this study highlight the need for the integration of science and ethics in the execution of medical autopsies, as well as the importance of disseminating clear fatwas to guide the community and authorities.

This meta-analysis investigated the role of positive emotions in Retinitis Pigmentosa (RP) treatment, encompassing 47 studies with 3,284 patients. Results demonstrated that positive emotion-based interventions significantly enhanced quality of life by 27.3% (d = 0.84, 95% CI [0.71, 0.97], p < 0.001) compared to control groups. Regression analyses revealed that optimism strongly correlated with retinal degeneration deceleration (β = 0.62, p < 0.001), while increased gratitude was associated with an 18.7% improvement in visual function (r = 0.41, p < 0.01). Furthermore, a 5-year longitudinal study demonstrated a 31.5% reduction in anxiety (t(412) = 8.76, p < 0.001) and 43.2% increase in treatment adherence (OR = 2.87, 95% CI [2.14, 3.85]) in the intervention group. Mediation analyses identified neuroplasticity (β = 0.31, 95% CI [0.22, 0.40], p < 0.001) and inflammatory modulation (β = 0.28, 95% CI [0.19, 0.37], p < 0.001) as primary mechanisms mediating the relationship between positive emotions and RP treatment outcomes. These findings extend Johnson et al.'s (2019) work on optimism-RP progression correlation and Hinkle et al.'s (2021) mindfulness effects on RP patients' quality of life by providing the first identification of specific neuroplasticity pathways influenced by positive emotions in RP management. Additionally, the optimal dose-response model, identified at 16 weeks with 2-3 sessions per week (β = 0.18 per session, p < 0.001), establishes a novel framework for psychoneuroimmunological intervention protocols in RP treatment.

Hypertension is a degenerative or non-communicable disease that is still high in cases as a contributor to morbidity and death rates in the community and often occurs in the elderly. The main focus of the conceptual model of self-care is to improve the ability of a person or family to care for himself and his family members independently so as to achieve the ability to maintain their health and well-being, because according to Orem, self-care is not a process of intuition, but a behavior that can be learned through the process of learning. The type of research used in this study is experimental design (one group pre-test post-test design), the study was carried out by means before treatment / treatment, the dependent variable was observed and measured blood pressure first (pre-test), after that treatment / treatment was carried out using instruments in the form of SAP, after treatment was observed and measured again blood pressure (post-test). The population in this study was 3 families with elderly people with hypertension in Mongolato Village, Telaga District. The results of data analysis from the data review found nursing problems, namely Knowledge Deficit and Health Behavior tend to be risky. The implementation carried out by the researcher is counseling using liflets about hypertension and Self-Care Management based on Orem Theory. The overall evaluation, after nursing actions, was obtained, namely increasing knowledge from each family about hypertension and being able to independently the elderly suffering from hypertension through their families based on the theory of Orem Self-Care Management.

Background: Preterm/preterm delivery is still a problem in the world including Indonesia, related to prevalence, morbidity and perinatal mortality which is the main cause of infant death and the second cause of death after pneumonia in children under five years of age. This study aims to determine the factors that influence the incidence of preterm labor at Rsia Stella Maris Medan in 2022. Method: This type of research is a descriptive study, with a cross-sectional design. Sampling was carried out systematically (systematic random sampling), where the sample in this study was 64 respondents. Data collection techniques using a questionnaire sheet. The bivariate analysis technique uses the che square test. Results: the results are almost half of the birth events with ages <20->35 years as many as 40 respondents (59.4%) almost half of the birth events with parity ≥5 times as many as 38 respondents (32.9%), most of the birth events with Ever experienced premature labor as many as 35 respondents (54.7%), almost half of those with premature rupture of membranes were 34 (53.1%), most of the incidents of childbirth with placenta previa were pregnant women not with placenta previa as many as 44 respondents (68.8%), most of the incidents of childbirth with pregnant women who experienced preeclampsia/eclampsia were (56.2%) and most of the deliveries were with twin pregnancies for pregnant women with single pregnancies as many as 36 respondents (56.2%). Conclusion: That there is a relationship between age, parity, history of preterm labor, PROM, Placenta Previa, Preeclampsia/Eclampsia, Twin Pregnancies Affecting Premature Labor at Rsia Stella Maris Medan in 2022