COVID-19 is a viral respiratory disease that has caused a global health emergency and was declared a pandemic by the World Health Organization. The lack of certain drug molecules or treatment strategies for this disease is making it worse. Therefore, effective drug molecules are urgently needed to fight COVID-19. Specific therapies for the SARS-COV2 virus are still being developed in several countries around the world. One of the molecular targets that is thought to be specific to SARS-COV 2 is 3CLpro or the main protease of the COVID-19 virus which is an important enzyme to be able to replicate related viruses. The purpose of this study is to explore the role of medicinal chemistry in the development of anti-sars-cov 2 drugs through the exploration of bioactive compounds from natural sources, namely green tea. Green tea (Camellia sinensis) also contains eight native monomeric catechins or polyphenolic compounds. The method used was literature review with analysis of 3 selected articles from international databases such as PubMed, ScienceDirect, and Springer, as well as SINTA accredited national journals. The results showed that all test compounds except caffein had stronger binding energy than lopinavir. Epicatecin and catechin have the same binding energy value as lopinavir, which is -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest bond among all test compounds because they have the most negative AG, namely -9.0 and 8.2 kcal/mol.
 
 

Dental and oral health problems are still a major challenge for early childhood, especially due to the lack of knowledge and skills in brushing teeth properly. This study aims to determine the effect of the snakes and ladders game as an educational method in improving the knowledge and skills of brushing teeth of early childhood at Ar-Rahimah Kindergarten, Jambi City. This study used a quantitative method with a quasi-experimental one group pretest-posttest design. The research sample was 40 Ar-Rahimah Kindergarten students. The research instruments were knowledge questionnaires and skill observation sheets. The intervention given was a snakes and ladders game that had been modified with educational content related to dental health, accompanied by a demonstration using a tooth phantom. Analysis using the Wilcoxon Signed Ranks Test showed that there was a significant effect between before and after treatment on knowledge (p = 0.000) and skills (p = 0.000). The conclusion of this study is that the snakes and ladders game media can improve the knowledge and skills of brushing teeth of early childhood. It is recommended that the use of snakes and ladders game media can be used as an innovative approach in children's dental health education.

Menstrual pain or dysmenorrhea is a common complaint experienced by adolescent girls throughout the world has shown that the incidence of dysmenorrhea is quite high, namely 43-93% of women experience dysmenorrhea and 5-10% of them experience very severe dysmenorrhea and leave their activities 1-3 days a month, where 8% of them have to leave school or work during menstruation The purpose of this study is to examine the effect of giving turmeric and tamarind with pineapple juice on reducing primary dysmenorrhea pain in TPMB "M".This study uses a qualitative research strategy, with a case study, which is a series of scientific activities carried out intensively, in detail and in depth about a program, event, and activity, both at the individual level, a group of people, institutions, or organizations to obtain in-depth knowledge about the event, this case study was conducted directly to adolescents who were menstruating and experiencing primary dysmenorrhea. The results of the study were conducted in Case 1, an adolescent who was experiencing Primary Dysmenorrhea pain with a pain scale of 9 after being given Turmeric Acid, the NRS value at Visit 1 was 7, Visit 2 was 5, Visit 3 was 3. While in Case 2 after being given Pineapple juice, the NRS value at Visit 1 was 7, Visit 2 was 4, Visit 3 was 2. both were the same in reducing pain, but consuming Turmeric Acid was more effective in reducing pain by 1 on the 2nd visit and the difference in pain reduction was 1 on the 3rd visit. It is hoped that this study can be used to add new knowledge about the treatment of dysmenorrhea pain in adolescents in a non-pharmacological way, namely by using turmeric acid and pineapple juice. as an alternative.

Individuals who experience GGK and have undergone hemodialysis will experience many changes in their lives. This can affect the patient's psychological condition. Changes that occur can have an impact on individual perceptions related to their lives including the quality of their lives and perceptions about themselves including self esteem. To find out the relationship of self esteem with the quality of life in chronic kidney failure patients who are undergoing hemodialysis in the hemodialysis room of RSUD R Syamsudin SH Sukabumi City in 2025. Research uses correlational design. The number of samples was 219 people. The instruments used were the CSEI and KDQOL-S questionnaire. The statistical test used is Chi Square's correlation. There is a relationship between self esteem and the quality of life of chronic kidney failure patients who are undergoing hemodialysis, the results of the chi square test with a p-value of 0.00 or smaller than the alpha value (a = 0.05). The results of this study can provide information for RSUD R Syamsudin SH to increase health knowledge and insight to improve the quality of life of chronic kidney failure patients in hemodialysis. One step that can be taken is to provide education to increase the patient's self esteem.

Degenerative diseases are chronic diseases that can affect a person's quality of life in the future. One example of degenerative diseases is diabetes mellitus and hypertension. Hypertension is defined as one of the most dangerous health problems worldwide because hypertension is a major risk factor that can cause cardiovascular diseases such as heart attack, heart failure, stroke. The purpose of this study was to determine the relationship between family history, type of work, and stress level on the incidence of hypertension in Kebonkalapa hamlet, Kutapohaci. The research method used a nonparametric test technique using the chi square statistical test and was processed using the IBM SPSS 25 application. The results of the analysis obtained from this study found that family history, type of work, and stress level were not associated with the incidence of hypertension in Kebonkalapa hamlet, Kutapohaci because the p-value was greater than 0.05.
 
 

Mental health is a condition in which a person is free from all symptoms of mental disorders. Anxiety disorder is the most common mental disorder experienced by adolescents and depression reaches 26.7%. The purpose of this study was to determine the knowledge and attitudes of adolescents through poster media both before and after interventions related to mental health. The type of research used is quantitative with one group pre-test post-test method, with intervention using poster media and questionnaires as data collection tools at SMAN 5 Jambi City. The sample in this study amounted to 30 respondents and was tested using the Paired T-Test statistical test. The pre-test results showed that the percentage of knowledge before the intervention was 66.7% to 100% after the intervention and the percentage of attitude before the intervention was 76.7% to 96.7%. After the intervention on mental health, there was an increase in knowledge with P-Value = <.001 and an increase in attitude with P-Value = <.001. This study shows that there is an influence on knowledge and attitudes before and after the intervention of poster media on mental health at SMAN 5 Jambi City. It is recommended to hold interactive discussions with counseling teachers in schools aimed at increasing adolescents' understanding of mental health and being able to reduce the stigma of the surrounding environment so that students do not feel afraid or embarrassed to seek help.

Dental and oral health problems in early childhood in Indonesia are still a serious concern. This study aims to determine the effect of audiovisual media on improving the knowledge and skills of brushing teeth of early childhood in An-Nahl Kindergarten, Jambi City. The research method used a quasi-experimental design with a one group pretest-posttest design. The sample of this study was 40 children aged 4-5 years, taken using a total sampling technique. The research instruments included a knowledge questionnaire and an observation sheet for brushing teeth skills. The results showed a significant increase in knowledge scores from 3.03 to 7.33 and skills from 2.43 to 6.80 after being given an intervention in the form of audiovisual media. In conclusion, audiovisual media is effective in improving the knowledge and skills of brushing teeth of early childhood.

Stunting is a global concern, impacting the quality of human resources.Purpose of Analysis of Factors Related to Stunting in Toddlers in Bangun Rejo Village, Tanjung Morawa. This study used a cross-sectional study design analytical method. The population of this study is 35 stunted toddlers in the February-March 2025 period. 16 respondents with moderate knowledge, the majority of toddlers were stunted with short height (75%), while the other 25% were very short. The results of the statistical test showed a P-Value of 0.000 (P < 0.05), 22 secondary education respondents, most of them toddlers experienced stunting, short height (72.7%), while the other 27.3% were very short. showed a P-Value of 0.003 (P < 0.05), 20 low-income respondents, 60% of toddlers experienced stunting very short height, while 40% were short. showed a P-Value of 0.015 (P < 0.05), indicating a significant relationship between income and stunting in toddlers, 24 respondents had undernourished status, 54.2% of toddlers experienced stunting, very short height, while 45.8% were short. showed a P-Value of 0.006 (P < 0.05), there was a significant relationship between nutritional status and stunting in toddlers. Knowledge, education, income, nutritional status are risk factors for stunting in toddlers.Increasing knowledge of child growth is very important to understand the factors that affect stunting and effective prevention strategies.

Hypertension is one of the major health problems frequently experienced by the elderly and can lead to serious complications if not properly managed. Simple physical activities such as massage can serve as a non-pharmacological intervention to help reduce blood pressure. This study aimed to determine the effect of physical activity in the form of massage on reducing blood pressure in elderly individuals with hypertension at PSTW "Meci Angi" in Bima City. This research employed a quasi-experimental design with a pre-post test control group design. The sample consisted of 20 elderly people divided into two groups, an experimental group and a control group, with 10 respondents in each group. Data were collected using an observation sheet to measure blood pressure before and after the intervention. The t-test analysis showed a significance value (2-tailed) of 0.009, which was less than α = 0.05, indicating a significant effect of physical activity on lowering blood pressure among the elderly. Therefore, massage as a simple form of physical activity can be considered an alternative intervention in managing hypertension among the elderly in social care institutions.

Background: Low back pain (LBP) is still one of the health problems, including in the dental profession. Doctor Dentists have a risk of experiencing Low Back Pain (LBP) when viewed from their static work activities. work activities that are static. The purpose of this study was to determine relationship between ergonomic factors and complaints of Low Back Pain (LBP) in general dentists practicing independently in Jambi City. general dentists practicing independently in Jambi City. Methods: This study is a quantitative study with an observational observational research design and using a cross sectional research design. The study population was general dentists practicing in Jambi City, totaling 204 people. Respondents in this study 70 people. Data collection using the ODI questionnaire for measurement LBP measurement, fingertip pulse oximeter for measurement of workload, Rapid Upper Limb Assessment (RULA) for work posture measurement, vibration meter for vibration measurement, and lux meter for lighting measurement. Data analysis using chi-square statistical test version 24. Results: The results showed the prevalence of complaints of Low Back Pain (LBP) in dentists was 60%. dentists amounted to 60%. The statistical test results show that the variables workload (p=0.000 <0.05), work posture (p=0.000 <0.05), length of work (p = 0.000 < 0.05), repetition (p = 0.003 < 0.05), lighting (p = 0.415 > 0,05). Conclusion: There is a relationship between workload, work posture, work duration, repetition with complaints of Low Back Pain (LBP) and there is no relationship between workload, work posture, work duration, repetition and lighting