Hypertension in pregnancy is one of the leading causes of maternal mortality, with a global prevalence of 5–10% (Khedagi & Bello, 2021). This study aims to analyze the effect of reproductive status—maternal age, gravidity, and parity—on the incidence of hypertension in pregnancy at Prof. Dr. Chairuddin P. Lubis Educational Hospital, Medan. A case-control design was employed with 96 respondents, consisting of 48 cases and 48 controls. Bivariate analysis revealed that pregnant women aged ?35 years have a 2.839-fold higher risk of developing hypertension compared to those aged <35 years (OR=2.839; 95% CI: 1.123–7.177; p=0.027). First pregnancy (primigravida) increases the risk by 2.742 times compared to multigravida (OR=2.742; 95% CI: 1.047–7.178; p=0.040), while nulliparous women have a 2.714-fold higher risk compared to those who have given birth (OR=2.714; 95% CI: 1.101–6.693; p=0.030). Multivariate analysis identified maternal age ?35 years and nulliparity as the most significant predictors (p=0.005). These findings align with studies by Wiranto & Putriningtyas (2021), Hinkosa et al. (2020), and Luo et al. (2020), which confirmed that advanced maternal age and nulliparity increase the risk of pregnancy complications. The novelty of this research lies in integrating all three reproductive status factors as simultaneous predictors of hypertension risk, providing a new perspective compared to previous studies focused on single variables. Based on these findings, early detection and targeted health education for high-risk mothers are strongly recommended.

Gross motor development in children aged 1–3 years is a crucial aspect of growth and development, influenced by various factors, one of which is nutritional status. Good nutritional status plays a role in optimizing children's growth and development, including gross motor skills. This study aims to analyze the relationship between nutritional status and gross motor development in children aged 1–3 years at the Posyandu within the working area of Situ Udik Community Health Center (Puskesmas). This study employs a quantitative design with a cross-sectional approach. The research sample consists of children aged 1–3 years selected using a random sampling technique. Nutritional status was measured using an anthropometric approach, specifically weight-for-age (W/A), while gross motor development was assessed using the validated Denver Development Screening Test (DDST II) observation sheet. Data analysis was conducted using the chi-square statistical test to determine the relationship between nutritional status and gross motor development. The results indicate a significant relationship between nutritional status and gross motor development in children aged 1–3 years (0.013, p ? 0.05). Children with good nutritional status tend to have optimal gross motor development compared to those with undernutrition or overnutrition. These findings suggest that good nutritional status is a supporting factor in early childhood gross motor development. Therefore, regular monitoring of nutritional status and parental nutrition education are essential steps in supporting children's optimal growth and development.

This qualitative study explores the role of pickleball in promoting healthy aging among elderly players in Indonesia. As the global elderly population continues to rise, the need for effective strategies to enhance physical, mental, and social well-being in older adults becomes more pressing. Pickleball, a low-impact sport that combines elements of tennis, badminton, and table tennis, has gained significant popularity worldwide due to its accessibility, moderate intensity, and low risk of injury. This study employed a phenomenological approach, conducting semi-structured interviews, participant observations, and focus group discussions with 19 elderly pickleball players aged 50 and above in Surabaya, Indonesia. The findings suggest that regular participation in pickleball leads to significant improvements in physical health, including enhanced strength, balance, flexibility, and cardiovascular endurance. The sport also has positive effects on mental well-being, helping to reduce stress, improve cognitive function, and provide a sense of purpose and accomplishment. Socially, pickleball fosters community engagement, reduces feelings of isolation, and strengthens intergenerational relationships, allowing older adults to connect with younger generations. However, barriers such as physical limitations, limited access to facilities, and unfavorable weather conditions hinder consistent participation. In conclusion, pickleball is a valuable and effective activity for promoting healthy aging by providing a holistic approach to improving the quality of life in older adults. Policymakers, healthcare providers, and community leaders are encouraged to invest in pickleball infrastructure, promote awareness, and support active aging initiatives to further enhance the well-being of elderly populations. This version now has 253 words, making it more closely aligned with your desired word count.

Takokak fruit contains bioactive compounds that can be used as antidiabetics. This study aims to identify bioactive compounds of ethanol extract of takokak fruit and antidiabetic test of n-Hexane fraction. The method used to obtain the extract is maceration using ethanol . Antidiabetic testing is carried out through in vivo testing with the Oral Glucose Tolerance Test (OGTT) method on white rats. Secondary metabolites are compounds contained in taakokak fruit that are identified as flavonoids, saponins, tannins, steroids and terpenoids . The results of the antidiabetic test showed that the n-Hexane fraction with glibencamide as a comparator has the ability as an antidiabetic in terms of the amount of difference in blood glucose levels in the test animal group from T 30 to T 120 . The average decrease in blood glucose levels in the negative control group (Na-CMC) was 108.67 mg/dL, the positive control group ( glibencamide ) 174.67 mg/dL, the 5% concentration fraction group 35.33 mg/dL, the 10% concentration fraction group 30.67 mg/dL, the 20% concentration fraction group 47.67 mg/dL.

Background:Toddlerhood is the most central phase of a child because the growth and development of children can run quickly, precisely the age of 0-2 years is the golden period of children, because brain development reaches 80%. Cases of BB/TB nutrition at the Kalibobo Health Center UPTD, 6 cases of malnutrition, 3 cases of undernutrition, 12 cases at risk of overnutrition. The task of parents, especially mothers, in the practice of caring for toddlers so that the basic needs of nurturing patterns, loving patterns and parenting patterns affect the process of child growth and development. Objective: To determine the relationship between nurturing patterns, loving patterns and parenting patterns to the nutritional status of toddlers in the Kalibobo Health Center UPTD Work Area. Method: Quantitative research type with a cross-sectional approach. The population of 222 toddlers became 69 toddler samples using the slovin formula. The sampling technique is purposive sampling. Data analysis using Statistical Program for Social Science (SPSS) software version 16.0 with the chi-square test. Results: The test of the relationship between the sharpening pattern p-value 0.30 (>0.05), the affection pattern p-value 0.00 (<0.05), and the parenting pattern p-value 0.00 (<0.05). Conclusion: The sharpening pattern and the nutritional status of toddlers have no relationship, the affection pattern and parenting pattern have a relationship with the nutritional status of toddlers in the Working Area of ??the Kalibobo Health Center UPTD. Suggestion: It is necessary to carry out counseling on the sharpening pattern, affection, parenting, types of activities and the importance of integrated health posts to mothers.

Iron deficiency is a common cause of anemia during pregnancy. The low consumption of Fe tablets is related to compliance with consumption. The purpose of this study was to determine the compliance of pregnant women taking iron tablets in the second trimester in Bukittinggi City. This was a qualitative study using a case study method. A purposive sampling technique was used, with the main informant being pregnant women in the second trimester in Baratan Village. Data were collected using interview techniques, observation, and documentation analysis and then validated using data triangulation, observer triangulation, theory triangulation, and method triangulation. The results of this study were analyzed based on data grouping. Testing data assumptions, alternative data explanations, and the results of the study were written. The compliance of pregnant women in taking Fe tablets shows the compliance of pregnant women in the second trimester in taking Fe tablets and how pregnant women know the benefits and impacts of not taking Fe tablets. Researchers know how long pregnant women take Fe tablets, and family support is a reinforcement for pregnant women if they forget when taking Fe tablets. Pregnant women who routinely have ANC will also receive Fe tablets from the midwife who checks for compliance with taking Fe is better when Fe tablets are also available. The opinion of researchers of primigravida pregnant women in the second trimester shows that the first, second, and third subjects are pregnant women in the second trimester who have experience taking Fe tablets. They reported the same complaints, namely nausea and vomiting after taking Fe tablets; even so, they remained obedient and routinely took Fe tablets every day, with and without being reminded by their families, they still routinely took Fe tablets. Some mothers understand the impact of not taking Fe tablets, namely, anemia and bleeding. During the interviews, all mothers said that they routinely checked their pregnancy every month with a midwife accompanied by their husbands.

Takokak fruit is one of the plants that can be used to lower blood sugar levels. This study aims to identify the bioactive compounds of ethanol extract of takokak fruit and test the antidiabetic ethyl acetate fraction. Antidiabetic testing was carried out by in vivo testing using the Oral Glucose Tolerance Test (OGTT) method to see the decrease in blood glucose levels using white rats as test animals. The test results showed that takokak fruit contains flavonoids, steroids, and tannins. Fractionation is the process of extracting compounds from the extract using two types of solvents that do not mix with each other. The results of the antidiabetic test showed that the ethyl acetate fraction with glibenclamide as a comparator had the ability as an antidiabetic measured by the amount of difference in the decrease in blood glucose levels in the test animal group T?? to T???. From the results obtained, the average decrease in blood glucose levels in the negative control group (Na CMC) was 5.8 mg/dL, the positive control group (Glibenclamide) 21.03 mg/dL, and the fraction group 9.86 mg/dL. Takokak fruit has antidiabetic activity. Compounds that have antidiabetic activity are flavonoids, tannins, and steroids.

Hypertension is a disorder characterized by elevated blood pressure originating from abnormalities in blood vessels, leading to impaired delivery of oxygen and nutrients to essential body tissues. Family involvement in assisting relatives afflicted with hypertension constitutes a supportive mechanism to facilitate effective self-care management of the condition.This study aimed to investigate the correlation between familial support and self-care management in hypertensive patients at Tuminting Health Center. Cross-sectional methods. The study sample comprised 49 individuals selected by purposive sampling. A questionnaire was employed as the study instrument. The gathered data was analyzed with the SPSS 16.0 software employing the Chi Square statistical test at a significance level (?) of <0.05. The results indicated that the predominant age group was 56-65 years, including 27 respondents, which represents 55.1%. The majority of respondents were female, totaling 39 individuals, accounting for 79.6%. The most common educational attainment was high school, with 22 respondents, corresponding to 44.9%. The statistical test yielded a P value of 0.0001, which is less than the alpha value (?) of ?0.05. This study concludes that a correlation exists between family support and self-care management in hypertension patients at Tuminting Health Center. The findings of this study are anticipated to serve as a resource for individuals with hypertension, emphasizing the importance of self-care management to prevent problems and facilitate recovery.

The predictive role of oxidative stress in the pathophysiology of human pregnancy is of particular interest, as oxidative stress is increased in normotensive pregnant women through systemic inflammatory response, reactive oxygen species (ROS), and reactive nitrogen species (RNS). This study involved 40 consenting pregnant women recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Data obtained were analyzed using GraphPad Prism 9. Results were expressed as mean ± SEM, with a P-value of ? 0.05 considered statistically significant. Malondialdehyde (MDA) increased from 3.75 ± 0.42 U/L in normotensive women to 4.53 ± 0.59 U/L in preeclamptic women. However, this increase was not statistically significant (p<0.05; 0.2903). Catalase activity decreased from 114 ± 8.07 U/L in normotensive women to 84.02 ± 21.58 U/L in preeclamptic women, but this decrease was also not statistically significant (p<0.05; 0.1909). Superoxide dismutase (SOD) increased from 40.82 ± 1.23 U/L in normotensive women to 71.90 ± 5.61 U/L in preeclamptic women. This increase was statistically significant (p<0.05; <0.0001). Glutathione peroxidase (GSH) decreased from 66.74 ± 10.35 U/L in normotensive women to 50.63 ± 8.96 U/L in preeclamptic women, but this decrease was not statistically significant (p<0.05; 0.2466). These findings suggest the potential predictive roles of these biomarkers in identifying and monitoring preeclampsia.

Background:PMBA is one of the government programs to reduce child mortality rates and improve the quality of life of mothers in accordance with improvements in maternal behavior in PMBA. PMBA includes IMD, Exclusive Breastfeeding, MP-ASI, Breastfeeding up to 2 years of age. Objective: To find out about the Relationship between Knowledge Level, Attitude and Mother's Behavior towards PMBA 6-59 Monthsin the Working Area of ??the Yabomaida Health Center, Paniai Regency. Method: This research method is correlational analytic with a cross-sectional approach. The research population consisted of 190 infants and children.withThe research sample consisted of 66 people who had a Relationship between the Level of Knowledge, Attitude and Behavior of Mothers towards PMBA 6-59 Months.in the Working Area of ??the Yabomaida Health Center, Paniai Regency.The sampling technique used purposive sampling. Data analysis used the Statistical program for social science (SPSS) version 16.0 computer application program and used the chi-square test. Results: the results of the relationship between the level of maternal knowledge of PMBA based on the p value = 0.04 (<0.05), while the mother's attitude towards PMBA based on the p value = 0.03 (<0.05), and the mother's behavior towards PMBA based on the p value = 0.02 (<0.05). Conclusion: There is an influence of PMBA on knowledge and attitudes and PMBA practices in the Yabomaida Health Center work area, Paniai Regency, which obtained the p value <0.05. Suggestion: the need for PMBA 6-59 months in the posyandu counseling andIn the Working Area of ??the Yabomaida Health Center, Paniai Regency.