Packaging plays an important role in maintaining the quality, stability, and effectiveness of medicines, both in the form of pharmaceutical preparations and herbal products. This review article aims to analyze the role of primary and secondary packaging materials through literature studies from various relevant journals. The method used was a literature review of four selected national and international journals that discussed the influence of packaging on product stability, information effectiveness, and product image in the eyes of consumers. The results of the study show that primary packaging functions to protect products directly from environmental influences, while secondary packaging functions in distribution, storage, and strengthening visual and branding aspects. Innovations such as the use of adsorbent plastics and visual redesign have been proven to increase stability and consumer confidence in the product. It can be concluded that packaging is a crucial aspect that not only maintains the physical-chemical quality of the product, but also shapes consumer perception and compliance.

Background: Research of glucose detection is important in diabetes management and biosensor development. Taking into account the large amount of water retention, the biocompatibility of hydrogels makes them ideal candidates for glucose detection. The PBA groups, when grafted to hydrogel matrices, improve the glucose-related response of the hydrogels significantly. Objective: To create a novel PBA (phenylboronic acid) holographic glucose sensor, MAAm-co-4VPBA, for uninterrupted monitoring of blood glucose levels, which demonstrates the first successful glucose measurement in whole blood using PBA sensors. Methods: Methylacrylamide (MAAm) was copolymerized with 4-vinyl phenyl boronic acid (4-VPBA) by means of free radical polymerization employing 1,6-hexanedioldiacrylate (HDODA) as a crosslinker and the photoinitiator 1-hydroxycyclohexyl phenyl ketone. The responsive glucose behavior of the resulting polymer was characterized in terms of swelling dynamics, ex vivo flow tests, and error grid analysis mechanisms. Results: The MAAm-co-4VPBA polymer exhibits reversible glucose binding via PBA-diol interactions that allow complexation at different pH and concentration levels. Modulation of the responsive elements of the microcapsules by hydrophobic PBA and hydrophilic MAAm units yields maximum swelling and shrinking dynamics at 37 trail degrees. The sensor successfully detected glucose in opaque biological fluids, blood plasma, without any interference from antibiotics or other therapeutics or endogenous compounds. Ex vivo tests showed real-time glucose monitoring without hysteresis. Most importantly, this work is the first to report the use of PBA-based sensors in whole blood for measuring glucose.
Conclusion: The MAAm-co-4VPBA holographic sensor possesses outstanding features such as accurate records and strong resistance to chemicals and slow response to detection, confirming its effectiveness in continuous glucose monitoring. Moreover, the ability to operate in the real world enables the aid in clinical diagnosis of diabetes.

Pharmaceutical packaging serves not only as a means of protecting the product but also as a source of information and quality assurance for consumers. However, various studies indicate that packaging defects remain a significant issue in the pharmaceutical industry. This article is a literature review that examines several studies related to the analysis of the causes of packaging defects in pharmaceutical preparations. Based on the review of multiple scientific journals, it was found that packaging defects are generally caused by a combination of technical and non-technical factors, such as machine failure, operator error, inappropriate raw material specifications, and insufficient quality control.

Woodball was first introduced in 2006 and has since grown rapidly across the country. In addition, many woodball clubs and communities have emerged, and woodball has become an officially recognized competitive sport since 2016. In 2016, woodball even became part of the national sports week (PON) in West Java. Woodball is a sport that combines elements of golf and croquet, emphasizing the accuracy of shots to pass through the goal with a wooden ball. Hand-eye coordination is one of the key factors that can influence the quality of an athlete's shots. Objective: To determine the relationship between hand-eye coordination and shot quality in woodball athletes in Bali Province. An observational analytical study with a cross-sectional approach involving 42 woodball athletes in Bali Province. Hand-eye coordination was measured using a 30-second ball catch-and-throw test, while shot quality was assessed using a skill test based on the number of balls successfully passing through the gate. Analysis was performed using Spearman's rho correlation test. The analysis revealed a significant relationship between eye-hand coordination and swing quality in woodball athletes (P < 0.05). The positive correlation coefficient indicates that better eye-hand coordination leads to higher swing quality. There is a significant relationship between eye-hand coordination and shot quality. Improving visual-motor coordination skills can contribute to the performance of woodball athletes.

Oxidative stress is caused by regular smoking. If oxidative stress is higher than the level of antioxidants, there is said to be oxidative stress. SOD, CAT and GPx enzymes in the plasma help to reduce the harm caused by oxidative stress. This study aimed to discover if smoking regularly had any impact on the enzymes found in adults. A total of 120 people, with 60 chronic smokers and 60 nonsmokers, took part in the study and each group of 60 had equal numbers of men and women. All donors of blood and plasma had their levels of SOD, CAT and GPx checked using regular spectrophotometric procedures. I carried out the analysis using SPSS software version 26.0. The levels of SOD (1.82 ± 0.29 U/mL), CAT (31.5 ± 4.8 IU/mL) and GPx (3.21 ± 0.52 IU/mL) were lower in smokers compared to non-smokers. The gender levels showed the same effect on the study results as the smoking levels and did not interact with one another. Generally, regular smoking can decrease the amount of this enzyme working in plasma, so the body becomes less able to protect itself from oxidation for both men and women. It indicates that smoking leads to a health issue and advises taking actions to decrease risks for smokers.
 

Several of the best-selling small-molecule medications and natural alkaloids contain piperidine, a crucial saturated heterocyclic scaffold with a wide variety of biological functions. The hydrazide-hydrazone moiety's exceptional use in the pharmacological and biological domains made it particularly appealing. Objective: Designing and synthesizing a novel set of 4-Piperidin-1-yl-benzoic acid substituted hydrazides, Ac1-c3 and Bc1-c5, as potentially antimicrobial agents and characterizing them using IR, 1H-NMR, and mass spectroscopy. Methods: By esterifying 4- Piperidin-1-yl-benzoic acid Ac1 and then treating with hydrazine hydrate it to produce Ac3 in a good yield. The hydrazide Ac3 was condensed with the proper aldehydes or ketone to synthesis the hydrazones Bc1–c5. The in vitro bacterial activity was evaluated anti two Gram-negative bacteria, Pseudomonas aeruginosa, and Candida albicans, as well as two Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis. Results: The majority of tested compounds demonstrated significant efficacy anti Pseudomonas aeruginosa, Candida albicans. Notably, compound Bc3 emerged as the most effective derivative within the series. Conclusions: The Compounds (Bc1–c4) that were synthesized demonstrated moderate to good antimicrobial activity against a number of bacterias species and Candida albicans.

An experiment was conducted to study the effect of adding different levels of urea fertilizer (ppmUrea-N0,75,150,225,300) on the effectiveness of bio-nitrification in the studied soil. The study treatments forthis experiment were (4 soils of different textures and locations × 5 urea levels × 3 replicates) in an experimentin which a completely randomized design (CRD) was used. It was incubated at laboratory temperature (25°C)for 40 days, during which the amount of formed nitrates and remaining ammonium was measured every tendays, noting the replacement of lost water every two days.The highest percentage of formed nitrates (39.8%) was recorded from the ammonium added to Basrah soilafter ten days of incubation, followed by Kut soil, which recorded 29.8%, and less than that in Shatra soils(24.2%) and Fajr soils (23.7%). After that, the efficiency of nitrification decreased in the subsequent incubationperiods up to 40 days of incubation.The percentage of ammonium remaining from urea added to the soil was recorded after the four incubationperiods at 20.0 ppm (when adding 225 ppm urea to the Qurna soil), which differed significantly from the rest ofthe studied soils.

Diabetes mellitus, especially type 2, is a growing epidemic with almost 90% of cases reported worldwide. Antioxidants are compounds that are in lower concentrations compared to the concentration of oxidizable compounds, can significantly prevent or inhibit the oxidation of the substrate. The formation of more stable oxidant compounds through intramolecular hydrogen bonds in the further oxidation process. Data collection was carried out using Google Scholar, Science Direct and PubMed databases. The literature sources used were in the form of research results that had been published in 2011-2021 in national and international journals. Providing antioxidants is an effort to inhibit the production of intracellular free radicals or increase the ability of defense enzymes against free radicals in order to prevent the emergence of oxidative stress and diabetes-related blood vessel complications. Various supplements containing antioxidants and/or factors that can increase the production of nitric oxide (NO) have the potential to improve endothelial dysfunction and mitochondrial function in cells, as well as reduce the activity of the NAD(P)H oxidase enzyme. 

The purpose of the study was to determine the description of juvenile delinquency behavior that occurs in students. The study used a descriptive research method in which the author tried to reveal and describe how Juvenile Delinquency in Students of SMAN X Lengayang in Pesisir Selatan. Descriptive research is one type of research that aims to describe systematically, factually, and accurately about the facts and characteristics of a particular population. From the tests that have been carried out, the results obtained are that the level of juvenile delinquency is included in the moderate category. In the gender category, 27 male students have a moderate level of delinquency and 36 female students have a moderate level of delinquency. As for the class category, class 10 has 22 people, class XI 17 people and class XII 24 people with a moderate level of delinquency. The highest level of delinquency is in class XII, this is due to the feeling of being the most senior in school.

Type 2 Diabetes Mellitus (DM) is a disease caused by impaired insulin function, impaired insulin secretion, or both, resulting in a hyperglycemic condition. Patients with type 2 DM generally exhibit characteristics such as a Random Blood Glucose level exceeding 200 mg/dL and an HbA1c  level exceeding 6.5%. The accuracy of medication administration to patients must also consider the rationality of antidiabetic therapy in order to influence the success rate of optimal therapy. This study aims to evaluate the rationality of patient appropriateness and indication appropriateness in outpatients with type 2 DM at Tabanan Regional Public Hospital (RSUD Tabanan). This study employed a semi-quantitative observational research design with a retrospective approach by reviewing patient medical records from the initiation of therapy. Sampling was conducted using purposive sampling, whereby samples had to meet predetermined inclusion criteria. The results indicated that the age group with the highest prevalence of DM patients at RSUD Tabanan was over 56 years old (74%), with a predominance of females (63%). The most common comorbidity among DM patients was hypertension alone (24.5%). Based on the findings, the percentage of patient appropriateness rationality among DM outpatients at RSUD Tabanan was 97.5%, while the percentage of indication appropriateness rationality in type 2 DM outpatients at RSUD Tabanan was 98.5%.