Every pregnant woman is strongly recommended to undergo comprehensive and quality antenatal care (ANC) at least four times, consisting of at least once in the first trimester (before 14 weeks of gestation), at least once in the second trimester (14–28 weeks of gestation), and at least twice in the third trimester (between 28–36 weeks and after 36 weeks of gestation), including at least one visit accompanied by the husband or a family member. The first ANC visit is highly recommended to be conducted between 8 and 12 weeks of gestation. The objective of this study is to identify the factors that influence the K4 coverage of antenatal visits among pregnant women at Bontomarannu Public Health Center, Galesong Selatan Subdistrict, Takalar Regency. This research uses a cross-sectional study design. The sample consisted of 60 pregnant women who underwent K4 antenatal examinations at Bontomarannu Public Health Center, selected through random sampling. The results showed that knowledge significantly affected the K4 coverage of antenatal visits (p = 0.000), occupation also had a significant influence (p = 0.004), and distance was another significant factor (p = 0.005). It can be concluded that knowledge, occupation, and distance all influence the K4 coverage of antenatal visits at Bontomarannu Public Health Center, Galesong Selatan Subdistrict, Takalar Regency.
 

Anemia is a common complication in cancer patients, especially in advanced stages, which affects quality of life and response to therapy. This study aims to analyze the relationship between cancer stage and hemoglobin (Hb) levels in female patients undergoing chemotherapy. This quantitative study used a cross-sectional design and involved 54 female cancer patients at the H. Adam Malik General Hospital Polyclinic, Medan. The sampling technique used convenience sampling. Data were analyzed using the Spearman's rho test to determine the relationship between cancer stage and Hb levels. The majority of respondents were in stage 3 (48.1%) and stage 4 (37.0%), with 63% experiencing moderate anemia (Hb 8–10 g/dL). The results of the Spearman test showed a significant positive correlation between cancer stage and Hb levels (r = 0.683; p = 0.000), indicating that the more advanced the cancer stage, the lower the hemoglobin levels tend to be. It was concluded that there was a significant relationship between cancer stage and hemoglobin levels in female patients. These results emphasize the importance of monitoring Hb levels in clinical management and nursing care of cancer patients, especially in advanced stages.

The No Smoking Area (KTR) is a form of protection for the community from the adverse effects of smoking, which is regulated in Regional Regulation Number 2 of 2016. This study aims to analyse the implementation of the KTR policy in the Regional Apparatus Organisation (OPD) of Merangin Regency by reviewing four aspects of policy implementation, namely communication, resources, disposition, and bureaucratic structure. This research used a descriptive qualitative approach with data collection techniques in the form of interviews, observation, and documentation. The research informants consisted of OPD parties involved in the implementation of KTR. The results showed that in the communication aspect, KTR policies have been socialised through print and electronic media, but delivery training has not been carried out optimally. In the resource aspect, limited human resources, funds, and facilities are the main obstacles in implementing KTR. In the disposition aspect, most OPDs show commitment in implementing KTR, but have not been supported by providing incentives or awards. In the aspect of bureaucratic structure, there is no special SOP or organisational structure in each OPD for KTR implementation, so the implementation is still not running optimally. In conclusion, the implementation of the KTR policy in Merangin Regency has not run optimally because there are still weaknesses in the four aspects, especially related to coordination, human resources, and supporting institutions.

Tuberculosis (TB) is currently a public health problem in the world, especially in Indonesia. Pulmonary TB is ranked 2nd as the main cause of death from infectious diseases after Human Immuno deficiency Virus (HIV). Pulmonary Tuberculosis is easily spread through the air when people who are sick with Pulmonary Tuberculosis release bacteria through the coughing mechanism. The spread of these bacteria is through sputum splashes or droplet nuclei released by TB sufferers through coughing, sneezing or talking face to face. The increase in TB cases is related to the degree of health in the community. The biggest factors that affect the degree of health are environmental factors and community behavior itself which can be detrimental to health. Risk factors for Tuberculosis transmission are environmental factors and behavioral factors, environmental factors include ventilation, housing density, temperature, lighting and humidity. While behavioral factors include smoking habits, spitting or throwing phlegm anywhere, coughing or sneezing without covering the mouth and the habit of not opening windows and not implementing clean and healthy living behavior (PHBS). This research method is a quantitative study with statistical tests with a cross-sectional design. This study was conducted at SMP 4 Ulee Rubek, North Aceh in November 2024. The research sample consisted of 15 children, Data collection techniques using questionnaires. Data analysis used descriptive statistical tests to test adolescents' knowledge about how to prevent TB. In addition to effective coughing, there are several ways to control pulmonary tuberculosis, namely by cultivating a clean and healthy life and cultivating ethical coughing behavior.

Occupational Health and Safety (K3) is an effort to provide safety guarantees and improve the health status of workers/laborers by preventing work-related accidents and diseases, controlling  workplace hazards,  health  promotion, treatment and  rehabilitation. Occupational Health and Safety efforts include workforce, work methods/methods, work tools, work processes and work environment. In the PTM room at the West Baktiya Health Center, the space is quite narrow due to the large number of patients visiting, so there is untidiness in the room even though the AC and windows are used. However, having 2 tables in the room makes the room increasingly narrow and difficult to work comfortably. This research aims to find out an overview of the implementation of Occupational Safety and Health in the PTM room. This research is a qualitative descriptive research with a case study design. The subjects of this research were 3 officers in the PTM room. The object of this research is the implementation of K3 and PTM rooms at the West Baktiya Community Health Center. Data was collected by participant observation and semi-structured interviews with informants. The risk factors for the PTM room at the West Baktiya Health Center, seen from occupational safety and health factors, are that it is quite clean, no animals were found that cause disease transmission such as cockroaches, rats and others. There are no occupational safety and health signs and standard operational procedures related to occupational safety and health, while fire prevention in the PTM room at the West Baktiya Public Health Center and the West Baktiya Community Health Center itself is quite good with APAR. There needs to be signs regarding occupational safety and health and SOPs regarding occupational safety and health, especially in the PTM room.

Stunting is a chronic nutrition problem that affects the growth and development of children. This study aims to analyze the relationship between exclusive breastfeeding and the incidence of stunting in children aged 2-24 months in Matang Maneh Village. The research used a quantitative approach with a survey method. Data were collected through structured questionnaires, and the relationship was analyzed using the chi-square test. The results showed a Pearson Chi-Square value of 5.185 with a significance level of 0.023 (p < 0.05). This indicates a significant relationship between exclusive breastfeeding and stunting. Children who did not receive exclusive breastfeeding had a higher risk of stunting compared to those who did. This study highlights the importance of exclusive breastfeeding in preventing stunting. These findings can serve as a basis for creating intervention programs  to  increase  exclusive  breastfeeding coverage  and reduce stunting prevalence, especially in Matang Maneh Village.

. The Framingham Risk Score (FRS) assesses coronary heart disease (CHD) risk and predicts acute coronary events. Metabolic markers like LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio play critical roles in atherosclerosis and cardiovascular risk. Elevated LDL cholesterol, fasting blood glucose, and uric acid contribute to plaque formation, inflammation, and vascular damage, while high triglycerides and low HDL cholesterol exacerbate atherogenesis. This study explores the relationship between these markers and FRS to enhance CHD risk prediction and support targeted cardiovascular interventions. This study analyzed LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio with Framingham Risk Score in 85 participants, excluding those with incomplete data or chronic illnesses. The analysis found significant correlations between metabolic parameters and the 10-year myocardial infarction risk. LDL cholesterol, triglycerides, and uric acid showed moderate positive associations with cardiovascular outcomes, while the triglyceride-to-HDL ratio and fasting blood glucose had weaker but significant correlations. These findings highlight lipid profiles and metabolic markers as key contributors to cardiovascular risk. This study highlights significant correlations between LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and the triglyceride/HDL ratio with 10-year cardiovascular risk. These findings emphasize the importance of lipid profiles, glycemic control, and metabolic markers in predicting coronary outcomes and guiding targeted preventive interventions for improved cardiovascular risk management.

Orthosiphon stamineus Benth., commonly known as kumis kucing, is a widely recognized medicinal herb in traditional medicine, particularly valued for its diuretic properties. This study aims to evaluate the potential of active compounds in O. stamineus as diuretic agents through an in silico approach using molecular docking methods. A total of 98 compounds were screened against three diuretic target receptors: 1Z9Y (furosemide receptor), 3HS4 (acetazolamide receptor), and 3VHU (spironolactone receptor). The docking results revealed that lithospermic acid I, dicaffeoyl tartaric acid, and orthosiponone C exhibited lower binding energies compared to standard ligands, indicating higher affinity and stronger molecular interaction stability. Molecular visualization showed that these compounds formed specific interactions, such as hydrogen bonds and π-π stacking, resembling the binding mechanisms of synthetic diuretics. This study highlights the significant potential of O. stamineus to be developed into a natural diuretic phytopharmaceutical. However, further validation through in vitro and in vivo studies is necessary to confirm their efficacy and safety in complex biological systems.
 
 

COVID-19 is a viral respiratory disease that has caused a global health emergency and was declared a pandemic by the World Health Organization. The lack of certain drug molecules or treatment strategies for this disease is making it worse. Therefore, effective drug molecules are urgently needed to fight COVID-19. Specific therapies for the SARS-COV2 virus are still being developed in several countries around the world. One of the molecular targets that is thought to be specific to SARS-COV 2 is 3CLpro or the main protease of the COVID-19 virus which is an important enzyme to be able to replicate related viruses. The purpose of this study is to explore the role of medicinal chemistry in the development of anti-sars-cov 2 drugs through the exploration of bioactive compounds from natural sources, namely green tea. Green tea (Camellia sinensis) also contains eight native monomeric catechins or polyphenolic compounds. The method used was literature review with analysis of 3 selected articles from international databases such as PubMed, ScienceDirect, and Springer, as well as SINTA accredited national journals. The results showed that all test compounds except caffein had stronger binding energy than lopinavir. Epicatecin and catechin have the same binding energy value as lopinavir, which is -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest bond among all test compounds because they have the most negative AG, namely -9.0 and 8.2 kcal/mol.
 
 

Dental and oral health problems are still a major challenge for early childhood, especially due to the lack of knowledge and skills in brushing teeth properly. This study aims to determine the effect of the snakes and ladders game as an educational method in improving the knowledge and skills of brushing teeth of early childhood at Ar-Rahimah Kindergarten, Jambi City. This study used a quantitative method with a quasi-experimental one group pretest-posttest design. The research sample was 40 Ar-Rahimah Kindergarten students. The research instruments were knowledge questionnaires and skill observation sheets. The intervention given was a snakes and ladders game that had been modified with educational content related to dental health, accompanied by a demonstration using a tooth phantom. Analysis using the Wilcoxon Signed Ranks Test showed that there was a significant effect between before and after treatment on knowledge (p = 0.000) and skills (p = 0.000). The conclusion of this study is that the snakes and ladders game media can improve the knowledge and skills of brushing teeth of early childhood. It is recommended that the use of snakes and ladders game media can be used as an innovative approach in children's dental health education.