Mercury (Hg) is illegally used in cosmetics as a skin whitener because it can inhibit the formation of melanin, but it poses health risks as it can accumulate in the body. The use of mercury-containing whitening lotions can cause serious side effects. This study aims to identify the presence of mercury in handbody lotion sold in online shops in Central Java without BPOM approval. The method used is Descriptive Qualitative with a color reaction test. The results show that out of 6 samples tested, samples A, B, C, D, and E were mercury-negative, while sample F tested positive for mercury based on two tests, namely the Rapid Test Kit and the Amalgam formation test.

Household waste is one of the major contributors to environmental problems. Waste management based on the 3Rs is an important strategy in reducing negative impacts on health and ecosystems. This study aims to review the literature on the relationship between knowledge, attitudes, and practices of the community in managing household waste based on the 3R principles. The method used was a literature study by collecting literature from Google Scholar and Science Direct. The results showed that good knowledge encourages positive attitudes and more effective waste management practices. Education, especially to housewives, is proven to increase awareness and active participation in sorting and processing waste. Successful waste management requires active community involvement, infrastructure support, and ongoing mentoring. In conclusion, the strong relationship between knowledge, attitude and practice shows the importance of an integrated approach to household waste management based on the 3R principles to create a clean, healthy and sustainable environment. The contribution of this research to science is through the review of various field studies from a number of regions in Indonesia, and emphasizes the urgency of community-based education, especially for strategic groups such as housewives. Educational efforts to increase active participation and awareness of the 3R principles can be used as a reference in designing intervention programs by both the government and non-governmental organizations.
 

Background: Atherosclerosis is a chronic inflammatory cardiovascular disorder strongly associated with elevated low-density lipoprotein cholesterol (LDL-C) levels and serves as a major predictor of adverse cardiovascular events. This study aimed to investigate the relationship between inflammatory markers (adiponectin and TNF-?) and key biochemical parameters in atherosclerosis patients. Methods:  A case-control study was conducted on 60 participants (aged 40–65 years) recruited from private cardiac clinics in Fallujah, Iraq, between October and December 2024. Subjects were stratified into two groups: 30 atherosclerosis patients (diagnosed by specialists) and 30 age-matched healthy controls. Blood samples were collected, centrifuged, and analyzed for CRP, TNF-?, adiponectin, PAI-1, MDA, GSH, sodium (Na), and magnesium (Mg) levels using standardized biochemical assays. Statistical analysis was performed using SPSS, with significance set at *p* ? 0.001. Results: Atherosclerosis patients exhibited significantly elevated serum levels of CRP (2.21 ± 14.46 vs. 1.07 ± 7.76 mg/dL), TNF-? (15.14 ± 120.86 vs. 4.27 ± 65.16 pg/mL), PAI-1 (6.52 ± 0.82 vs. 2.02 ± 0.42 ng/dL), MDA (590.26 ± 29.64 vs. 155.52 ± 25.19 ng/mL), and Na (140.16 ± 1.18 vs. 125.46 ± 6.17 nmol/L) compared to controls (*p* ? 0.001). Conversely, adiponectin (0.18 ± 1.81 vs. 0.67 ± 4.18 mg/dL), GSH (22.79 ± 1.37 vs. 40.81 ± 3.05 ?g/mL), and Mg (1.46 ± 0.175 vs. 1.84 ± 0.67 nmol/L) were markedly reduced in patients. ROC curve analysis demonstrated perfect diagnostic accuracy (AUC = 1.0) for CRP, TNF-?, and adiponectin in distinguishing patients from controls. Conclusion: The study highlights pronounced dysregulation of inflammatory, oxidative, and metabolic pathways in atherosclerosis, with CRP, TNF-?, and adiponectin serving as robust discriminative biomarkers. These findings underscore the potential of targeting these pathways for therapeutic intervention and early diagnosis.

Biochemical pathways are the complex pathways of chemical reactions vital to maintain cellular homeostasis, control metabolism and modulate responses to physiological stimuli. Recent developments in the omics technologies, gene editing tools, and systems biology have significantly deepened our understanding of these pathways, changing the scientific paradigm from linear reactions to complex and interrelated regulatory networks. This review examines the changing face of metabolic and signaling pathways including but not limited to glycolysis, TCA cycle, MAPK, PI3K/AKT and JAK/STAT and their role in health and disease. Particular attention is paid to pathway analysis innovations, including CRISPR/Cas9, single-cell and spatial transcriptomics, and computational modelling and their revolutionary effect on discovery of new drug targets and pathway specific therapeutics. In reviewing the most recent advances in cancer metabolism, immune signaling, and cross-pathway interactions, this paper emphasizes the translational promise of pathway-centric research for personalized medicine, especially in oncology, neurodegeneration, cardiovascular, and autoimmune diseases. The review attempts to bridge basic biochemical research with clinical applications, and provides a window into the manner in which pathway-based interventions are influencing the future of precision therapeutics.

Several of the best-selling small-molecule medications and natural alkaloids contain piperidine, a crucial saturated heterocyclic scaffold with a wide variety of biological functions. The hydrazide-hydrazone moiety's exceptional use in the pharmacological and biological domains made it particularly appealing. Objective: Designing and synthesizing a novel set of 4-Piperidin-1-yl-benzoic acid substituted hydrazides, Ac1-c3 and Bc1-c5, as potentially antimicrobial agents and characterizing them using IR, 1H-NMR, and mass spectroscopy. Methods: By esterifying 4- Piperidin-1-yl-benzoic acid Ac1 and then treating with hydrazine hydrate it to produce Ac3 in a good yield. The hydrazide Ac3 was condensed with the proper aldehydes or ketone to synthesis the hydrazones Bc1–c5. The in vitro bacterial activity was evaluated anti two Gram-negative bacteria, Pseudomonas aeruginosa, and Candida albicans, as well as two Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis. Results: The majority of tested compounds demonstrated significant efficacy anti Pseudomonas aeruginosa, Candida albicans. Notably, compound Bc3 emerged as the most effective derivative within the series. Conclusions: The Compounds (Bc1–c4) that were synthesized demonstrated moderate to good antimicrobial activity against a number of bacterias species and Candida albicans.

Drug packaging not only serves as a protective barrier for pharmaceutical products but also functions as a strategic element in conveying information and ensuring consumer rights. This study is a literature review of five journals that discuss packaging innovation, legal aspects of labeling, consumer protection, and packaging design from both technological and regulatory perspectives. The aim of this study is to compare the dimensions of innovation, information, and protection in drug packaging. A narrative review method with a qualitative descriptive approach was used. The results show that innovations such as the use of adsorbent plastic and efficiency in packaging systems significantly affect product stability and production speed. Meanwhile, the inclusion of composition details and halal labeling on packaging serves as a form of consumer protection from health risks and rights violations. It is concluded that a multidimensional approach to drug packaging is essential in creating a pharmaceutical distribution system that is efficient, safe, and ethical.

Anemia is a common health problem among adolescent girls, which can affect their growth and development. Thi study aims to identify factors that influence the occurrence of anemia in adolescent girls. Both biological and environmental factors contribute to anemia. The method used was a comprehensive literature review, by collecting data from various relevant sources including journals and research reports. The result emphasized the importance of knowledge about adolescent girls health, as well as lack of iron consumtion, irregular sleep patterns and long-duration or irregular menstruation, so there is a need for education n each village to reduce the risk of anemia in adolescent girls. The conclusion of this study shows that the impact of anemia  affects physical health, quality of life, productivity and social well-being. Addressing anemia should be a priority in public health policy.

Woodball was first introduced in 2006 and has since grown rapidly across the country. In addition, many woodball clubs and communities have emerged, and woodball has become an officially recognized competitive sport since 2016. In 2016, woodball even became part of the national sports week (PON) in West Java. Woodball is a sport that combines elements of golf and croquet, emphasizing the accuracy of shots to pass through the goal with a wooden ball. Hand-eye coordination is one of the key factors that can influence the quality of an athlete's shots. Objective: To determine the relationship between hand-eye coordination and shot quality in woodball athletes in Bali Province. An observational analytical study with a cross-sectional approach involving 42 woodball athletes in Bali Province. Hand-eye coordination was measured using a 30-second ball catch-and-throw test, while shot quality was assessed using a skill test based on the number of balls successfully passing through the gate. Analysis was performed using Spearman's rho correlation test. The analysis revealed a significant relationship between eye-hand coordination and swing quality in woodball athletes (P < 0.05). The positive correlation coefficient indicates that better eye-hand coordination leads to higher swing quality. There is a significant relationship between eye-hand coordination and shot quality. Improving visual-motor coordination skills can contribute to the performance of woodball athletes.

Abstract. Background: Slimming drugs, such as phentermine, are widely used for weight reduction but are known to induce oxidative stress, particularly affecting hepatic and renal tissues. Selenium nanoparticles (SeNPs), especially those biosynthesized using natural sources like spirulina platensis, have demonstrated promising antioxidant and protective activities in biological systems.
Objective: This study aimed to assess the protective effects of selenium nanoparticles synthesized from spirulina platensis extract on renal and hepatic functions in male rats exposed to phentermine induced oxidative stress.
Methods: Twenty-six adult male wistar rats were divided into five experimental groups: control group (dosed with water n=5), SeNPs group (dosed with SeNPs n=5), phentermine group (dosed with phentermine n=5), SeNPs then phentermine group (dosed with SeNPs then phentermine n=5), phentermine then SeNPs group (dosed with phentermine then SeNPs n=5). The experiment lasted for 45 days, the measurement of cytokines IL-6, IL-12, TOS and TO-AC.
Results: Phentermine administration significantly increased cytokines IL-6, IL-12 indicating marked oxidative stress and immune activation. Treatment with SeNPs alone or in combination with phentermine notably improved these parameters. The group dosed with SeNPs prior to phentermine (SeNPs then phentermine) showed the most prominent protective effects with values approaching those of the control.
Conclusions: Selenium nanoparticles from spirulina platensis demonstrated significant protective, antioxidant, and immunomodulatory effects against phentermine induced immune disturbances. These findings support their potential

Pharmaceutical packaging plays an important role in maintaining the stability, safety, and effectiveness of drug products during storage and distribution. Drug stability can be affected by various environmental factors such as temperature, humidity, oxygen, and light. Therefore, packaging innovation is a crucial strategy to extend the shelf life of drugs and maintain product quality, especially for sensitive preparations such as injections, transdermal patches, and biologics. This study is a literature review that aims to evaluate the impact of packaging innovation on the physical and chemical stability of pharmaceutical products. This study confirms that packaging selection is not just a technical aspect, but a vital strategy in ensuring pharmaceutical quality. Further research is needed to integrate smart packaging and advanced barrier technologies into modern pharmaceutical distribution systems.