Cystography examination technique with clinical Bladder Stone in the Radiology Installation of RSPAU dr. Suhardi Hardjolukito in the AnteroPosterior (AP) projection uses a perpendicular vertical beam direction. Meanwhile, according to Lampignano & Kendrick, (2018) Cystography examination in the AnteroPosterior (AP) projection, the beam direction is angled 10˚-15˚ towards the caudad. The purpose of this study was to determine the Cystography examination procedure and the role of the antero posterior (AP) projection in cystography examination with clinical bladder stone using a perpendicular beam direction to the image receptor in the Radiology Installation of RSPAU dr. Suhardi Hardjolukito. This research method uses qualitative descriptive with a case study approach. This research was conducted at the Radiology Installation of RSPAU dr. Suhardi Hardjolukito from March to May 2025. The objects in this study were patients undergoing Cystography examination, with the research subjects consisting of one patient who experienced a case of Batu Buli. After the data was reduced, the data presentation was carried out in narrative form and then reviewed with a theoretical basis so that conclusions could be drawn. The results of this study indicate that the examination procedure for Cystography with clinical Batu Buli at the Radiology Installation of RSPAU dr. Suhardi Hardjolukito includes patient preparation, preparation of tools and materials, examination techniques, and gradual injection of contrast media. The gradual administration of contrast medium is effective for monitoring the patient's condition and preventing complications such as bladder rupture. This modification of the technique demonstrates that standard procedures can be adapted while maintaining optimal diagnostic quality.

The Dayak Sanggau community practices a number of cultural traditions during pregnancy, childbirth, and the postpartum period, reflecting a blend of spiritual beliefs and medical needs. This study employed a qualitative method with a literature review (library research) approach to explore pregnancy, childbirth, and postpartum practices among the Dayak Sanggau people. The findings identified supportive practices such as spousal involvement and basic check-ups by traditional midwives, as well as potentially harmful practices including non-sterile vaginal examinations, childbirth in the kitchen area, and the use of alcoholic herbal concoctions for infants. The conclusion emphasizes the importance of understanding local culture and integrating medical education so that positive traditional practices can be preserved, while risky ones are minimized through culturally sensitive interventions.

Diabetic retinopathy is a microvascular complication that often occurs in people with type 2 diabetes mellitus and is a major cause of blindness in older adults and the elderly. This study aims to describe the characteristics of diabetic retinopathy in people with type 2 diabetes mellitus through a literature review of 10 journals published between 2022 and 2025. The results of the analysis show that the prevalence of diabetic retinopathy globally reaches 35%, with the main risk factors including long duration of diabetes (>5 years), high HbA1c levels (>7%), and poor glycemic control. The majority of cases of diabetic retinopathy are found in the non-proliferative stage (65%), which is characterized by microaneurysms and retinal hemorrhages, while the proliferative stage is less common but has a high risk of causing blindness. The study also revealed that patients with comorbidities such as hypertension and dyslipidemia tend to experience more severe diabetic retinopathy. Further stages of diabetic retinopathy if not managed properly can cause vision-threatening conditions. However, low patient compliance in metabolic control and eye examination is a major challenge. Management of diabetic retinopathy requires a holistic approach that includes patient education, regular screening, and comprehensive risk factor control to prevent progression of diabetic retinopathy and maintain the quality of life of patients with type 2 diabetes mellitus.

Stunting is a chronic nutritional problem in toddlers caused by a lack of nutritional intake for a long time so that the child becomes too short for his age. Based on the results of the Indonesian Nutrition Standards Survey (SSGI) in 2022 in Riau province, it reached 17.0%. The prevalence rate of stunting in Pekanbaru reached around 16.8% in 2022. According to the Health Office in 2022, Lima Puluh Health Center recorded the highest prevalence of stunting at 4.47% or 60 cases. One of the risk factors that contributes to stunting is the low coverage of complete basic immunization, which can prevent infectious diseases that can interfere with children's growth and development. However, the lack of public knowledge and awareness of the importance of complete basic immunization increases the risk of infection. The long-term impacts of stunting include cognitive impairment, developmental delays, and low productivity in the future. Knowing the relationship between the completeness of basic immunization and the incidence of stunting in toddlers aged 24-36 months in the Lima Puluh Health Center work area, Pekanbaru City. to determine the relationship between the completeness of basic immunization and the incidence of stunting in toddlers aged 24-36 months in the Lima Puluh Health Center work area, Pekanbaru City. From the results of data analysis, a relationship has been found between the completeness of immunization and the incidence of stunting in toddlers aged 24-36 months in the Lima Puluh Health Center work area (p-value = 0.03; OR of 11.66; (95% CI = 1.22-110.95). Completeness of basic immunization is related and is a risk factor for stunting in toddlers aged 24-36 months in the Limapuluh Health Center work area.

Coronary Heart Disease (CHD) is the leading cause of death in Indonesia. CHD is a disease caused by blockages in blood vessels (atherosclerosis) that disrupt blood flow to the heart. There are several risk factors for CHD, including smoking and hypertension. The purpose of this study was to determine the relationship between smoking and hypertension in patients with CHD. This research method uses the methodliterature review. Data were obtained from secondary data using documentation techniques. This documentation was done by searching for articles through Google Scholar and Pubmed. The selected articles were in accordance with the research variables and inclusion criteria. The articles were analyzed using the procedurecompare, contrast, criticize, synthesize, dan summarize. From the study, 3 articles were obtained that had data related to smoking and CHD variables (p < 0.05) and 3 articles that had data related to hypertension and CHD variables (p < 0.05). Conclusion: There is a significant relationship between smoking and hypertension in CHD patients.

Daun meniran dan daun kenikir adalah tanaman herbal yang bermanfaat dalam menyembuhkan luka sayat. Manfaat tersebut didukung senyawa yang terkandung didalam daun meniran dan daun kenikir yaitu saponin, flavonoid, alkaloid, tannin, steroid, terpenoid. Penelitian bertujuan untuk melihat kecepatan proses penyembuhan luka sayatan dengan menggunakan gel kombinasi ekstrak daun meniran dan daun kenikir. Hewan percobaan yang digunakan berupa tikus putih jantan, berjumlah 25 ekor dengan masing-masing kelompok perlakuan berjumlah 5 ekor yaitu kelompok kontrol positif (Bioplacenton®), kontrol negatif (basis), dan kelompok perlakuan variasi kombinasi ekstrak daun meniran : daun kenikir (10%:15%,15% :10%,20%:5%). Pengamatan dilakukan selama 14 hari, kemudian data yang didapatkan diolah dengan One Way Anova dan post hock test tukey. Hasil yang didapatkan dalam penelitian menunjukkan formula yang mampu memberikan kesembuhan luka paling cepat adalah formula 1 dengan variasi konsentrasi ekstrak daun meniran : daun kenikir 10%:15%, yaitu pada hari ke 4.

Cancer is one of the leading causes of death in the world, with the incidence rate continuing to increase every year. Conventional treatments such as chemotherapy and radiotherapy often have limitations, especially related to selectivity towards cancer cells and toxic side effects caused to normal cells. Therefore, an alternative approach that is more effective and safe is needed. One promising approach is the utilization of bioactive compounds from natural materials that are optimized through a medicinal chemistry approach. This study aims to examine the potential of natural compounds such as epigallocatechin gallate (EGCG) from green tea, berberine from Berberis vulgaris, curcumin from turmeric (Curcuma longa), and cardiotonic steroids (CTS) from Digitalis purpurea and Nerium oleander as anticancer agents, as well as their optimization strategies through structural modification, increased stability, and modern delivery technology. The method used is a systematic literature review of scientific articles from 2020 to 2025 obtained through the PubMed, ScienceDirect, and Google Scholar databases. The results of the study indicate that these compounds have various anticancer mechanisms of action, such as apoptosis induction, cell cycle inhibition, and activation of specific signaling pathways such as PI3K/Akt, MAPK, and ferroptosis. However, challenges such as low bioavailability, poor stability, and toxicity are still obstacles in their application. Through a medicinal chemistry approach, these compounds can be structurally modified or reformulated to improve their clinical effectiveness. In conclusion, the combination of natural wealth with medicinal chemistry innovation opens up great opportunities in the development of more selective, effective, and safe anticancer therapies in the future.
 
 

This study aims to analyze the Pareto distribution of stock quality in 16 Apotek Kimia Farma outlets in Southeast Sulawesi during the period of January to October 2024, with a focus on inventory management based on ABC analysis. The research employed a descriptive quantitative design with a longitudinal (time series) approach, involving descriptive, trend, comparative, and correlation analyses to evaluate stock distribution and its stability. The findings show that, overall, the stock distribution in Kimia Farma outlets follows the Pareto principle, with category A accounting for an average of 73-86% of total sales value. However, significant variations were found across outlets, with outlets such as KF 004 and KF Hasanuddin Kendari showing high stability in category A distribution, while outlets like KF BULOG and KF Kolaka exhibited greater fluctuations. Seasonal patterns were also identified, with a decrease in category A percentages in April-May and October. Based on these findings, optimizing inventory management strategies based on Pareto distribution can enhance stock management efficiency, with recommendations to focus on category A, conduct regular evaluations of categories B and C, and adjust for seasonal patterns. This study suggests the implementation of more flexible inventory management strategies for each outlet to improve operational efficiency and customer service.

Psoriasis is a chronic inflammatory disease that attacks the skin and can occur at any age with various clinical variations. The diagnosis is generally made clinically, but in atypical cases a biopsy is required for confirmation. The combination of clinical and histopathological examination provides more accurate diagnosis results. This study aims to assess the suitability of clinical diagnosis and histopathological examination results in psoriasis vulgaris in Semarang Regency. This cross-sectional observational study was conducted by the department of dermatology, venereology and aesthetics at Diponegoro University. A total of 10 samples were clinically diagnosed as psoriasis vulgaris or other morphological types of psoriasis vulgaris at a Dermatology Polyclinic in Semarang Regency, over a period of 2 years. The clinical manifestations of 10 cases with a clinical diagnosis of psoriasis vulgaris assessed from the typical predilection and the presence of scaly plaques tended to be consistent with the histopathological diagnosis but were not statistically significant. Concordance between clinical diagnosis and histopathological diagnosis was observed in 8 (80%) cases and discordance in 2 (20%) cases. Based on the research results, it can be concluded that there is a high level of agreement (80%) between clinical diagnosis and histopathological features in cases of psoriasis vulgaris.

Chronic Energy Deficiency (CED) is a manifestation of malnutrition characterized by an inadequate energy intake over a prolonged period in pregnant women, resulting in adverse health outcomes due to a relative or absolute deficiency of one or more essential nutrients. The 2023 SKI results indicate that malnutrition among pregnant women remains a problem, with nearly 3 out of 10 pregnant women experiencing anemia and 17% at risk of CED. According to data from the Jambi City Health Office, Putri Ayu Public Health Center (Puskesmas Putri Ayu) has the highest number of CED cases, with 67 affected pregnant women. The main objective of this study is to explain the underlying factors contributing to the high prevalence of Chronic Energy Deficiency (CED) and to inform the development of evidence-based health interventions aimed at reducing this condition. This study employed a quantitative research method with a case-control design. The sampling technique used was purposive total sampling, involving 78 pregnant women in the Putri Ayu Public Health Center area, Jambi City. Data collection was conducted in October 2024, using a questionnaire as the research instrument. Data were analyzed using the chi-square test. The results showed a significant relationship between CED and parity (p=0.034), anemia (p=0.013), attitude (p=0.000), and the role of health workers (p=0.000). No significant relationship was found between CED and age (p=1.000), pregnancy spacing (p=0.615), and knowledge (p=0.359) in pregnant women. The findings indicate that parity, anemia, attitude, and the role of health workers are significantly associated with the occurrence of CED in pregnant women, while age, pregnancy spacing, and knowledge are not significantly associated.