This study aims to determine the effect of interest rates on profit growth of PT Bank Rakyat Indonesia Tbk Salubarani Branch Tana Toraja Regency. The data used in this study are secondary data and use data collection procedures, especially the documentation method. The data used in this study are financial statement data of PT Bank Rakyat Indonesia Tbk Salubarani Branch, Tana Toraja Regency. The results showed that the effect of interest rates on profit growth was very influential. The higher the interest given, the higher the profit growth.