This research aims to determine the effect of rewards and work motivation on employee performance at the Andalas Health Center, Makassar City. The object of this research is the Andalas Health Center, Makassar City. Data collection methods include observation, interviews and questionnaires. The data analysis used is quantitative descriptive. The results of this research prove that rewards and work motivation have a significant positive effect on the performance of employees at the Andalas Health Center, Makassar City.