This study aims to explore the impact of supply chain automation on workers’ well-being in the sustainable industrial sector through a Systematic Literature Review (SLR) approach. The transformation driven by Industry 4.0 technologies such as artificial intelligence (AI), Internet of Things (IoT), and blockchain, has presented significant challenges and opportunities. This study identifies the impacts of automation on workers’ economic, social, and psychological aspects, including changes in skills requirements, reduction of manual employment, and its effects on mental health. In addition, this study also highlights the importance of sustainability in automation implementation, by balancing economic efficiency, environmental preservation, and social welfare. By integrating the results of studies from various literatures, this study provides recommendations for policies that support sustainability and social inclusiveness, as well as strategic guidance for industries in adopting supply chain automation sustainably.