This research aims to improve the accuracy of liver disease classification using Quantum Feature Engineering (QFE) and the Synthetic Minority Over-sampling Tech-nique and Tomek Links (SMOTE-Tomek) data balancing technique. Four machine learning models were compared in this research, namely eXtreme Gradient Boosting (XGB), Random Forest (RF), Support Vector Machine (SVM), and Logistic Regression (LR) on the Indian Liver Patient Dataset (ILPD) dataset. QFE is applied to capture correlations and complex patterns in the data, while SMOTE-Tomek is used to address data imbalances. The results showed that QFE significantly improved LR performance in terms of recall and specificity up to 99%, which is very important in medical diagnosis. The combination of QFE and SMOTE-Tomek gives the best results for the XGB method with an accuracy of 81%, recall of 90%, and f1-score of 83%. This study concludes that the use of QFE and data balancing techniques can improve liver disease classification performance in general.
