<p><strong>Abstract</strong></p><p>This study aims to uncover the relationship between <em>subjective well-being</em> and <em>burnout</em> in nurses working in the COVID-19 isolation room of dr. Doris Sylvanus Hospital. This research is quantitative research by examining the relationship between two variables or correlational. The sample in this study was 53 nurses who worked in the COVID-19 isolation room and was taken with total sampling techniques. The data collection technique consists of three psychological scales that measure <em>burnout</em>, namely MBI-HSS and two separate scales that measure <em>subjective well-being </em>such as SWLS and SPANE. Pearson's correlation test results show r = -0.620 (p < 0.05), which means that there is a significant negative relationship between <em>subjective well-being</em> and <em>burnout</em>, where the higher <em>subjective well-being</em> the lower the <em>burnout</em> in nurses working in the COVID-19 isolation room, and vice versa. An effective contribution of<em> subjective well-being</em> 38.5% affected <em>burnout</em> and 61.5% was the effect of other variables.</p><p><strong><br /></strong></p><p><strong>Abstrak</strong></p><p>Penelitian ini bertujuan untuk mengungkap hubungan antara <em>subjective well-being </em>dengan <em>burnout</em> pada perawat yang bekerja pada ruang isolasi COVID-19 RSUD dr. Doris Sylvanus. Penelitian ini merupakan penelitian kuantitatif dengan menguji hubungan di antara dua variabel atau korelasional. Sampel dalam penelitian ini merupakan 53 perawat yang bekerja pada ruang isolasi COVID-19 serta diambil dengan teknik sampling total. Teknik pengumpulan data terdiri dari tiga skala psikologi yang mengukur <em>burnout </em>yaitu MBI-HSS serta dua skala terpisah yang mengukur <em>subjective well-being</em> seperti SWLS dan SPANE. Hasil uji korelasi pearson menunjukan r = -0,620 (p < 0,05), yang memiliki arti bahwa terdapat hubungan negatif yang signifikan antara <em>subjective well-being</em> dengan <em>burnout</em>, dimana semakin tinggi <em>subjective well-being</em> maka semakin rendah <em>burnout</em> pada perawat yang bekerja pada ruang isolasi COVID-19, begitu pula dengan sebaliknya. Sumbangan efektif <em>subjective well-being</em> sebesar 38,5% memengaruhi <em>burnout</em> serta 61,5% merupakan pengaruh dari variabel-variabel lain.</p>