In the era of the industrial revolution 4.0, a skill is needed that can lead someone to success in their life. These skills are 4C skills, namely Critical Thinking, Communication, Creative Thinking, and Collaboration skills. These 4C skills are needed in the 21st century. 4C skills can be trained through learning in educational institutions. (1) Critical Thinking and Creative Thinking, can be trained with an approach that begins with problems such as with problem-based learning strategies, project-based learning, cooperative group investigation, inquiry learning which in the implementation of these strategies, is continued with challenges in the form of different ways of solving problems by looking at the problem from various perspectives. (2) Collaboration or working together can be trained through cooperative learning strategies and other learning strategies that are implemented in groups by bringing up cooperative learning values. (3) Communication can be trained through: compiling activity results reports, project assignment presentations, group/class discussions, online learning, and other activities that create interaction between students with other students, lecturers, and with other school/campus communities.