This study aims to design and produce Student Worksheets (LKPD) based on the Student Teams Achievement Division (STAD) on class XI human respiratory system material. This type of research is Research and Development (Reasearch & Development) with the ADDIE model (Analysis, Design, Development, Implementation and Evaluation). The subjects of this study were 2 material expert validator lecturers and 2 learning expert validator lecturers, the assessment of 1 biology teacher, and the responses of class XI MIPA-3 students of SMAN 1 Labuhan Deli T.A. 2022/2023. Data analysis used quantitative and qualitative descriptive analysis. The results showed that the development of STAD-based LKPD obtained validation results by material experts of 96.88% in the "very feasible" category, validation by learning experts of 90.13% in the "very feasible" category, assessment by biology teachers of 93.42 % in the "very feasible" category, the student response was 94.96% in the "very feasible" category, and the results of the effectiveness test obtained an N-gain score of 0.72 which was included in the "high" category and was considered effective in being used in the learning process biology in the material of the human respiratory system.