This study aims to address the challenges and propose solutions for the Optimization of Blockchain-Based Cybersecurity Systems to Enhance Resilience Against Ransomware Attacks using a Systematic Literature Review (SLR) approach. Blockchain is increasingly recognized as a transformative technology in cybersecurity due to its decentralized structure, transparency, and robustness in securing data. Despite these advantages, its widespread adoption is hindered by several challenges, including scalability, interoperability, high energy consumption, and limited access to representative ransomware datasets. This research highlights that integrating blockchain with advanced technologies such as data analytics, machine learning, and Explainable AI (XAI) can significantly enhance its effectiveness in combating ransomware.The findings reveal that Graph Convolutional Neural Networks (GCN) enable real-time detection of ransomware patterns in network traffic with an accuracy of up to 95%. Furthermore, Layer-2 solutions like the Lightning Network and sharding effectively alleviate the load on main blockchains, thereby increasing transaction throughput. Efficient consensus mechanisms, including Proof of Stake (PoS) and Delegated Proof of Stake (DPoS), address energy consumption issues, making blockchain more adaptable to IoT and resource-constrained environments. These approaches have proven successful in enabling early detection, mitigation, and prevention of ransomware in IoT systems, cloud infrastructures, and smart grid networks. The implications of this study underscore the potential of blockchain as a critical component of proactive and adaptive cybersecurity systems. However, overcoming existing challenges requires further development of hybrid frameworks that integrate blockchain with data analytics and machine learning technologies. In addition, efforts should focus on standardizing global security protocols to enhance interoperability and creating robust, diverse ransomware datasets to support more accurate detection systems. Future research should also explore methods to minimize latency and improve blockchain efficiency in real-time cybersecurity applications.